Research Topics
Genomes and GenesSpecies | JONATHAN M COVAULTSummaryAffiliation: University of Connecticut Health Center Country: USA Publications
Research Grants
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Detail Information
Publications
Alcohol exposure during late adolescence increases drinking in adult Wistar rats, an effect that is not reduced by finasterideVerica Milivojevic
Department of Psychiatry, Alcohol Research Center, University of Connecticut Health Center, Farmington, CT 06030 2103, USA
Alcohol Alcohol 48:28-38. 2013....- Markers in the 5'-region of GABRG1 associate to alcohol dependence and are in linkage disequilibrium with markers in the adjacent GABRA2 geneJonathan Covault
Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, CT 06030 1410, USA
Neuropsychopharmacology 33:837-48. 2008.... 
Allelic and haplotypic association of GABRA2 with alcohol dependenceJonathan Covault
Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, Connecticut 06030 2103, USA
Am J Med Genet B Neuropsychiatr Genet 129:104-9. 2004..003). These findings replicate and extend recently reported findings, which together underscore the potential contribution of polymorphic variation at the GABRA2 locus to the risk for alcohol dependence...- GABRA2 alleles moderate the subjective effects of alcohol, which are attenuated by finasterideAmira Pierucci-Lagha
Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, CT 06030, USA
Neuropsychopharmacology 30:1193-203. 2005..The effects of finasteride provide indirect evidence for a mediating role of neuroactive steroids in some of the subjective effects of alcohol... - Association between alcoholism and gamma-amino butyric acid alpha2 receptor subtype in a Russian populationJaakko Lappalainen
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
Alcohol Clin Exp Res 29:493-8. 2005..The goal of this study was to test whether GABRA2 is associated with alcohol dependence in a sample of Russian alcohol-dependent men... - Interpopulation linkage disequilibrium patterns of GABRA2 and GABRG1 genes at the GABA cluster locus on human chromosome 4Chupong Ittiwut
Department of Psychiatry, Yale School of Medicine, New Haven, CT 06510, USA
Genomics 91:61-9. 2008..These findings may aid in understanding the genetic association of this locus with alcohol dependence in several populations... - Variation in GABRA2 predicts drinking behavior in project MATCH subjectsLance O Bauer
Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, Connecticut 06030 2103, USA
Alcohol Clin Exp Res 31:1780-7. 2007..The present study examines the association of a GABRA2 SNP with another definition of alcohol involvement and with the effects of psychosocial treatment... - CNR1 variation modulates risk for drug and alcohol dependenceLingjun Zuo
Department of Psychiatry, Yale University School of Medicine, 950 Campbell Avenue, New Haven, CT 06516, USA
Biol Psychiatry 62:616-26. 2007..Following initial reports of association of CNR1 with SD, we studied multiple markers at this locus in a large case-control sample... - Association study of the CNR1 gene exon 3 alternative promoter region polymorphisms and substance dependenceAryeh I Herman
Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut, USA
Am J Med Genet B Neuropsychiatr Genet 141:499-503. 2006..These findings fail to replicate the original report of an association between SNPs adjacent to an alternative CNR1 exon 3 transcription start site and polysubstance abuse... - Association of markers in the 3' region of the GluR5 kainate receptor subunit gene to alcohol dependenceHenry R Kranzler
Alcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, University Health Center, Farmington, CT 06030 2103, USA
Alcohol Clin Exp Res 33:925-30. 2009..We focused specifically on this gene because topiramate, a glutamate modulator that binds to the GluR5 subunit, has shown robust efficacy in the treatment of AD... - Targeted naltrexone for problem drinkersHenry R Kranzler
Department of Psychiatry, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030 2103, USA
J Clin Psychopharmacol 29:350-7. 2009.... - Placebo-controlled trial of zonisamide for the treatment of alcohol dependenceAlbert J Arias
Alcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
J Clin Psychopharmacol 30:318-22. 2010..This pilot clinical trial evaluated the safety, tolerability, and efficacy of zonisamide for the treatment of alcohol dependence... - Effects of aripiprazole on subjective and physiological responses to alcoholHenry R Kranzler
Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, Connecticut 06030 2103, USA
Alcohol Clin Exp Res 32:573-9. 2008..The present study examined whether aripiprazole modifies the behavioral and physiological effects of a moderate dose of alcohol in a group of social drinkers... - Alleles of a functional serotonin transporter promoter polymorphism are associated with major depression in alcoholicsMaggie Nellissery
Department of Psychiatry, University of Connecticut School of Medicine, Farmington 06030 2103, USA
Alcohol Clin Exp Res 27:1402-8. 2003..Because the convergence of these disorders may provide a refined phenotype, we examined the association of serotonin (5-HT) transporter linked polymorphic region (5-HTTLPR) alleles to comorbid alcohol dependence and major depression... - Quantitative real-time PCR for gene dosage determinations in microdeletion genotypesJonathan Covault
