Kenneth H Cowan

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. pmc RAC1 GTPase plays an important role in γ-irradiation induced G2/M checkpoint activation
    Ying Yan
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE, USA
    Breast Cancer Res 14:R60. 2012
  2. ncbi request reprint Paclitaxel chemotherapy after autologous stem-cell transplantation and engraftment of hematopoietic cells transduced with a retrovirus containing the multidrug resistance complementary DNA (MDR1) in metastatic breast cancer patients
    K H Cowan
    National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Clin Cancer Res 5:1619-28. 1999
  3. ncbi request reprint A pilot study of dose intense doxorubicin and cyclophosphamide followed by infusional paclitaxel in high-risk primary breast cancer
    Jo Anne Zujewski
    National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Breast Cancer Res Treat 81:41-51. 2003
  4. ncbi request reprint Brca1-deficient murine mammary epithelial cells have increased sensitivity to CDDP and MMS
    Magdalene K Sgagias
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
    Cell Cycle 3:1451-6. 2004
  5. ncbi request reprint Recombinant adenovirus-mediated p14(ARF) overexpression sensitizes human breast cancer cells to cisplatin
    Xiyun Deng
    Medicine Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 10N226, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 296:792-8. 2002
  6. ncbi request reprint BCL-2 antisense and cisplatin combination treatment of MCF-7 breast cancer cells with or without functional p53
    Hesham Basma
    Department of Biochemistry and Molecular Biology, College of Medicine, Omaha, NE 68198 5870, USA
    J Biomed Sci 12:999-1011. 2005
  7. pmc Heregulin-dependent delay in mitotic progression requires HER4 and BRCA1
    Rebecca S Muraoka-Cook
    Lineberger Comprehensive Cancer Center, University of North Carolina Chapel Hill, 102 Mason Farm Road, Chapel Hill, NC 27599, USA
    Mol Cell Biol 26:6412-24. 2006
  8. ncbi request reprint BRCA1-induced apoptosis involves inactivation of ERK1/2 activities
    Ying Yan
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
    J Biol Chem 277:33422-30. 2002
  9. pmc Gamma-irradiation-induced DNA damage checkpoint activation involves feedback regulation between extracellular signal-regulated kinase 1/2 and BRCA1
    Ying Yan
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
    Cancer Res 68:5113-21. 2008
  10. ncbi request reprint BRCA1-mediated G2/M cell cycle arrest requires ERK1/2 kinase activation
    Ying Yan
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Oncogene 24:3285-96. 2005

Research Grants

  1. UECC ANIMAL FACILITY IMPROVEMENT GRANT
    Kenneth Cowan; Fiscal Year: 2004
  2. UNMC EPPLEY CANCER CENTER SUPPORT GRANT
    Kenneth Cowan; Fiscal Year: 2007

Collaborators

Detail Information

Publications10

  1. pmc RAC1 GTPase plays an important role in γ-irradiation induced G2/M checkpoint activation
    Ying Yan
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE, USA
    Breast Cancer Res 14:R60. 2012
    ..In the present studies, we investigated the role of Ras-related C3 botulinum toxin substrate 1 (Rac1) guanosine triphosphatase (GTPase) in IR-induced G2/M checkpoint response and ERK1/2 activation, as well as in cell survival after IR...
  2. ncbi request reprint Paclitaxel chemotherapy after autologous stem-cell transplantation and engraftment of hematopoietic cells transduced with a retrovirus containing the multidrug resistance complementary DNA (MDR1) in metastatic breast cancer patients
    K H Cowan
    National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Clin Cancer Res 5:1619-28. 1999
    ....
  3. ncbi request reprint A pilot study of dose intense doxorubicin and cyclophosphamide followed by infusional paclitaxel in high-risk primary breast cancer
    Jo Anne Zujewski
    National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Breast Cancer Res Treat 81:41-51. 2003
    ..Administration of dose dense AC followed by infusional paclitaxel in 14-day cycles is feasible and this regimen is active in breast cancer...
  4. ncbi request reprint Brca1-deficient murine mammary epithelial cells have increased sensitivity to CDDP and MMS
    Magdalene K Sgagias
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
    Cell Cycle 3:1451-6. 2004
    ..These studies support the role of BRCA1 in the CDDP-induced and MMS-induced DNA damage and repair by p53-independent pathways...
  5. ncbi request reprint Recombinant adenovirus-mediated p14(ARF) overexpression sensitizes human breast cancer cells to cisplatin
    Xiyun Deng
    Medicine Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 10N226, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 296:792-8. 2002
    ..These results demonstrate that the proper combination of Adp14(ARF) with conventional chemotherapeutic drug(s) could have potential benefits in treating breast cancer that carries wild-type p53 gene...
  6. ncbi request reprint BCL-2 antisense and cisplatin combination treatment of MCF-7 breast cancer cells with or without functional p53
    Hesham Basma
    Department of Biochemistry and Molecular Biology, College of Medicine, Omaha, NE 68198 5870, USA
    J Biomed Sci 12:999-1011. 2005
    ..Bcl-2 antisense and cisplatin combination treatment is a potentially useful therapeutic strategy for breast cancer irrespective of p53 status...
  7. pmc Heregulin-dependent delay in mitotic progression requires HER4 and BRCA1
    Rebecca S Muraoka-Cook
    Lineberger Comprehensive Cancer Center, University of North Carolina Chapel Hill, 102 Mason Farm Road, Chapel Hill, NC 27599, USA
    Mol Cell Biol 26:6412-24. 2006
    ..BRCA1-positive MECs displayed heregulin-dependent mitotic delay; however, the isogenic BRCA1-negative MECs did not. These results suggest that heregulin-mediated growth inhibition in HER4-postive breast cancer cells requires BRCA1...
  8. ncbi request reprint BRCA1-induced apoptosis involves inactivation of ERK1/2 activities
    Ying Yan
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
    J Biol Chem 277:33422-30. 2002
    ..The studies presented in this report indicate that the response to BRCA1 expression is determined by the regulation of both the JNK and ERK1/2 signaling pathways in cells...
  9. pmc Gamma-irradiation-induced DNA damage checkpoint activation involves feedback regulation between extracellular signal-regulated kinase 1/2 and BRCA1
    Ying Yan
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska 68198 6805, USA
    Cancer Res 68:5113-21. 2008
    ..These results implicate an important interaction between BRCA1 and ERK1/2 in the regulation of cellular response after IR-induced DNA damage in MCF-7 cells...
  10. ncbi request reprint BRCA1-mediated G2/M cell cycle arrest requires ERK1/2 kinase activation
    Ying Yan
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Oncogene 24:3285-96. 2005
    ..These results implicate a critical role of ERK1/2 signaling in the regulation of BRCA1 function on controlling the G2/M checkpoint responses...

Research Grants4

  1. UECC ANIMAL FACILITY IMPROVEMENT GRANT
    Kenneth Cowan; Fiscal Year: 2004
    ..This proposal will provide information relative to this renovation and completion of the project will allow UNMC to provide improved quantity and quality animal housing for research animals at the UECC. ..
  2. UNMC EPPLEY CANCER CENTER SUPPORT GRANT
    Kenneth Cowan; Fiscal Year: 2007
    ..abstract_text> ..