Rolf J Craven

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. ncbi A novel group of genes regulates susceptibility to antineoplastic drugs in highly tumorigenic breast cancer cells
    Julia C Mallory
    Department of Molecular and Biomedical Pharmacology, Markey Cancer Center, MS-305 University of Kentucky Medical Center, University of Kentucky, Lexington, Kentucky 40536, USA
    Mol Pharmacol 68:1747-56. 2005
  2. ncbi Regulation of iron homeostasis mediated by the heme-binding protein Dap1 (damage resistance protein 1) via the P450 protein Erg11/Cyp51
    Rolf J Craven
    Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington, Kentucky 40536, USA
    J Biol Chem 282:36543-51. 2007
  3. ncbi Pgrmc1 (progesterone receptor membrane component 1) associates with epidermal growth factor receptor and regulates erlotinib sensitivity
    Ikhlas S Ahmed
    Department of Molecular and Biomedical Pharmacology, Markey Cancer Center, University of Kentucky, Lexington, Kentucky 40536, USA
    J Biol Chem 285:24775-82. 2010
  4. ncbi Progesterone receptor membrane component 1 (Pgrmc1): a heme-1 domain protein that promotes tumorigenesis and is inhibited by a small molecule
    Ikhlas S Ahmed
    Department of Molecular and Biomedical Pharmacology, Markey Cancer Center, University of Kentucky, Lexington, Kentucky 40536, USA
    J Pharmacol Exp Ther 333:564-73. 2010
  5. ncbi Hpr6 (heme-1 domain protein) regulates the susceptibility of cancer cells to chemotherapeutic drugs
    Gerard Crudden
    Department of Molecular and Biomedical Pharmacology, Markey Cancer Center, MS 305 University of Kentucky Medical Center, Lexington, KY 40536 0298, USA
    J Pharmacol Exp Ther 316:448-55. 2006
  6. ncbi Dap1p, a heme-binding protein that regulates the cytochrome P450 protein Erg11p/Cyp51p in Saccharomyces cerevisiae
    Julia C Mallory
    Department of Molecular and Biomedical Pharmacology, University of Kentucky, MS 305 UKMC, Lexington, KY 40536, USA
    Mol Cell Biol 25:1669-79. 2005
  7. ncbi Elevated progesterone receptor membrane component 1/sigma-2 receptor levels in lung tumors and plasma from lung cancer patients
    Shakeel U R Mir
    Department of Molecular and Biomedical Pharmacology, Markey Cancer Center, University of Kentucky, Lexington, KY, USA
    Int J Cancer 131:E1-9. 2012
  8. ncbi Neutrophil gelatinase-associated lipocalin (NGAL) expression is dependent on the tumor-associated sigma-2 receptor S2RPgrmc1
    Shakeel U R Mir
    Department of Molecular and Biomedical Pharmacology, Markey Cancer Center, University of Kentucky, Lexington, Kentucky 40536, USA
    J Biol Chem 287:14494-501. 2012
  9. ncbi PGRMC1 (progesterone receptor membrane component 1): a targetable protein with multiple functions in steroid signaling, P450 activation and drug binding
    Hannah J Rohe
    Department of Molecular and Biomedical Pharmacology, University of Kentucky, MS 305 UKMC, Lexington, Kentucky 40536, United States
    Pharmacol Ther 121:14-9. 2009
  10. ncbi S2R(Pgrmc1): the cytochrome-related sigma-2 receptor that regulates lipid and drug metabolism and hormone signaling
    Ikhlas S A Ahmed
    University of Kentucky, Markey Cancer Center, Department of Molecular and Biomedical Pharmacology, Lexington, KY 40536, USA
    Expert Opin Drug Metab Toxicol 8:361-70. 2012

Research Grants

  1. Y vh 1 p: phosphatase inhibitor of telomere signaling
    Rolf Craven; Fiscal Year: 2003

Collaborators

  • Susanne Arnold
  • Martin Bard
  • DAVID KAETZEL
  • Ikhlas S Ahmed
  • Gerard Crudden
  • Shakeel U R Mir
  • Ikhlas S A Ahmed
  • Hannah J Rohe
  • Julia C Mallory
  • Katherine E Twist
  • Randal A Hand
  • Melissa K Ranney
  • Elena Kurenova
  • XiHui Yang
  • William G Cance
  • Lucia Beviglia
  • Ling Jin
  • Cora Chamberlain
  • Marlene N Mattingly
  • Kelly R Potts
  • Rachel E Chitti
  • Christopher Saunders
  • Ben L Johnson
  • Ralf Loesel
  • Amelia Oliva
  • Caiqing Mo
  • Arnold Stromberg
  • Charles A Pierson
  • Albert S Baldwin
  • Zheng Gang Liu
  • Li-Hui Xu
  • Steven K Hanks
  • Zheng-Gang Liu
  • Li hui Xu
  • LiHui Xu
  • Nan Jia
  • Vita Golubovskaya

