S C Cramer

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Functional imaging in stroke recovery
    Steven C Cramer
    Department of Neurology, University of California Irvine Medical Center, 101 The City Dr S, Bldg 53, Room 203, Orange, CA 92868 4280, USA
    Stroke 35:2695-8. 2004
  2. ncbi request reprint Robot-based hand motor therapy after stroke
    Craig D Takahashi
    Department of Neurology, University of California, Irvine Medical Center, 101 The City Drive South, Building 53 Room 203, Orange, CA 92868 4280, USA
    Brain 131:425-37. 2008
  3. ncbi request reprint A pilot study of somatotopic mapping after cortical infarct
    S C Cramer
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Stroke 31:668-71. 2000
  4. ncbi request reprint Motor cortex activation is related to force of squeezing
    Steven C Cramer
    MGH NMR Center, Department of Radiology, Charlestown, Massachusetts, USA
    Hum Brain Mapp 16:197-205. 2002
  5. ncbi request reprint A functional MRI study of three motor tasks in the evaluation of stroke recovery
    S C Cramer
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Neurorehabil Neural Repair 15:1-8. 2001
  6. ncbi request reprint Functional magnetic resonance imaging in stroke recovery
    Steven C Cramer
    Department of Neurology, University of Washington, 1959 NE Pacific, Room RR650, Box 356465, Seattle, Washington 98195 6465, USA
    Phys Med Rehabil Clin N Am 14:S47-55. 2003
  7. ncbi request reprint Motor cortex activation is preserved in patients with chronic hemiplegic stroke
    Steven C Cramer
    Department of Neurology, University of Washington, 1959 NE Pacific Street, Room RR650, Box 356465, Seattle, WA 98195 6565, USA
    Ann Neurol 52:607-16. 2002
  8. ncbi request reprint Mapping clinically relevant plasticity after stroke
    S C Cramer
    Department of Neurology, University of Washington, Seattle 98195 6465, USA
    Neuropharmacology 39:842-51. 2000
  9. ncbi request reprint Stroke recovery. Lessons from functional MR imaging and other methods of human brain mapping
    S C Cramer
    Department of Neurology, University of Washington, Seattle, USA
    Phys Med Rehabil Clin N Am 10:875-86, ix. 1999
  10. ncbi request reprint Computerized measurement of motor performance after stroke
    S C Cramer
    Department of Neurology, Massachusetts General Hospital, Boston, USA
    Stroke 28:2162-8. 1997

Collaborators

Detail Information

Publications57

  1. ncbi request reprint Functional imaging in stroke recovery
    Steven C Cramer
    Department of Neurology, University of California Irvine Medical Center, 101 The City Dr S, Bldg 53, Room 203, Orange, CA 92868 4280, USA
    Stroke 35:2695-8. 2004
    ....
  2. ncbi request reprint Robot-based hand motor therapy after stroke
    Craig D Takahashi
    Department of Neurology, University of California, Irvine Medical Center, 101 The City Drive South, Building 53 Room 203, Orange, CA 92868 4280, USA
    Brain 131:425-37. 2008
    ..A robot-based therapy showed improvements in hand motor function after chronic stroke. Reorganization of motor maps during the current therapy was task-specific, a finding useful when considering generalization of rehabilitation therapy...
  3. ncbi request reprint A pilot study of somatotopic mapping after cortical infarct
    S C Cramer
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Stroke 31:668-71. 2000
    ..Animal studies have described remodeling of sensory and motor representational maps after cortical infarct. These changes may contribute to return of function after stroke...
  4. ncbi request reprint Motor cortex activation is related to force of squeezing
    Steven C Cramer
    MGH NMR Center, Department of Radiology, Charlestown, Massachusetts, USA
    Hum Brain Mapp 16:197-205. 2002
    ..This relationship was found across the full spectrum of forces that the human hand is capable of generating. Use of a valid, reliable method for assessing motor behavior during functional MRI may be important to clinical applications...
