Research Topics
| S C CramerSummaryAffiliation: University of Washington Country: USA Publications
| Collaborators
|
Detail Information
Publications
Functional imaging in stroke recoverySteven C Cramer
Department of Neurology, University of California Irvine Medical Center, 101 The City Dr S, Bldg 53, Room 203, Orange, CA 92868 4280, USA
Stroke 35:2695-8. 2004....- Robot-based hand motor therapy after strokeCraig D Takahashi
Department of Neurology, University of California, Irvine Medical Center, 101 The City Drive South, Building 53 Room 203, Orange, CA 92868 4280, USA
Brain 131:425-37. 2008..A robot-based therapy showed improvements in hand motor function after chronic stroke. Reorganization of motor maps during the current therapy was task-specific, a finding useful when considering generalization of rehabilitation therapy... - A pilot study of somatotopic mapping after cortical infarctS C Cramer
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Stroke 31:668-71. 2000..Animal studies have described remodeling of sensory and motor representational maps after cortical infarct. These changes may contribute to return of function after stroke... - Motor cortex activation is related to force of squeezingSteven C Cramer
MGH NMR Center, Department of Radiology, Charlestown, Massachusetts, USA
Hum Brain Mapp 16:197-205. 2002..This relationship was found across the full spectrum of forces that the human hand is capable of generating. Use of a valid, reliable method for assessing motor behavior during functional MRI may be important to clinical applications... - A functional MRI study of three motor tasks in the evaluation of stroke recoveryS C Cramer
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, USA
Neurorehabil Neural Repair 15:1-8. 2001..The results may be useful for future studies of motor recovery after stroke... - Functional magnetic resonance imaging in stroke recoverySteven C Cramer
Department of Neurology, University of Washington, 1959 NE Pacific, Room RR650, Box 356465, Seattle, Washington 98195 6465, USA
Phys Med Rehabil Clin N Am 14:S47-55. 2003..Functional MR imaging provides insights into brain plasticity after stroke and remains a valuable tool in the study of motor recovery after stroke... - Motor cortex activation is preserved in patients with chronic hemiplegic strokeSteven C Cramer
Department of Neurology, University of Washington, 1959 NE Pacific Street, Room RR650, Box 356465, Seattle, WA 98195 6565, USA
Ann Neurol 52:607-16. 2002.... - Mapping clinically relevant plasticity after strokeS C Cramer
Department of Neurology, University of Washington, Seattle 98195 6465, USA
Neuropharmacology 39:842-51. 2000..With the advent of treatments targeting stroke recovery, measurement of post-stroke restorative events may also have value as a surrogate end point in clinical trials... - Stroke recovery. Lessons from functional MR imaging and other methods of human brain mappingS C Cramer
Department of Neurology, University of Washington, Seattle, USA
Phys Med Rehabil Clin N Am 10:875-86, ix. 1999..After a unilateral brain insult, lasting changes take place in both hemispheres and along the rim of a cortical infarct. Such information may be of value in the design of therapies targeting stroke recovery... - Computerized measurement of motor performance after strokeS C Cramer
Department of Neurology, Massachusetts General Hospital, Boston, USA
Stroke 28:2162-8. 1997..Computerized methods sensitive to small changes in neurological status may be of value for studying and measuring stroke recovery... - A functional MRI study of subjects recovered from hemiparetic strokeS C Cramer
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass, USA
Stroke 28:2518-27. 1997..We used functional magnetic resonance imaging to compare brain activations in normal controls and subjects who recovered from hemiparetic stroke... - Pharmacological elevation of blood pressure in acute stroke. Clinical effects and safetyG Rordorf
Department of Neurology and Stroke Service, Massachusetts General Hospital, Boston 02114, USA
Stroke 28:2133-8. 1997..The aim of our study was to determine whether induced hypertension in stroke is safe and to examine its effects on neurological deficits in patients presenting with acute cerebral ischemia... - Quantitative assessment of mirror movements after strokeG Nelles
Department of Neurology, Massachusetts General Hospital, Boston, USA
Stroke 29:1182-7. 1998..We measured MM in stroke and control subjects and evaluated whether MM after stroke are related to motor function... - Changes in motor cortex activation after recovery from spinal cord inflammationS C Cramer
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, USA
Mult Scler 7:364-70. 2001..The expanded activation in motor cortex, seen with several forms of spinal cord insult may have maximal utility when corticospinal tract axons are preserved... - Instructional treatment associated with changes in brain activation in children with dyslexiaE H Aylward
Department of Radiology, University of Washington, Seattle 98195, USA
Neurology 61:212-9. 2003..To assess the effects of reading instruction on fMRI brain activation in children with dyslexia... - Brain activation during face perception: evidence of a developmental changeE H Aylward
Department of Radiology, University of Washington, Seattle, WA 98195, USA
J Cogn Neurosci 17:308-19. 2005..The current results provide biological insight into changes in visual processing of faces that occur with normal development... - Diffusion abnormalities in patients with Wernicke encephalopathyM J Doherty
Department of Neurology, University of Washington, Seattle 98195, USA
Neurology 58:655-7. 2002..DWI abnormalities may suggest early thiamine deficiency and are useful in diagnosing Wernicke encephalopathy... - Regional ischemia and ischemic injury in patients with acute middle cerebral artery stroke as defined by early diffusion-weighted and perfusion-weighted MRIG Rordorf
Department of Neurology, Massachusetts General Hospital, Boston 02114, USA
Stroke 29:939-43. 1998..MRI can now delineate very early infarction by diffusion-weighted imaging (DWI) and abnormal tissue perfusion by perfusion-weighted imaging (PWI)... - Predictors of mortality in stroke patients admitted to an intensive care unitG Rordorf
Department of Neurology, Massachusetts General Hospital, Boston 02114 2696, USA
Crit Care Med 28:1301-5. 2000..Improved pathophysiologic insight and prognostic information regarding in-hospital risk of mortality among stroke patients admitted to an intensive care unit... 
