Research Topics
Species | S CraftSummaryAffiliation: University of Washington Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Accelerated decline in apolipoprotein E-epsilon4 homozygotes with Alzheimer's diseaseS Craft
Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, and Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle 98018, USA
Neurology 51:149-53. 1998..The current study examined rate of decline in the largest sample of APOE-genotyped AD patients for whom longitudinal cognitive data have been reported...- Insulin dose-response effects on memory and plasma amyloid precursor protein in Alzheimer's disease: interactions with apolipoprotein E genotypeSuzanne Craft
Geriatric Research, Education, and Clinical Center, Veteran Affairs Puget Sound Health Care System, 1660 South Columbian Way, Seattle, WA 98108, USA
Psychoneuroendocrinology 28:809-22. 2003.... - Insulin resistance syndrome and Alzheimer disease: pathophysiologic mechanisms and therapeutic implicationsSuzanne Craft
Department of Psychiatry and Behavioral Sciences, Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, University of Washington School of Medicine, Seattle, WA 98108, USA
Alzheimer Dis Assoc Disord 20:298-301. 2006..These convergent effects may impair memory and induce AD pathology. Therapeutic strategies focused on preventing or correcting insulin abnormalities may thus benefit adults with age-related memory impairment and AD... - Insulin resistance syndrome and Alzheimer's disease: age- and obesity-related effects on memory, amyloid, and inflammationSuzanne Craft
Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98108, USA
Neurobiol Aging 26:65-9. 2005..This constellation of events may have deleterious effects on memory. Treatments focused on preventing or correcting insulin abnormalities may be of therapeutic benefit for adults with age-related memory impairment and AD... - Insulin resistance and Alzheimer's disease pathogenesis: potential mechanisms and implications for treatmentSuzanne Craft
Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA
Curr Alzheimer Res 4:147-52. 2007..These convergent effects may impair memory and induce AD pathology. Therapeutic strategies focused on preventing or correcting insulin abnormalities may thus benefit a subset of adults with age-related memory impairment and AD... 
The role of metabolic disorders in Alzheimer disease and vascular dementia: two roads convergedSuzanne Craft
Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound, Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, 98108, USA
Arch Neurol 66:300-5. 2009..Identification of such convergent factors will not only provide important insight into the causes and interdependencies of late-life dementias but will also inspire novel strategies for treating and preventing these disorders...- Insulin and neurodegenerative disease: shared and specific mechanismsSuzanne Craft
Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Medical Center, Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, 98108, USA
Lancet Neurol 3:169-78. 2004..We conclude by considering whether insulin dysregulation contributes to neurodegenerative disorders through disease-specific or general mechanisms... - Insulin effects on glucose metabolism, memory, and plasma amyloid precursor protein in Alzheimer's disease differ according to apolipoprotein-E genotypeS Craft
Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington 98108, USA
Ann N Y Acad Sci 903:222-8. 2000.... - Enhancement of memory in Alzheimer disease with insulin and somatostatin, but not glucoseS Craft
Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Wash 98108, USA
Arch Gen Psychiatry 56:1135-40. 1999..We address this question by examining memory and counterregulatory hormone response during hyperglycemia when endogenous insulin was suppressed by concomitant infusion of the somatostatin analogue octreotide (Sandostatin)... - Intranasal insulin improves cognition and modulates beta-amyloid in early ADM A Reger
Department of Psychiatry and Behavioral Science, University of Washington School of Medicine, Seattle, WA, USA
Neurology 70:440-8. 2008..After intranasal administration, insulin-like peptides follow extracellular pathways to the brain within 15 minutes... - Testosterone supplementation improves spatial and verbal memory in healthy older menM M Cherrier
Department of Psychiatry and Behavioral Sciences, University of Washington Medical School, Seattle, WA 98195, USA
