Research Topics
Species | James M CrawfordSummaryAffiliation: University of Florida Country: USA Publications
| Collaborators
|
Detail Information
Publications
The origins of bladder cancerJames M Crawford
Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL 32610 0275, USA
Lab Invest 88:686-93. 2008..Effort must now be given to identifying the biological function of these novel FR genes...
Original research in pathology: judgment, or evidence-based medicine?James M Crawford
Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL 32610 0275, USA
Lab Invest 87:104-14. 2007..The ability of clinical faculty in academic departments of pathology to pursue original scholarship must be supported if our specialty is to retain its preeminence as an investigative scientific discipline in the age of EBM...- Evidence-based interpretation of liver biopsiesJames M Crawford
Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA
Lab Invest 86:326-34. 2006..The remainder of our discipline rests predominantly upon the time-honored identification of disease process through the publication of narrative case series... - Pathology as the enabler of human researchJames M Crawford
Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL 32610 0275, USA
Lab Invest 85:1058-64. 2005..It is our earnest hope that Academic Pathology can play a leading role in the remarkable advances to be made as the 21st century unfolds... - Development of the intrahepatic biliary treeJames M Crawford
Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida 32610 0275, USA
Semin Liver Dis 22:213-26. 2002..Thus, from the earliest time of hepatocellular bile formation beginning around the 12th week, there is a patent passage to the alimentary canal... - Adeno-associated virus-mediated IL-10 gene therapy inhibits diabetes recurrence in syngeneic islet cell transplantation of NOD miceY Clare Zhang
Department of Pathology, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610-0275, USA
Diabetes 52:708-16. 2003..These studies support the utility of immunoregulatory cytokine gene therapy delivered by rAAV for preventing autoimmune disease recurrence in transplant-based therapies for type 1 diabetes... - Sustained viral response to interferon and ribavirin in liver transplant recipients with recurrent hepatitis CManal F Abdelmalek
Department of Medicine, Section of Hepatobiliary Diseases University of Florida, Gainesville, FL 32610 0214, USA
Liver Transpl 10:199-207. 2004..05). In conclusion, loss of HCV after treatment of recurrent chronic hepatitis C with interferon and ribavirin is durable, and the durability of the SVR is associated with improvement in hepatic inflammation and regression of fibrosis... - Hepatitis C virus triggers apoptosis of a newly developed hepatoma cell line through antiviral defense systemHaizhen Zhu
Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida, USA
Gastroenterology 133:1649-59. 2007..However, the interaction between HCV and hepatocyte innate antiviral defense systems is not understood. The aim of this study was to examine how human hepatocytes respond to HCV infection... - Defective Jak-Stat activation in hepatoma cells is associated with hepatitis C viral IFN-alpha resistanceHaizhen Zhu
Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, 32610, USA
J Interferon Cytokine Res 25:528-39. 2005..Our study implies that long-term IFN stimulation in vitro selects cells that exhibit alterations in the host Jak-Stat signaling pathway, thereby representing a potential mechanism by which HCV resists IFN therapy... - One-year protocol liver biopsy can stratify fibrosis progression in liver transplant recipients with recurrent hepatitis C infectionRoberto J Firpi
Division of Gastroenterology, Hepatology, and Nutrition Section of Hepatobiliary Diseases, University of Florida, Gainesville, FL 32610 0214, USA
Liver Transpl 10:1240-7. 2004..A liver biopsy performed at 1 year posttransplant can help identify those patients more likely to develop progressive disease and may allow better targeting of antiviral therapy... - Therapeutic level of functional human alpha 1 antitrypsin (hAAT) secreted from murine muscle transduced by adeno-associated virus (rAAV1) vectorYuanqing Lu
Department of Pharmaceutics, University of Florida College of Pharmacy, Gainesville, FL 32610, USA
