Steven Cramer

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Genetic variation in the human brain dopamine system influences motor learning and its modulation by L-Dopa
    Kristin M Pearson-Fuhrhop
    Department of Anatomy and Neurobiology, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 8:e61197. 2013
  2. doi request reprint Safety, pharmacokinetics, and pharmacodynamics of escalating repeat doses of GSK249320 in patients with stroke
    Steven C Cramer
    Department of Neurology, University of California, Irvine, CA 92868, USA
    Stroke 44:1337-42. 2013
  3. pmc Patient-reported measures provide unique insights into motor function after stroke
    Jill Campbell Stewart
    Departments of Neurology and Anatomy and Neurobiology, University of California, Irvine, CA, USA
    Stroke 44:1111-6. 2013
  4. ncbi request reprint Correlation between genetic polymorphisms and stroke recovery: analysis of the GAIN Americas and GAIN International Studies
    S C Cramer
    Department of Neurology and Anatomy, University of California, Irvine, CA, USA
    Eur J Neurol 19:718-24. 2012
  5. pmc Organization of a United States county system for comprehensive acute stroke care
    Steven C Cramer
    University of California Irvine Medical Center, 101 The City Drive South, Building 53 Room 203, Orange, CA 92868, USA
    Stroke 43:1089-93. 2012
  6. pmc The beta-hCG+erythropoietin in acute stroke (BETAS) study: a 3-center, single-dose, open-label, noncontrolled, phase IIa safety trial
    Steven C Cramer
    University of California, Irvine Medical Center, 101 The City Drive South, Building 53, Room 203, Orange, CA 92868 4280, USA
    Stroke 41:927-31. 2010
  7. ncbi request reprint Somatotopy and movement representation sites following cortical stroke
    Steven C Cramer
    Department of Neurology, University of Washington, Seattle, WA, USA
    Exp Brain Res 168:25-32. 2006
  8. ncbi request reprint Use of functional MRI to guide decisions in a clinical stroke trial
    Steven C Cramer
    University of California, Irvine, Calif, USA
    Stroke 36:e50-2. 2005
  9. ncbi request reprint Brain motor system function after chronic, complete spinal cord injury
    Steven C Cramer
    Department of Neurology, University of California, Irvine, UCI Medical Center, Orange, CA 92868 4280, USA
    Brain 128:2941-50. 2005
  10. ncbi request reprint Activity in the peri-infarct rim in relation to recovery from stroke
    Steven C Cramer
    Department of Neurology, University of Washington, Seattle, USA
    Stroke 37:111-5. 2006

Research Grants

  1. Motor Function after Stroke
    Steven C Cramer; Fiscal Year: 2010
  2. Safety of Autologous Marrow Stromal Cells After Stroke
    Steven Cramer; Fiscal Year: 2003
  3. Motor Function after Stroke
    Steven Cramer; Fiscal Year: 2009
  4. Safety of Autologous Marrow Stromal Cells After Stroke
    Steven Cramer; Fiscal Year: 2005
  5. RECOVERY FROM STROKE: A CLINICAL & FUNCTIONAL MRI STUDY
    Steven Cramer; Fiscal Year: 2003
  6. Motor Function after Stroke
    Steven C Cramer; Fiscal Year: 2010
  7. Safety of repetitive TMS in chronic subcortical stroke
    Steven Cramer; Fiscal Year: 2006
  8. Safety of repetitive TMS in chronic subcortical stroke
    Steven Cramer; Fiscal Year: 2005
  9. Motor Function after Stroke
    Steven Cramer; Fiscal Year: 2009
  10. Motor Function after Stroke
    Steven C Cramer; Fiscal Year: 2011

Detail Information

Publications76

  1. pmc Genetic variation in the human brain dopamine system influences motor learning and its modulation by L-Dopa
    Kristin M Pearson-Fuhrhop
    Department of Anatomy and Neurobiology, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 8:e61197. 2013
    ..These findings may have clinical applications in post-stroke rehabilitation or the treatment of Parkinson's disease...
  2. doi request reprint Safety, pharmacokinetics, and pharmacodynamics of escalating repeat doses of GSK249320 in patients with stroke
    Steven C Cramer
    Department of Neurology, University of California, Irvine, CA 92868, USA
    Stroke 44:1337-42. 2013
    ..The current study evaluated GSK249320, a monoclonal antibody that blocks the axon outgrowth inhibition molecule myelin-associated glycoprotein and also protects oligodendrocytes...