Neurology 57:80-8. 2001..To determine the relationship between exogenous testosterone administration and cognitive abilities in a population of healthy older men... - Cognitive and neuroendocrine response to transdermal estrogen in postmenopausal women with Alzheimer's disease: results of a placebo-controlled, double-blind, pilot studyS Asthana
Geriatric Research, Education and Clinical Center GRECC, VA Puget Sound Health Care System, American Lake Division, Tacoma, WA 98493, USA
Psychoneuroendocrinology 24:657-77. 1999.... - Insulin metabolism in Alzheimer's disease differs according to apolipoprotein E genotype and genderS Craft
Geriatric Research, Education, and Clinical Center, Veteran Affairs Puget Sound Health Care System, University of Washington School of Medicine, Seattle, Wash
Neuroendocrinology 70:146-52. 1999.... - Testosterone improves spatial memory in men with Alzheimer disease and mild cognitive impairmentM M Cherrier
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA
Neurology 64:2063-8. 2005..To determine the efficacy of testosterone (T) supplementation on cognition in a sample of men with Alzheimer disease (AD) or mild cognitive impairment (MCI)... - Differential modulation of plasma beta-amyloid by insulin in patients with Alzheimer diseaseJ J Kulstad
Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, WA 98108, USA
Neurology 66:1506-10. 2006..Abnormal regulation of peripheral Abeta by insulin may contribute to AD risk... - Characterization of verbal and spatial memory changes from moderate to supraphysiological increases in serum testosterone in healthy older menM M Cherrier
Department of Psychiatry and Behavioral Sciences, University of Washington Medical School, Seattle, WA 98195, USA
Psychoneuroendocrinology 32:72-9. 2007..The objective of this study was to compare the cognitive responses of older, eugonadal men in whom moderate or large increases in serum testosterone levels was induced by exogenous testosterone supplementation... - The role of aromatization in testosterone supplementation: effects on cognition in older menM M Cherrier
Department of Psychiatry and Behavioral Sciences, University of Washington Medical School, Seattle, WA, USA
Neurology 64:290-6. 2005..To determine the contribution of conversion of testosterone (T) to estradiol on cognitive processing in a population of healthy older men who received T supplementation... - High-dose estradiol improves cognition for women with AD: results of a randomized studyS Asthana
Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle Tacoma, Tacoma, WA 98493, USA
Neurology 57:605-12. 2001..To characterize the cognitive and neuroendocrine response to treatment with a high dose of estrogen for postmenopausal women with AD... - Relationship between testosterone supplementation and insulin-like growth factor-I levels and cognition in healthy older menM M Cherrier
Department of Psychiatry and Behavioral Sciences, University of Washington Medical School, 1959 NE Pacific, Box 356560, Seattle, WA 98195, USA
Psychoneuroendocrinology 29:65-82. 2004..This study examined potential changes in insulin-like growth factor (IGF) IGF-I, IGF-II and IGF-related binding proteins in response to T administration in older men and their relationship to cognitive functioning... - Insulin increases CSF Abeta42 levels in normal older adultsG S Watson
Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle 98108, USA
Neurology 60:1899-903. 2003..In vitro studies show that insulin enhances the release of beta-amyloid protein (Abeta) or inhibits its degradation, either of which might increase amyloid burden... - Intranasal insulin administration dose-dependently modulates verbal memory and plasma amyloid-beta in memory-impaired older adultsMark A Reger
Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
J Alzheimers Dis 13:323-31. 2008..These findings suggest that groups with different genetic risks for AD may show differential dose-response curves following intranasal insulin administration... - Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotypeM A Reger
Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, 1660 S, Columbian Way, S182 GRECC, Seattle, WA 98108, USA
Neurobiol Aging 27:451-8. 2006..These findings suggest that intranasal insulin administration may have therapeutic benefit without the risk of peripheral hypoglycemia and provide further evidence for apolipoprotein E (APOE) related differences in insulin metabolism... 
