Morton Cowan

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Hematopoietic stem cell transplantation for severe combined immunodeficiency diseases
    Morton J Cowan
    Pediatric Blood and Marrow Transplant Division, UCSF Children s Hospital, 505 Parnassus Avenue, San Francisco, California, USA
    Biol Blood Marrow Transplant 14:73-5. 2008
  2. doi request reprint Megadose CD34(+) cell grafts improve recovery of T cell engraftment but not B cell immunity in patients with severe combined immunodeficiency disease undergoing haplocompatible nonmyeloablative transplantation
    Christopher C Dvorak
    Division of Pediatric Blood and Marrow Transplant, University of California San Francisco Children s Hospital, San Francisco, CA, USA
    Biol Blood Marrow Transplant 14:1125-33. 2008
  3. doi request reprint Development of herpes simplex virus stomatitis during receipt of cidofovir therapy
    Christopher C Dvorak
    Division of Pediatric Blood and Marrow Transplant, University of California, San Francisco, California 94143 1278, USA
    Clin Infect Dis 49:e92-5. 2009
  4. doi request reprint Allogeneic hematopoietic cell transplantation for refractory myasthenia gravis
    Jonathan Strober
    UCSF Children s Hospital, 505 Parnassus Ave, M 659, San Francisco, CA 94143 1278, USA
    Arch Neurol 66:659-61. 2009
  5. doi request reprint Primary graft failure after umbilical cord blood transplant rescued by parental haplocompatible stem cell transplantation
    Christopher C Dvorak
    Division of Pediatric Blood and Marrow Transplant, UCSF Children s Hospital, University of California, San Francisco, CA, USA
    J Pediatr Hematol Oncol 31:300-3. 2009
  6. doi request reprint Airway management in children with mucopolysaccharidoses
    Andrea H Yeung
    Department of Otolaryngology Head and Neck Surgery, University of California, San Francisco, 400 Parnassus Ave, A730, San Francisco, CA 94143 0342, USA
    Arch Otolaryngol Head Neck Surg 135:73-9. 2009
  7. doi request reprint Maternal T-cell engraftment associated with severe hemophagocytosis of the bone marrow in untreated X-linked severe combined immunodeficiency
    Christopher C Dvorak
    Division of Pediatric Stem Cell Transplantation, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA
    J Pediatr Hematol Oncol 30:396-400. 2008
  8. pmc Radiosensitive severe combined immunodeficiency disease
    Christopher C Dvorak
    Division of Pediatric Blood and Marrow Transplantation, University of California, San Francisco, 505 Parnassus Avenue, M 659, San Francisco, CA 94143 1278, USA
    Immunol Allergy Clin North Am 30:125-42. 2010
  9. pmc A non-leaky Artemis-deficient mouse that accurately models the human severe combined immune deficiency phenotype, including resistance to hematopoietic stem cell transplantation
    Zheng Xiao
    Blood and Marrow Transplant Division, Department of Pediatrics, University of California San Francisco Children s Hospital, San Francisco, California 94143 1278, USA
    Biol Blood Marrow Transplant 15:1-11. 2009
  10. ncbi request reprint Targeted disruption of the Artemis murine counterpart results in SCID and defective V(D)J recombination that is partially corrected with bone marrow transplantation
    Lanying Li
    Department of Pediatrics, University of California, San Francisco, CA 94143, USA
    J Immunol 174:2420-8. 2005