Detail Information

Publications18

  1. ncbi A novel group of genes regulates susceptibility to antineoplastic drugs in highly tumorigenic breast cancer cells
    Julia C Mallory
    Department of Molecular and Biomedical Pharmacology, Markey Cancer Center, MS-305 University of Kentucky Medical Center, University of Kentucky, Lexington, Kentucky 40536, USA
    Mol Pharmacol 68:1747-56. 2005
    ..The induced genes regulate drug susceptibility positively and negatively and may be novel targets for therapeutic intervention...
  2. ncbi Regulation of iron homeostasis mediated by the heme-binding protein Dap1 (damage resistance protein 1) via the P450 protein Erg11/Cyp51
    Rolf J Craven
    Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington, Kentucky 40536, USA
    J Biol Chem 282:36543-51. 2007
    ....
  3. ncbi Pgrmc1 (progesterone receptor membrane component 1) associates with epidermal growth factor receptor and regulates erlotinib sensitivity
    Ikhlas S Ahmed
    Department of Molecular and Biomedical Pharmacology, Markey Cancer Center, University of Kentucky, Lexington, Kentucky 40536, USA
    J Biol Chem 285:24775-82. 2010
    ....
  4. ncbi Progesterone receptor membrane component 1 (Pgrmc1): a heme-1 domain protein that promotes tumorigenesis and is inhibited by a small molecule
    Ikhlas S Ahmed
    Department of Molecular and Biomedical Pharmacology, Markey Cancer Center, University of Kentucky, Lexington, Kentucky 40536, USA
    J Pharmacol Exp Ther 333:564-73. 2010
    ..Our data support a role for Pgrmc1 in promoting cancer-associated phenotypes and provide a therapeutic approach for targeting Pgrmc1 with a small molecule in lung and breast cancer...
  5. ncbi Hpr6 (heme-1 domain protein) regulates the susceptibility of cancer cells to chemotherapeutic drugs
    Gerard Crudden
    Department of Molecular and Biomedical Pharmacology, Markey Cancer Center, MS 305 University of Kentucky Medical Center, Lexington, KY 40536 0298, USA
    J Pharmacol Exp Ther 316:448-55. 2006
    ..Our findings support a model in which Hpr6, similar to its yeast homolog, binds to heme and regulates susceptibility to damaging agents...
  6. ncbi Dap1p, a heme-binding protein that regulates the cytochrome P450 protein Erg11p/Cyp51p in Saccharomyces cerevisiae
    Julia C Mallory
    Department of Molecular and Biomedical Pharmacology, University of Kentucky, MS 305 UKMC, Lexington, KY 40536, USA
    Mol Cell Biol 25:1669-79. 2005
    ..Dap1p homologues have been identified in numerous eukaryotes, including mammals, suggesting that the Dap1p-cytochrome P450 protein pathway is broadly conserved in eukaryotic species...
  7. ncbi Elevated progesterone receptor membrane component 1/sigma-2 receptor levels in lung tumors and plasma from lung cancer patients
    Shakeel U R Mir
    Department of Molecular and Biomedical Pharmacology, Markey Cancer Center, University of Kentucky, Lexington, KY, USA
    Int J Cancer 131:E1-9. 2012
    ..Together, the results demonstrate that Pgrmc1 is a potential tumor and serum biomarker, as well as a therapeutic target, for lung cancer...
  8. ncbi Neutrophil gelatinase-associated lipocalin (NGAL) expression is dependent on the tumor-associated sigma-2 receptor S2RPgrmc1
    Shakeel U R Mir
    Department of Molecular and Biomedical Pharmacology, Markey Cancer Center, University of Kentucky, Lexington, Kentucky 40536, USA
    J Biol Chem 287:14494-501. 2012
    ..Our results are consistent with a model in which S2R(Pgrmc1) increases NGAL/LCN2 levels by activating NFκB via EGFR...
  9. ncbi PGRMC1 (progesterone receptor membrane component 1): a targetable protein with multiple functions in steroid signaling, P450 activation and drug binding
    Hannah J Rohe
    Department of Molecular and Biomedical Pharmacology, University of Kentucky, MS 305 UKMC, Lexington, Kentucky 40536, United States
    Pharmacol Ther 121:14-9. 2009
    ..Together with its biological role in promoting tumor survival, PGRMC1 is an attractive target for therapeutic intervention in cancer and related malignancies...
  10. ncbi S2R(Pgrmc1): the cytochrome-related sigma-2 receptor that regulates lipid and drug metabolism and hormone signaling
