F Crawford

Summary

Affiliation: University of South Florida
Country: USA

Publications

  1. ncbi The alpha-2 macroglobulin gene is not associated with Alzheimer's disease in a case-control sample
    F Crawford
    Roskamp Institute, University of South Florida, Tampa 33613, USA
    Neurosci Lett 270:133-6. 1999
  2. ncbi Gender-specific association of the angiotensin converting enzyme gene with Alzheimer's disease
    F Crawford
    Roskamp Institute, University of South Florida, 3515 E Fletcher Avenue, Tampa, FL 336113, USA
    Neurosci Lett 280:215-9. 2000
  3. ncbi No genetic association between polymorphisms in the Tau gene and Alzheimer's disease in clinic or population based samples
    F Crawford
    Roskamp Institute, University of South Florida, Tampa 33613, USA
    Neurosci Lett 266:193-6. 1999
  4. ncbi A polymorphism in the cystatin C gene is a novel risk factor for late-onset Alzheimer's disease
    F C Crawford
    Roskamp Institute University of South Florida, Tampa, FL 33613, USA
    Neurology 55:763-8. 2000
  5. ncbi Alzheimer's beta-amyloid vasoactivity: identification of a novel beta-amyloid conformational intermediate
    F Crawford
    Roskamp Institute, University of South Florida, Tampa 33613, USA
    FEBS Lett 436:445-8. 1998
  6. ncbi Characteristics of the in vitro vasoactivity of beta-amyloid peptides
    F Crawford
    Roskamp Laboratory, Department of Psychiatry, University of South Florida, Tampa 33613, USA
    Exp Neurol 150:159-68. 1998
  7. ncbi Activation of microglial cells by the CD40 pathway: relevance to multiple sclerosis
    J Tan
    The Roskamp Institute, Department of Psychiatry, University of South Florida, Tampa 33613, USA
    J Neuroimmunol 97:77-85. 1999
  8. ncbi Alzheimers disease is not associated with the hypertension genetic risk factors PLA(2) or G protein beta3, either independently or interactively with apolipoprotein E
    T Town
    The Roskamp Institute, Department of Psychiatry, University of South Florida, Tampa, Florida 33613, USA
    Am J Med Genet 88:465-8. 1999
  9. ncbi No association between the low density lipoprotein receptor-related protein (LRP) gene and late-onset Alzheimer's disease in a community-based sample
    D Fallin
    Department of Psychiatry, University of South Florida, Tampa 33613, USA
    Neurosci Lett 233:145-7. 1997
  10. ncbi Role of peroxynitrite in the vasoactive and cytotoxic effects of Alzheimer's beta-amyloid1-40 peptide
    D Paris
    Department of Psychiatry, University of South Florida, 3515 East Fletcher Avenue, Tampa, Florida, 33613, USA
    Exp Neurol 152:116-22. 1998