  5. ncbi request reprint A functional MRI study of three motor tasks in the evaluation of stroke recovery
    S C Cramer
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Neurorehabil Neural Repair 15:1-8. 2001
    ..The results may be useful for future studies of motor recovery after stroke...
  6. ncbi request reprint Functional magnetic resonance imaging in stroke recovery
    Steven C Cramer
    Department of Neurology, University of Washington, 1959 NE Pacific, Room RR650, Box 356465, Seattle, Washington 98195 6465, USA
    Phys Med Rehabil Clin N Am 14:S47-55. 2003
    ..Functional MR imaging provides insights into brain plasticity after stroke and remains a valuable tool in the study of motor recovery after stroke...
  7. ncbi request reprint Motor cortex activation is preserved in patients with chronic hemiplegic stroke
    Steven C Cramer
    Department of Neurology, University of Washington, 1959 NE Pacific Street, Room RR650, Box 356465, Seattle, WA 98195 6565, USA
    Ann Neurol 52:607-16. 2002
    ....
  8. ncbi request reprint Mapping clinically relevant plasticity after stroke
    S C Cramer
    Department of Neurology, University of Washington, Seattle 98195 6465, USA
    Neuropharmacology 39:842-51. 2000
    ..With the advent of treatments targeting stroke recovery, measurement of post-stroke restorative events may also have value as a surrogate end point in clinical trials...
  9. ncbi request reprint Stroke recovery. Lessons from functional MR imaging and other methods of human brain mapping
    S C Cramer
    Department of Neurology, University of Washington, Seattle, USA
    Phys Med Rehabil Clin N Am 10:875-86, ix. 1999
    ..After a unilateral brain insult, lasting changes take place in both hemispheres and along the rim of a cortical infarct. Such information may be of value in the design of therapies targeting stroke recovery...
  10. ncbi request reprint Computerized measurement of motor performance after stroke
    S C Cramer
    Department of Neurology, Massachusetts General Hospital, Boston, USA
    Stroke 28:2162-8. 1997
    ..Computerized methods sensitive to small changes in neurological status may be of value for studying and measuring stroke recovery...
  11. ncbi request reprint A functional MRI study of subjects recovered from hemiparetic stroke
    S C Cramer
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass, USA
    Stroke 28:2518-27. 1997
    ..We used functional magnetic resonance imaging to compare brain activations in normal controls and subjects who recovered from hemiparetic stroke...
  12. ncbi request reprint Pharmacological elevation of blood pressure in acute stroke. Clinical effects and safety
    G Rordorf
    Department of Neurology and Stroke Service, Massachusetts General Hospital, Boston 02114, USA
    Stroke 28:2133-8. 1997
    ..The aim of our study was to determine whether induced hypertension in stroke is safe and to examine its effects on neurological deficits in patients presenting with acute cerebral ischemia...
  13. ncbi request reprint Quantitative assessment of mirror movements after stroke
    G Nelles
    Department of Neurology, Massachusetts General Hospital, Boston, USA
    Stroke 29:1182-7. 1998
    ..We measured MM in stroke and control subjects and evaluated whether MM after stroke are related to motor function...
  14. ncbi request reprint Changes in motor cortex activation after recovery from spinal cord inflammation
    S C Cramer
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Mult Scler 7:364-70. 2001
    ..The expanded activation in motor cortex, seen with several forms of spinal cord insult may have maximal utility when corticospinal tract axons are preserved...
  15. ncbi request reprint Instructional treatment associated with changes in brain activation in children with dyslexia
    E H Aylward
    Department of Radiology, University of Washington, Seattle 98195, USA
    Neurology 61:212-9. 2003
    ..To assess the effects of reading instruction on fMRI brain activation in children with dyslexia...
  16. ncbi request reprint Brain activation during face perception: evidence of a developmental change
    E H Aylward
    Department of Radiology, University of Washington, Seattle, WA 98195, USA
    J Cogn Neurosci 17:308-19. 2005
    ..The current results provide biological insight into changes in visual processing of faces that occur with normal development...
