Research Topics
| L M CoussensSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesisL M Coussens
Cancer Research Institute, University of California, San Francisco 94143, USA
Cell 103:481-90. 2000..Thus, inflammatory cells can be coconspirators in carcinogenesis...- Inflammation and cancerLisa M Coussens
Cancer Research Institute, Department of Pathology, University of California, San Francisco, California 94143, USA
Nature 420:860-7. 2002..These insights are fostering new anti-inflammatory therapeutic approaches to cancer development... 
Paradoxical roles of the immune system during cancer developmentKarin E de Visser
Department of Molecular Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
Nat Rev Cancer 6:24-37. 2006....- Optical imaging of the peri-tumoral inflammatory response in breast cancerAkhilesh K Sista
Department of Radiology and Biomedical Engineering, University of California, San Francisco, USA
J Transl Med 7:94. 2009..The purpose of this study was to determine whether injected fluorescently-labeled monocytes accumulate within murine breast tumors and are visible with optical imaging... - Inflammation and breast cancer. Balancing immune response: crosstalk between adaptive and innate immune cells during breast cancer progressionDavid G DeNardo
Department of Pathology, University of California, San Francisco, 2340 Sutter Street, San Francisco, CA 94143, USA
Breast Cancer Res 9:212. 2007..Herein we review this body of literature and summarize important new findings revealing the paradoxical role of innate and adaptive leukocytes as regulators of breast carcinogenesis... - Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesisL M Coussens
Hormone Research Institute, University of California, San Francisco San Francisco, California 94143 0534, USA
Genes Dev 13:1382-97. 1999.... - Distinctive features of angiogenesis and lymphangiogenesis determine their functionality during de novo tumor developmentAlexandra Eichten
Department of Pathology, University of California at San Francisco, San Francisco, California 94115, USA
Cancer Res 67:5211-20. 2007..Strategies to normalize intratumoral hemodynamics would therefore enhance therapeutic delivery to otherwise poorly accessible central regions of solid tumors... - Epithelial carcinogenesis: dynamic interplay between neoplastic cells and their microenvironmentLeon C L Van Kempen
Cancer Research Institute, University of California, San Francisco, CA 94115, USA
Differentiation 70:610-23. 2002.... - The interplay between innate and adaptive immunity regulates cancer developmentK E de Visser
Cancer Research Institute, University of California, San Francisco, 2340 Sutter St, N 261, San Francisco, CA 94143, USA
Cancer Immunol Immunother 54:1143-52. 2005.... - The Bcl-2 repertoire of mesothelioma spheroids underlies acquired apoptotic multicellular resistanceD Barbone
Lung Biology Center, San Francisco General Hospital, University of California San Francisco, 1001 Potrero Avenue, San Francisco, CA 94110, USA
Cell Death Dis 2:e174. 2011..Therefore, mesothelioma, a highly resistant tumor, may have an intrinsic sensitivity to Bcl-2 blockade that can be exploited therapeutically... - Tumor stroma and regulation of cancer developmentThea D Tlsty
Department of Pathology and Comprehensive Cancer Center, University of California, San Francisco, California 94115, USA
Annu Rev Pathol 1:119-50. 2006.... - TIMP-1 alters susceptibility to carcinogenesisJin Sae Rhee
Medical Scientist Training Program, Cancer Research Institute, University of California, San Francisco, California, USA
Cancer Res 64:952-61. 2004..The combined implications of these studies suggest that TIMP-1 is an important contributor to epithelial neoplastic progression and supports the concept that TIMP-1 exerts differential regulation on tissues in a stage-dependent manner... - Stromal regulation of vessel stability by MMP14 and TGFbetaNor E Sounni
Cancer Research Institute, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143, USA
Dis Model Mech 3:317-32. 2010..Antagonists of this pathway could be therapeutically exploited to improve the delivery of therapeutics or molecular contrast agents into tissues where chronic damage or neoplastic disease limits their efficient delivery... - Matrix metalloproteinase-2 and -9 expression increases in Mycoplasma-infected airways but is not required for microvascular remodelingPeter Baluk
Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0130, USA
Am J Physiol Lung Cell Mol Physiol 287:L307-17. 2004..We conclude that despite major increases in expression, MMP-2 and MMP-9 are not essential for microvascular remodeling in M. pulmonis-induced chronic airway inflammation... - Extrinsic regulators of epithelial tumor progression: metalloproteinasesG Bergers
Hormone Research Institute, University of California, 1090 HSW Box 0534, San Francisco, California 94143, USA
Curr Opin Genet Dev 10:120-7. 2000.... - Polarized immune responses differentially regulate cancer developmentMagnus Johansson
Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA
Immunol Rev 222:145-54. 2008..Herein, we review clinical and experimental studies investigating cellular and molecular mechanisms utilized by neoplastic tissues to alternatively polarize immune responses that favor either pro- or anti-tumor immunity... - De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependentKarin E de Visser
Cancer Research Institute, University of California, San Francisco, California 94143, USA
Cancer Cell 7:411-23. 2005..g., chronic inflammation, angiogenic vasculature, hyperproliferative epidermis. These findings support a model in which B lymphocytes are required for establishing chronic inflammatory states that promote de novo carcinogenesis... - Soluble mediators of inflammation during tumor developmentStephen C Robinson
Cancer Research Institute, University of California, San Francisco, 94143, USA
Adv Cancer Res 93:159-87. 2005..This chapter focuses on the clinical and experimental data implicating proinflammatory cytokines and chemokines as important potentiators of carcinogenesis... - Matrix metalloproteinase inhibitors and cancer: trials and tribulationsLisa M Coussens
Department of Pathology and Cancer Research Institute, University of California, 2340 Sutter Street, San Francisco, CA 94143, USA
Science 295:2387-92. 2002..The important lessons learned from the MPI experience may be of great value for future studies of MPIs and for cancer drug development in general... - IKKalpha at the crossroads of inflammation and metastasisNesrine I Affara
Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA
Cell 129:25-6. 2007..This leads to repression of maspin, a critical suppressor of metastasis, and thus commits malignant prostatic epithelial cells to a metastatic fate... - Three-dimensional visualization of blood and lymphatic vasculature in tissue whole mounts using confocal microscopyAlexandra Eichten
University of California at San Francisco, San Francisco, CA, USA
Curr Protoc Cytom . 2005..Together, these approaches allow functional and morphological analysis of blood vasculature distinct from endothelial cells within the lymphatic vascular network and surrounding support cells... - FcRgamma activation regulates inflammation-associated squamous carcinogenesisPauline Andreu
Department of Pathology, University of California, San Francisco, 94143, USA
Cancer Cell 17:121-34. 2010..These findings support a model in which B cells, humoral immunity, and activating FcgammaRs are required for establishing chronic inflammatory programs that promote de novo carcinogenesis... - Analysis of immune cell infiltrates during squamous carcinoma developmentSimon R Junankar
Cancer Research Institute, University of California, San Francisco, San Francisco, California 94143, USA
J Investig Dermatol Symp Proc 11:36-43. 2006..Herein, we provide detailed methodology facilitating these analyses... - Immune cells as mediators of solid tumor metastasisDavid G DeNardo
Department of Pathology, University of California, San Francisco, San Francisco, CA, 94143, USA
Cancer Metastasis Rev 27:11-8. 2008..This review focuses on recent literature revealing new mechanisms whereby immune cells regulate metastatic progression, with a primary focus on breast cancer... - Early neoplastic progression is complement independentKarin E de Visser
Cancer Research Institute, University of California, San Francisco, 2340 Sutter Street, San Francisco, CA 94143, USA
Neoplasia 6:768-76. 2004..keratinocyte hyperproliferation or angiogenesis. Taken together, these data suggest that complement-independent pathways are critical for leukocyte recruitment into neoplastic tissue and leukocyte-mediated potentiation of tumorigenesis... - EMX2 is epigenetically silenced and suppresses growth in human lung cancerJ Okamoto
Department of Surgery, University of California, San Francisco, CA 94115, USA
Oncogene 29:5969-75. 2010..Taken together, our study suggests that EMX2 may have important roles as a novel suppressor in human lung cancer... 
Inflaming gastrointestinal oncogenic programmingDavid G DeNardo
Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA
Cancer Cell 14:7-9. 2008....- Delineating protease functions during cancer developmentNesrine I Affara
Department of Pathology, University of California, San Francisco, San Francisco, CA, USA
Methods Mol Biol 539:1-32. 2009.... - MMP9 potentiates pulmonary metastasis formationLeon C L Van Kempen
Cancer Research Institute, University of California, San Francisco 2340 Sutter Street, San Francisco, CA 94143, USA
Cancer Cell 2:251-2. 2002.... - RECKing MMP function: implications for cancer developmentJin-Sae Rhee
Medical Scientist Training Program and Cancer Research Institute, University of California, San Francisco, 2340 Sutter St, 94143, USA
Trends Cell Biol 12:209-11. 2002..Homozygous loss of RECK results in embryonic lethality and attenuated tumor development in adults - thus providing further support for an efficacious role for protease inhibitors as anticancer therapeutics... - Immune enhancement of skin carcinogenesis by CD4+ T cellsDylan Daniel
Department of Biochemistry and Biophysics, Diabetes and Comprehensive Cancer Centers, University of California at San Francisco, 94143, USA
J Exp Med 197:1017-28. 2003..The data reveal an unexpected capability of CD4 T cells, whereby, proinflammatory CD4+ T cells, apparently responding to bacterial infection of dysplastic skin lesions, can inadvertently enhance neoplastic progression to invasive cancer... - Humoral immunity, inflammation and cancerTing Ting Tan