    Ikhlas S A Ahmed
    University of Kentucky, Markey Cancer Center, Department of Molecular and Biomedical Pharmacology, Lexington, KY 40536, USA
    Expert Opin Drug Metab Toxicol 8:361-70. 2012
    ..In summary, S2R(Pgrmc1) is a promising therapeutic target for cancer and possibly cholesterol synthesis but research to date has not identified a major role in P450-mediated drug metabolism...
  11. ncbi Overexpression of the cytochrome p450 activator hpr6 (heme-1 domain protein/human progesterone receptor) in tumors
    Gerard Crudden
    Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington, KY 40536 0298, USA
    Tumour Biol 26:142-6. 2005
    ..Because these processes are frequently misregulated in tumors, we have examined the expression of Hpr6 in a group of clinical tumor samples and cancer cell lines...
  12. ncbi Multiple pathways regulating the anti-apoptotic protein clusterin in breast cancer
    Melissa K Ranney
    Department of Molecular and Biomedical Pharmacology, Markey Cancer Center, University of Kentucky, MS 305 UKMC, Lexington, KY 40536, USA
    Biochim Biophys Acta 1772:1103-11. 2007
    ..Thus, chemotherapy-HDI combinations are capable of overcoming an innate anti-apoptotic pathway of tumor cells, suggesting that chemotherapy-HDI combinations have potential for treating advanced stage breast cancer...
  13. ncbi Potential roles of 3'-5' exonuclease activity of NM23-H1 in DNA repair and malignant progression
    David M Kaetzel
    Department of Molecular and Biomedical Pharmacology, College of Medicine, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    J Bioenerg Biomembr 38:163-7. 2006
    ....
  14. ncbi Saccharomyces cerevisiae Dap1p, a novel DNA damage response protein related to the mammalian membrane-associated progesterone receptor
    Randal A Hand
    Department of Surgery, Division of Surgical Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Eukaryot Cell 2:306-17. 2003
    ..This is the first evidence linking a MAPR family member to sterol regulation or the response to damage, and these functions are probably conserved in a variety of eukaryotes...
  15. ncbi Focal adhesion kinase suppresses apoptosis by binding to the death domain of receptor-interacting protein
    Elena Kurenova
    Department of Surgery, University of Florida, Gainesville, Florida 32610, USA
    Mol Cell Biol 24:4361-71. 2004
    ..We thus propose that FAK overexpression in human tumors provides a survival signal function by binding to RIP and inhibiting its interaction with the death receptor complex...
  16. ncbi Hpr6.6 protein mediates cell death from oxidative damage in MCF-7 human breast cancer cells
    Randal A Hand
    Division of Surgical Oncology, Department of Surgery, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA
    J Cell Biochem 90:534-47. 2003
    ..6-mediated cell death, suggesting that Hpr6.6 regulates cell death through a novel oxidative damage response pathway. Our work indicates a key regulatory function for Hpr6.6 in epithelial tissues exposed to oxidative damage...
  17. ncbi Focal adhesion kinase N-terminus in breast carcinoma cells induces rounding, detachment and apoptosis
    Lucia Beviglia
    Department of Surgery, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Biochem J 373:201-10. 2003
    ..Thus FAK-NT contributes to cellular adhesion and survival pathways in breast cancer cells which are not required for survival in non-malignant breast epithelial cells...
  18. ncbi Regulation of genome stability by TEL1 and MEC1, yeast homologs of the mammalian ATM and ATR genes
    Rolf J Craven
    Department of Biology and Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina 27599 3280, USA
    Genetics 161:493-507. 2002
    ..Similar chromosome rearrangements have been detected in mammalian cells with mutations in ATM (related to TEL1) and ATR (related to MEC1) and in mammalian cells that approach cell crisis...

Research Grants1

  1. Y vh 1 p: phosphatase inhibitor of telomere signaling
    Rolf Craven; Fiscal Year: 2003
    ..This study is related to health because Atm is the human homologue of Mec lp and Tel lp, and Atm is a key regulator of aging, telomere structure, and cancer. ..