Dana C Crawford

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint The patterns of natural variation in human genes
    Dana C Crawford
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
    Annu Rev Genomics Hum Genet 6:287-312. 2005
  2. pmc Haplotype diversity across 100 candidate genes for inflammation, lipid metabolism, and blood pressure regulation in two populations
    Dana C Crawford
    Department of Genome Sciences, University of Washington, Seattle 98195 7730, USA
    Am J Hum Genet 74:610-22. 2004
  3. ncbi request reprint Definition and clinical importance of haplotypes
    Dana C Crawford
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
    Annu Rev Med 56:303-20. 2005
  4. pmc Allelic spectrum of the natural variation in CRP
    Dana C Crawford
    Department of Genome Sciences, University of Washington, 1705 NE Pacific, Seattle, WA 98195 7730, USA
    Hum Genet 119:496-504. 2006
  5. pmc Genetic risk factors for BMI and obesity in an ethnically diverse population: results from the population architecture using genomics and epidemiology (PAGE) study
    Megan D Fesinmeyer
    Department of Biostatistics and Biomathematics, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Obesity (Silver Spring) 21:835-46. 2013
  6. pmc Genetic variation associated with circulating monocyte count in the eMERGE Network
    David R Crosslin
    Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA, USA
    Hum Mol Genet 22:2119-27. 2013
  7. ncbi request reprint Genetic variation is associated with C-reactive protein levels in the Third National Health and Nutrition Examination Survey
    Dana C Crawford
    Department of Genome Sciences, University of Washington, Seattle, USA
    Circulation 114:2458-65. 2006
  8. pmc Identifying host genetic risk factors in the context of public health surveillance for invasive pneumococcal disease
    Jairam R Lingappa
    Department of Global Health, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 6:e23413. 2011
  9. pmc Imputation of coding variants in African Americans: better performance using data from the exome sequencing project
    Qing Duan
    Department of Genetics and Department of Computer Science, University of North Carolina, Chapel Hill, NC 27599, USA, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA, Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA, Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA, Renaissance Computing Institute, University of North Carolina, Chapel Hill, NC 27599, USA, Department of Statistics and Department of Genetics, Rutgers University, Piscataway, NJ 08854, USA, Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA, Department of Epidemiology, University of Washington, Seattle, WA 98195, USA, Division of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA, Department of Epidemiology and Medicine, University of Iowa, Iowa City, IA 52242, Division of Cardiology, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA, Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, France
    Bioinformatics 29:2744-9. 2013
  10. pmc Pattern of sequence variation across 213 environmental response genes
    Robert J Livingston
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195 7730, USA
    Genome Res 14:1821-31. 2004