Predictors of surface disruption with MR imaging in asymptomatic carotid artery stenosisH R Underhill
Department of Radiology, University of Washington, Seattle, WA 98109, USA
AJNR Am J Neuroradiol 31:487-93. 2010..In this prospective observational study, we sought to determine the characteristics of the carotid lesion that predict the development of new surface disruption...- Brain activation during execution and motor imagery of novel and skilled sequential hand movementsMichael G Lacourse
Neuromotor Rehabilitation Research Laboratory, Long Beach Veteran s Affairs Healthcare System, CA 90822, USA
Neuroimage 27:505-19. 2005.... - Somatotopy and movement representation sites following cortical strokeSteven C Cramer
Department of Neurology, University of Washington, Seattle, WA, USA
Exp Brain Res 168:25-32. 2006..Greater injury and larger behavioral deficits are associated with distinct effects on movement representation sites. Changes in motor organization within and between hemispheres arise independently after stroke... - Stroke recovery and its imagingCraig D Takahashi
Department of Neurology, University of California at Irvine, CA 92868-4280, USA
Neuroimaging Clin N Am 15:681-95, xii. 2005..Key challenges for the future are to develop standardized approaches to help address certain questions, determine the psychometric qualities of these measures, and define the clinical usefulness of these methods... - BDNF val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortexJeffrey A Kleim
Brain Research Rehabilitation Center, Malcom Randall VA Hospital, 1601 SW Archer Road, Gainesville, Florida 32608, USA
Nat Neurosci 9:735-7. 2006..The results suggest that BDNF is involved in mediating experience-dependent plasticity of human motor cortex... - Effects of motor imagery training after chronic, complete spinal cord injurySteven C Cramer
Department of Neurology, Associate, Reeve Irvine Research Center, University of California, Irvine, USA
Exp Brain Res 177:233-42. 2007..Motor imagery might be of value as one component of a restorative intervention... - Functional imaging of intervention effects in stroke motor rehabilitationTimea Hodics
Department of Neurology, Georgetown University Hospital, Washington, DC 20007, USA
Arch Phys Med Rehabil 87:S36-42. 2006..To assess intervention-specific effects on cortical reorganization after stroke as shown by available functional neuroimaging studies... - Predicting functional gains in a stroke trialSteven C Cramer
Department of Anatomy, University of California, Irvine, CA, USA
Stroke 38:2108-14. 2007..The current study tested the hypothesis that, after adjusting for a number of clinical assessments, a measure of brain function at baseline would improve prediction of behavioral gains after treatment... - Systematic assessment of training-induced changes in corticospinal output to hand using frameless stereotaxic transcranial magnetic stimulationJeffrey A Kleim
Brain Rehabilitation Research Center, Malcom Randall VA Hospital, 1601 SW Archer Road, Gainesville, Florida 32608, USA
Nat Protoc 2:1675-84. 2007..The protocol allows for reliably and repeatedly detecting changes in corticospinal output to FDI muscle in response to brief periods of motor training... - Motor cortex stimulation for the enhancement of recovery from stroke: a prospective, multicenter safety studyJeffrey A Brown
Department of Neurosurgery, Wayne State University, Detroit, Michigan, USA
Neurosurgery 58:464-73. 2006.... - Changes in motor system function and recovery after strokeSteven C Cramer
Department of Neurology, University of California, Irvine, CA, USA
Restor Neurol Neurosci 22:231-8. 2004..Some of these changes have been found to correlate with features of injury, behavior, or treatment-induced behavioral gains. A current challenge is to extend these findings to improve clinical decision making... - Motor recovery and cortical reorganization after constraint-induced movement therapy in stroke patients: a preliminary studyJudith D Schaechter