  3. pmc Patient-reported measures provide unique insights into motor function after stroke
    Jill Campbell Stewart
    Departments of Neurology and Anatomy and Neurobiology, University of California, Irvine, CA, USA
    Stroke 44:1111-6. 2013
    ..The current study investigated the relationship that patient-reported measures have with standard impairment and disability scales after stroke...
  4. ncbi request reprint Correlation between genetic polymorphisms and stroke recovery: analysis of the GAIN Americas and GAIN International Studies
    S C Cramer
    Department of Neurology and Anatomy, University of California, Irvine, CA, USA
    Eur J Neurol 19:718-24. 2012
    ..Associations with mitochondrial genotype were also explored...
  5. pmc Organization of a United States county system for comprehensive acute stroke care
    Steven C Cramer
    University of California Irvine Medical Center, 101 The City Drive South, Building 53 Room 203, Orange, CA 92868, USA
    Stroke 43:1089-93. 2012
    ..The current report describes the experience of implementing a county-wide system of spoke-and-hub stroke neurology receiving centers (SNRC) that incorporated several comprehensive stroke center recommendations...
  6. pmc The beta-hCG+erythropoietin in acute stroke (BETAS) study: a 3-center, single-dose, open-label, noncontrolled, phase IIa safety trial
    Steven C Cramer
    University of California, Irvine Medical Center, 101 The City Drive South, Building 53, Room 203, Orange, CA 92868 4280, USA
    Stroke 41:927-31. 2010
    ..The current study directly translated these results by evaluating safety of this sequential growth factor therapy through a 3-center, single-dose, open-label, noncontrolled, Phase IIa trial...
  7. ncbi request reprint Somatotopy and movement representation sites following cortical stroke
    Steven C Cramer
    Department of Neurology, University of Washington, Seattle, WA, USA
    Exp Brain Res 168:25-32. 2006
    ..Greater injury and larger behavioral deficits are associated with distinct effects on movement representation sites. Changes in motor organization within and between hemispheres arise independently after stroke...
  8. ncbi request reprint Use of functional MRI to guide decisions in a clinical stroke trial
    Steven C Cramer
    University of California, Irvine, Calif, USA
    Stroke 36:e50-2. 2005
    ..The anatomical location for the target, hand motor area, varies across subjects, and so was localized with functional MRI (fMRI). This report describes the experience of incorporating standardized fMRI into a multisite stroke trial...
  9. ncbi request reprint Brain motor system function after chronic, complete spinal cord injury
    Steven C Cramer
    Department of Neurology, University of California, Irvine, UCI Medical Center, Orange, CA 92868 4280, USA
    Brain 128:2941-50. 2005
    ..Because brain function is central to voluntary movement, interventions that aim to improve motor function after chronic SCI likely also need to attend to these abnormalities of brain function...
  10. ncbi request reprint Activity in the peri-infarct rim in relation to recovery from stroke
    Steven C Cramer
    Department of Neurology, University of Washington, Seattle, USA
    Stroke 37:111-5. 2006
    ..The current study hypothesized that in patients with good outcome after stroke, brain activation in peri-infarct tissue would be greater than normal...
  11. ncbi request reprint Predicting functional gains in a stroke trial
    Steven C Cramer
    Department of Anatomy, University of California, Irvine, CA, USA
    Stroke 38:2108-14. 2007
    ..The current study tested the hypothesis that, after adjusting for a number of clinical assessments, a measure of brain function at baseline would improve prediction of behavioral gains after treatment...
  12. ncbi request reprint Patent foramen ovale and stroke: prognosis and treatment in young adults
    Steven C Cramer
    Department of Neurology, UC Irvine Medical Center, University of CA Irvine, Orange, CA 92868 4280, USA
    J Thromb Thrombolysis 20:85-91. 2005
    ..Additional studies are needed, such as those focused on lower extremity veins or the cardiac interatrial septum, to guide therapy in specific stroke subpopulations...