J Gene Med 8:730-5. 2006..These results provide strong support for the functionality of AAT in ongoing clinical studies of muscle-directed AAT gene therapy... - Gene expression associated with interferon alfa antiviral activity in an HCV replicon cell lineHaizhen Zhu
Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville 32610, USA
Hepatology 37:1180-8. 2003..Our results also suggest that IFN-alpha-induced target genes may play an important role in IFN-alpha anti-HCV activity... - The antigen for Hep Par 1 antibody is the urea cycle enzyme carbamoyl phosphate synthetase 1Samantha L Butler
Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL 32610, USA
Lab Invest 88:78-88. 2008..In conclusion, we have identified the antigen for Hep Par 1 antibody as a urea cycle enzyme CPS1. Our results should encourage further investigation of potential role that CPS1 expression plays in liver pathobiology and carcinogenesis... - The pathology of cholestasisMelissa K Li
University of Florida College of Medicine, Gainesville, Florida 32610-0275, USA
Semin Liver Dis 24:21-42. 2004..Most of the histological features of cholestasis are nonspecific. Hence, both practicing physician and pathologist should have sound knowledge of the pathology of cholestasis... - Glucose-responsive expression of the human insulin promoter in HepG2 human hepatoma cellsBrant R Burkhardt
Department of Pathology, University of Florida, Gainesville, Florida 32610, USA
Ann N Y Acad Sci 1005:237-41. 2003..Our results suggest that the human insulin promoter represents a strong candidate as a robust, glucose-responsive promoter for regulated hepatic insulin production... - Hepatic oval (stem) cell expression of endothelial differentiation gene receptors for lysophosphatidic acid in mouse chronic liver injuryYuri Y Sautin
Department of Pathology, Immunology and Laboratory Medicine, Hepatobiliary Program, University of Florida, Gainesville, FL 32610, USA
J Hematother Stem Cell Res 11:643-9. 2002..As a result, LPA and its analogs may represent critical endogenous mediators, which regulate survival, increase motility, and modulate proliferation and differentiation of hepatocyte progenitors in regenerating liver... - Early histologic changes in fibrosing cholestatic hepatitis CLisa R Dixon
University of Florida, College of Medicine, Department of Pathology, Immunology, and Laboratory Medicine, Gainesville, FL 32610 0275, USA
Liver Transpl 13:219-26. 2007..When studying the evolution of these cases, the first abnormality to appear is RHCV and cholestasis, fibrosis develops soon after, and both continue to worsen until the point of allograft failure or patient death... - Hepatocellular carcinoma arising from ectopic liver tissue in the pancreasDiana Cardona
Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, 1600 SW Archer Road, Gainesville, FL 32610, USA
Virchows Arch 450:225-9. 2007..These results support that this tumor in the pancreas is hepatocellular carcinoma, most likely arising from ectopic liver tissue within the pancreas... - Radiation pneumonitis in mice: a severe injury model for pneumocyte engraftment from bone marrowNeil D Theise
Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
Exp Hematol 30:1333-8. 2002..To better understand the process by which pneumocytes can be derived from bone marrow cells, we investigated the in vivo kinetics of such engraftment following lethal irradiation... - Hepatitic inherited metabolic disordersMay Arroyo
University of Florida College of Medicine, Gainesville, Florida 32610-0275, USA
Semin Diagn Pathol 23:182-9. 2006..Distinguishing features include absence of elevated serum gamma-glutamyl transpeptidase (GGT) in PFIC-1 and PFIC-2, and elevated GGT in PFIC-3. However, molecular studies are required for a confident diagnosis of the rare PFIC syndromes... - Total fibrous obliteration of main portal vein and portal foam cell venopathy in chronic hepatic allograft rejectionDhanpat Jain
Department of Pathology, Yale University School of Medicine, New Haven, CT 06520 8023, USA
Arch Pathol Lab Med 128:64-7. 2004..Chronic hepatic allograft rejection is characterized by arteriopathy and bile duct loss. Pathology of the portal vein or its branches is not considered to play a major role in chronic rejection... - Adeno-associated virus transduction of islets with interleukin-4 results in impaired metabolic function in syngeneic marginal islet mass transplantationY Clare Zhang
Department of Pathology, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610, USA
