ROGER W CRAIG

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. doi request reprint Structure, sarcomeric organization, and thin filament binding of cardiac myosin-binding protein-C
    Roger Craig
    Department of Cell and Developmental Biology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA, 01655, USA
    Pflugers Arch 466:425-31. 2014
  2. pmc Isolation, electron microscopy and 3D reconstruction of invertebrate muscle myofilaments
    Roger Craig
    Department of Cell Biology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Methods 56:33-43. 2012
  3. pmc Analysis of tarantula skeletal muscle protein sequences and identification of transcriptional isoforms
    Jingui Zhu
    Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, PR China
    BMC Genomics 10:117. 2009
  4. ncbi request reprint Crossbridge and tropomyosin positions observed in native, interacting thick and thin filaments
    R Craig
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Mol Biol 311:1027-36. 2001
  5. ncbi request reprint Structure and function of myosin filaments
    Roger Craig
    Department of Cell Biology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Curr Opin Struct Biol 16:204-12. 2006
  6. ncbi request reprint Helical order in tarantula thick filaments requires the "closed" conformation of the myosin head
    M E Zoghbi
    Department of Cell Biology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    J Mol Biol 342:1223-36. 2004
  7. pmc Purification of native myosin filaments from muscle
    C Hidalgo
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Biophys J 81:2817-26. 2001
  8. ncbi request reprint Mechanism of phosphorylation of the regulatory light chain of myosin from tarantula striated muscle
    C Hidalgo
    Departamento de Biología Estructural, Instituto Venezolano de Investigaciones Cientificas, Caracas
    J Muscle Res Cell Motil 22:51-9. 2001
  9. ncbi request reprint The tip of the coiled-coil rod determines the filament formation of smooth muscle and nonmuscle myosin
    M Ikebe
    Departments of Physiology and Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Biol Chem 276:30293-300. 2001
  10. pmc Functional analysis of Tpr: identification of nuclear pore complex association and nuclear localization domains and a role in mRNA export
    P Bangs
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Cell Biol 143:1801-12. 1998

Research Grants

  1. Structural Basis of Muscle Regulation
    Roger Craig; Fiscal Year: 2007
  2. STRUCTURAL BASIS OF SMOOTH MUSCLE CONTRACTION
    Roger Craig; Fiscal Year: 2002
  3. STRUCTURE OF CONTRACTILE FILAMENTS OF MUSCLE
    Roger Craig; Fiscal Year: 1992
  4. MOLECULAR STRUCTURE OF CONTRACTILE FILAMENTS OF MUSCLE
    Roger Craig; Fiscal Year: 1999
  5. Structural Basis of Muscle Regulation
    Roger Craig; Fiscal Year: 2009
  6. Scanning Electron Microscope for Core EM Facility
    Roger Craig; Fiscal Year: 2007
  7. CCD Digital Imaging System for Core EM Facility
    Roger Craig; Fiscal Year: 2004
  8. Structural Basis of Muscle Regulation
    ROGER W CRAIG; Fiscal Year: 2010

