S Craft

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi Accelerated decline in apolipoprotein E-epsilon4 homozygotes with Alzheimer's disease
    S Craft
    Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, and Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle 98018, USA
    Neurology 51:149-53. 1998
  2. ncbi Insulin dose-response effects on memory and plasma amyloid precursor protein in Alzheimer's disease: interactions with apolipoprotein E genotype
    Suzanne Craft
    Geriatric Research, Education, and Clinical Center, Veteran Affairs Puget Sound Health Care System, 1660 South Columbian Way, Seattle, WA 98108, USA
    Psychoneuroendocrinology 28:809-22. 2003
  3. ncbi Insulin resistance syndrome and Alzheimer disease: pathophysiologic mechanisms and therapeutic implications
    Suzanne Craft
    Department of Psychiatry and Behavioral Sciences, Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, University of Washington School of Medicine, Seattle, WA 98108, USA
    Alzheimer Dis Assoc Disord 20:298-301. 2006
  4. ncbi Insulin resistance syndrome and Alzheimer's disease: age- and obesity-related effects on memory, amyloid, and inflammation
    Suzanne Craft
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98108, USA
    Neurobiol Aging 26:65-9. 2005
  5. ncbi Insulin resistance and Alzheimer's disease pathogenesis: potential mechanisms and implications for treatment
    Suzanne Craft
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA
    Curr Alzheimer Res 4:147-52. 2007
  6. pmc The role of metabolic disorders in Alzheimer disease and vascular dementia: two roads converged
    Suzanne Craft
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound, Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, 98108, USA
    Arch Neurol 66:300-5. 2009
  7. ncbi Insulin and neurodegenerative disease: shared and specific mechanisms
    Suzanne Craft
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Medical Center, Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, 98108, USA
    Lancet Neurol 3:169-78. 2004
  8. ncbi Insulin effects on glucose metabolism, memory, and plasma amyloid precursor protein in Alzheimer's disease differ according to apolipoprotein-E genotype
    S Craft
    Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington 98108, USA
    Ann N Y Acad Sci 903:222-8. 2000
  9. ncbi Enhancement of memory in Alzheimer disease with insulin and somatostatin, but not glucose
    S Craft
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Wash 98108, USA
    Arch Gen Psychiatry 56:1135-40. 1999
  10. ncbi Intranasal insulin improves cognition and modulates beta-amyloid in early AD
    M A Reger
    Department of Psychiatry and Behavioral Science, University of Washington School of Medicine, Seattle, WA, USA
    Neurology 70:440-8. 2008

Research Grants

Detail Information

Publications53

  1. ncbi Accelerated decline in apolipoprotein E-epsilon4 homozygotes with Alzheimer's disease
    S Craft
    Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, and Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle 98018, USA
    Neurology 51:149-53. 1998
    ..The current study examined rate of decline in the largest sample of APOE-genotyped AD patients for whom longitudinal cognitive data have been reported...
  2. ncbi Insulin dose-response effects on memory and plasma amyloid precursor protein in Alzheimer's disease: interactions with apolipoprotein E genotype
    Suzanne Craft
    Geriatric Research, Education, and Clinical Center, Veteran Affairs Puget Sound Health Care System, 1660 South Columbian Way, Seattle, WA 98108, USA
    Psychoneuroendocrinology 28:809-22. 2003
    ....
  3. ncbi Insulin resistance syndrome and Alzheimer disease: pathophysiologic mechanisms and therapeutic implications
    Suzanne Craft
    Department of Psychiatry and Behavioral Sciences, Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, University of Washington School of Medicine, Seattle, WA 98108, USA
    Alzheimer Dis Assoc Disord 20:298-301. 2006
    ..These convergent effects may impair memory and induce AD pathology. Therapeutic strategies focused on preventing or correcting insulin abnormalities may thus benefit adults with age-related memory impairment and AD...
  4. ncbi Insulin resistance syndrome and Alzheimer's disease: age- and obesity-related effects on memory, amyloid, and inflammation
    Suzanne Craft
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98108, USA
    Neurobiol Aging 26:65-9. 2005
    ..This constellation of events may have deleterious effects on memory. Treatments focused on preventing or correcting insulin abnormalities may be of therapeutic benefit for adults with age-related memory impairment and AD...
