Research Topics
Genomes and GenesSpecies | Steven CramerSummaryAffiliation: University of California Country: USA Publications
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Publications
Safety, Pharmacokinetics, and Pharmacodynamics of Escalating Repeat Doses of GSK249320 in Patients With StrokeSteven C Cramer
University of California, Irvine Medical Center, 200 S Manchester Ave, Suite 206, Orange, CA 92868
Stroke 44:1337-42. 2013..The current study evaluated GSK249320, a monoclonal antibody that blocks the axon outgrowth inhibition molecule myelin-associated glycoprotein and also protects oligodendrocytes...
Patient-reported measures provide unique insights into motor function after strokeJill Campbell Stewart
Departments of Neurology and Anatomy and Neurobiology, University of California, Irvine, CA, USA
Stroke 44:1111-6. 2013..The current study investigated the relationship that patient-reported measures have with standard impairment and disability scales after stroke...- Correlation between genetic polymorphisms and stroke recovery: analysis of the GAIN Americas and GAIN International StudiesS C Cramer
Department of Neurology and Anatomy, University of California, Irvine, CA, USA
Eur J Neurol 19:718-24. 2012..Associations with mitochondrial genotype were also explored... - Organization of a United States county system for comprehensive acute stroke careSteven C Cramer
University of California Irvine Medical Center, 101 The City Drive South, Building 53 Room 203, Orange, CA 92868, USA
Stroke 43:1089-93. 2012..The current report describes the experience of implementing a county-wide system of spoke-and-hub stroke neurology receiving centers (SNRC) that incorporated several comprehensive stroke center recommendations... 
Predicting functional gains in a stroke trialSteven C Cramer
Department of Anatomy, University of California, Irvine, CA, USA
Stroke 38:2108-14. 2007..The current study tested the hypothesis that, after adjusting for a number of clinical assessments, a measure of brain function at baseline would improve prediction of behavioral gains after treatment...- The EXCITE trial: a major step forward for restorative therapies in strokeSteven C Cramer
Department of Neurology, University of California, Irvine, Irvine, CA, USA
Stroke 38:2204-5. 2007 - Effects of motor imagery training after chronic, complete spinal cord injurySteven C Cramer
Department of Neurology, Associate, Reeve Irvine Research Center, University of California, Irvine, USA
Exp Brain Res 177:233-42. 2007..Motor imagery might be of value as one component of a restorative intervention... - Repairing the human brain after stroke. II. Restorative therapiesSteven C Cramer
Department of Neurology, University of California, Irvine, CA 92868 4280, USA
Ann Neurol 63:549-60. 2008..Considerations for clinical trials of restorative therapies are provided, emphasizing both similarities and points of divergence with acute stroke clinical trial design... - Activity in the peri-infarct rim in relation to recovery from strokeSteven C Cramer
Department of Neurology, University of Washington, Seattle, USA
Stroke 37:111-5. 2006..The current study hypothesized that in patients with good outcome after stroke, brain activation in peri-infarct tissue would be greater than normal... - Brain motor system function after chronic, complete spinal cord injurySteven C Cramer
Department of Neurology, University of California, Irvine, UCI Medical Center, Orange, CA 92868 4280, USA
Brain 128:2941-50. 2005..Because brain function is central to voluntary movement, interventions that aim to improve motor function after chronic SCI likely also need to attend to these abnormalities of brain function... - Patent foramen ovale and stroke: prognosis and treatment in young adultsSteven C Cramer
Department of Neurology, UC Irvine Medical Center, University of CA Irvine, Orange, CA 92868 4280, USA
J Thromb Thrombolysis 20:85-91. 2005..Additional studies are needed, such as those focused on lower extremity veins or the cardiac interatrial septum, to guide therapy in specific stroke subpopulations... - Neuroplasticity and brain repair after strokeSteven C Cramer
Department of Neurology, University of California, Irvine, CA 92868 4280, USA
Curr Opin Neurol 21:76-82. 2008.... - Repairing the human brain after stroke: I. Mechanisms of spontaneous recoverySteven C Cramer
Departments of Neurology and Anatomy and Neurobiology, University of California, Irvine, Irvine, CA 92868 4280, USA
Ann Neurol 63:272-87. 2008..Such measures gain importance when viewed as covariates in therapeutic trials of restorative agents that target stroke recovery... - Use of imaging in restorative stroke trialsSteven C Cramer