  13. doi request reprint Repairing the human brain after stroke. II. Restorative therapies
    Steven C Cramer
    Department of Neurology, University of California, Irvine, CA 92868 4280, USA
    Ann Neurol 63:549-60. 2008
    ..Considerations for clinical trials of restorative therapies are provided, emphasizing both similarities and points of divergence with acute stroke clinical trial design...
  14. ncbi request reprint Effects of motor imagery training after chronic, complete spinal cord injury
    Steven C Cramer
    Department of Neurology, Associate, Reeve Irvine Research Center, University of California, Irvine, USA
    Exp Brain Res 177:233-42. 2007
    ..Motor imagery might be of value as one component of a restorative intervention...
  15. doi request reprint Repairing the human brain after stroke: I. Mechanisms of spontaneous recovery
    Steven C Cramer
    Departments of Neurology and Anatomy and Neurobiology, University of California, Irvine, Irvine, CA 92868 4280, USA
    Ann Neurol 63:272-87. 2008
    ..Such measures gain importance when viewed as covariates in therapeutic trials of restorative agents that target stroke recovery...
  16. ncbi request reprint The EXCITE trial: a major step forward for restorative therapies in stroke
    Steven C Cramer
    Department of Neurology, University of California, Irvine, Irvine, CA, USA
    Stroke 38:2204-5. 2007
  17. ncbi request reprint Randomized, placebo-controlled, double-blind study of ropinirole in chronic stroke
    Steven C Cramer
    Department of Neurology, University of California, Irvine, USA
    Stroke 40:3034-8. 2009
    ..The current study hypothesized that increased dopaminergic tone via the dopamine agonist ropinirole, when combined with physiotherapy (PT), would significantly and safely increase gait velocity...
  18. ncbi request reprint Use of imaging in restorative stroke trials
    Steven C Cramer
    University of California, Irvine Medical Center, 101 The City Drive South, Building 53 Room 203, Orange, CA 92868 4280, USA
    Stroke 40:S28-9. 2009
    ..These issues are considered in this review, with specific examples provided...
  19. doi request reprint Neuroplasticity and brain repair after stroke
    Steven C Cramer
    Department of Neurology, University of California, Irvine, CA 92868 4280, USA
    Curr Opin Neurol 21:76-82. 2008
    ....
  20. ncbi request reprint Patent foramen ovale and its relationship to stroke
    Steven C Cramer
    Department of Neurology, University of California, Irvine Medical Center, University of California, Irvine, 101 The City Drive South, Orange, CA 92868 4280, USA
    Cardiol Clin 23:7-11. 2005
    ..This article discusses the relationship between patent foramen ovale and stroke, particularly in reference to paradoxical embolism as a cause of cryptogenic stroke...
  21. pmc Harnessing neuroplasticity for clinical applications
    Steven C Cramer
    Department of Neurology, UC Irvine Medical Centre, 101 The City Drive South, Bldg 53, Rm 203, Orange, CA 92868 4280, USA
    Brain 134:1591-609. 2011
    ..Integration of information across disciplines should enhance opportunities for the translation of neuroplasticity and circuit retraining research into effective clinical therapies...
  22. ncbi request reprint Mapping individual brains to guide restorative therapy after stroke: rationale and pilot studies
    Steven C Cramer
    University of California, Irvine, Department of Neurology, UCI Medical Center, 101 The City Drive South, Building 53, Room 203, Orange, CA 92868 4280, USA
    Neurol Res 25:811-4. 2003
    ..Initial details are presented of a study using this approach to evaluate such a therapy...
  23. ncbi request reprint Increased pelvic vein thrombi in cryptogenic stroke: results of the Paradoxical Emboli from Large Veins in Ischemic Stroke (PELVIS) study
    Steven C Cramer
    University of Washington, Seattle, USA
    Stroke 35:46-50. 2004
    ..The Paradoxical Emboli From Large Veins in Ischemic Stroke (PELVIS) study hypothesized that patients with cryptogenic stroke have an increased prevalence of pelvic deep venous thrombosis (DVT)...
  24. doi request reprint An overview of therapies to promote repair of the brain after stroke
    Steven C Cramer
    Departments of Neurology and Anatomy and Neurobiology, University of California, Irvine, California, USA
    Head Neck 33:S5-7. 2011
    ..Most have a time window measured in days or weeks and so have the potential to help a large fraction of patients. This review considers these therapies, as well as points to consider in translating their application to human trials...