  17. ncbi request reprint Diffusion abnormalities in patients with Wernicke encephalopathy
    M J Doherty
    Department of Neurology, University of Washington, Seattle 98195, USA
    Neurology 58:655-7. 2002
    ..DWI abnormalities may suggest early thiamine deficiency and are useful in diagnosing Wernicke encephalopathy...
  18. ncbi request reprint Regional ischemia and ischemic injury in patients with acute middle cerebral artery stroke as defined by early diffusion-weighted and perfusion-weighted MRI
    G Rordorf
    Department of Neurology, Massachusetts General Hospital, Boston 02114, USA
    Stroke 29:939-43. 1998
    ..MRI can now delineate very early infarction by diffusion-weighted imaging (DWI) and abnormal tissue perfusion by perfusion-weighted imaging (PWI)...
  19. ncbi request reprint Predictors of mortality in stroke patients admitted to an intensive care unit
    G Rordorf
    Department of Neurology, Massachusetts General Hospital, Boston 02114 2696, USA
    Crit Care Med 28:1301-5. 2000
    ..Improved pathophysiologic insight and prognostic information regarding in-hospital risk of mortality among stroke patients admitted to an intensive care unit...
  20. pmc Predictors of surface disruption with MR imaging in asymptomatic carotid artery stenosis
    H R Underhill
    Department of Radiology, University of Washington, Seattle, WA 98109, USA
    AJNR Am J Neuroradiol 31:487-93. 2010
    ..In this prospective observational study, we sought to determine the characteristics of the carotid lesion that predict the development of new surface disruption...
  21. ncbi request reprint Brain activation during execution and motor imagery of novel and skilled sequential hand movements
    Michael G Lacourse
    Neuromotor Rehabilitation Research Laboratory, Long Beach Veteran s Affairs Healthcare System, CA 90822, USA
    Neuroimage 27:505-19. 2005
    ....
  22. ncbi request reprint Somatotopy and movement representation sites following cortical stroke
    Steven C Cramer
    Department of Neurology, University of Washington, Seattle, WA, USA
    Exp Brain Res 168:25-32. 2006
    ..Greater injury and larger behavioral deficits are associated with distinct effects on movement representation sites. Changes in motor organization within and between hemispheres arise independently after stroke...
  23. ncbi request reprint Stroke recovery and its imaging
    Craig D Takahashi
    Department of Neurology, University of California at Irvine, CA 92868 4280, USA
    Neuroimaging Clin N Am 15:681-95, xii. 2005
    ..Key challenges for the future are to develop standardized approaches to help address certain questions, determine the psychometric qualities of these measures, and define the clinical usefulness of these methods...
  24. ncbi request reprint BDNF val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortex
    Jeffrey A Kleim
    Brain Research Rehabilitation Center, Malcom Randall VA Hospital, 1601 SW Archer Road, Gainesville, Florida 32608, USA
    Nat Neurosci 9:735-7. 2006
    ..The results suggest that BDNF is involved in mediating experience-dependent plasticity of human motor cortex...
  25. ncbi request reprint Effects of motor imagery training after chronic, complete spinal cord injury
    Steven C Cramer
    Department of Neurology, Associate, Reeve Irvine Research Center, University of California, Irvine, USA
    Exp Brain Res 177:233-42. 2007
    ..Motor imagery might be of value as one component of a restorative intervention...
  26. ncbi request reprint Functional imaging of intervention effects in stroke motor rehabilitation
    Timea Hodics
    Department of Neurology, Georgetown University Hospital, Washington, DC 20007, USA
    Arch Phys Med Rehabil 87:S36-42. 2006
    ..To assess intervention-specific effects on cortical reorganization after stroke as shown by available functional neuroimaging studies...