University of California, Irvine Medical Center, 101 The City Drive South, Building 53 Room 203, Orange, CA 92868 4280, USA
Stroke 40:S28-9. 2009..These issues are considered in this review, with specific examples provided... - Randomized, placebo-controlled, double-blind study of ropinirole in chronic strokeSteven C Cramer
Department of Neurology, University of California, Irvine, USA
Stroke 40:3034-8. 2009..The current study hypothesized that increased dopaminergic tone via the dopamine agonist ropinirole, when combined with physiotherapy (PT), would significantly and safely increase gait velocity... - Increased prevalence of val(66)met BDNF genotype among subjects with cervical dystoniaSteven C Cramer
Department of Neurology, University of California, Irvine, CA, USA
Neurosci Lett 468:42-5. 2010..This was not true of ApoE genotype, which was similarly distributed across subject groups. The current findings suggest that the BDNF val(66)met polymorphism might play a role in the pathogenesis of cervical dystonia in some subjects... - The beta-hCG+erythropoietin in acute stroke (BETAS) study: a 3-center, single-dose, open-label, noncontrolled, phase IIa safety trialSteven C Cramer
University of California, Irvine Medical Center, 101 The City Drive South, Building 53, Room 203, Orange, CA 92868 4280, USA
Stroke 41:927-31. 2010..The current study directly translated these results by evaluating safety of this sequential growth factor therapy through a 3-center, single-dose, open-label, noncontrolled, Phase IIa trial... - Stratifying patients with stroke in trials that target brain repairSteven C Cramer
University of California Irvine Medical Center, Orange, CA 92868 4280, USA
Stroke 41:S114-6. 2010..Potential approaches to such stratification are considered, including measures of brain injury or of poststroke brain function... - Harnessing neuroplasticity for clinical applicationsSteven C Cramer
Department of Neurology, UC Irvine Medical Centre, 101 The City Drive South, Bldg 53, Rm 203, Orange, CA 92868 4280, USA
Brain 134:1591-609. 2011..Integration of information across disciplines should enhance opportunities for the translation of neuroplasticity and circuit retraining research into effective clinical therapies... - Listening to fluoxetine: a hot message from the FLAME trial of poststroke motor recoverySteven C Cramer
Department of Neurology, University of California, Irvine, CA, USA
Int J Stroke 6:315-6. 2011..Therapies that target restorative events have a time window measured in days-weeks and so hold the potential to help many patients with stroke... - An overview of therapies to promote repair of the brain after strokeSteven C Cramer
Departments of Neurology and Anatomy and Neurobiology, University of California, Irvine, California, USA
Head Neck 33:S5-7. 2011..Most have a time window measured in days or weeks and so have the potential to help a large fraction of patients. This review considers these therapies, as well as points to consider in translating their application to human trials... - Somatotopy and movement representation sites following cortical strokeSteven C Cramer
Department of Neurology, University of Washington, Seattle, WA, USA
Exp Brain Res 168:25-32. 2006..Greater injury and larger behavioral deficits are associated with distinct effects on movement representation sites. Changes in motor organization within and between hemispheres arise independently after stroke... - Use of functional MRI to guide decisions in a clinical stroke trialSteven C Cramer
University of California, Irvine, Calif, USA
Stroke 36:e50-2. 2005..The anatomical location for the target, hand motor area, varies across subjects, and so was localized with functional MRI (fMRI). This report describes the experience of incorporating standardized fMRI into a multisite stroke trial... - Patent foramen ovale and its relationship to strokeSteven C Cramer
Department of Neurology, University of California, Irvine Medical Center, University of California, Irvine, 101 The City Drive South, Orange, CA 92868 4280, USA
Cardiol Clin 23:7-11. 2005..This article discusses the relationship between patent foramen ovale and stroke, particularly in reference to paradoxical embolism as a cause of cryptogenic stroke... - Increased pelvic vein thrombi in cryptogenic stroke: results of the Paradoxical Emboli from Large Veins in Ischemic Stroke (PELVIS) studySteven C Cramer
University of Washington, Seattle, USA
Stroke 35:46-50. 2004..The Paradoxical Emboli From Large Veins in Ischemic Stroke (PELVIS) study hypothesized that patients with cryptogenic stroke have an increased prevalence of pelvic deep venous thrombosis (DVT)... - Changes in motor system function and recovery after strokeSteven C Cramer