  25. ncbi request reprint Improved understanding of cortical injury by incorporating measures of functional anatomy
    Kit R Crafton
    University of California Irvine, Department of Neurology, UCI Medical Centre, 101 The City Drive South, Building 53 Room 203 Orange, CA 92868 4280, USA
    Brain 126:1650-9. 2003
    ..In the current cross-sectional study, incorporating an understanding of normal tissue function into lesion measurement provided improved insights into the behavioural consequences of focal brain injury...
  26. pmc Increased prevalence of val(66)met BDNF genotype among subjects with cervical dystonia
    Steven C Cramer
    Department of Neurology, University of California, Irvine, CA, USA
    Neurosci Lett 468:42-5. 2010
    ..This was not true of ApoE genotype, which was similarly distributed across subject groups. The current findings suggest that the BDNF val(66)met polymorphism might play a role in the pathogenesis of cervical dystonia in some subjects...
  27. ncbi request reprint Paradoxical emboli from calf and pelvic veins in cryptogenic stroke
    Steven C Cramer
    University of California Irvine Medical Center, Department of Neurology, 101 The City Drive South, Building 53, Room 203, Orange, CA 92868 4280, USA
    J Neuroimaging 13:218-23. 2003
    ..The identification of deep venous thromboses (DVTs) in this population would strengthen this hypothesis. The purpose of this study was to image the subdiaphragmatic venous system in a cohort of patients with cryptogenic strokes...
  28. doi request reprint Listening to fluoxetine: a hot message from the FLAME trial of poststroke motor recovery
    Steven C Cramer
    Department of Neurology, University of California, Irvine, CA, USA
    Int J Stroke 6:315-6. 2011
    ..Therapies that target restorative events have a time window measured in days-weeks and so hold the potential to help many patients with stroke...
  29. pmc A system for addressing incidental findings in neuroimaging research
    Steven C Cramer
    Department of Neurology, University of California, Irvine, USA
    Neuroimage 55:1020-3. 2011
    ..To our knowledge the current system is the first to provide a specific means for evaluation of incidental findings in neuroimaging research...
  30. ncbi request reprint Functional imaging in stroke recovery
    Steven C Cramer
    Department of Neurology, University of California Irvine Medical Center, 101 The City Dr S, Bldg 53, Room 203, Orange, CA 92868 4280, USA
    Stroke 35:2695-8. 2004
    ....
  31. doi request reprint Stratifying patients with stroke in trials that target brain repair
    Steven C Cramer
    University of California Irvine Medical Center, Orange, CA 92868 4280, USA
    Stroke 41:S114-6. 2010
    ..Potential approaches to such stratification are considered, including measures of brain injury or of poststroke brain function...
  32. ncbi request reprint Changes in motor system function and recovery after stroke
    Steven C Cramer
    Department of Neurology, University of California, Irvine, CA, USA
    Restor Neurol Neurosci 22:231-8. 2004
    ..Some of these changes have been found to correlate with features of injury, behavior, or treatment-induced behavioral gains. A current challenge is to extend these findings to improve clinical decision making...
  33. ncbi request reprint Motor cortex organization after stroke is related to side of stroke and level of recovery
    Anna C Zemke
    Department of Neurology, University of Washington, Seattle, USA
    Stroke 34:e23-8. 2003
    ..The present study hypothesized that side of stroke and level of recovery influence motor system organization after stroke...
  34. pmc BDNF val66met polymorphism influences motor system function in the human brain
    Stephanie A McHughen
    Department of Anatomy and Neurobiology, University of California, Irvine, CA 92697, USA
    Cereb Cortex 20:1254-62. 2010
    ..The broader implications of these findings are considered...
  35. ncbi request reprint Robot-based hand motor therapy after stroke
    Craig D Takahashi
    Department of Neurology, University of California, Irvine Medical Center, 101 The City Drive South, Building 53 Room 203, Orange, CA 92868 4280, USA
    Brain 131:425-37. 2008
    ..A robot-based therapy showed improvements in hand motor function after chronic stroke. Reorganization of motor maps during the current therapy was task-specific, a finding useful when considering generalization of rehabilitation therapy...