  5. ncbi Insulin resistance and Alzheimer's disease pathogenesis: potential mechanisms and implications for treatment
    Suzanne Craft
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA
    Curr Alzheimer Res 4:147-52. 2007
    ..These convergent effects may impair memory and induce AD pathology. Therapeutic strategies focused on preventing or correcting insulin abnormalities may thus benefit a subset of adults with age-related memory impairment and AD...
  6. pmc The role of metabolic disorders in Alzheimer disease and vascular dementia: two roads converged
    Suzanne Craft
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound, Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, 98108, USA
    Arch Neurol 66:300-5. 2009
    ..Identification of such convergent factors will not only provide important insight into the causes and interdependencies of late-life dementias but will also inspire novel strategies for treating and preventing these disorders...
  7. ncbi Insulin and neurodegenerative disease: shared and specific mechanisms
    Suzanne Craft
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Medical Center, Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, 98108, USA
    Lancet Neurol 3:169-78. 2004
    ..We conclude by considering whether insulin dysregulation contributes to neurodegenerative disorders through disease-specific or general mechanisms...
  8. ncbi Insulin effects on glucose metabolism, memory, and plasma amyloid precursor protein in Alzheimer's disease differ according to apolipoprotein-E genotype
    S Craft
    Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington 98108, USA
    Ann N Y Acad Sci 903:222-8. 2000
    ....
  9. ncbi Enhancement of memory in Alzheimer disease with insulin and somatostatin, but not glucose
    S Craft
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Wash 98108, USA
    Arch Gen Psychiatry 56:1135-40. 1999
    ..We address this question by examining memory and counterregulatory hormone response during hyperglycemia when endogenous insulin was suppressed by concomitant infusion of the somatostatin analogue octreotide (Sandostatin)...
  10. ncbi Intranasal insulin improves cognition and modulates beta-amyloid in early AD
    M A Reger
    Department of Psychiatry and Behavioral Science, University of Washington School of Medicine, Seattle, WA, USA
    Neurology 70:440-8. 2008
    ..After intranasal administration, insulin-like peptides follow extracellular pathways to the brain within 15 minutes...
  11. ncbi Testosterone supplementation improves spatial and verbal memory in healthy older men
    M M Cherrier
    Department of Psychiatry and Behavioral Sciences, University of Washington Medical School, Seattle, WA 98195, USA
    Neurology 57:80-8. 2001
    ..To determine the relationship between exogenous testosterone administration and cognitive abilities in a population of healthy older men...
  12. ncbi Cognitive and neuroendocrine response to transdermal estrogen in postmenopausal women with Alzheimer's disease: results of a placebo-controlled, double-blind, pilot study
    S Asthana
    Geriatric Research, Education and Clinical Center GRECC, VA Puget Sound Health Care System, American Lake Division, Tacoma, WA 98493, USA
    Psychoneuroendocrinology 24:657-77. 1999
    ....
  13. ncbi Insulin metabolism in Alzheimer's disease differs according to apolipoprotein E genotype and gender
    S Craft
    Geriatric Research, Education, and Clinical Center, Veteran Affairs Puget Sound Health Care System, University of Washington School of Medicine, Seattle, Wash
    Neuroendocrinology 70:146-52. 1999
    ....
  14. ncbi Testosterone improves spatial memory in men with Alzheimer disease and mild cognitive impairment
    M M Cherrier
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA
    Neurology 64:2063-8. 2005
    ..To determine the efficacy of testosterone (T) supplementation on cognition in a sample of men with Alzheimer disease (AD) or mild cognitive impairment (MCI)...
  15. ncbi Differential modulation of plasma beta-amyloid by insulin in patients with Alzheimer disease
    J J Kulstad
    Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, WA 98108, USA
    Neurology 66:1506-10. 2006
    ..Insulin regulates levels of the amyloid beta-peptide (Abeta) in vitro in neuronal cultures and in vivo in the CSF of normal older adults...