Department of Neurology, University of California, Irvine, CA, USA
Restor Neurol Neurosci 22:231-8. 2004..Some of these changes have been found to correlate with features of injury, behavior, or treatment-induced behavioral gains. A current challenge is to extend these findings to improve clinical decision making... - Improved understanding of cortical injury by incorporating measures of functional anatomyKit R Crafton
University of California Irvine, Department of Neurology, UCI Medical Centre, 101 The City Drive South, Building 53 Room 203 Orange, CA 92868 4280, USA
Brain 126:1650-9. 2003..In the current cross-sectional study, incorporating an understanding of normal tissue function into lesion measurement provided improved insights into the behavioural consequences of focal brain injury... - Functional imaging in stroke recoverySteven C Cramer
Department of Neurology, University of California Irvine Medical Center, 101 The City Dr S, Bldg 53, Room 203, Orange, CA 92868 4280, USA
Stroke 35:2695-8. 2004.... - A system for addressing incidental findings in neuroimaging researchSteven C Cramer
Department of Neurology, University of California, Irvine, USA
Neuroimage 55:1020-3. 2011..To our knowledge the current system is the first to provide a specific means for evaluation of incidental findings in neuroimaging research... - Mapping individual brains to guide restorative therapy after stroke: rationale and pilot studiesSteven C Cramer
University of California, Irvine, Department of Neurology, UCI Medical Center, 101 The City Drive South, Building 53, Room 203, Orange, CA 92868 4280, USA
Neurol Res 25:811-4. 2003..Initial details are presented of a study using this approach to evaluate such a therapy... - Paradoxical emboli from calf and pelvic veins in cryptogenic strokeSteven C Cramer
University of California Irvine Medical Center, Department of Neurology, 101 The City Drive South, Building 53, Room 203, Orange, CA 92868 4280, USA
J Neuroimaging 13:218-23. 2003..The identification of deep venous thromboses (DVTs) in this population would strengthen this hypothesis. The purpose of this study was to image the subdiaphragmatic venous system in a cohort of patients with cryptogenic strokes... - BDNF val66met polymorphism influences motor system function in the human brainStephanie A McHughen
Department of Anatomy and Neurobiology, University of California, Irvine, CA 92697, USA
Cereb Cortex 20:1254-62. 2010..The broader implications of these findings are considered... - Motor cortex organization after stroke is related to side of stroke and level of recoveryAnna C Zemke
Department of Neurology, University of Washington, Seattle, USA
Stroke 34:e23-8. 2003..The findings may have implications for treatment after stroke... - Robot-based hand motor therapy after strokeCraig D Takahashi
Department of Neurology, University of California, Irvine Medical Center, 101 The City Drive South, Building 53 Room 203, Orange, CA 92868 4280, USA
Brain 131:425-37. 2008..A robot-based therapy showed improvements in hand motor function after chronic stroke. Reorganization of motor maps during the current therapy was task-specific, a finding useful when considering generalization of rehabilitation therapy... - Do robotic and non-robotic arm movement training drive motor recovery after stroke by a common neural mechanism? Experimental evidence and a computational modelDavid J Reinkensmeyer
Department of Mechanical and Aerospace Engineering, University of California, Irvine, CA 92697, USA
Conf Proc IEEE Eng Med Biol Soc 2009:2439-41. 2009..Robot-assisted and unassisted training would in theory equally drive this search process... - Altered white matter integrity in temporal lobe epilepsy: association with cognitive and clinical profilesJeffrey D Riley
Department of Neurology, University of California, Irvine, CA 92868, USA
Epilepsia 51:536-45. 2010..However, limited data exist regarding the extent of white matter tract abnormalities, cognitive effects of these abnormalities, and relationship to clinical factors. The current study examined these issues in subjects with chronic TLE... - Motor cortex activation is preserved in patients with chronic hemiplegic strokeSteven C Cramer
Department of Neurology, University of Washington, 1959 NE Pacific Street, Room RR650, Box 356465, Seattle, WA 98195 6565, USA
Ann Neurol 52:607-16. 2002.... - Cortical activation during foot movements: II effect of movement rate and sideShehzad Huda
Department of Neurology and Anatomy and Neurobiology, University of California, Irvine, California, USA