  36. ncbi request reprint Do robotic and non-robotic arm movement training drive motor recovery after stroke by a common neural mechanism? Experimental evidence and a computational model
    David J Reinkensmeyer
    Department of Mechanical and Aerospace Engineering, University of California, Irvine, CA 92697, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:2439-41. 2009
    ..Robot-assisted and unassisted training would in theory equally drive this search process...
  37. pmc Altered white matter integrity in temporal lobe epilepsy: association with cognitive and clinical profiles
    Jeffrey D Riley
    Department of Neurology, University of California, Irvine, CA 92868, USA
    Epilepsia 51:536-45. 2010
    ..However, limited data exist regarding the extent of white matter tract abnormalities, cognitive effects of these abnormalities, and relationship to clinical factors. The current study examined these issues in subjects with chronic TLE...
  38. doi request reprint Cortical activation during foot movements: II effect of movement rate and side
    Shehzad Huda
    Department of Neurology and Anatomy and Neurobiology, University of California, Irvine, California, USA
    Neuroreport 19:1573-7. 2008
    ..Results might have utility in trials of restorative therapies...
  39. ncbi request reprint Motor cortex activation is preserved in patients with chronic hemiplegic stroke
    Steven C Cramer
    Department of Neurology, University of Washington, 1959 NE Pacific Street, Room RR650, Box 356465, Seattle, WA 98195 6565, USA
    Ann Neurol 52:607-16. 2002
    ....
  40. ncbi request reprint Cerebral and cerebellar motor activation abnormalities in a subject with Joubert syndrome: functional magnetic resonance imaging (MRI) study
    Melissa A Parisi
    Department of Pediatrics, University of Washington, School of Medicine, Seattle 98195, USA
    J Child Neurol 19:214-8. 2004
    ..Malformation of the hindbrain could result in recruitment of alternative pathways, similar to what has been observed following ischemic injury to the developing or mature central nervous system...
  41. ncbi request reprint Age and features of movement influence motor overflow
    Julie A Bodwell
    Department of Neurology, University of Washington, Seattle, Washington, USA
    J Am Geriatr Soc 51:1735-9. 2003
    ..To measure the magnitude and prevalence of motor overflow to the arm at rest during attempted unilateral arm movements...
  42. ncbi request reprint Functional imaging of intervention effects in stroke motor rehabilitation
    Timea Hodics
    Department of Neurology, Georgetown University Hospital, Washington, DC 20007, USA
    Arch Phys Med Rehabil 87:S36-42. 2006
    ..To assess intervention-specific effects on cortical reorganization after stroke as shown by available functional neuroimaging studies...
  43. doi request reprint A tele-assessment system for monitoring treatment effects in subjects with spinal cord injury
    Nuray Yozbatiran
    Department of Neurology, University of California, Irvine, California, USA
    J Telemed Telecare 16:152-7. 2010
    ..Intra-rater reliability was better than inter-rater reliability. Use of telemedicine to remotely monitor changes in patients with SCI appears promising...
  44. doi request reprint Comparison of error-amplification and haptic-guidance training techniques for learning of a timing-based motor task by healthy individuals
    Marie Hélène Milot
    Department of Mechanical and Aerospace Engineering, University of California, Irvine, 4200 Engineering Gateway, Irvine, CA 92697, USA
    Exp Brain Res 201:119-31. 2010
    ..These results suggest that both techniques help enhanced performance of a timing task, but learning is optimized if training subjects with the appropriate technique based on their baseline skill level...
  45. pmc The effect of haptic guidance, aging, and initial skill level on motor learning of a steering task
    Laura Marchal-Crespo
    Department of Mechanical and Aerospace Engineering, Henry Samueli School of Engineering, 4200 Engineering Gateway Building, Irvine, CA 92697 3975, USA
    Exp Brain Res 201:209-20. 2010
    ..This study demonstrates that training with haptic guidance can benefit long-term retention of a driving skill for young and for some old drivers. Training with haptic guidance is more useful for people with less initial skill...
  46. pmc Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects
    E C Mormino
    Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA
    Brain 132:1310-23. 2009
    ..This pattern suggests that declining EM in older individuals may be caused by Abeta-induced hippocampus atrophy...
  47. doi request reprint Cortical activation during executed, imagined, and observed foot movements
    Elizabeth L R Orr
    Department of Neurology and Anatomy, University of California, Irvine, CA 92868, USA
    Neuroreport 19:625-30. 2008
    ..The findings suggest the utility of continued efforts to develop motor imagery and observation programs for improving lower extremity function in a range of clinical settings...