  16. pmc Characterization of verbal and spatial memory changes from moderate to supraphysiological increases in serum testosterone in healthy older men
    M M Cherrier
    Department of Psychiatry and Behavioral Sciences, University of Washington Medical School, Seattle, WA 98195, USA
    Psychoneuroendocrinology 32:72-9. 2007
    ..The objective of this study was to compare the cognitive responses of older, eugonadal men in whom moderate or large increases in serum testosterone levels was induced by exogenous testosterone supplementation...
  17. ncbi The role of aromatization in testosterone supplementation: effects on cognition in older men
    M M Cherrier
    Department of Psychiatry and Behavioral Sciences, University of Washington Medical School, Seattle, WA, USA
    Neurology 64:290-6. 2005
    ..To determine the contribution of conversion of testosterone (T) to estradiol on cognitive processing in a population of healthy older men who received T supplementation...
  18. ncbi High-dose estradiol improves cognition for women with AD: results of a randomized study
    S Asthana
    Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle Tacoma, Tacoma, WA 98493, USA
    Neurology 57:605-12. 2001
    ..To characterize the cognitive and neuroendocrine response to treatment with a high dose of estrogen for postmenopausal women with AD...
  19. ncbi Relationship between testosterone supplementation and insulin-like growth factor-I levels and cognition in healthy older men
    M M Cherrier
    Department of Psychiatry and Behavioral Sciences, University of Washington Medical School, 1959 NE Pacific, Box 356560, Seattle, WA 98195, USA
    Psychoneuroendocrinology 29:65-82. 2004
    ..This study examined potential changes in insulin-like growth factor (IGF) IGF-I, IGF-II and IGF-related binding proteins in response to T administration in older men and their relationship to cognitive functioning...
  20. ncbi Insulin increases CSF Abeta42 levels in normal older adults
    G S Watson
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle 98108, USA
    Neurology 60:1899-903. 2003
    ..In vitro studies show that insulin enhances the release of beta-amyloid protein (Abeta) or inhibits its degradation, either of which might increase amyloid burden...
  21. pmc Intranasal insulin administration dose-dependently modulates verbal memory and plasma amyloid-beta in memory-impaired older adults
    Mark A Reger
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    J Alzheimers Dis 13:323-31. 2008
    ..These findings suggest that groups with different genetic risks for AD may show differential dose-response curves following intranasal insulin administration...
  22. ncbi Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype
    M A Reger
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, 1660 S, Columbian Way, S182 GRECC, Seattle, WA 98108, USA
    Neurobiol Aging 27:451-8. 2006
    ..These findings suggest that intranasal insulin administration may have therapeutic benefit without the risk of peripheral hypoglycemia and provide further evidence for apolipoprotein E (APOE) related differences in insulin metabolism...
  23. doi Insulin resistance and pathological brain ageing
    B Cholerton
    Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98108, USA
    Diabet Med 28:1463-75. 2011
    ..Fortunately, insulin resistance-associated conditions are amenable to both pharmacologic and lifestyle interventions that may reduce the deleterious impact of insulin resistance on the ageing brain...
  24. pmc Statin users without an APOE-epsilon4 allele have increased insulin resistance
    Brian T Vanfossen
    GRECC, VA Puget Sound Health Care System, Seattle, WA 98108, USA
    J Alzheimers Dis 19:1149-53. 2010
    ..0169), and with non-users who were epsilon4- (p=0.0003) or epsilon4+ (p=0.0006). These results suggest that statin use may modulate insulin levels for individuals without an APOE epsilon4 allele...
  25. pmc Effects of insulin and octreotide on memory and growth hormone in Alzheimer's disease
    G Stennis Watson
    Geriatric Research, Education, and Clinical Center, VA Puget Sound Healthcare System, Seattle, WA, USA
    J Alzheimers Dis 18:595-602. 2009
    ..0299). Thus, insulin and octreotide appear to regulate memory in older adults. APOE epsilon4 genotype modulates responses to insulin and octreotide. Finally, insulin may regulate GH levels during euglycemia...