Neuroreport 19:1573-7. 2008..Results might have utility in trials of restorative therapies... - Cerebral and cerebellar motor activation abnormalities in a subject with Joubert syndrome: functional magnetic resonance imaging (MRI) studyMelissa A Parisi
Department of Pediatrics, University of Washington, School of Medicine, Seattle 98195, USA
J Child Neurol 19:214-8. 2004..Malformation of the hindbrain could result in recruitment of alternative pathways, similar to what has been observed following ischemic injury to the developing or mature central nervous system... - Age and features of movement influence motor overflowJulie A Bodwell
Department of Neurology, University of Washington, Seattle, Washington, USA
J Am Geriatr Soc 51:1735-9. 2003..The results support the hypotheses that healthy aging is associated with an increase in the degree to which brain function is bilaterally organized... - Functional imaging of intervention effects in stroke motor rehabilitationTimea Hodics
Department of Neurology, Georgetown University Hospital, Washington, DC 20007, USA
Arch Phys Med Rehabil 87:S36-42. 2006..To assess intervention-specific effects on cortical reorganization after stroke as shown by available functional neuroimaging studies... - A tele-assessment system for monitoring treatment effects in subjects with spinal cord injuryNuray Yozbatiran
Department of Neurology, University of California, Irvine, California, USA
J Telemed Telecare 16:152-7. 2010..Intra-rater reliability was better than inter-rater reliability. Use of telemedicine to remotely monitor changes in patients with SCI appears promising... - Robotics, motor learning, and neurologic recoveryDavid J Reinkensmeyer
Department of Mechanical and Aerospace Engineering, University of California, Irvine, California 92697 3975, USA
Annu Rev Biomed Eng 6:497-525. 2004..In addition to providing insight into motor control, robotic paradigms may eventually enhance motor learning and rehabilitation beyond the levels possible with conventional training techniques... - Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjectsE C Mormino
Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA
Brain 132:1310-23. 2009..This pattern suggests that declining EM in older individuals may be caused by Abeta-induced hippocampus atrophy... - Automating arm movement training following severe stroke: functional exercises with quantitative feedback in a gravity-reduced environmentRobert J Sanchez
Department of Mechanical and Aerospace Engienering, University of California, Irvine, CA 92697 3975, USA
IEEE Trans Neural Syst Rehabil Eng 14:378-89. 2006..001). These results demonstrate the feasibility of automating upper-extremity rehabilitation therapy for people with severe stroke using passive gravity assistance, a grip sensor, and simple virtual reality software... - The effect of haptic guidance, aging, and initial skill level on motor learning of a steering taskLaura Marchal-Crespo
Department of Mechanical and Aerospace Engineering, Henry Samueli School of Engineering, 4200 Engineering Gateway Building, Irvine, CA 92697 3975, USA
Exp Brain Res 201:209-20. 2010..This study demonstrates that training with haptic guidance can benefit long-term retention of a driving skill for young and for some old drivers. Training with haptic guidance is more useful for people with less initial skill... - Vulnerability of the frontal-temporal connections in temporal lobe epilepsyJack J Lin
Department of Neurology, University of California, Irvine, CA, USA
Epilepsy Res 82:162-70. 2008..We therefore investigated the integrity of two major frontal-temporal white matter association tracts, uncinate fasciculus (UF) and arcuate fasciculus (AF), and their clinical correlates... - Cortical activation during executed, imagined, and observed foot movementsElizabeth L R Orr
Department of Neurology and Anatomy, University of California, Irvine, CA 92868, USA
Neuroreport 19:625-30. 2008..The findings suggest the utility of continued efforts to develop motor imagery and observation programs for improving lower extremity function in a range of clinical settings... - Comparison of error-amplification and haptic-guidance training techniques for learning of a timing-based motor task by healthy individualsMarie Hélène Milot
Department of Mechanical and Aerospace Engineering, University of California, Irvine, 4200 Engineering Gateway, Irvine, CA 92697, USA
Exp Brain Res 201:119-31. 2010..These results suggest that both techniques help enhanced performance of a timing task, but learning is optimized if training subjects with the appropriate technique based on their baseline skill level... - The case for modality-specific outcome measures in clinical trials of stroke recovery-promoting agentsSteven C Cramer