  48. ncbi request reprint Automating arm movement training following severe stroke: functional exercises with quantitative feedback in a gravity-reduced environment
    Robert J Sanchez
    Department of Mechanical and Aerospace Engienering, University of California, Irvine, CA 92697 3975, USA
    IEEE Trans Neural Syst Rehabil Eng 14:378-89. 2006
    ..001). These results demonstrate the feasibility of automating upper-extremity rehabilitation therapy for people with severe stroke using passive gravity assistance, a grip sensor, and simple virtual reality software...
  49. doi request reprint Vulnerability of the frontal-temporal connections in temporal lobe epilepsy
    Jack J Lin
    Department of Neurology, University of California, Irvine, CA, USA
    Epilepsy Res 82:162-70. 2008
    ..We therefore investigated the integrity of two major frontal-temporal white matter association tracts, uncinate fasciculus (UF) and arcuate fasciculus (AF), and their clinical correlates...
  50. ncbi request reprint Robotics, motor learning, and neurologic recovery
    David J Reinkensmeyer
    Department of Mechanical and Aerospace Engineering, University of California, Irvine, California 92697 3975, USA
    Annu Rev Biomed Eng 6:497-525. 2004
    ..In addition to providing insight into motor control, robotic paradigms may eventually enhance motor learning and rehabilitation beyond the levels possible with conventional training techniques...
  51. ncbi request reprint A standardized approach to performing the action research arm test
    Nuray Yozbatiran
    Departments of Neurology and Anatomy, University of California, Irvine Medical Center, Orange, CA 92868 4280, USA
    Neurorehabil Neural Repair 22:78-90. 2008
    ..The ARAT, when performed in a standardized manner, is a useful tool for assessment of arm motor deficits after stroke...
  52. ncbi request reprint Brain function early after stroke in relation to subsequent recovery
    Hoang Nhan
    Department of Neurology, University of Washington, Seattle, WA, USA
    J Cereb Blood Flow Metab 24:756-63. 2004
    ..The findings may be useful for restorative interventions introduced during the weeks after a stroke...
  53. ncbi request reprint The case for modality-specific outcome measures in clinical trials of stroke recovery-promoting agents
    Steven C Cramer
    Department of Neurology, University of California, Irvine, CA, USA
    Stroke 38:1393-5. 2007
    ..The use of such end points may result in a more selective labeling of stroke recovery treatments...
  54. ncbi request reprint Stroke recovery and its imaging
    Craig D Takahashi
    Department of Neurology, University of California at Irvine, CA 92868 4280, USA
    Neuroimaging Clin N Am 15:681-95, xii. 2005
    ..Key challenges for the future are to develop standardized approaches to help address certain questions, determine the psychometric qualities of these measures, and define the clinical usefulness of these methods...
  55. pmc Extracranial-intracranial bypass surgery for stroke prevention in hemodynamic cerebral ischemia: the Carotid Occlusion Surgery Study randomized trial
    William J Powers
    Department of Neurology, Box 7025, Room 2131, 170 Manning Dr, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    JAMA 306:1983-92. 2011
    ..Patients with symptomatic atherosclerotic internal carotid artery occlusion (AICAO) and hemodynamic cerebral ischemia are at high risk for subsequent stroke when treated medically...
  56. doi request reprint Brain plasticity and genetic factors
    Kristin M Pearson-Fuhrhop
    Department of Anatomy and Neurobiology, University of California, Irvine, Orange, USA
    Top Stroke Rehabil 16:282-99. 2009
    ..A better understanding of genetic influences on recovery and response to therapy might allow improved treatment after stroke...
  57. doi request reprint Slope of the intracranial pressure waveform after traumatic brain injury
    Franklin D Westhout
    Department of Neurological Surgery, School of Medicine, University of California Irvine, Orange, CA, USA
    Surg Neurol 70:70-4; discussion 74. 2008
    ..This study used digital methods to examine ICP and the slope of the ICP waveform in relation to the respiratory cycle in subjects with TBI...
  58. pmc Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease
    David A Wolk
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:10256-61. 2010
    ....