  27. ncbi request reprint Predicting functional gains in a stroke trial
    Steven C Cramer
    Department of Anatomy, University of California, Irvine, CA, USA
    Stroke 38:2108-14. 2007
    ..The current study tested the hypothesis that, after adjusting for a number of clinical assessments, a measure of brain function at baseline would improve prediction of behavioral gains after treatment...
  28. ncbi request reprint Systematic assessment of training-induced changes in corticospinal output to hand using frameless stereotaxic transcranial magnetic stimulation
    Jeffrey A Kleim
    Brain Rehabilitation Research Center, Malcom Randall VA Hospital, 1601 SW Archer Road, Gainesville, Florida 32608, USA
    Nat Protoc 2:1675-84. 2007
    ..The protocol allows for reliably and repeatedly detecting changes in corticospinal output to FDI muscle in response to brief periods of motor training...
  29. ncbi request reprint Motor cortex stimulation for the enhancement of recovery from stroke: a prospective, multicenter safety study
    Jeffrey A Brown
    Department of Neurosurgery, Wayne State University, Detroit, Michigan, USA
    Neurosurgery 58:464-73. 2006
    ....
  30. ncbi request reprint Changes in motor system function and recovery after stroke
    Steven C Cramer
    Department of Neurology, University of California, Irvine, CA, USA
    Restor Neurol Neurosci 22:231-8. 2004
    ..Some of these changes have been found to correlate with features of injury, behavior, or treatment-induced behavioral gains. A current challenge is to extend these findings to improve clinical decision making...
  31. ncbi request reprint Motor recovery and cortical reorganization after constraint-induced movement therapy in stroke patients: a preliminary study
    Judith D Schaechter
    Massachusetts General Hospital NMR Center, Department of Radiology, Charlestown, MA 02129, USA
    Neurorehabil Neural Repair 16:326-38. 2002
    ..These data provide preliminary evidence that gains in motor function produced by CIMT in chronic stroke patients may be associated with a shift in laterality of motor cortical activation toward the undamaged hemisphere...
  32. ncbi request reprint Motor cortex stimulation for enhancement of recovery after stroke: case report
    Jeffrey A Brown
    Department of Neurological Surgery, Wayne State University School of Medicine, 4160 John R Suite 930, Detroit, MI 48201, USA
    Neurol Res 25:815-8. 2003
    ....
  33. ncbi request reprint Motor cortex organization after stroke is related to side of stroke and level of recovery
    Anna C Zemke
    Department of Neurology, University of Washington, Seattle, USA
    Stroke 34:e23-8. 2003
    ..The present study hypothesized that side of stroke and level of recovery influence motor system organization after stroke...
  34. ncbi request reprint Cerebral and cerebellar motor activation abnormalities in a subject with Joubert syndrome: functional magnetic resonance imaging (MRI) study
    Melissa A Parisi
    Department of Pediatrics, University of Washington, School of Medicine, Seattle 98195, USA
    J Child Neurol 19:214-8. 2004
    ..Malformation of the hindbrain could result in recruitment of alternative pathways, similar to what has been observed following ischemic injury to the developing or mature central nervous system...
  35. ncbi request reprint Mapping individual brains to guide restorative therapy after stroke: rationale and pilot studies
    Steven C Cramer
    University of California, Irvine, Department of Neurology, UCI Medical Center, 101 The City Drive South, Building 53, Room 203, Orange, CA 92868 4280, USA
    Neurol Res 25:811-4. 2003
    ..Initial details are presented of a study using this approach to evaluate such a therapy...
  36. ncbi request reprint Brain function early after stroke in relation to subsequent recovery
    Hoang Nhan
    Department of Neurology, University of Washington, Seattle, WA, USA
    J Cereb Blood Flow Metab 24:756-63. 2004
    ..The findings may be useful for restorative interventions introduced during the weeks after a stroke...
  37. ncbi request reprint FMRI investigation of cross-cultural music comprehension
    Steven J Morrison
    School of Music, University of Washington, Seattle, WA 98195 3450, USA
    Neuroimage 20:378-84. 2003
    ..Our findings indicate that listening to culturally different musics may activate similar neural resources but with dissimilar results in recall performance...