Department of Neurology, University of California, Irvine, CA, USA
Stroke 38:1393-5. 2007..The use of such end points may result in a more selective labeling of stroke recovery treatments... - Brain function early after stroke in relation to subsequent recoveryHoang Nhan
Department of Neurology, University of Washington, Seattle, WA, USA
J Cereb Blood Flow Metab 24:756-63. 2004..The findings may be useful for restorative interventions introduced during the weeks after a stroke... - A standardized approach to performing the action research arm testNuray Yozbatiran
Departments of Neurology and Anatomy, University of California, Irvine Medical Center, Orange, CA 92868 4280, USA
Neurorehabil Neural Repair 22:78-90. 2008..The ARAT, when performed in a standardized manner, is a useful tool for assessment of arm motor deficits after stroke... - Stroke recovery and its imagingCraig D Takahashi
Department of Neurology, University of California at Irvine, CA 92868-4280, USA
Neuroimaging Clin N Am 15:681-95, xii. 2005..Key challenges for the future are to develop standardized approaches to help address certain questions, determine the psychometric qualities of these measures, and define the clinical usefulness of these methods... - Extracranial-intracranial bypass surgery for stroke prevention in hemodynamic cerebral ischemia: the Carotid Occlusion Surgery Study randomized trialWilliam J Powers
Department of Neurology, Box 7025, Room 2131, 170 Manning Dr, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
JAMA 306:1983-92. 2011..Patients with symptomatic atherosclerotic internal carotid artery occlusion (AICAO) and hemodynamic cerebral ischemia are at high risk for subsequent stroke when treated medically... - Functional magnetic resonance imaging in stroke recoverySteven C Cramer
Department of Neurology, University of Washington, 1959 NE Pacific, Room RR650, Box 356465, Seattle, Washington 98195 6465, USA
Phys Med Rehabil Clin N Am 14:S47-55. 2003..Functional MR imaging provides insights into brain plasticity after stroke and remains a valuable tool in the study of motor recovery after stroke... - Brain plasticity and genetic factorsKristin M Pearson-Fuhrhop
Department of Anatomy and Neurobiology, University of California, Irvine, Orange, USA
Top Stroke Rehabil 16:282-99. 2009..A better understanding of genetic influences on recovery and response to therapy might allow improved treatment after stroke... - Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's diseaseDavid A Wolk
Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 107:10256-61. 2010.... - Slope of the intracranial pressure waveform after traumatic brain injuryFranklin D Westhout
Department of Neurological Surgery, School of Medicine, University of California Irvine, Orange, CA, USA
Surg Neurol 70:70-4; discussion 74. 2008..This study used digital methods to examine ICP and the slope of the ICP waveform in relation to the respiratory cycle in subjects with TBI... - Anatomy and physiology predict response to motor cortex stimulation after strokeSarvenaz Nouri
Department of Neurology, University of California, Irvine, CA, USA
Neurology 77:1076-83. 2011..The current retrospective analysis examined subjects randomized to stimulation in order to identify features distinguishing responders from nonresponders... - Anatomy of stroke injury predicts gains from therapyJeff D Riley
University of California, Irvine Medical Center, Orange, CA 92868 4280, USA
Stroke 42:421-6. 2011..The current study addressed the hypothesis that behavioral gains from therapy targeting distal upper extremity are predicted by the structural integrity of key motor system white matter tracts... - Association between carotid plaque characteristics and subsequent ischemic cerebrovascular events: a prospective assessment with MRI--initial resultsNorihide Takaya
Department of Radiology, University of Washington, Seattle, WA, USA
Stroke 37:818-23. 2006..Findings from this prospective study provide a basis for larger multicenter studies to assess the risk of plaque features for subsequent ischemic events... - Clinical issues in animal models of stroke and rehabilitationSteven C Cramer
Department of Neurology, University of California Irvine, Irvine, CA, USA
ILAR J 44:83-4. 2003 - Biomarkers of recovery after strokeMarie Hélène Milot
Department of Neurology and Anatomy, University of California, Irvine, California 92868 4280, USA
Curr Opin Neurol 21:654-9. 2008..This review considers advances in use of biomarkers to understand recovery from stroke, and to serve as a surrogate measure of stroke recovery, including in a clinical trial context... - Imaging motor recovery after strokeNuray Yozbatiran