Insulin resistance and pathological brain ageingB Cholerton
Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98108, USA
Diabet Med 28:1463-75. 2011..Fortunately, insulin resistance-associated conditions are amenable to both pharmacologic and lifestyle interventions that may reduce the deleterious impact of insulin resistance on the ageing brain...- Statin users without an APOE-epsilon4 allele have increased insulin resistanceBrian T Vanfossen
GRECC, VA Puget Sound Health Care System, Seattle, WA 98108, USA
J Alzheimers Dis 19:1149-53. 2010..0169), and with non-users who were epsilon4- (p=0.0003) or epsilon4+ (p=0.0006). These results suggest that statin use may modulate insulin levels for individuals without an APOE epsilon4 allele... - Effects of insulin and octreotide on memory and growth hormone in Alzheimer's diseaseG Stennis Watson
Geriatric Research, Education, and Clinical Center, VA Puget Sound Healthcare System, Seattle, WA, USA
J Alzheimers Dis 18:595-602. 2009..0299). Thus, insulin and octreotide appear to regulate memory in older adults. APOE epsilon4 genotype modulates responses to insulin and octreotide. Finally, insulin may regulate GH levels during euglycemia... - Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: a preliminary studyG Stennis Watson
Geriatric Research, Education, and Clinical Center, Research and Development Service, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
Am J Geriatr Psychiatry 13:950-8. 2005..Future confirmation in a larger study is needed to fully demonstrate rosiglitazone's therapeutic potential... - Effects of aerobic exercise on mild cognitive impairment: a controlled trialLaura D Baker
Departments of Psychiatry and BehavioralScience, University of Washington School of Medicine, Seattle, Washington, USA
Arch Neurol 67:71-9. 2010..To examine the effects of aerobic exercise on cognition and other biomarkers associated with Alzheimer disease pathology for older adults with mild cognitive impairment, and assess the role of sex as a predictor of response... - Pathological correlates of dementia in a longitudinal, population-based sample of agingJoshua A Sonnen
Department of Pathology, University of Washington, Seattle, WA, USA
Ann Neurol 62:406-13. 2007..Our goal was to determine the independent pathological correlates associated with dementia in a typical US population... - Different patterns of cerebral injury in dementia with or without diabetesJoshua A Sonnen
Department of Pathology, University of Washington, Seattle, USA
Arch Neurol 66:315-22. 2009..Diabetes mellitus (DM) increases the risk of dementia in the elderly. However, its underlying mechanisms, its connection with Alzheimer disease and vascular cognitive impairment, and effects of therapy remain unclear... - Cognitive changes associated with supplementation of testosterone or dihydrotestosterone in mildly hypogonadal men: a preliminary reportMonique M Cherrier
Department of Psychiatry and Behavioral Sciences, University of Washington Medical School, Seattle, Washington 98108, USA
J Androl 24:568-76. 2003..Further, our results suggest that aromatization of T to E(2) may regulate verbal memory in men, whereas nonaromatizable androgens may regulate spatial memory... - Insulin resistance, inflammation, and cognition in Alzheimer's Disease: lessons for multiple sclerosisG Stennis Watson
Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98108, USA
J Neurol Sci 245:21-33. 2006..Ongoing studies will determine whether thiazolidinediones improve cognitive functioning for patients with type 2 diabetes or Alzheimer's disease. Future studies are needed to examine the effects of thiazolidinediones on patients with MS... - Neuropathology in the adult changes in thought study: a reviewJoshua A Sonnen
Department of Pathology, University of Washington, Seattle, WA 98104 2420, USA
J Alzheimers Dis 18:703-11. 2009..This study examines correlations between clinical characteristics including extensive, longitudinal medication histories, and longitudinal cognitive testing against structural and biochemical features of disease... - Insulin effects on CSF norepinephrine and cognition in Alzheimer's diseaseG Stennis Watson
Geriatric Research, Education, and Clinical Center (GRECC, Veterans Affairs Puget Sound Health Care System, and Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98108-1532, USA
Neurobiol Aging 27:38-41. 2006..These findings demonstrate that raising peripheral insulin levels can modulate CNS NE levels and suggest that insulin-stimulated increases in NE may modulate cognitive functions... - Salivary cortisol and memory function in human agingGe Li
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195, USA
Neurobiol Aging 27:1705-14. 2006..Previous studies have suggested that elevated glucocorticoid concentrations alter hippocampal neuronal morphology, inhibit neurogenesis, and impair cognition... - The relationship between neuropsychological functioning and driving ability in dementia: a meta-analysisMark A Reger