  59. ncbi request reprint Functional magnetic resonance imaging in stroke recovery
    Steven C Cramer
    Department of Neurology, University of Washington, 1959 NE Pacific, Room RR650, Box 356465, Seattle, Washington 98195 6465, USA
    Phys Med Rehabil Clin N Am 14:S47-55. 2003
    ..Functional MR imaging provides insights into brain plasticity after stroke and remains a valuable tool in the study of motor recovery after stroke...
  60. pmc Anatomy and physiology predict response to motor cortex stimulation after stroke
    Sarvenaz Nouri
    Department of Neurology, University of California, Irvine, CA, USA
    Neurology 77:1076-83. 2011
    ..The current retrospective analysis examined subjects randomized to stimulation in order to identify features distinguishing responders from nonresponders...
  61. pmc Anatomy of stroke injury predicts gains from therapy
    Jeff D Riley
    University of California, Irvine Medical Center, Orange, CA 92868 4280, USA
    Stroke 42:421-6. 2011
    ..The current study addressed the hypothesis that behavioral gains from therapy targeting distal upper extremity are predicted by the structural integrity of key motor system white matter tracts...
  62. ncbi request reprint Clinical issues in animal models of stroke and rehabilitation
    Steven C Cramer
    Department of Neurology, University of California Irvine, Irvine, CA, USA
    ILAR J 44:83-4. 2003
  63. ncbi request reprint Association between carotid plaque characteristics and subsequent ischemic cerebrovascular events: a prospective assessment with MRI--initial results
    Norihide Takaya
    Department of Radiology, University of Washington, Seattle, WA, USA
    Stroke 37:818-23. 2006
    ..We tested the hypothesis that the characteristics of carotid plaque, as assessed by MRI, are possible predictors of future ipsilateral cerebrovascular events...
  64. pmc Imaging motor recovery after stroke
    Nuray Yozbatiran
    Department of Neurology, University of California, Irvine, CA 92868, USA
    NeuroRx 3:482-8. 2006
    ..Brain mapping studies have characterized a number of processes and principles relevant to recovery from stroke in humans. The findings have potential application to improving therapeutics that aim to restore function after stroke...
  65. pmc Biomarkers of recovery after stroke
    Marie Hélène Milot
    Department of Neurology and Anatomy, University of California, Irvine, California 92868 4280, USA
    Curr Opin Neurol 21:654-9. 2008
    ..This review considers advances in use of biomarkers to understand recovery from stroke, and to serve as a surrogate measure of stroke recovery, including in a clinical trial context...
  66. ncbi request reprint Motor cortex stimulation for enhancement of recovery after stroke: case report
    Jeffrey A Brown
    Department of Neurological Surgery, Wayne State University School of Medicine, 4160 John R Suite 930, Detroit, MI 48201, USA
    Neurol Res 25:815-8. 2003
    ....
  67. pmc Neuroimaging in stroke recovery: a position paper from the First International Workshop on Neuroimaging and Stroke Recovery
    Jean Claude Baron
    Cerebrovasc Dis 18:260-7. 2004
  68. ncbi request reprint Role of antiplatelet therapy in cardiovascular disease II: Ischemic stroke
    Jeffrey J Cavendish
    Department of Cardiology, Naval Medical Center, San Diego, CA 92134, USA
    Curr Med Res Opin 20:1845-9. 2004
    ..As illustrated in this paper, antiplatelet agents (e.g. clopidogrel, aspirin, dipyridamole) are the cornerstone of therapy for prevention of recurrent ischemic stroke...
  69. ncbi request reprint Brain activation during execution and motor imagery of novel and skilled sequential hand movements
    Michael G Lacourse
    Neuromotor Rehabilitation Research Laboratory, Long Beach Veteran s Affairs Healthcare System, CA 90822, USA
    Neuroimage 27:505-19. 2005
    ....
  70. ncbi request reprint Motor cortex stimulation for the enhancement of recovery from stroke: a prospective, multicenter safety study
    Jeffrey A Brown
    Department of Neurosurgery, Wayne State University, Detroit, Michigan, USA
    Neurosurgery 58:464-73. 2006
    ....
