Genomes and Genes
Dana C Crawford
Affiliation: University of Washington
- The patterns of natural variation in human genesDana C Crawford
Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
Annu Rev Genomics Hum Genet 6:287-312. 2005..Therefore, many different approaches may be required to identify the elusive genotypes associated with common human phenotypes...
- Haplotype diversity across 100 candidate genes for inflammation, lipid metabolism, and blood pressure regulation in two populationsDana C Crawford
Department of Genome Sciences, University of Washington, Seattle 98195 7730, USA
Am J Hum Genet 74:610-22. 2004....
- Definition and clinical importance of haplotypesDana C Crawford
Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA
Annu Rev Med 56:303-20. 2005..Finally, we discuss the latest concepts for the analysis of haplotypes related to human disease, including haplotype blocks, the International HapMap Project, and the future directions of these resources...
- Allelic spectrum of the natural variation in CRPDana C Crawford
Department of Genome Sciences, University of Washington, 1705 NE Pacific, Seattle, WA 98195 7730, USA
Hum Genet 119:496-504. 2006..Collectively, these data suggest that several different types re-sequencing and genotyping approaches may be required to fully understand the complete spectrum of alleles that impact human phenotypes...
- Genetic risk factors for BMI and obesity in an ethnically diverse population: results from the population architecture using genomics and epidemiology (PAGE) studyMegan D Fesinmeyer
Department of Biostatistics and Biomathematics, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
Obesity (Silver Spring) 21:835-46. 2013..However, studies of this complex trait have focused on ancestrally European populations, despite the high prevalence of obesity in some minority groups...
- Genetic variation associated with circulating monocyte count in the eMERGE NetworkDavid R Crosslin
Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA, USA
Hum Mol Genet 22:2119-27. 2013..68×10(-17), β = -0.23) at the integrin, alpha 4 gene on chromosome 2. The novel IRF8 results and further replications provide supporting evidence of genetic regions associated with monocyte count...
- Genetic variation is associated with C-reactive protein levels in the Third National Health and Nutrition Examination SurveyDana C Crawford
Department of Genome Sciences, University of Washington, Seattle, USA
Circulation 114:2458-65. 2006..Increased serum C-reactive protein (CRP) is an independent risk factor for cardiovascular disease. Previous studies have suggested that genetic variation within the CRP gene is associated with serum CRP...
- Identifying host genetic risk factors in the context of public health surveillance for invasive pneumococcal diseaseJairam R Lingappa
Department of Global Health, University of Washington, Seattle, Washington, United States of America
PLoS ONE 6:e23413. 2011....
- Imputation of coding variants in African Americans: better performance using data from the exome sequencing projectQing Duan
Department of Genetics and Department of Computer Science, University of North Carolina, Chapel Hill, NC 27599, USA, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA, Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA, Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA, Renaissance Computing Institute, University of North Carolina, Chapel Hill, NC 27599, USA, Department of Statistics and Department of Genetics, Rutgers University, Piscataway, NJ 08854, USA, Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA, Department of Epidemiology, University of Washington, Seattle, WA 98195, USA, Division of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA, Department of Epidemiology and Medicine, University of Iowa, Iowa City, IA 52242, Division of Cardiology, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA, Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, France
Bioinformatics 29:2744-9. 2013..We recommend using haplotypes from Exome Sequencing Project alone or concatenation of the two panels over quality score-based post-imputation selection or IMPUTE2's two-panel combination...
- Pattern of sequence variation across 213 environmental response genesRobert J Livingston
Department of Genome Sciences, University of Washington, Seattle, Washington 98195 7730, USA
Genome Res 14:1821-31. 2004..The implications for the use of these data in direct and indirect association studies of environmentally induced diseases are discussed...
- Effects of smoking on the genetic risk of obesity: the population architecture using genomics and epidemiology studyMegan D Fesinmeyer
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
BMC Med Genet 14:6. 2013..Although smoking behavior is known to affect body mass index (BMI), the potential for smoking to influence genetic associations with BMI is largely unexplored...
- Genetic variants associated with the white blood cell count in 13,923 subjects in the eMERGE NetworkDavid R Crosslin
Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA 98195, USA
Hum Genet 131:639-52. 2012..Variants in this region have been reported to be associated with WBC, neutrophil count, and inflammatory diseases including asthma and Crohn's disease...
- Evidence for substantial fine-scale variation in recombination rates across the human genomeDana C Crawford
Department of Genome Sciences, University of Washington, Box 354322, Seattle, Washington 98195, USA
Nat Genet 36:700-6. 2004..No primary sequence characteristics are consistently associated with precise hot-spot location, although G+C content and nucleotide diversity are correlated with local recombination rate...
- Single nucleotide polymorphism discovery in TBX1 in individuals with and without 22q11.2 deletion syndromeCarrie L Heike
Department of Pediatrics, Division of Craniofacial Medicine, University of Washington and Seattle Children s Hospital, Seattle, Washington 98105 5371, USA
Birth Defects Res A Clin Mol Teratol 88:54-63. 2010..The purpose of this study was to further characterize the sequence variability in TBX1 by identifying all common SNPs in this gene...
- LPA and PLG sequence variation and kringle IV-2 copy number in two populationsDana C Crawford
Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University, Nashville, TN 37232, USA
Hum Hered 66:199-209. 2008..African-descent populations have, on average, higher levels of Lp(a), suggesting other genetic factors contribute to Lp(a) level variability across populations...
- A common VLDLR polymorphism interacts with APOE genotype in the prediction of carotid artery disease riskDana C Crawford
Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University, Nashville, TN, USA
J Lipid Res 49:588-96. 2008..These findings may further our understanding of VLDLR function, its ligand APOE, and ultimately the pathogenesis of CAAD in the general population...
- Problems with genome-wide association studiesScott M Williams
Science 316:1840-2. 2007
- Characterization of beta-globin haplotypes using blood spots from a population-based cohort of newborns with homozygous HbSDana C Crawford
National Center on Birth Defects and Developmental Disabilities, Division of Applied Public Health Training, Epidemiology Program Office, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
Genet Med 4:328-35. 2002..A population-based cohort from three state newborn screening programs was used to describe beta-globin gene cluster variation...
- Integrating host genomics with surveillance for invasive bacterial diseasesDana C Crawford
Vanderbilt University, Nashville, Tennessee, USA
Emerg Infect Dis 14:1138-40. 2008..Using nDBS specimens, we resequenced CD46, putative host gene receptor for Neisseria meningitidis, and identified variants associated with susceptibility to this disease...
- Identifying the genotype behind the phenotype: a role model found in VKORC1 and its association with warfarin dosingDana C Crawford
Vanderbilt University, Center for Human Genetics Research, 519 Light Hall, Nashville, TN 37232, USA
Pharmacogenomics 8:487-96. 2007..These future avenues will be best explored using diverse approaches encompassing clinical, statistical and genomic methods currently being developed for genotype-phenotype studies in human populations...
- Prevalence of the fragile X syndrome in African-AmericansDana C Crawford
Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Am J Med Genet 110:226-33. 2002..Further population-based studies in diverse populations are necessary to explore the possibility that the prevalence of the fragile X syndrome differs among world populations...
- Paternally transmitted FMR1 alleles are less stable than maternally transmitted alleles in the common and intermediate size rangeAmy K Sullivan
Department of Human Genetics, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
Am J Hum Genet 70:1532-44. 2002..This difference that depends on repeat size suggests either a different mutational mechanism of instability or an increase in selection against sperm as their repeat size increases...