Massachusetts General Hospital NMR Center, Department of Radiology, Charlestown, MA 02129, USA
Neurorehabil Neural Repair 16:326-38. 2002..These data provide preliminary evidence that gains in motor function produced by CIMT in chronic stroke patients may be associated with a shift in laterality of motor cortical activation toward the undamaged hemisphere... - Motor cortex stimulation for enhancement of recovery after stroke: case reportJeffrey A Brown
Department of Neurological Surgery, Wayne State University School of Medicine, 4160 John R Suite 930, Detroit, MI 48201, USA
Neurol Res 25:815-8. 2003.... - Motor cortex organization after stroke is related to side of stroke and level of recoveryAnna C Zemke
Department of Neurology, University of Washington, Seattle, USA
Stroke 34:e23-8. 2003..The findings may have implications for treatment after stroke... - Cerebral and cerebellar motor activation abnormalities in a subject with Joubert syndrome: functional magnetic resonance imaging (MRI) studyMelissa A Parisi
Department of Pediatrics, University of Washington, School of Medicine, Seattle 98195, USA
J Child Neurol 19:214-8. 2004..Malformation of the hindbrain could result in recruitment of alternative pathways, similar to what has been observed following ischemic injury to the developing or mature central nervous system... - Mapping individual brains to guide restorative therapy after stroke: rationale and pilot studiesSteven C Cramer
University of California, Irvine, Department of Neurology, UCI Medical Center, 101 The City Drive South, Building 53, Room 203, Orange, CA 92868 4280, USA
Neurol Res 25:811-4. 2003..Initial details are presented of a study using this approach to evaluate such a therapy... - Brain function early after stroke in relation to subsequent recoveryHoang Nhan
Department of Neurology, University of Washington, Seattle, WA, USA
J Cereb Blood Flow Metab 24:756-63. 2004..The findings may be useful for restorative interventions introduced during the weeks after a stroke... - FMRI investigation of cross-cultural music comprehensionSteven J Morrison
School of Music, University of Washington, Seattle, WA 98195 3450, USA
Neuroimage 20:378-84. 2003..Our findings indicate that listening to culturally different musics may activate similar neural resources but with dissimilar results in recall performance... - Use of functional MRI to guide decisions in a clinical stroke trialSteven C Cramer
University of California, Irvine, Calif, USA
Stroke 36:e50-2. 2005..The anatomical location for the target, hand motor area, varies across subjects, and so was localized with functional MRI (fMRI). This report describes the experience of incorporating standardized fMRI into a multisite stroke trial... - The case for modality-specific outcome measures in clinical trials of stroke recovery-promoting agentsSteven C Cramer
Department of Neurology, University of California, Irvine, CA, USA
Stroke 38:1393-5. 2007..The use of such end points may result in a more selective labeling of stroke recovery treatments... - Editorial comment--Implementing results of stroke recovery research into clinical practiceSteven C Cramer
Stroke 34:1752-3. 2003 - Improved understanding of cortical injury by incorporating measures of functional anatomyKit R Crafton
University of California Irvine, Department of Neurology, UCI Medical Centre, 101 The City Drive South, Building 53 Room 203 Orange, CA 92868 4280, USA
Brain 126:1650-9. 2003..In the current cross-sectional study, incorporating an understanding of normal tissue function into lesion measurement provided improved insights into the behavioural consequences of focal brain injury... - A standardized approach to performing the action research arm testNuray Yozbatiran
Departments of Neurology and Anatomy, University of California, Irvine Medical Center, Orange, CA 92868 4280, USA
Neurorehabil Neural Repair 22:78-90. 2008..The ARAT, when performed in a standardized manner, is a useful tool for assessment of arm motor deficits after stroke... 