Department of Psychiatry, MC 2103, UCHC, Farmington, CT 06030-2103, USA
Biotechniques 35:594-6, 598. 2003 - Nogo 3'-untranslated region CAA insertion: failure to replicate association with schizophrenia and demonstration of marked population difference in frequency of the insertionJonathan Covault
Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
Brain Res Mol Brain Res 120:197-200. 2004..We found a similar frequency of the CAA insertion for patients and controls in both populations, but a large difference in CAA insertion frequency between the two racial groups... - Association of a long-chain fatty acid-CoA ligase 4 gene polymorphism with depression and with enhanced niacin-induced dermal erythemaJonathan Covault
Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut 06030 2103, USA
Am J Med Genet B Neuropsychiatr Genet 127:42-7. 2004..38%; P = 0.003) and a non-significant excess of the T allele in schizophrenia (44%; P = 0.29). The allele frequency for subjects with alcohol dependence did not differ from controls... - Interactive effects of the serotonin transporter 5-HTTLPR polymorphism and stressful life events on college student drinking and drug useJonathan Covault
Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut, USA
Biol Psychiatry 61:609-16. 2007..We examined this polymorphism as it interacted with negative life events to predict drinking and drug use in college students... - Population-specific effects of the Asn40Asp polymorphism at the mu-opioid receptor gene (OPRM1) on HPA-axis activationCarlos A Hernandez-Avila
Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, Connecticut 06030 2103, USA
Pharmacogenet Genomics 17:1031-8. 2007.... 
A functional serotonin transporter gene polymorphism and depressive effects associated with interferon-alpha treatmentAmira Pierucci-Lagha
Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
Psychosomatics 51:137-48. 2010..Interferon-alpha (IFN-alpha) treatment frequently induces depression, potentially leading to early dose reductions or a shorter duration of treatment, which can adversely affect outcomes, including quality of life...- Tryptophan hydroxylase 2 gene and alcohol use among college studentsPaul Gacek
Public Health Program, Department of Community Medicine and Health Care, University of Connecticut Health Center, Farmington, CT 06030 6325, USA
Addict Biol 13:440-8. 2008.... - A serotonin transporter gene polymorphism (5-HTTLPR), drinking-to-cope motivation, and negative life events among college studentsStephen Armeli
Department of Community Medicine, MC 6325, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut 06030 6325, USA
J Stud Alcohol Drugs 69:814-23. 2008..We examined reward drinking (drinking-to-enhance motives) as a comparison and to see whether these effects varied across gender... - Effects of rapid tryptophan depletion on mood and urge to drink in patients with co-morbid major depression and alcohol dependenceAmira Pierucci-Lagha
Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington 06030, USA
Psychopharmacology (Berl) 171:340-8. 2004..These findings may also help to identify alcoholics who are at greatest risk for MDD... - Population admixture modulates risk for alcohol dependenceLingjun Zuo
Department of Psychiatry, Yale University School of Medicine, VA Psychiatry 116A2, West Haven, CT 06516, USA
Hum Genet 125:605-13. 2009..We cannot exclude the possibility that the results might have been influenced by selection bias due to the multisite nature of the study... - Effects of opioid receptor gene variation on targeted nalmefene treatment in heavy drinkersAlbert J Arias
Alcohol Research Center, University of Connecticut School of Medicine, Farmington, Connecticut 06030 2103, USA
Alcohol Clin Exp Res 32:1159-66. 2008..We examined opioid receptor gene polymorphisms as moderators of the therapeutic effects of the opioid antagonist nalmefene... - Subjective effects and changes in steroid hormone concentrations in humans following acute consumption of alcoholAmira Pierucci-Lagha
Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, CT 06030, and Department of Psychiatry and Behavioral Sciences, Durham VA Medical Center, NC 27705, USA
Psychopharmacology (Berl) 186:451-61. 2006..Efforts to replicate these findings should aim to specify more clearly the nature and time course of the effects... - Effects of prenatal tobacco exposure on gene expression profiling in umbilical cord tissueNaveed Hussain
Department of Pediatrics, University of Connecticut School of Medicine, Farmington, CT 06030, USA
Pediatr Res 64:147-53. 2008..Validation of the three somatomammotropin genes showed a high correlation between qPCR and microarray expression. We conclude that maternal smoking may be associated with altered gene expression in the offspring...
Research Grants
- Pharmacogenetics of Alcohol: Treatment ImplicationsJonathan Covault; Fiscal Year: 2007....
- Novel Methods to Study Substance Use in College StudentsJonathan Covault; Fiscal Year: 2007....
- Pharmacogenetics of Alcohol: Treatment ImplicationsJonathan Covault; Fiscal Year: 2009....