JONATHAN M COVAULT

Summary

Affiliation: University of Connecticut Health Center
Country: USA

Publications

  1. pmc Human miR-1271 is a miR-96 paralog with distinct non-conserved brain expression pattern
    Kevin P Jensen
    Alcohol Research Center, Department of Psychiatry, University of Connecticut Health Center, Farmington, CT 06030, USA
    Nucleic Acids Res 39:701-11. 2011
  2. pmc A GABRA2 variant is associated with increased stimulation and 'high' following alcohol administration
    Albert J Arias
    Corresponding author Department of Psychiatry, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 1410, USA
    Alcohol Alcohol 49:1-9. 2014
  3. pmc Alcohol exposure during late adolescence increases drinking in adult Wistar rats, an effect that is not reduced by finasteride
    Verica Milivojevic
    Department of Psychiatry, Alcohol Research Center, University of Connecticut Health Center, Farmington, CT 06030 2103, USA
    Alcohol Alcohol 48:28-38. 2013
  4. pmc Markers in the 5'-region of GABRG1 associate to alcohol dependence and are in linkage disequilibrium with markers in the adjacent GABRA2 gene
    Jonathan Covault
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, CT 06030 1410, USA
    Neuropsychopharmacology 33:837-48. 2008
  5. ncbi request reprint Allelic and haplotypic association of GABRA2 with alcohol dependence
    Jonathan Covault
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, Connecticut 06030 2103, USA
    Am J Med Genet B Neuropsychiatr Genet 129:104-9. 2004
  6. ncbi request reprint GABRA2 alleles moderate the subjective effects of alcohol, which are attenuated by finasteride
    Amira Pierucci-Lagha
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, CT 06030, USA
    Neuropsychopharmacology 30:1193-203. 2005
  7. ncbi request reprint Association between alcoholism and gamma-amino butyric acid alpha2 receptor subtype in a Russian population
    Jaakko Lappalainen
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Alcohol Clin Exp Res 29:493-8. 2005
  8. pmc Interpopulation linkage disequilibrium patterns of GABRA2 and GABRG1 genes at the GABA cluster locus on human chromosome 4
    Chupong Ittiwut
    Department of Psychiatry, Yale School of Medicine, New Haven, CT 06510, USA
    Genomics 91:61-9. 2008
  9. pmc Association study of the CNR1 gene exon 3 alternative promoter region polymorphisms and substance dependence
    Aryeh I Herman
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut, USA
    Am J Med Genet B Neuropsychiatr Genet 141:499-503. 2006
  10. ncbi request reprint CNR1 variation modulates risk for drug and alcohol dependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, 950 Campbell Avenue, New Haven, CT 06516, USA
    Biol Psychiatry 62:616-26. 2007

Research Grants

  1. Pharmacogenetics of Alcohol: Treatment Implications
    Jonathan Covault; Fiscal Year: 2006
  2. Pharmacogenetics of Alcohol: Treatment Implications
    Jonathan Covault; Fiscal Year: 2007
  3. Novel Methods to Study Substance Use in College Students
    Jonathan Covault; Fiscal Year: 2007
  4. Pharmacogenetics of Alcohol: Treatment Implications
    Jonathan Covault; Fiscal Year: 2009