Detail Information

Publications22

  1. ncbi request reprint The patterns of natural variation in human genes
    Dana C Crawford
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
    Annu Rev Genomics Hum Genet 6:287-312. 2005
    ..Therefore, many different approaches may be required to identify the elusive genotypes associated with common human phenotypes...
  2. pmc Haplotype diversity across 100 candidate genes for inflammation, lipid metabolism, and blood pressure regulation in two populations
    Dana C Crawford
    Department of Genome Sciences, University of Washington, Seattle 98195 7730, USA
    Am J Hum Genet 74:610-22. 2004
    ....
  3. ncbi request reprint Definition and clinical importance of haplotypes
    Dana C Crawford
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
    Annu Rev Med 56:303-20. 2005
    ..Finally, we discuss the latest concepts for the analysis of haplotypes related to human disease, including haplotype blocks, the International HapMap Project, and the future directions of these resources...
  4. pmc Allelic spectrum of the natural variation in CRP
    Dana C Crawford
    Department of Genome Sciences, University of Washington, 1705 NE Pacific, Seattle, WA 98195 7730, USA
    Hum Genet 119:496-504. 2006
    ..Collectively, these data suggest that several different types re-sequencing and genotyping approaches may be required to fully understand the complete spectrum of alleles that impact human phenotypes...
  5. pmc Genetic risk factors for BMI and obesity in an ethnically diverse population: results from the population architecture using genomics and epidemiology (PAGE) study
    Megan D Fesinmeyer
    Department of Biostatistics and Biomathematics, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Obesity (Silver Spring) 21:835-46. 2013
    ..However, studies of this complex trait have focused on ancestrally European populations, despite the high prevalence of obesity in some minority groups...
  6. pmc Genetic variation associated with circulating monocyte count in the eMERGE Network
    David R Crosslin
    Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA, USA
    Hum Mol Genet 22:2119-27. 2013
    ..68×10(-17), β = -0.23) at the integrin, alpha 4 gene on chromosome 2. The novel IRF8 results and further replications provide supporting evidence of genetic regions associated with monocyte count...
  7. ncbi request reprint Genetic variation is associated with C-reactive protein levels in the Third National Health and Nutrition Examination Survey
    Dana C Crawford
    Department of Genome Sciences, University of Washington, Seattle, USA
    Circulation 114:2458-65. 2006
    ..Increased serum C-reactive protein (CRP) is an independent risk factor for cardiovascular disease. Previous studies have suggested that genetic variation within the CRP gene is associated with serum CRP...
  8. pmc Identifying host genetic risk factors in the context of public health surveillance for invasive pneumococcal disease
    Jairam R Lingappa
    Department of Global Health, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 6:e23413. 2011
    ....
  9. pmc Imputation of coding variants in African Americans: better performance using data from the exome sequencing project
    Qing Duan
    Department of Genetics and Department of Computer Science, University of North Carolina, Chapel Hill, NC 27599, USA, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA, Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA, Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA, Renaissance Computing Institute, University of North Carolina, Chapel Hill, NC 27599, USA, Department of Statistics and Department of Genetics, Rutgers University, Piscataway, NJ 08854, USA, Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA, Department of Epidemiology, University of Washington, Seattle, WA 98195, USA, Division of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA, Department of Epidemiology and Medicine, University of Iowa, Iowa City, IA 52242, Division of Cardiology, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA, Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, France
    Bioinformatics 29:2744-9. 2013
    ..We recommend using haplotypes from Exome Sequencing Project alone or concatenation of the two panels over quality score-based post-imputation selection or IMPUTE2's two-panel combination...
  10. pmc Pattern of sequence variation across 213 environmental response genes
    Robert J Livingston
    Department of Genome Sciences, University of Washington, Seattle, Washington 98195 7730, USA
    Genome Res 14:1821-31. 2004
    ..The implications for the use of these data in direct and indirect association studies of environmentally induced diseases are discussed...
  11. pmc Effects of smoking on the genetic risk of obesity: the population architecture using genomics and epidemiology study
    Megan D Fesinmeyer
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    BMC Med Genet 14:6. 2013
    ..Although smoking behavior is known to affect body mass index (BMI), the potential for smoking to influence genetic associations with BMI is largely unexplored...
  12. pmc Genetic variants associated with the white blood cell count in 13,923 subjects in the eMERGE Network
    David R Crosslin
    Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA 98195, USA
    Hum Genet 131:639-52. 2012
    ..Variants in this region have been reported to be associated with WBC, neutrophil count, and inflammatory diseases including asthma and Crohn's disease...
  13. ncbi request reprint Evidence for substantial fine-scale variation in recombination rates across the human genome
    Dana C Crawford
    Department of Genome Sciences, University of Washington, Box 354322, Seattle, Washington 98195, USA
    Nat Genet 36:700-6. 2004
    ..No primary sequence characteristics are consistently associated with precise hot-spot location, although G+C content and nucleotide diversity are correlated with local recombination rate...
  14. ncbi request reprint Single nucleotide polymorphism discovery in TBX1 in individuals with and without 22q11.2 deletion syndrome
    Carrie L Heike
    Department of Pediatrics, Division of Craniofacial Medicine, University of Washington and Seattle Children s Hospital, Seattle, Washington 98105 5371, USA
    Birth Defects Res A Clin Mol Teratol 88:54-63. 2010
    ..The purpose of this study was to further characterize the sequence variability in TBX1 by identifying all common SNPs in this gene...
  15. pmc LPA and PLG sequence variation and kringle IV-2 copy number in two populations
    Dana C Crawford
    Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University, Nashville, TN 37232, USA
    Hum Hered 66:199-209. 2008
    ..African-descent populations have, on average, higher levels of Lp(a), suggesting other genetic factors contribute to Lp(a) level variability across populations...
  16. ncbi request reprint A common VLDLR polymorphism interacts with APOE genotype in the prediction of carotid artery disease risk
    Dana C Crawford
    Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University, Nashville, TN, USA
    J Lipid Res 49:588-96. 2008
    ..These findings may further our understanding of VLDLR function, its ligand APOE, and ultimately the pathogenesis of CAAD in the general population...
  17. ncbi request reprint Problems with genome-wide association studies
    Scott M Williams
    Science 316:1840-2. 2007
  18. ncbi request reprint Characterization of beta-globin haplotypes using blood spots from a population-based cohort of newborns with homozygous HbS
    Dana C Crawford
    National Center on Birth Defects and Developmental Disabilities, Division of Applied Public Health Training, Epidemiology Program Office, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Genet Med 4:328-35. 2002
    ..A population-based cohort from three state newborn screening programs was used to describe beta-globin gene cluster variation...
  19. pmc Integrating host genomics with surveillance for invasive bacterial diseases
    Dana C Crawford
    Vanderbilt University, Nashville, Tennessee, USA
    Emerg Infect Dis 14:1138-40. 2008
    ..Using nDBS specimens, we resequenced CD46, putative host gene receptor for Neisseria meningitidis, and identified variants associated with susceptibility to this disease...
  20. pmc Identifying the genotype behind the phenotype: a role model found in VKORC1 and its association with warfarin dosing
    Dana C Crawford
    Vanderbilt University, Center for Human Genetics Research, 519 Light Hall, Nashville, TN 37232, USA
    Pharmacogenomics 8:487-96. 2007
    ..These future avenues will be best explored using diverse approaches encompassing clinical, statistical and genomic methods currently being developed for genotype-phenotype studies in human populations...
  21. ncbi request reprint Prevalence of the fragile X syndrome in African-Americans
    Dana C Crawford
    Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Med Genet 110:226-33. 2002
    ..Further population-based studies in diverse populations are necessary to explore the possibility that the prevalence of the fragile X syndrome differs among world populations...
  22. pmc Paternally transmitted FMR1 alleles are less stable than maternally transmitted alleles in the common and intermediate size range
    Amy K Sullivan
    Department of Human Genetics, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
    Am J Hum Genet 70:1532-44. 2002
    ..This difference that depends on repeat size suggests either a different mutational mechanism of instability or an increase in selection against sperm as their repeat size increases...