Department of Neurology, University of California, Irvine, CA 92868, USA
NeuroRx 3:482-8. 2006..Brain mapping studies have characterized a number of processes and principles relevant to recovery from stroke in humans. The findings have potential application to improving therapeutics that aim to restore function after stroke... - Brain activation during execution and motor imagery of novel and skilled sequential hand movementsMichael G Lacourse
Neuromotor Rehabilitation Research Laboratory, Long Beach Veteran s Affairs Healthcare System, CA 90822, USA
Neuroimage 27:505-19. 2005.... - Role of antiplatelet therapy in cardiovascular disease II: Ischemic strokeJeffrey J Cavendish
Department of Cardiology, Naval Medical Center, San Diego, CA 92134, USA
Curr Med Res Opin 20:1845-9. 2004..As illustrated in this paper, antiplatelet agents (e.g. clopidogrel, aspirin, dipyridamole) are the cornerstone of therapy for prevention of recurrent ischemic stroke... - Motor recovery and cortical reorganization after constraint-induced movement therapy in stroke patients: a preliminary studyJudith D Schaechter
Massachusetts General Hospital NMR Center, Department of Radiology, Charlestown, MA 02129, USA
Neurorehabil Neural Repair 16:326-38. 2002..These data provide preliminary evidence that gains in motor function produced by CIMT in chronic stroke patients may be associated with a shift in laterality of motor cortical activation toward the undamaged hemisphere... - Motor cortex stimulation for enhancement of recovery after stroke: case reportJeffrey A Brown
Department of Neurological Surgery, Wayne State University School of Medicine, 4160 John R Suite 930, Detroit, MI 48201, USA
Neurol Res 25:815-8. 2003.... - Motor cortex stimulation for the enhancement of recovery from stroke: a prospective, multicenter safety studyJeffrey A Brown
Department of Neurosurgery, Wayne State University, Detroit, Michigan, USA
Neurosurgery 58:464-73. 2006.... - BDNF val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortexJeffrey A Kleim
Brain Research Rehabilitation Center, Malcom Randall VA Hospital, 1601 SW Archer Road, Gainesville, Florida 32608, USA
Nat Neurosci 9:735-7. 2006..The results suggest that BDNF is involved in mediating experience-dependent plasticity of human motor cortex... - Systematic assessment of training-induced changes in corticospinal output to hand using frameless stereotaxic transcranial magnetic stimulationJeffrey A Kleim
Brain Rehabilitation Research Center, Malcom Randall VA Hospital, 1601 SW Archer Road, Gainesville, Florida 32608, USA
Nat Protoc 2:1675-84. 2007..The protocol allows for reliably and repeatedly detecting changes in corticospinal output to FDI muscle in response to brief periods of motor training... - Neuroimaging in stroke recovery: a position paper from the First International Workshop on Neuroimaging and Stroke RecoveryJean-Claude Baron
Cerebrovasc Dis 18:260-7. 2004 - Editorial comment--spasticity after stroke: what's the catch?Steven C Cramer
Stroke 35:139-40. 2004 - Editorial comment--Implementing results of stroke recovery research into clinical practiceSteven C Cramer
Stroke 34:1752-3. 2003 - Motor cortex activation is related to force of squeezingSteven C Cramer
MGH NMR Center, Department of Radiology, Charlestown, Massachusetts, USA
Hum Brain Mapp 16:197-205. 2002..This relationship was found across the full spectrum of forces that the human hand is capable of generating. Use of a valid, reliable method for assessing motor behavior during functional MRI may be important to clinical applications...
Research Grants
- Motor Function after StrokeSteven C Cramer; Fiscal Year: 2010..The studies described here aim to ask important questions that, when answered, will bring these new therapies a major step closer to widespread use. ..
- Motor Function after StrokeSteven C Cramer; Fiscal Year: 2011..The studies described here aim to ask important questions that, when answered, will bring these new therapies a major step closer to widespread use. ..
- Safety of repetitive TMS in chronic subcortical strokeSteven Cramer; Fiscal Year: 2006..The long-term goal of these studies is to develop a safe and efficacious method for facilitating motor cortex function in order to improve motor status of patients with stroke-related weakness. ..
- Safety of Autologous Marrow Stromal Cells After StrokeSteven Cramer; Fiscal Year: 2005..This study is a Phase I safety trial, and thus represents the first step in evaluating autologous MSC transfusion in this regard. ..
- RECOVERY FROM STROKE: A CLINICAL & FUNCTIONAL MRI STUDYSteven Cramer; Fiscal Year: 2003..3) MGH-NMR Center (Charlestown, MA), located two miles from (1) and (2), is a pioneering fMRI center. ..