  26. ncbi Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: a preliminary study
    G Stennis Watson
    Geriatric Research, Education, and Clinical Center, Research and Development Service, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    Am J Geriatr Psychiatry 13:950-8. 2005
    ..Authors evaluated the effects of the PPAR-gamma agonist rosiglitazone on cognition and plasma levels of the APP derivative beta-amyloid (Abeta) in humans...
  27. pmc Effects of aerobic exercise on mild cognitive impairment: a controlled trial
    Laura D Baker
    Departments of Psychiatry and BehavioralScience, University of Washington School of Medicine, Seattle, Washington, USA
    Arch Neurol 67:71-9. 2010
    ..To examine the effects of aerobic exercise on cognition and other biomarkers associated with Alzheimer disease pathology for older adults with mild cognitive impairment, and assess the role of sex as a predictor of response...
  28. ncbi Pathological correlates of dementia in a longitudinal, population-based sample of aging
    Joshua A Sonnen
    Department of Pathology, University of Washington, Seattle, WA, USA
    Ann Neurol 62:406-13. 2007
    ..Our goal was to determine the independent pathological correlates associated with dementia in a typical US population...
  29. pmc Different patterns of cerebral injury in dementia with or without diabetes
    Joshua A Sonnen
    Department of Pathology, University of Washington, Seattle, USA
    Arch Neurol 66:315-22. 2009
    ..Diabetes mellitus (DM) increases the risk of dementia in the elderly. However, its underlying mechanisms, its connection with Alzheimer disease and vascular cognitive impairment, and effects of therapy remain unclear...
  30. ncbi Cognitive changes associated with supplementation of testosterone or dihydrotestosterone in mildly hypogonadal men: a preliminary report
    Monique M Cherrier
    Department of Psychiatry and Behavioral Sciences, University of Washington Medical School, Seattle, Washington 98108, USA
    J Androl 24:568-76. 2003
    ..Further, our results suggest that aromatization of T to E(2) may regulate verbal memory in men, whereas nonaromatizable androgens may regulate spatial memory...
  31. ncbi Insulin resistance, inflammation, and cognition in Alzheimer's Disease: lessons for multiple sclerosis
    G Stennis Watson
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98108, USA
    J Neurol Sci 245:21-33. 2006
    ..Ongoing studies will determine whether thiazolidinediones improve cognitive functioning for patients with type 2 diabetes or Alzheimer's disease. Future studies are needed to examine the effects of thiazolidinediones on patients with MS...
  32. ncbi Neuropathology in the adult changes in thought study: a review
    Joshua A Sonnen
    Department of Pathology, University of Washington, Seattle, WA 98104 2420, USA
    J Alzheimers Dis 18:703-11. 2009
    ..This study examines correlations between clinical characteristics including extensive, longitudinal medication histories, and longitudinal cognitive testing against structural and biochemical features of disease...
  33. ncbi Insulin effects on CSF norepinephrine and cognition in Alzheimer's disease
    G Stennis Watson
    Geriatric Research, Education, and Clinical Center GRECC, Veterans Affairs Puget Sound Health Care System, and Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98108 1532, USA
    Neurobiol Aging 27:38-41. 2006
    ..These findings demonstrate that raising peripheral insulin levels can modulate CNS NE levels and suggest that insulin-stimulated increases in NE may modulate cognitive functions...
  34. ncbi Salivary cortisol and memory function in human aging
    Ge Li
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA
    Neurobiol Aging 27:1705-14. 2006
    ..Previous studies have suggested that elevated glucocorticoid concentrations alter hippocampal neuronal morphology, inhibit neurogenesis, and impair cognition...
  35. ncbi The relationship between neuropsychological functioning and driving ability in dementia: a meta-analysis
    Mark A Reger
    Geriatric Research, Education, and Clinical Center GRECC, Veterans Affairs Puget Sound Health Care System VAPSHCS, Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, WA, USA
    Neuropsychology 18:85-93. 2004
    ..Other effects were small or nonsignificant. Implications for basing driving recommendations on neuropsychological testing are discussed...