  38. ncbi request reprint Use of functional MRI to guide decisions in a clinical stroke trial
    Steven C Cramer
    University of California, Irvine, Calif, USA
    Stroke 36:e50-2. 2005
    ..The anatomical location for the target, hand motor area, varies across subjects, and so was localized with functional MRI (fMRI). This report describes the experience of incorporating standardized fMRI into a multisite stroke trial...
  39. ncbi request reprint The case for modality-specific outcome measures in clinical trials of stroke recovery-promoting agents
    Steven C Cramer
    Department of Neurology, University of California, Irvine, CA, USA
    Stroke 38:1393-5. 2007
    ..The use of such end points may result in a more selective labeling of stroke recovery treatments...
  40. ncbi request reprint Editorial comment--Implementing results of stroke recovery research into clinical practice
    Steven C Cramer
    Stroke 34:1752-3. 2003
  41. ncbi request reprint Improved understanding of cortical injury by incorporating measures of functional anatomy
    Kit R Crafton
    University of California Irvine, Department of Neurology, UCI Medical Centre, 101 The City Drive South, Building 53 Room 203 Orange, CA 92868 4280, USA
    Brain 126:1650-9. 2003
    ..In the current cross-sectional study, incorporating an understanding of normal tissue function into lesion measurement provided improved insights into the behavioural consequences of focal brain injury...
  42. ncbi request reprint A standardized approach to performing the action research arm test
    Nuray Yozbatiran
    Departments of Neurology and Anatomy, University of California, Irvine Medical Center, Orange, CA 92868 4280, USA
    Neurorehabil Neural Repair 22:78-90. 2008
    ..The ARAT, when performed in a standardized manner, is a useful tool for assessment of arm motor deficits after stroke...
  43. doi request reprint Neuroplasticity and brain repair after stroke
    Steven C Cramer
    Department of Neurology, University of California, Irvine, CA 92868 4280, USA
    Curr Opin Neurol 21:76-82. 2008
    ....
  44. doi request reprint Cortical activation during executed, imagined, and observed foot movements
    Elizabeth L R Orr
    Department of Neurology and Anatomy, University of California, Irvine, CA 92868, USA
    Neuroreport 19:625-30. 2008
    ..The findings suggest the utility of continued efforts to develop motor imagery and observation programs for improving lower extremity function in a range of clinical settings...
  45. doi request reprint Repairing the human brain after stroke: I. Mechanisms of spontaneous recovery
    Steven C Cramer
    Departments of Neurology and Anatomy and Neurobiology, University of California, Irvine, Irvine, CA 92868 4280, USA
    Ann Neurol 63:272-87. 2008
    ..Such measures gain importance when viewed as covariates in therapeutic trials of restorative agents that target stroke recovery...
  46. ncbi request reprint Paradoxical emboli from calf and pelvic veins in cryptogenic stroke
    Steven C Cramer
    University of California Irvine Medical Center, Department of Neurology, 101 The City Drive South, Building 53, Room 203, Orange, CA 92868 4280, USA
    J Neuroimaging 13:218-23. 2003
    ..The identification of deep venous thromboses (DVTs) in this population would strengthen this hypothesis. The purpose of this study was to image the subdiaphragmatic venous system in a cohort of patients with cryptogenic strokes...
  47. pmc Imaging motor recovery after stroke
    Nuray Yozbatiran
    Department of Neurology, University of California, Irvine, CA 92868, USA
    NeuroRx 3:482-8. 2006
    ..Brain mapping studies have characterized a number of processes and principles relevant to recovery from stroke in humans. The findings have potential application to improving therapeutics that aim to restore function after stroke...