Detail Information

Publications29

  1. pmc Human miR-1271 is a miR-96 paralog with distinct non-conserved brain expression pattern
    Kevin P Jensen
    Alcohol Research Center, Department of Psychiatry, University of Connecticut Health Center, Farmington, CT 06030, USA
    Nucleic Acids Res 39:701-11. 2011
    ..Given the expression patterns and nature of the target genes, miR-1271 may have a significant, although non-conserved, role in regulating aspects of neural development or function in humans...
  2. pmc A GABRA2 variant is associated with increased stimulation and 'high' following alcohol administration
    Albert J Arias
    Corresponding author Department of Psychiatry, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 1410, USA
    Alcohol Alcohol 49:1-9. 2014
    ....
  3. pmc Alcohol exposure during late adolescence increases drinking in adult Wistar rats, an effect that is not reduced by finasteride
    Verica Milivojevic
    Department of Psychiatry, Alcohol Research Center, University of Connecticut Health Center, Farmington, CT 06030 2103, USA
    Alcohol Alcohol 48:28-38. 2013
    ....
  4. pmc Markers in the 5'-region of GABRG1 associate to alcohol dependence and are in linkage disequilibrium with markers in the adjacent GABRA2 gene
    Jonathan Covault
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, CT 06030 1410, USA
    Neuropsychopharmacology 33:837-48. 2008
    ....
  5. ncbi request reprint Allelic and haplotypic association of GABRA2 with alcohol dependence
    Jonathan Covault
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, Connecticut 06030 2103, USA
    Am J Med Genet B Neuropsychiatr Genet 129:104-9. 2004
    ..003). These findings replicate and extend recently reported findings, which together underscore the potential contribution of polymorphic variation at the GABRA2 locus to the risk for alcohol dependence...
  6. ncbi request reprint GABRA2 alleles moderate the subjective effects of alcohol, which are attenuated by finasteride
    Amira Pierucci-Lagha
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, CT 06030, USA
    Neuropsychopharmacology 30:1193-203. 2005
    ..The effects of finasteride provide indirect evidence for a mediating role of neuroactive steroids in some of the subjective effects of alcohol...
  7. ncbi request reprint Association between alcoholism and gamma-amino butyric acid alpha2 receptor subtype in a Russian population
    Jaakko Lappalainen
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Alcohol Clin Exp Res 29:493-8. 2005
    ..The goal of this study was to test whether GABRA2 is associated with alcohol dependence in a sample of Russian alcohol-dependent men...
  8. pmc Interpopulation linkage disequilibrium patterns of GABRA2 and GABRG1 genes at the GABA cluster locus on human chromosome 4
    Chupong Ittiwut
    Department of Psychiatry, Yale School of Medicine, New Haven, CT 06510, USA
    Genomics 91:61-9. 2008
    ..These findings may aid in understanding the genetic association of this locus with alcohol dependence in several populations...
  9. pmc Association study of the CNR1 gene exon 3 alternative promoter region polymorphisms and substance dependence
    Aryeh I Herman
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut, USA
    Am J Med Genet B Neuropsychiatr Genet 141:499-503. 2006
    ..These findings fail to replicate the original report of an association between SNPs adjacent to an alternative CNR1 exon 3 transcription start site and polysubstance abuse...
  10. ncbi request reprint CNR1 variation modulates risk for drug and alcohol dependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, 950 Campbell Avenue, New Haven, CT 06516, USA
    Biol Psychiatry 62:616-26. 2007
    ..Following initial reports of association of CNR1 with SD, we studied multiple markers at this locus in a large case-control sample...
  11. pmc Variation in GABRA2 predicts drinking behavior in project MATCH subjects
    Lance O Bauer
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, Connecticut 06030 2103, USA
    Alcohol Clin Exp Res 31:1780-7. 2007
    ..The present study examines the association of a GABRA2 SNP with another definition of alcohol involvement and with the effects of psychosocial treatment...
  12. pmc Effects of aripiprazole on subjective and physiological responses to alcohol
    Henry R Kranzler
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, Connecticut 06030 2103, USA
    Alcohol Clin Exp Res 32:573-9. 2008
    ..The present study examined whether aripiprazole modifies the behavioral and physiological effects of a moderate dose of alcohol in a group of social drinkers...
  13. ncbi request reprint Quantitative real-time PCR for gene dosage determinations in microdeletion genotypes
    Jonathan Covault
    Department of Psychiatry, MC 2103, UCHC, Farmington, CT 06030 2103, USA
    Biotechniques 35:594-6, 598. 2003
  14. ncbi request reprint Alleles of a functional serotonin transporter promoter polymorphism are associated with major depression in alcoholics
    Maggie Nellissery
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington 06030 2103, USA
    Alcohol Clin Exp Res 27:1402-8. 2003
    ..Because the convergence of these disorders may provide a refined phenotype, we examined the association of serotonin (5-HT) transporter linked polymorphic region (5-HTTLPR) alleles to comorbid alcohol dependence and major depression...
  15. pmc Association of markers in the 3' region of the GluR5 kainate receptor subunit gene to alcohol dependence
    Henry R Kranzler
    Alcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, University Health Center, Farmington, CT 06030 2103, USA
    Alcohol Clin Exp Res 33:925-30. 2009
    ..We focused specifically on this gene because topiramate, a glutamate modulator that binds to the GluR5 subunit, has shown robust efficacy in the treatment of AD...
  16. pmc Targeted naltrexone for problem drinkers
    Henry R Kranzler
    Department of Psychiatry, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030 2103, USA