  36. ncbi Effects of exercise and nutrition on memory in Japanese Americans with impaired glucose tolerance
    G Stennis Watson
    Geriatric Research, Education and Clinical Center, VA Puget Sound Health Care System, 1660 S Columbian Way, Seattle, Washington 98108, USA
    Diabetes Care 29:135-6. 2006
  37. ncbi Hyperinsulinemia provokes synchronous increases in central inflammation and beta-amyloid in normal adults
    Mark A Fishel
    Department of Neurology, University of Washington, Seattle, WA 98108, USA
    Arch Neurol 62:1539-44. 2005
    ..Hyperinsulinemia induces inflammation and is a risk factor for Alzheimer disease. Thus, insulin abnormalities may contribute to Alzheimer disease pathophysiology through effects on the inflammatory network...
  38. ncbi Modulation of memory by insulin and glucose: neuropsychological observations in Alzheimer's disease
    G Stennis Watson
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Medical Center, 1660 South Columbian Way, Seattle, WA 98108, USA
    Eur J Pharmacol 490:97-113. 2004
    ..Collectively, these findings support an association among Alzheimer's disease, impaired glucose metabolism, and reduced insulin sensitivity...
  39. ncbi Intracerebroventricular insulin enhances memory in a passive-avoidance task
    C R Park
    Interdisciplinary Program in Neurobiology and Behavior, University of Washington, Seattle, WA 98125, USA
    Physiol Behav 68:509-14. 2000
    ..This difference is consistent with an enhanced memory for the negative consequences of entering...
  40. ncbi The role of insulin resistance in the pathogenesis of Alzheimer's disease: implications for treatment
    G Stennis Watson
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA
    CNS Drugs 17:27-45. 2003
    ..Based on this evidence, we propose that treatment of insulin resistance may reduce the risk or retard the development of Alzheimer's disease...
  41. ncbi 17beta-estradiol reduces plasma Abeta40 for HRT-naïve postmenopausal women with Alzheimer disease: a preliminary study
    Laura D Baker
    Geriatric Research, Education, and Clinical Center, the VA Puget Sound Health Care System, Seattle Tacoma, WA, USA
    Am J Geriatr Psychiatry 11:239-44. 2003
    ..The authors evaluated the effects of estrogen administration on plasma concentration of one by-product of APP processing, Abeta40, for postmenopausal women with AD...
  42. ncbi Intranasal insulin administration: a method for dissociating central and peripheral effects of insulin
    Mark A Reger
    Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, University of Washington School of Medicine, Seattle, Washington 98108, USA
    Drugs Today (Barc) 42:729-39. 2006
    ..Furthermore, intranasal insulin administration may offer a novel treatment strategy for disorders associated with central insulin abnormalities, such as diabetes and neurodegenerative diseases...
  43. pmc Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 allele
    David G Cook
    Geriatric Research, Education, and Clinical Center, Veteran Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    Am J Pathol 162:313-9. 2003
    ..These findings show that reduced IDE expression is associated with a significant risk factor for AD and suggest that IDE may interact with APOE status to affect Abeta metabolism...
  44. ncbi Cognitive effects of short-term manipulation of serum sex steroids in healthy young men
    Monique M Cherrier
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, 1959 NE Pacific, Seattle, WA 98195, USA
    J Clin Endocrinol Metab 87:3090-6. 2002
    ..These results suggest that short-term changes in sex steroid levels have effects on cognitive function in healthy young men...
  45. ncbi Effects of chronic glucocorticoid administration on insulin-degrading enzyme and amyloid-beta peptide in the aged macaque
    J Jacob Kulstad
    Geriatric Research, Education, and Clinical Center, Veteran s Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    J Neuropathol Exp Neurol 64:139-46. 2005
    ..These findings support the notion that glucocorticoids regulate IDE and provide a mechanism whereby increased glucocorticoid levels may contribute to AD pathology...
  46. pmc Peripheral amyloid-beta levels regulate amyloid-beta clearance from the central nervous system
    Marcos A Marques
    Geriatric Research, Education, and Clinical Center, Seattle, WA, USA
    J Alzheimers Dis 16:325-9. 2009
    ..We found that elevating peripheral Abetalevels significantly decreased [125I]-Abeta(1-40) brain clearance, thus supporting the hypothesis that peripheral Abeta levels regulate Abeta clearance from the central nervous system...