  71. ncbi request reprint BDNF val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortex
    Jeffrey A Kleim
    Brain Research Rehabilitation Center, Malcom Randall VA Hospital, 1601 SW Archer Road, Gainesville, Florida 32608, USA
    Nat Neurosci 9:735-7. 2006
    ..The results suggest that BDNF is involved in mediating experience-dependent plasticity of human motor cortex...
  72. ncbi request reprint Systematic assessment of training-induced changes in corticospinal output to hand using frameless stereotaxic transcranial magnetic stimulation
    Jeffrey A Kleim
    Brain Rehabilitation Research Center, Malcom Randall VA Hospital, 1601 SW Archer Road, Gainesville, Florida 32608, USA
    Nat Protoc 2:1675-84. 2007
    ..The protocol allows for reliably and repeatedly detecting changes in corticospinal output to FDI muscle in response to brief periods of motor training...
  73. ncbi request reprint Motor recovery and cortical reorganization after constraint-induced movement therapy in stroke patients: a preliminary study
    Judith D Schaechter
    Massachusetts General Hospital NMR Center, Department of Radiology, Charlestown, MA 02129, USA
    Neurorehabil Neural Repair 16:326-38. 2002
    ..These data provide preliminary evidence that gains in motor function produced by CIMT in chronic stroke patients may be associated with a shift in laterality of motor cortical activation toward the undamaged hemisphere...
  74. ncbi request reprint Motor cortex activation is related to force of squeezing
    Steven C Cramer
    MGH NMR Center, Department of Radiology, Charlestown, Massachusetts, USA
    Hum Brain Mapp 16:197-205. 2002
    ..This relationship was found across the full spectrum of forces that the human hand is capable of generating. Use of a valid, reliable method for assessing motor behavior during functional MRI may be important to clinical applications...
  75. ncbi request reprint Editorial comment--spasticity after stroke: what's the catch?
    Steven C Cramer
    Stroke 35:139-40. 2004
  76. ncbi request reprint Editorial comment--Implementing results of stroke recovery research into clinical practice
    Steven C Cramer
    Stroke 34:1752-3. 2003

Research Grants10

  1. Motor Function after Stroke
    Steven C Cramer; Fiscal Year: 2010
    ..The studies described here aim to ask important questions that, when answered, will bring these new therapies a major step closer to widespread use. ..
  2. Safety of Autologous Marrow Stromal Cells After Stroke
    Steven Cramer; Fiscal Year: 2003
    ..This study is a Phase I safety trial, and thus represents the first step in evaluating autologous MSC transfusion in this regard. ..
  3. Motor Function after Stroke
    Steven Cramer; Fiscal Year: 2009
    ..The studies described here aim to ask important questions that, when answered, will bring these new therapies a major step closer to widespread use. ..
  4. Safety of Autologous Marrow Stromal Cells After Stroke
    Steven Cramer; Fiscal Year: 2005
    ..This study is a Phase I safety trial, and thus represents the first step in evaluating autologous MSC transfusion in this regard. ..
  5. RECOVERY FROM STROKE: A CLINICAL & FUNCTIONAL MRI STUDY
    Steven Cramer; Fiscal Year: 2003
    ..3) MGH-NMR Center (Charlestown, MA), located two miles from (1) and (2), is a pioneering fMRI center. ..
  6. Motor Function after Stroke
    Steven C Cramer; Fiscal Year: 2010
    ..The studies described here aim to ask important questions that, when answered, will bring these new therapies a major step closer to widespread use. ..
  7. Safety of repetitive TMS in chronic subcortical stroke
    Steven Cramer; Fiscal Year: 2006
    ..The long-term goal of these studies is to develop a safe and efficacious method for facilitating motor cortex function in order to improve motor status of patients with stroke-related weakness. ..
  8. Safety of repetitive TMS in chronic subcortical stroke
    Steven Cramer; Fiscal Year: 2005
    ..The long-term goal of these studies is to develop a safe and efficacious method for facilitating motor cortex function in order to improve motor status of patients with stroke-related weakness. ..
  9. Motor Function after Stroke
    Steven Cramer; Fiscal Year: 2009
    ..The studies described here aim to ask important questions that, when answered, will bring these new therapies a major step closer to widespread use. ..
  10. Motor Function after Stroke
    Steven C Cramer; Fiscal Year: 2011
    ..The studies described here aim to ask important questions that, when answered, will bring these new therapies a major step closer to widespread use. ..