Geriatric Research, Education, and Clinical Center GRECC, Veterans Affairs Puget Sound Health Care System VAPSHCS, Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, WA, USA
Neuropsychology 18:85-93. 2004..Other effects were small or nonsignificant. Implications for basing driving recommendations on neuropsychological testing are discussed... - Effects of exercise and nutrition on memory in Japanese Americans with impaired glucose toleranceG Stennis Watson
Geriatric Research, Education and Clinical Center, VA Puget Sound Health Care System, 1660 S. Columbian Way, Seattle, Washington 98108, USA
Diabetes Care 29:135-6. 2006 - Hyperinsulinemia provokes synchronous increases in central inflammation and beta-amyloid in normal adultsMark A Fishel
Department of Neurology, University of Washington, Seattle, WA 98108, USA
Arch Neurol 62:1539-44. 2005..05). CONCLUSION: Moderate hyperinsulinemia can elevate inflammatory markers and Abeta42 in the periphery and the brain, thereby potentially increasing the risk of Alzheimer disease... - Modulation of memory by insulin and glucose: neuropsychological observations in Alzheimer's diseaseG Stennis Watson
Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Medical Center, 1660 South Columbian Way, Seattle, WA 98108, USA
Eur J Pharmacol 490:97-113. 2004..Collectively, these findings support an association among Alzheimer's disease, impaired glucose metabolism, and reduced insulin sensitivity... - Intracerebroventricular insulin enhances memory in a passive-avoidance taskC R Park
Interdisciplinary Program in Neurobiology and Behavior, University of Washington, Seattle, WA 98125, USA
Physiol Behav 68:509-14. 2000..This difference is consistent with an enhanced memory for the negative consequences of entering... - The role of insulin resistance in the pathogenesis of Alzheimer's disease: implications for treatmentG Stennis Watson
Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA
CNS Drugs 17:27-45. 2003..Based on this evidence, we propose that treatment of insulin resistance may reduce the risk or retard the development of Alzheimer's disease... - 17beta-estradiol reduces plasma Abeta40 for HRT-naïve postmenopausal women with Alzheimer disease: a preliminary studyLaura D Baker
Geriatric Research, Education, and Clinical Center, the VA Puget Sound Health Care System, Seattle/Tacoma, WA, USA
Am J Geriatr Psychiatry 11:239-44. 2003..This finding suggests that the hormone may serve as an Abeta-lowering agent for HRT-naïve AD women, which may, in turn, have ultimate ramifications for the progression of AD pathology... - Intranasal insulin administration: a method for dissociating central and peripheral effects of insulinMark A Reger
Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, University of Washington School of Medicine, Seattle, Washington 98108, USA
Drugs Today (Barc) 42:729-39. 2006..Furthermore, intranasal insulin administration may offer a novel treatment strategy for disorders associated with central insulin abnormalities, such as diabetes and neurodegenerative diseases... - Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 alleleDavid G Cook
Geriatric Research, Education, and Clinical Center, Veteran Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
Am J Pathol 162:313-9. 2003..These findings show that reduced IDE expression is associated with a significant risk factor for AD and suggest that IDE may interact with APOE status to affect Abeta metabolism... - Cognitive effects of short-term manipulation of serum sex steroids in healthy young menMonique M Cherrier
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, 1959 NE Pacific, Seattle, WA 98195, USA
J Clin Endocrinol Metab 87:3090-6. 2002..These results suggest that short-term changes in sex steroid levels have effects on cognitive function in healthy young men... - Effects of chronic glucocorticoid administration on insulin-degrading enzyme and amyloid-beta peptide in the aged macaqueJ Jacob Kulstad
Geriatric Research, Education, and Clinical Center, Veteran's Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
J Neuropathol Exp Neurol 64:139-46. 2005..These findings support the notion that glucocorticoids regulate IDE and provide a mechanism whereby increased glucocorticoid levels may contribute to AD pathology... - Peripheral amyloid-beta levels regulate amyloid-beta clearance from the central nervous systemMarcos A Marques
Geriatric Research, Education, and Clinical Center, Seattle, WA, USA
J Alzheimers Dis 16:325-9. 2009..We found that elevating peripheral Abetalevels significantly decreased [125I]-Abeta(1-40) brain clearance, thus supporting the hypothesis that peripheral Abeta levels regulate Abeta clearance from the central nervous system... - Diet intervention and cerebrospinal fluid biomarkers in amnestic mild cognitive impairmentJennifer L Bayer-Carter
Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
Arch Neurol 68:743-52. 2011.... - Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): results of a randomized, controlled trial of naproxen and celecoxibBarbara K Martin
Arch Neurol 65:896-905. 2008..CONCLUSIONS: Use of naproxen or celecoxib did not improve cognitive function. There was weak evidence for a detrimental effect of naproxen... - Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer miceWard A Pedersen
Department of Pathology, Creighton University Medical Center, 601 N 30th Street, Suite 2469, Omaha, NE 68131, USA
Exp Neurol 199:265-73. 2006.... - Effects of beta-hydroxybutyrate on cognition in memory-impaired adultsMark A Reger
Accera, Inc, Aurora, CO 80010, USA
Neurobiol Aging 25:311-4. 2004..02). Additional research is warranted to determine the therapeutic benefits of MCTs for patients with AD and how APOE-4 status may mediate beta-OHB efficacy... - Asymmetries in visual-spatial processing following childhood strokeJeffrey Schatz
Department of Psychology, University of South Carolina, Columbia, SC 29208, USA
Neuropsychology 18:340-52. 2004..Recovery of visual-spatial processing in children following childhood stroke is task specific. Certain visual-spatial functions typically mediated by the left hemisphere appear less vulnerable to disruption... - Visual attention in preschool children prenatally exposed to cocaine: implications for behavioral regulationAmy K Heffelfinger
Department of Neurology, Medical College of Wisconsin, Milwaukee, USA
J Int Neuropsychol Soc 8:12-21. 2002..Overall, our findings suggest that children with prenatal cocaine exposure demonstrate specific impairments in visual attention and behavioral regulation... - Insulin resistance and cognitive impairment: a view through the prism of epidemiologySuzanne Craft
Arch Neurol 62:1043-4. 2005
Research Grants
- The Effects of Rosiglitazone in Patients with MCISuzanne Craft; Fiscal Year: 2006..Additionally, treatment-related imaging data from the trial will strengthen the ADNI data repository. ..
- Therapeutic Effects of Intranasal Insulin in ADSuzanne Craft; Fiscal Year: 2007..We will also obtain critical information about the overarching theory that lowered CNS insulin and peripheral insulin resistance contribute to AD pathophysiology. ..
- MCI, Insulin and Cholesterol in a Community SampleSuzanne Craft; Fiscal Year: 2007..The results of this study will provide valuable information concerning the incidence and natural history of MCI, and its relation to various risk factors that may be amenable to therapeutic intervention. ..
- NEUROBEHAVIOR, NEUROENDOCRINOLOGY, AND GENETICS OF ADSuzanne Craft; Fiscal Year: 2007..As such, it will provide a much-needed approach to the training of clinical research scientists whose work will address these complex disorders. ..
- GLUCOSE REGULATION AND MEMORY IN ALZHEIMER'S DISEASESuzanne Craft; Fiscal Year: 2007..The proposed studies will provide important information about the mechanisms through which peripheral insulin resistance increases the risk of AD, and about therapeutic approaches to ameliorating this risk. ..
- The Effects of Rosiglitazone in Patients with MCISuzanne Craft; Fiscal Year: 2007..In doing so, we will lay the groundwork for future full-scale clinical trials of PPAR-gamma, agonists. ..
- MCI, Insulin and Cholesterol in a Community SampleSuzanne Craft; Fiscal Year: 2007..The results of this study will provide valuable information concerning the incidence and natural history of MCI, and its relation to various risk factors that may be amenable to therapeutic intervention. ..
- MCI, Insulin and Cholesterol in a Community SampleSuzanne Craft; Fiscal Year: 2010..The results of this study will provide valuable information concerning the incidence and natural history of MCI, and its relation to various risk factors that may be amenable to therapeutic intervention. ..
- GLUCOSE REGULATION AND MEMORY IN ALZHEIMERS DISEASESuzanne Craft; Fiscal Year: 1999..The results of these studies will provide important information about mechanisms disrupting glucose regulation in probable AD, and about the role these mechanisms play in the cognitive deficits that characterize the disorder. ..
- GLUCOSE REGULATION AND MEMORY IN ALZHEIMER'S DISEASESuzanne Craft; Fiscal Year: 2004....
- Insulin Resistance and CNS Function in Type 2 DiabetesSuzanne Craft; Fiscal Year: 2004..Finally, these studies have the potential to elucidate relationships between T2DM and other disorders in which memory is impaired, such as Alzheimer?s disease...
- The Effects of Rosiglitazone in Patients with MCISuzanne Craft; Fiscal Year: 2009..In doing so, we will lay the groundwork for future full-scale clinical trials of PPAR-gamma, agonists. ..