Research Grants

Collaborators

Detail Information

Publications15

  1. doi request reprint Hematopoietic stem cell transplantation for severe combined immunodeficiency diseases
    Morton J Cowan
    Pediatric Blood and Marrow Transplant Division, UCSF Children s Hospital, 505 Parnassus Avenue, San Francisco, California, USA
    Biol Blood Marrow Transplant 14:73-5. 2008
    ....
  2. doi request reprint Megadose CD34(+) cell grafts improve recovery of T cell engraftment but not B cell immunity in patients with severe combined immunodeficiency disease undergoing haplocompatible nonmyeloablative transplantation
    Christopher C Dvorak
    Division of Pediatric Blood and Marrow Transplant, University of California San Francisco Children s Hospital, San Francisco, CA, USA
    Biol Blood Marrow Transplant 14:1125-33. 2008
    ....
  3. doi request reprint Development of herpes simplex virus stomatitis during receipt of cidofovir therapy
    Christopher C Dvorak
    Division of Pediatric Blood and Marrow Transplant, University of California, San Francisco, California 94143 1278, USA
    Clin Infect Dis 49:e92-5. 2009
    ..All patients responded well to treatment with either acyclovir or ganciclovir. Despite the in vitro susceptibility of HSV to cidofovir, once-weekly treatment with this agent may not be adequate prophylaxis in pediatric patients...
  4. doi request reprint Allogeneic hematopoietic cell transplantation for refractory myasthenia gravis
    Jonathan Strober
    UCSF Children s Hospital, 505 Parnassus Ave, M 659, San Francisco, CA 94143 1278, USA
    Arch Neurol 66:659-61. 2009
    ..To describe a patient with intractable myasthenia gravis (MG) who was treated with a matched sibling peripheral blood stem cell transplantation...
  5. doi request reprint Primary graft failure after umbilical cord blood transplant rescued by parental haplocompatible stem cell transplantation
    Christopher C Dvorak
    Division of Pediatric Blood and Marrow Transplant, UCSF Children s Hospital, University of California, San Francisco, CA, USA
    J Pediatr Hematol Oncol 31:300-3. 2009
    ....
  6. doi request reprint Airway management in children with mucopolysaccharidoses
    Andrea H Yeung
    Department of Otolaryngology Head and Neck Surgery, University of California, San Francisco, 400 Parnassus Ave, A730, San Francisco, CA 94143 0342, USA
    Arch Otolaryngol Head Neck Surg 135:73-9. 2009
    ..To review of the natural history of airway disease in children with muccopolysaccharidoses (MPSs), which represent a group of hereditary progressive disorders caused by excessive accumulation of glycosaminoglycans in various tissues...
  7. doi request reprint Maternal T-cell engraftment associated with severe hemophagocytosis of the bone marrow in untreated X-linked severe combined immunodeficiency
    Christopher C Dvorak
    Division of Pediatric Stem Cell Transplantation, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA
    J Pediatr Hematol Oncol 30:396-400. 2008
    ..Hemophagocytosis was most likely owing to maternal graft-versus-host disease, as perforin-expressing CD8 T cells, presumably of maternal origin, were prominent in the bone marrow and there was no concurrent severe infection...
  8. pmc Radiosensitive severe combined immunodeficiency disease
    Christopher C Dvorak
    Division of Pediatric Blood and Marrow Transplantation, University of California, San Francisco, 505 Parnassus Avenue, M 659, San Francisco, CA 94143 1278, USA
    Immunol Allergy Clin North Am 30:125-42. 2010
    ....
  9. pmc A non-leaky Artemis-deficient mouse that accurately models the human severe combined immune deficiency phenotype, including resistance to hematopoietic stem cell transplantation
    Zheng Xiao
    Blood and Marrow Transplant Division, Department of Pediatrics, University of California San Francisco Children s Hospital, San Francisco, California 94143 1278, USA
    Biol Blood Marrow Transplant 15:1-11. 2009
    ....
  10. ncbi request reprint Targeted disruption of the Artemis murine counterpart results in SCID and defective V(D)J recombination that is partially corrected with bone marrow transplantation
    Lanying Li
    Department of Pediatrics, University of California, San Francisco, CA 94143, USA
    J Immunol 174:2420-8. 2005
    ....
  11. pmc A novel missense RAG-1 mutation results in T-B-NK+ SCID in Athabascan-speaking Dine Indians from the Canadian Northwest Territories
    Zheng Xiao
    Pediatric Bone Marrow Transplant Division, University of California San Francisco Children s Hospital, San Francisco, CA 94143 1278, USA
    Eur J Hum Genet 17:205-12. 2009
    ..Our results indicate that the novel R776W missense mutation in RAG-1 is causal in the T(-)B(-)NK(+) SCID phenotype in Athabascan-speaking Dine Indians from the Canadian Northwest Territories...
  12. ncbi request reprint Prenatal diagnosis and carrier detection for Athabascan severe combined immunodeficiency disease
    Lanying Li
    Department of Pediatrics, University of California San Francisco, San Francisco, CA 84143 1278, USA
    Prenat Diagn 22:763-8. 2002
    ..In this study we compared polymorphic markers linked to SCIDA and the point mutation which creates an NspI site on exon 8 for prenatal diagnosis and carrier detection...
  13. ncbi request reprint A founder mutation in Artemis, an SNM1-like protein, causes SCID in Athabascan-speaking Native Americans
    Lanying Li
    Department of Pediatrics, University of California, San Francisco, CA 94143, USA
    J Immunol 168:6323-9. 2002
    ..Finally, we found that the SCIDA primary transcript (Artemis) encodes a nuclear protein...
  14. ncbi request reprint Artemis deficiency confers a DNA double-strand break repair defect and Artemis phosphorylation status is altered by DNA damage and cell cycle progression
    Junhua Wang
    Life Sciences Division, Department of Molecular Biology, Lawrence Berkeley National Laboratory, Mail Stop 74 157, 1 Cyclotron Road, Berkeley, CA 94720, USA
    DNA Repair (Amst) 4:556-70. 2005
    ....
  15. ncbi request reprint Multilineage engraftment with minimal graft-versus-host disease following in utero transplantation of S-59 psoralen/ultraviolet a light-treated, sensitized T cells and adult T cell-depleted bone marrow in fetal mice
    Swati Bhattacharyya
    Bone Marrow Transplant Division, Department of Pediatrics, University of California, San Francisco 94143, USA
    J Immunol 169:6133-40. 2002
    ..In this study we have shown that PCT-treated T cells that are cytotoxic but nonproliferative can provide an engraftment advantage to donor cells, presumably by destroying host hemopoietic cells without causing GvHD...

Research Grants16

  1. GENE LINKAGE STUDY OF IMMUNODEFICIENCY IN NAVAJO INDIANS
    Morton Cowan; Fiscal Year: 2001
    ..The results of this study will lead to better understanding of the maturation of T and B cell immunity and novel approaches to manipulating the immune system as well as more specific agents for treating certain malignancies. ..
  2. TOLERANCE POST IN UTERO TRANSPLANTATION
    Morton Cowan; Fiscal Year: 2000
    ....
  3. GENE LINKAGE STUDY OF IMMUNODEFICIENCY IN NAVAJO INDIANS
    Morton Cowan; Fiscal Year: 1993
    ..Eventually, we plan to identify and characterize the gene which causes SCID in this native American population and understand its role in regulating immune function...
  4. TOLERANCE POST IN UTERO TRANSPLANTATION
    Morton Cowan; Fiscal Year: 2005
    ....