Neuroplasticity and brain repair after strokeSteven C Cramer
Department of Neurology, University of California, Irvine, CA 92868 4280, USA
Curr Opin Neurol 21:76-82. 2008....- Cortical activation during executed, imagined, and observed foot movementsElizabeth L R Orr
Department of Neurology and Anatomy, University of California, Irvine, CA 92868, USA
Neuroreport 19:625-30. 2008..The findings suggest the utility of continued efforts to develop motor imagery and observation programs for improving lower extremity function in a range of clinical settings... - Repairing the human brain after stroke: I. Mechanisms of spontaneous recoverySteven C Cramer
Departments of Neurology and Anatomy and Neurobiology, University of California, Irvine, Irvine, CA 92868 4280, USA
Ann Neurol 63:272-87. 2008..Such measures gain importance when viewed as covariates in therapeutic trials of restorative agents that target stroke recovery... - Paradoxical emboli from calf and pelvic veins in cryptogenic strokeSteven C Cramer
University of California Irvine Medical Center, Department of Neurology, 101 The City Drive South, Building 53, Room 203, Orange, CA 92868 4280, USA
J Neuroimaging 13:218-23. 2003..The identification of deep venous thromboses (DVTs) in this population would strengthen this hypothesis. The purpose of this study was to image the subdiaphragmatic venous system in a cohort of patients with cryptogenic strokes... - Imaging motor recovery after strokeNuray Yozbatiran
Department of Neurology, University of California, Irvine, CA 92868, USA
NeuroRx 3:482-8. 2006..Brain mapping studies have characterized a number of processes and principles relevant to recovery from stroke in humans. The findings have potential application to improving therapeutics that aim to restore function after stroke... - Automating arm movement training following severe stroke: functional exercises with quantitative feedback in a gravity-reduced environmentRobert J Sanchez
Department of Mechanical and Aerospace Engienering, University of California, Irvine, CA 92697 3975, USA
IEEE Trans Neural Syst Rehabil Eng 14:378-89. 2006..001). These results demonstrate the feasibility of automating upper-extremity rehabilitation therapy for people with severe stroke using passive gravity assistance, a grip sensor, and simple virtual reality software... - Role of antiplatelet therapy in cardiovascular disease II: Ischemic strokeJeffrey J Cavendish
Department of Cardiology, Naval Medical Center, San Diego, CA 92134, USA
Curr Med Res Opin 20:1845-9. 2004..As illustrated in this paper, antiplatelet agents (e.g. clopidogrel, aspirin, dipyridamole) are the cornerstone of therapy for prevention of recurrent ischemic stroke... - Patent foramen ovale and its relationship to strokeSteven C Cramer
Department of Neurology, University of California, Irvine Medical Center, University of California, Irvine, 101 The City Drive South, Orange, CA 92868 4280, USA
Cardiol Clin 23:7-11. 2005..This article discusses the relationship between patent foramen ovale and stroke, particularly in reference to paradoxical embolism as a cause of cryptogenic stroke... - Robotics, motor learning, and neurologic recoveryDavid J Reinkensmeyer
Department of Mechanical and Aerospace Engineering, University of California, Irvine, California 92697 3975, USA
Annu Rev Biomed Eng 6:497-525. 2004..In addition to providing insight into motor control, robotic paradigms may eventually enhance motor learning and rehabilitation beyond the levels possible with conventional training techniques... - Age and features of movement influence motor overflowJulie A Bodwell
Department of Neurology, University of Washington, Seattle, Washington, USA
J Am Geriatr Soc 51:1735-9. 2003..The results support the hypotheses that healthy aging is associated with an increase in the degree to which brain function is bilaterally organized... - Patent foramen ovale and stroke: prognosis and treatment in young adultsSteven C Cramer
Department of Neurology, UC Irvine Medical Center, University of CA Irvine, Orange, CA 92868 4280, USA
J Thromb Thrombolysis 20:85-91. 2005..Additional studies are needed, such as those focused on lower extremity veins or the cardiac interatrial septum, to guide therapy in specific stroke subpopulations... - Brain motor system function after chronic, complete spinal cord injurySteven C Cramer
Department of Neurology, University of California, Irvine, UCI Medical Center, Orange, CA 92868 4280, USA
Brain 128:2941-50. 2005..Because brain function is central to voluntary movement, interventions that aim to improve motor function after chronic SCI likely also need to attend to these abnormalities of brain function... - Activity in the peri-infarct rim in relation to recovery from strokeSteven C Cramer
Department of Neurology, University of Washington, Seattle, USA
Stroke 37:111-5. 2006..The current study hypothesized that in patients with good outcome after stroke, brain activation in peri-infarct tissue would be greater than normal... - Increased pelvic vein thrombi in cryptogenic stroke: results of the Paradoxical Emboli from Large Veins in Ischemic Stroke (PELVIS) studySteven C Cramer
University of Washington, Seattle, USA
Stroke 35:46-50. 2004..The Paradoxical Emboli From Large Veins in Ischemic Stroke (PELVIS) study hypothesized that patients with cryptogenic stroke have an increased prevalence of pelvic deep venous thrombosis (DVT)... - Neuroimaging in stroke recovery: a position paper from the First International Workshop on Neuroimaging and Stroke RecoveryJean-Claude Baron
Cerebrovasc Dis 18:260-7. 2004