Collaborators

Detail Information

Publications25

  1. ncbi The alpha-2 macroglobulin gene is not associated with Alzheimer's disease in a case-control sample
    F Crawford
    Roskamp Institute, University of South Florida, Tampa 33613, USA
    Neurosci Lett 270:133-6. 1999
    ..In a subset of our larger sample we have also investigated the A2M Val1000lle polymorphism, and again find no evidence for association. We conclude that there is no genetic association between A2M and AD in our case-control sample...
  2. ncbi Gender-specific association of the angiotensin converting enzyme gene with Alzheimer's disease
    F Crawford
    Roskamp Institute, University of South Florida, 3515 E Fletcher Avenue, Tampa, FL 336113, USA
    Neurosci Lett 280:215-9. 2000
    ..However, the results may also be a consequence of the known anomalies that arise in genetic association studies as a consequence of sample selection...
  3. ncbi No genetic association between polymorphisms in the Tau gene and Alzheimer's disease in clinic or population based samples
    F Crawford
    Roskamp Institute, University of South Florida, Tampa 33613, USA
    Neurosci Lett 266:193-6. 1999
    ..Therefore our data do not suggest any association between these variations in the Tau gene and Alzheimer's disease...
  4. ncbi A polymorphism in the cystatin C gene is a novel risk factor for late-onset Alzheimer's disease
    F C Crawford
    Roskamp Institute University of South Florida, Tampa, FL 33613, USA
    Neurology 55:763-8. 2000
    ..To investigate whether or not a coding polymorphism in the cystatin C gene (CST3) contributes risk for AD...
  5. ncbi Alzheimer's beta-amyloid vasoactivity: identification of a novel beta-amyloid conformational intermediate
    F Crawford
    Roskamp Institute, University of South Florida, Tampa 33613, USA
    FEBS Lett 436:445-8. 1998
    ..This is the first time that A beta conformational intermediates have been identified and a biological activity associated with them...
  6. ncbi Characteristics of the in vitro vasoactivity of beta-amyloid peptides
    F Crawford
    Roskamp Laboratory, Department of Psychiatry, University of South Florida, Tampa 33613, USA
    Exp Neurol 150:159-68. 1998
    ..The disruptive and degenerative effects of such a cycle would lead to the complete destruction of cerebral vessels and consequently neuronal degeneration in the affected areas...
  7. ncbi Activation of microglial cells by the CD40 pathway: relevance to multiple sclerosis
    J Tan
    The Roskamp Institute, Department of Psychiatry, University of South Florida, Tampa 33613, USA
    J Neuroimmunol 97:77-85. 1999
    ....
  8. ncbi Alzheimers disease is not associated with the hypertension genetic risk factors PLA(2) or G protein beta3, either independently or interactively with apolipoprotein E
    T Town
    The Roskamp Institute, Department of Psychiatry, University of South Florida, Tampa, Florida 33613, USA
    Am J Med Genet 88:465-8. 1999
    ..These results do not support a shared genetic etiology between hypertension and AD. Possibly, a clinical association between these diseases could be due to pathophysiologic interactions...
  9. ncbi No association between the low density lipoprotein receptor-related protein (LRP) gene and late-onset Alzheimer's disease in a community-based sample
    D Fallin
    Department of Psychiatry, University of South Florida, Tampa 33613, USA
    Neurosci Lett 233:145-7. 1997
    ..Further, despite the biochemical relationship between LRP and the ApoE protein, we find no significant statistical interaction between the alleles at these loci...
  10. ncbi Role of peroxynitrite in the vasoactive and cytotoxic effects of Alzheimer's beta-amyloid1-40 peptide
    D Paris
    Department of Psychiatry, University of South Florida, 3515 East Fletcher Avenue, Tampa, Florida, 33613, USA
    Exp Neurol 152:116-22. 1998
    ..However, compounds that clear free radicals intracellularly may well be beneficial...
  11. ncbi The -491A/T apolipoprotein E promoter polymorphism association with Alzheimer's disease: independent risk and linkage disequilibrium with the known APOE polymorphism
    T Town
    Roskamp Laboratories, University of South Florida, Department of Psychiatry, Tampa 33613, USA
    Neurosci Lett 252:95-8. 1998
    ..Furthermore, when considering the known APOE and -491A/T polymorphisms alone, APOE epsilon4 status is the best predictor of the disease...
  12. ncbi Soluble Alzheimers beta-amyloid constricts the cerebral vasculature in vivo
    Z Suo
    Roskamp Institute, University of South Florida, Tampa 33613, USA
    Neurosci Lett 257:77-80. 1998
    ..These data suggest that Abeta has a direct and specific constrictive effect on cerebral vessels in vivo, which may contribute to the cerebral hypoperfusion observed early in the AD process...
  13. ncbi Confirmation of association between D10S583 and Alzheimer's disease in a case--control sample