  48. ncbi request reprint Automating arm movement training following severe stroke: functional exercises with quantitative feedback in a gravity-reduced environment
    Robert J Sanchez
    Department of Mechanical and Aerospace Engienering, University of California, Irvine, CA 92697 3975, USA
    IEEE Trans Neural Syst Rehabil Eng 14:378-89. 2006
    ..001). These results demonstrate the feasibility of automating upper-extremity rehabilitation therapy for people with severe stroke using passive gravity assistance, a grip sensor, and simple virtual reality software...
  49. ncbi request reprint Role of antiplatelet therapy in cardiovascular disease II: Ischemic stroke
    Jeffrey J Cavendish
    Department of Cardiology, Naval Medical Center, San Diego, CA 92134, USA
    Curr Med Res Opin 20:1845-9. 2004
    ..As illustrated in this paper, antiplatelet agents (e.g. clopidogrel, aspirin, dipyridamole) are the cornerstone of therapy for prevention of recurrent ischemic stroke...
  50. ncbi request reprint Patent foramen ovale and its relationship to stroke
    Steven C Cramer
    Department of Neurology, University of California, Irvine Medical Center, University of California, Irvine, 101 The City Drive South, Orange, CA 92868 4280, USA
    Cardiol Clin 23:7-11. 2005
    ..This article discusses the relationship between patent foramen ovale and stroke, particularly in reference to paradoxical embolism as a cause of cryptogenic stroke...
  51. ncbi request reprint Robotics, motor learning, and neurologic recovery
    David J Reinkensmeyer
    Department of Mechanical and Aerospace Engineering, University of California, Irvine, California 92697 3975, USA
    Annu Rev Biomed Eng 6:497-525. 2004
    ..In addition to providing insight into motor control, robotic paradigms may eventually enhance motor learning and rehabilitation beyond the levels possible with conventional training techniques...
  52. ncbi request reprint Age and features of movement influence motor overflow
    Julie A Bodwell
    Department of Neurology, University of Washington, Seattle, Washington, USA
    J Am Geriatr Soc 51:1735-9. 2003
    ..To measure the magnitude and prevalence of motor overflow to the arm at rest during attempted unilateral arm movements...
  53. ncbi request reprint Patent foramen ovale and stroke: prognosis and treatment in young adults
    Steven C Cramer
    Department of Neurology, UC Irvine Medical Center, University of CA Irvine, Orange, CA 92868 4280, USA
    J Thromb Thrombolysis 20:85-91. 2005
    ..Additional studies are needed, such as those focused on lower extremity veins or the cardiac interatrial septum, to guide therapy in specific stroke subpopulations...
  54. ncbi request reprint Brain motor system function after chronic, complete spinal cord injury
    Steven C Cramer
    Department of Neurology, University of California, Irvine, UCI Medical Center, Orange, CA 92868 4280, USA
    Brain 128:2941-50. 2005
    ..Because brain function is central to voluntary movement, interventions that aim to improve motor function after chronic SCI likely also need to attend to these abnormalities of brain function...
  55. ncbi request reprint Activity in the peri-infarct rim in relation to recovery from stroke
    Steven C Cramer
    Department of Neurology, University of Washington, Seattle, USA
    Stroke 37:111-5. 2006
    ..The current study hypothesized that in patients with good outcome after stroke, brain activation in peri-infarct tissue would be greater than normal...
  56. ncbi request reprint Increased pelvic vein thrombi in cryptogenic stroke: results of the Paradoxical Emboli from Large Veins in Ischemic Stroke (PELVIS) study
    Steven C Cramer
    University of Washington, Seattle, USA
    Stroke 35:46-50. 2004
    ..The Paradoxical Emboli From Large Veins in Ischemic Stroke (PELVIS) study hypothesized that patients with cryptogenic stroke have an increased prevalence of pelvic deep venous thrombosis (DVT)...
  57. pmc Neuroimaging in stroke recovery: a position paper from the First International Workshop on Neuroimaging and Stroke Recovery
    Jean Claude Baron
    Cerebrovasc Dis 18:260-7. 2004