  47. pmc Diet intervention and cerebrospinal fluid biomarkers in amnestic mild cognitive impairment
    Jennifer L Bayer-Carter
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
    Arch Neurol 68:743-52. 2011
    ....
  48. pmc Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): results of a randomized, controlled trial of naproxen and celecoxib
    Barbara K Martin
    Arch Neurol 65:896-905. 2008
    ..Observational studies have shown reduced risk of Alzheimer dementia in users of nonsteroidal anti-inflammatory drugs...
  49. ncbi Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice
    Ward A Pedersen
    Department of Pathology, Creighton University Medical Center, 601 N 30th Street, Suite 2469, Omaha, NE 68131, USA
    Exp Neurol 199:265-73. 2006
    ....
  50. ncbi Effects of beta-hydroxybutyrate on cognition in memory-impaired adults
    Mark A Reger
    Accera, Inc, Aurora, CO 80010, USA
    Neurobiol Aging 25:311-4. 2004
    ..02). Additional research is warranted to determine the therapeutic benefits of MCTs for patients with AD and how APOE-4 status may mediate beta-OHB efficacy...
  51. ncbi Asymmetries in visual-spatial processing following childhood stroke
    Jeffrey Schatz
    Department of Psychology, University of South Carolina, Columbia, SC 29208, USA
    Neuropsychology 18:340-52. 2004
    ..Recovery of visual-spatial processing in children following childhood stroke is task specific. Certain visual-spatial functions typically mediated by the left hemisphere appear less vulnerable to disruption...
  52. ncbi Visual attention in preschool children prenatally exposed to cocaine: implications for behavioral regulation
    Amy K Heffelfinger
    Department of Neurology, Medical College of Wisconsin, Milwaukee, USA
    J Int Neuropsychol Soc 8:12-21. 2002
    ..Overall, our findings suggest that children with prenatal cocaine exposure demonstrate specific impairments in visual attention and behavioral regulation...
  53. ncbi Insulin resistance and cognitive impairment: a view through the prism of epidemiology
    Suzanne Craft
    Arch Neurol 62:1043-4. 2005

Research Grants33

  1. The Effects of Rosiglitazone in Patients with MCI
    Suzanne Craft; Fiscal Year: 2006
    ..Additionally, treatment-related imaging data from the trial will strengthen the ADNI data repository. ..
  2. Therapeutic Effects of Intranasal Insulin in AD
    Suzanne Craft; Fiscal Year: 2007
    ..We will also obtain critical information about the overarching theory that lowered CNS insulin and peripheral insulin resistance contribute to AD pathophysiology. ..
  3. MCI, Insulin and Cholesterol in a Community Sample
    Suzanne Craft; Fiscal Year: 2007
    ..The results of this study will provide valuable information concerning the incidence and natural history of MCI, and its relation to various risk factors that may be amenable to therapeutic intervention. ..
  4. NEUROBEHAVIOR, NEUROENDOCRINOLOGY, AND GENETICS OF AD
    Suzanne Craft; Fiscal Year: 2007
    ..As such, it will provide a much-needed approach to the training of clinical research scientists whose work will address these complex disorders. ..
  5. GLUCOSE REGULATION AND MEMORY IN ALZHEIMER'S DISEASE
    Suzanne Craft; Fiscal Year: 2007
    ..The proposed studies will provide important information about the mechanisms through which peripheral insulin resistance increases the risk of AD, and about therapeutic approaches to ameliorating this risk. ..
  6. The Effects of Rosiglitazone in Patients with MCI
    Suzanne Craft; Fiscal Year: 2007
    ..In doing so, we will lay the groundwork for future full-scale clinical trials of PPAR-gamma, agonists. ..
  7. MCI, Insulin and Cholesterol in a Community Sample
    Suzanne Craft; Fiscal Year: 2007
    ..The results of this study will provide valuable information concerning the incidence and natural history of MCI, and its relation to various risk factors that may be amenable to therapeutic intervention. ..