    G Ait-Ghezala
    Roskamp Institute, University of South Florida, 3515 E Fletcher Avenue, Tampa, FL 33613, USA
    Neurosci Lett 325:87-90. 2002
    ..The ongoing investigation of the genetic source of association and linkage in this region is clearly warranted...
  14. ncbi Inhibition of Alzheimer's beta-amyloid induced vasoactivity and proinflammatory response in microglia by a cGMP-dependent mechanism
    D Paris
    The Roskamp Institute, University of South Florida, 3515 East Fletcher Avenue, Tampa, Florida 33613, USA
    Exp Neurol 157:211-21. 1999
    ..Our results suggest that therapeutic intervention aimed at reduction of microglial-mediated inflammation via inhibition of cGMP-PDE or elevation of cGMP may be beneficial in the treatment of AD...
  15. ncbi CD45 opposes beta-amyloid peptide-induced microglial activation via inhibition of p44/42 mitogen-activated protein kinase
    J Tan
    The Roskamp Institute, Department of Psychiatry, University of South Florida, Tampa, Florida 33613, USA
    J Neurosci 20:7587-94. 2000
    ..Taken together, these results suggest that therapeutic agents that stimulate the CD45 PTP signaling pathway may be effective in suppressing microglial activation associated with AD...
  16. ncbi Association of a functional mu-opioid receptor allele (+118A) with alcohol dependency
    T Town
    The Roskamp Institute, University of South Florida, Tampa, Florida 33613, USA
    Am J Med Genet 88:458-61. 1999
    ..These results suggest that, at the molecular level, the endogenous mu-opioid receptor system is a contributing factor to the etiology of alcoholism...
  17. ncbi Alzheimer's beta-amyloid peptides induce inflammatory cascade in human vascular cells: the roles of cytokines and CD40
    Z Suo
    Roskamp Institute, 3515 E Fletcher Avenue, University of South Florida, Tampa, FL 33613, USA
    Brain Res 807:110-7. 1998
    ..Collectively, these findings support the hypothesis that the Abeta-induced inflammatory responses in vascular cells may play a significant role in the pathogenesis of CAA and AD...
  18. ncbi A beta vasoactivity in vivo
    Z Suo
    Roskamp Institute, Tampa, Florida 33613, USA
    Ann N Y Acad Sci 903:156-63. 2000
    ..These data suggest that A beta has a direct and specific constrictive effect on cerebral vessels in vivo, which may contribute to the cerebral hypoperfusion observed early in the AD process...
  19. ncbi Cholesterol accumulates in senile plaques of Alzheimer disease patients and in transgenic APP(SW) mice
    T Mori
    Roskamp Institute, University of South Florida, Tampa, 33613, USA
    J Neuropathol Exp Neurol 60:778-85. 2001
    ..Taken together, our results imply a link between cholesterol and AD pathogenesis and suggest that cholesterol plays an important role in the formation and/or progression of senile plaques...
  20. ncbi Microglial activation resulting from CD40-CD40L interaction after beta-amyloid stimulation
    J Tan
    The Roskamp Institute, University of South Florida, 3515 East Fletcher Avenue, Tampa, FL 33613, USA
    Science 286:2352-5. 1999
    ..Finally, abnormal tau phosphorylation was reduced in Tg APPsw animals deficient for CD40L, suggesting that the CD40-CD40L interaction is an early event in AD pathogenesis...
  21. doi Apolipoprotein E-genotype dependent hippocampal and cortical responses to traumatic brain injury
    F Crawford
    Roskamp Institute, Sarasota, FL 34243, USA
    Neuroscience 159:1349-62. 2009
    ....
  22. ncbi The microtubule associated protein Tau gene and Alzheimer's disease--an association study and meta-analysis
    C Russ
    Department of Neuroscience, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Neurosci Lett 314:92-6. 2001
    ....
  23. ncbi Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene
    M C Chartier-Harlin
    Department of Biochemistry, St Mary s Hospital Medical School, Imperial College, London, UK
    Nature 353:844-6. 1991
    ..The occurrence of a second allelic variant at codon 717 linked to the Alzheimer's phenotype supports the hypothesis that they are pathogenic mutations...
  24. ncbi Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
    A Goate
    Department of Biochemistry, St Mary s Hospital Medical School, London, UK
    Nature 349:704-6. 1991
    ..Screening other cases of familial AD revealed a second unrelated family in which this variant occurs. This suggests that some cases of AD could be caused by mutations in the APP gene...
  25. ncbi A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid
    M Mullan
    Alzheimer s Disease Research Laboratories, Suncoast Gerontology Center, Tampa, Florida
    Nat Genet 1:345-7. 1992
    ..This mutation occurs at the amino terminal of beta-amyloid and may be pathogenic because it occurs at or close to the endosomal/lysosomal cleavage site of the molecule. Thus, pathogenic mutations in APP frame the beta-amyloid sequence...