Collaborators

Detail Information

Publications11

  1. doi request reprint Structure, sarcomeric organization, and thin filament binding of cardiac myosin-binding protein-C
    Roger Craig
    Department of Cell and Developmental Biology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA, 01655, USA
    Pflugers Arch 466:425-31. 2014
    ..We also discuss the effects that phosphorylation of cMyBP-C has on some of these structural features and how this might relate to cMyBP-C function in the beating heart. ..
  2. pmc Isolation, electron microscopy and 3D reconstruction of invertebrate muscle myofilaments
    Roger Craig
    Department of Cell Biology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Methods 56:33-43. 2012
    ..It also highlights some of the key insights into filament function that have come from these studies...
  3. pmc Analysis of tarantula skeletal muscle protein sequences and identification of transcriptional isoforms
    Jingui Zhu
    Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, PR China
    BMC Genomics 10:117. 2009
    ..Tarantula has been used as a model system for studying skeletal muscle structure and function, yet data on the genes expressed in tarantula muscle are lacking...
  4. ncbi request reprint Crossbridge and tropomyosin positions observed in native, interacting thick and thin filaments
    R Craig
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Mol Biol 311:1027-36. 2001
    ....
  5. ncbi request reprint Structure and function of myosin filaments
    Roger Craig
    Department of Cell Biology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Curr Opin Struct Biol 16:204-12. 2006
    ..Additionally, sequence analysis suggests probable interactions between myosin tails in the backbone, whereas crystallographic and EM studies are starting to reveal tail interactions directly in three dimensions...
  6. ncbi request reprint Helical order in tarantula thick filaments requires the "closed" conformation of the myosin head
    M E Zoghbi
    Department of Cell Biology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    J Mol Biol 342:1223-36. 2004
    ..We suggest that helical order requires the closed conformation of the myosin head but is not dependent on the hydrolysis of ATP...
  7. pmc Purification of native myosin filaments from muscle
    C Hidalgo
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Biophys J 81:2817-26. 2001
    ..Such preparations should be useful for thick filament structural and biochemical studies...
  8. ncbi request reprint Mechanism of phosphorylation of the regulatory light chain of myosin from tarantula striated muscle
    C Hidalgo
    Departamento de Biología Estructural, Instituto Venezolano de Investigaciones Cientificas, Caracas
    J Muscle Res Cell Motil 22:51-9. 2001
    ..At still higher Ca2+ concentrations we find partial inhibition of RLC phosphorylation, suggesting an additional mechanism by which the muscle cell can fine tune contractile activity by controlling the level of free Ca2+...
  9. ncbi request reprint The tip of the coiled-coil rod determines the filament formation of smooth muscle and nonmuscle myosin
    M Ikebe
    Departments of Physiology and Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Biol Chem 276:30293-300. 2001
    ..We conclude that the C-terminal end of the coiled-coil domain, but not the nonhelical tail piece, of myosin II is critical for myosin filament formation both in vitro and in vivo...
  10. pmc Functional analysis of Tpr: identification of nuclear pore complex association and nuclear localization domains and a role in mRNA export
    P Bangs
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Cell Biol 143:1801-12. 1998
    ....
  11. ncbi request reprint Electron microscopy of the actin-myosin head complex in the presence of ATP
    L L Frado
    Department of Cell Biology, University of Massachusetts Medical School, Worcester 01655
    J Mol Biol 223:391-7. 1992
    ..In the presence of ATP, attached molecules showed a less ordered structure, often with only one head attached. We conclude that configurations other than the rigor structure occur during the actomyosin cross-bridge cycle...

Research Grants24

  1. Structural Basis of Muscle Regulation
    Roger Craig; Fiscal Year: 2007
    ..Defining molecular mechanisms in healthy muscle is essential to understanding structural defects in skeletal and cardiac myopathies. ..
  2. STRUCTURAL BASIS OF SMOOTH MUSCLE CONTRACTION
    Roger Craig; Fiscal Year: 2002
    ..Preliminary data are presented showing the feasibility of our goals. ..
  3. STRUCTURE OF CONTRACTILE FILAMENTS OF MUSCLE
    Roger Craig; Fiscal Year: 1992
    ..Such knowledge is essential to an understanding of defects in structure that occur in diseased states...
  4. MOLECULAR STRUCTURE OF CONTRACTILE FILAMENTS OF MUSCLE
    Roger Craig; Fiscal Year: 1999
    ..And it will deepen our understanding of the structure of healthy muscle, which is essential to an understanding of structural defects that occur in diseased states. ..
  5. Structural Basis of Muscle Regulation
    Roger Craig; Fiscal Year: 2009
    ..Insights into the molecular basis of relaxation that emerge from our work will lay the foundation for understanding the cause of such diseases, and also how muscles are activated. ..
  6. Scanning Electron Microscope for Core EM Facility
    Roger Craig; Fiscal Year: 2007
    ..Many have a direct bearing on the understanding of human disease. Results provided by this instrument will play a key role in advancing our knowledge in these areas. ..
  7. CCD Digital Imaging System for Core EM Facility
    Roger Craig; Fiscal Year: 2004
    ..A third TEM will continue to operate with film for researchers who prefer this medium. ..
  8. Structural Basis of Muscle Regulation
    ROGER W CRAIG; Fiscal Year: 2010
    ..Insights into the molecular basis of relaxation that emerge from our work will lay the foundation for understanding the cause of such diseases, and also how muscles are activated. ..