    J Clin Psychopharmacol 29:350-7. 2009
    ....
  17. ncbi request reprint Nogo 3'-untranslated region CAA insertion: failure to replicate association with schizophrenia and demonstration of marked population difference in frequency of the insertion
    Jonathan Covault
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    Brain Res Mol Brain Res 120:197-200. 2004
    ..We found a similar frequency of the CAA insertion for patients and controls in both populations, but a large difference in CAA insertion frequency between the two racial groups...
  18. ncbi request reprint Association of a long-chain fatty acid-CoA ligase 4 gene polymorphism with depression and with enhanced niacin-induced dermal erythema
    Jonathan Covault
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut 06030 2103, USA
    Am J Med Genet B Neuropsychiatr Genet 127:42-7. 2004
    ..38%; P = 0.003) and a non-significant excess of the T allele in schizophrenia (44%; P = 0.29). The allele frequency for subjects with alcohol dependence did not differ from controls...
  19. ncbi request reprint Interactive effects of the serotonin transporter 5-HTTLPR polymorphism and stressful life events on college student drinking and drug use
    Jonathan Covault
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut, USA
    Biol Psychiatry 61:609-16. 2007
    ..We examined this polymorphism as it interacted with negative life events to predict drinking and drug use in college students...
  20. pmc Placebo-controlled trial of zonisamide for the treatment of alcohol dependence
    Albert J Arias
    Alcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    J Clin Psychopharmacol 30:318-22. 2010
    ..This pilot clinical trial evaluated the safety, tolerability, and efficacy of zonisamide for the treatment of alcohol dependence...
  21. pmc A serotonin transporter gene polymorphism (5-HTTLPR), drinking-to-cope motivation, and negative life events among college students
    Stephen Armeli
    Department of Community Medicine, MC 6325, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut 06030 6325, USA
    J Stud Alcohol Drugs 69:814-23. 2008
    ..We examined reward drinking (drinking-to-enhance motives) as a comparison and to see whether these effects varied across gender...
  22. pmc Tryptophan hydroxylase 2 gene and alcohol use among college students
    Paul Gacek
    Public Health Program, Department of Community Medicine and Health Care, University of Connecticut Health Center, Farmington, CT 06030 6325, USA
    Addict Biol 13:440-8. 2008
    ....
  23. pmc A functional serotonin transporter gene polymorphism and depressive effects associated with interferon-alpha treatment
    Amira Pierucci-Lagha
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    Psychosomatics 51:137-48. 2010
    ..Interferon-alpha (IFN-alpha) treatment frequently induces depression, potentially leading to early dose reductions or a shorter duration of treatment, which can adversely affect outcomes, including quality of life...
  24. ncbi request reprint Population-specific effects of the Asn40Asp polymorphism at the mu-opioid receptor gene (OPRM1) on HPA-axis activation
    Carlos A Hernandez-Avila
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, Connecticut 06030 2103, USA
    Pharmacogenet Genomics 17:1031-8. 2007
    ....
  25. ncbi request reprint Effects of rapid tryptophan depletion on mood and urge to drink in patients with co-morbid major depression and alcohol dependence
    Amira Pierucci-Lagha
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington 06030, USA
    Psychopharmacology (Berl) 171:340-8. 2004
    ..Rapid tryptophan depletion (RTD) has been used to study central serotonin function and may therefore be useful in understanding co-morbid alcohol dependence (AD) and major depressive disorder (MDD)...
  26. pmc Population admixture modulates risk for alcohol dependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, VA Psychiatry 116A2, West Haven, CT 06516, USA
    Hum Genet 125:605-13. 2009
    ..We cannot exclude the possibility that the results might have been influenced by selection bias due to the multisite nature of the study...
  27. pmc Effects of opioid receptor gene variation on targeted nalmefene treatment in heavy drinkers
    Albert J Arias
    Alcohol Research Center, University of Connecticut School of Medicine, Farmington, Connecticut 06030 2103, USA
    Alcohol Clin Exp Res 32:1159-66. 2008
    ..We examined opioid receptor gene polymorphisms as moderators of the therapeutic effects of the opioid antagonist nalmefene...
  28. ncbi request reprint Subjective effects and changes in steroid hormone concentrations in humans following acute consumption of alcohol
    Amira Pierucci-Lagha
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, CT 06030, and Department of Psychiatry and Behavioral Sciences, Durham VA Medical Center, NC 27705, USA
    Psychopharmacology (Berl) 186:451-61. 2006
    ..This study examined the effects of alcohol on plasma steroid hormone concentrations on the hypothesis that the endocrine effects mediate some of the subjective effects of alcohol...
  29. pmc Effects of prenatal tobacco exposure on gene expression profiling in umbilical cord tissue
    Naveed Hussain
    Department of Pediatrics, University of Connecticut School of Medicine, Farmington, CT 06030, USA
    Pediatr Res 64:147-53. 2008
    ..Validation of the three somatomammotropin genes showed a high correlation between qPCR and microarray expression. We conclude that maternal smoking may be associated with altered gene expression in the offspring...

Research Grants7

  1. Pharmacogenetics of Alcohol: Treatment Implications
    Jonathan Covault; Fiscal Year: 2006
    ....
  2. Pharmacogenetics of Alcohol: Treatment Implications
    Jonathan Covault; Fiscal Year: 2007
    ....
  3. Novel Methods to Study Substance Use in College Students
    Jonathan Covault; Fiscal Year: 2007
    ....
  4. Pharmacogenetics of Alcohol: Treatment Implications
    Jonathan Covault; Fiscal Year: 2009
    ....