Transplantation 74:1184-6. 2002..Islet expression of IL-4 led to impaired metabolic function in mice receiving a marginal mass of syngeneic islets... - EDG receptors and hepatic pathophysiology of LPA and S1P: EDG-ology of liver injuryStanislav I Svetlov
Department of Pathology, University of Florida College of Medicine, 1600 Archer Rd, P O Box 100275, Gainesville FL 32610, USA
Biochim Biophys Acta 1582:251-6. 2002..The underlying mechanisms recruited by LPA and S1P in pathogenesis of liver injury remain to be investigated... - Validation of novel optical imaging technologies: the pathologists' viewWendy A Wells
Dartmouth Medical School, Department of Pathology, 1 Rope Ferry Road, Hanover, New Hampshire 03755, USA
J Biomed Opt 12:051801. 2007.... - Combination of interferon alfa-2b and ribavirin in liver transplant recipients with histological recurrent hepatitis CRoberto J Firpi
Department of Medicine, Section of Hepatobiliary Diseases, University of Florida, Gainesville, FL 32610, USA
Liver Transpl 8:1000-6. 2002..In summary, combination therapy is a reasonable antiviral option for recurrent HCV infection for established post-LT hepatitis and appears to prevent histological progression of disease if viral eradication is successful... - The impact of review articlesCatherine M Ketcham
Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, PO Box 100275, Gainesville, FL 32610 0275, USA
Lab Invest 87:1174-85. 2007..These data are presented with the hope that authors and editors will carefully consider their respective roles in ensuring that the body of review literature will be of maximum benefit to the scientific and biomedical community... - Cholesterol crystal morphology in acalculous gallbladder diseaseKristin Landi
Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA
J Clin Gastroenterol 36:364-6. 2003..CONCLUSIONS: Birefringent needles and dots should be recognized as cholesterol crystals during bile microscopy. These crystal morphologies may predominate in some patients with a clinical diagnosis of acalculous gallbladder disease... - Utilization of acidophil bodies in the diagnosis of recurrent hepatitis C infection after orthotopic liver transplantationRomil Saxena
Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
Mod Pathol 15:897-903. 2002..Lobular inflammation was not a reliable indicator of the initial onset of RHCV... - Adequacy of pathology resident training for employment: a survey report from the Future of Pathology Task GroupMary E Kass
College of American Pathologists, Northfield, Ill, USA
Arch Pathol Lab Med 131:545-55. 2007.... - A clinical and histopathologic perspective on evolving noninvasive and invasive alternatives for liver biopsyDirk J van Leeuwen
Section of Gastroenterology and Hepatology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Hanover, New Hampshire 03756, USA
Clin Gastroenterol Hepatol 6:491-6. 2008.... 
Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopyPei Lin Hsiung
Department of Pediatrics, Radiology and Microbiology and Immunology, Stanford University School of Medicine, 318 Campus Dr, Rm E 150, Stanford, California 94305, USA
Nat Med 14:454-8. 2008..This methodology represents a promising diagnostic imaging approach for the early detection of colorectal cancer and potentially of other epithelial malignancies...- Can impact factor data be trusted?Catherine M Ketcham
Lab Invest 88:340-1. 2008 - Donor T cell-derived TNF is required for graft-versus-host disease and graft-versus-tumor activity after bone marrow transplantationCornelius Schmaltz
Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
Blood 101:2440-5. 2003..We could not detect TNF in the serum of our transplant recipients, suggesting that T cells contribute to GVHD and GVL via membrane-bound or locally released TNF... - Dr Stanley RobbinsJames M Crawford
Lab Invest 84:393. 2004 - Detection of endogenous biomolecules in Barrett's esophagus by Fourier transform infrared spectroscopyThomas D Wang
Division of Gastroenterology, Stanford University School of Medicine, Palo Alto Veterans Affairs Health Care System, Palo Alto, CA 94304, USA
Proc Natl Acad Sci U S A 104:15864-9. 2007.... - Nomenclature of the finer branches of the biliary tree: canals, ductules, and ductular reactions in human liversTania A Roskams
Department of Pathology, University Hospitals, University of Leuven, Leuven, Belgium
Hepatology 39:1739-45. 2004....