  8. MCI, Insulin and Cholesterol in a Community Sample
    Suzanne Craft; Fiscal Year: 2009
    ..The results of this study will provide valuable information concerning the incidence and natural history of MCI, and its relation to various risk factors that may be amenable to therapeutic intervention. ..
  9. MCI, Insulin and Cholesterol in a Community Sample
    Suzanne Craft; Fiscal Year: 2010
    ..The results of this study will provide valuable information concerning the incidence and natural history of MCI, and its relation to various risk factors that may be amenable to therapeutic intervention. ..
  10. The Effects of Rosiglitazone in Patients with MCI
    Suzanne Craft; Fiscal Year: 2006
    ..In doing so, we will lay the groundwork for future full-scale clinical trials of PPAR-gamma, agonists. ..
  11. MCI, Insulin and Cholesterol in a Community Sample
    Suzanne Craft; Fiscal Year: 2006
    ..The results of this study will provide valuable information concerning the incidence and natural history of MCI, and its relation to various risk factors that may be amenable to therapeutic intervention. ..
  12. Therapeutic Effects of Intranasal Insulin in AD
    Suzanne Craft; Fiscal Year: 2006
    ..We will also obtain critical information about the overarching theory that lowered CNS insulin and peripheral insulin resistance contribute to AD pathophysiology. ..
  13. GLUCOSE REGULATION AND MEMORY IN ALZHEIMERS DISEASE
    Suzanne Craft; Fiscal Year: 1999
    ..The results of these studies will provide important information about mechanisms disrupting glucose regulation in probable AD, and about the role these mechanisms play in the cognitive deficits that characterize the disorder. ..
  14. GLUCOSE REGULATION AND MEMORY IN ALZHEIMER'S DISEASE
    Suzanne Craft; Fiscal Year: 2000
    ....
  15. GLUCOSE REGULATION AND MEMORY IN ALZHEIMER'S DISEASE
    Suzanne Craft; Fiscal Year: 2001
    ....
  16. Insulin Resistance and CNS Function in Type 2 Diabetes
    Suzanne Craft; Fiscal Year: 2002
    ..Finally, these studies have the potential to elucidate relationships between T2DM and other disorders in which memory is impaired, such as Alzheimer?s disease...
  17. GLUCOSE REGULATION AND MEMORY IN ALZHEIMER'S DISEASE
    Suzanne Craft; Fiscal Year: 2002
    ....
  18. Insulin Resistance and CNS Function in Type 2 Diabetes
    Suzanne Craft; Fiscal Year: 2003
    ..Finally, these studies have the potential to elucidate relationships between T2DM and other disorders in which memory is impaired, such as Alzheimer?s disease...
  19. GLUCOSE REGULATION AND MEMORY IN ALZHEIMER'S DISEASE
    Suzanne Craft; Fiscal Year: 2003
    ....
  20. GLUCOSE REGULATION AND MEMORY IN ALZHEIMER'S DISEASE
    Suzanne Craft; Fiscal Year: 2004
    ....
  21. Insulin Resistance and CNS Function in Type 2 Diabetes
    Suzanne Craft; Fiscal Year: 2004
    ..Finally, these studies have the potential to elucidate relationships between T2DM and other disorders in which memory is impaired, such as Alzheimer?s disease...
  22. Insulin Resistance and CNS Function in Type 2 Diabetes
    Suzanne Craft; Fiscal Year: 2004
    ..Finally, these studies have the potential to elucidate relationships between T2DM and other disorders in which memory is impaired, such as Alzheimer?s disease...
  23. The Effects of Rosiglitazone in Patients with MCI
    Suzanne Craft; Fiscal Year: 2005
    ..In doing so, we will lay the groundwork for future full-scale clinical trials of PPAR-gamma, agonists. ..
  24. The Effects of Rosiglitazone in Patients with MCI
    Suzanne Craft; Fiscal Year: 2009
    ..In doing so, we will lay the groundwork for future full-scale clinical trials of PPAR-gamma, agonists. ..