Department of Pathology, University of California, San Francisco 2340 Sutter St, San Francisco, CA 94143, USA
Curr Opin Immunol 19:209-16. 2007.... - Cancer and inflammation: promise for biologic therapySandra Demaria
Department of Pathology, New York University School of Medicine, New York, NY, USA
J Immunother 33:335-51. 2010.... - Type I collagen is a genetic modifier of matrix metalloproteinase 2 in murine skeletal developmentMikala Egeblad
Department of Anatomy, University of California, San Francisco, San Francisco, California 94143 0452, USA
Dev Dyn 236:1683-93. 2007..Developmental Dynamics 236:1683-1693, 2007. (c) 2007 Wiley-Liss, Inc... - Immune cells as anti-cancer therapeutic targets and toolsMagnus Johansson
Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA
J Cell Biochem 101:918-26. 2007.... - Interactions between lymphocytes and myeloid cells regulate pro- versus anti-tumor immunityDavid G DeNardo
Department of Pathology, University of California, 513 Parnassus Ave, HSW 450C, San Francisco, CA 94143, USA
Cancer Metastasis Rev 29:309-16. 2010..Here, we detail the diversity of heterogeneous B and T lymphocyte populations and their impacts on solid tumor development through their abilities to regulate myeloid cell function in solid tumors... - Lymphocytes in cancer development: polarization towards pro-tumor immunityBrian Ruffell
Department of Pathology, University of California, San Francisco, CA 94143, United States
Cytokine Growth Factor Rev 21:3-10. 2010..This includes, in addition to the role of T regulatory cells, a role for natural killer T cells and CD4(+) T helper cells in suppressing anti-tumor immunity and promoting cancer growth and metastasis... - The contribution of bone marrow-derived cells to the tumor vasculature in neuroblastoma is matrix metalloproteinase-9 dependentSonata Jodele
Division of Hematology Oncology, University of Southern California and The Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
Cancer Res 65:3200-8. 2005..Taken together, the data show that in neuroblastoma, MMP-9 plays a critical role in the recruitment of bone marrow-derived cells to the tumor microenvironment where they positively contribute to angiogenesis and tumor progression... - The initial steps of ovarian cancer cell metastasis are mediated by MMP-2 cleavage of vitronectin and fibronectinHilary A Kenny
Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, University of Chicago, Chicago, Illinois 60637, USA
J Clin Invest 118:1367-79. 2008..These findings indicate that MMP-2 expressed by metastatic OvCa cells functionally regulates their attachment to peritoneal surfaces... - The tumor microenvironment: a critical determinant of neoplastic evolutionLeon C L T van Kempen
University Medical Center Nijmegen, Department of Pathology, Nijmegen, The Netherlands
Eur J Cell Biol 82:539-48. 2003.... - Stromal matrix metalloproteinase-9 regulates the vascular architecture in neuroblastoma by promoting pericyte recruitmentChristophe F Chantrain
Department of Pediatrics and Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Cancer Res 64:1675-86. 2004..Taken together, the data demonstrate that in neuroblastoma, stromally derived MMP-9 contributes to angiogenesis by promoting blood vessel morphogenesis and pericyte recruitment... - Hu/Mu ProtIn oligonucleotide microarray: dual-species array for profiling protease and protease inhibitor gene expression in tumors and their microenvironmentDonald R Schwartz
Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, USA
Mol Cancer Res 5:443-54. 2007.... - Inflammation, proteases and cancerLeon C L Van Kempen
Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Geert Grooteplein 24, 6525 GA Nijmegen, The Netherlands
Eur J Cancer 42:728-34. 2006..This review highlights recent insights into the role of chronic inflammation associated with cancer development and examines proteolytic pathways activated by infiltrating leukocytes during neoplastic programming of tissues... - Tumor progression and metastasis from genetic to microenvironmental determinants: a workshop of the tumor progression and metastasis NIH study section in honor of Dr. Martin L. Padarathsingh, May 31, 2006, Georgetown, Washington, DCYVES A DE CLERCK
University of Southern California Keck School of Medicine, Los Angeles, California 90027, USA
Cancer Biol Ther 5:1588-99. 2006 - The inflammatory tumor microenvironment and its impact on cancer developmentKarin E de Visser
Department of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
Contrib Microbiol 13:118-37. 2006..The following chapter focuses on the inflammatory components and processes engaged during cancer development and the impact of the inflammatory microenvironment... - Cancer: an inflammatory linkFran Balkwill
Nature 431:405-6. 2004 - Tissue inhibitor of metalloproteinases-1 promotes liver metastasis by induction of hepatocyte growth factor signalingCharlotte Kopitz
Institut für Experimentelle Onkologie und Therapieforschung, Universitat Munchen, Munich, Germany
Cancer Res 67:8615-23. 2007..Similar TIMP-1-associated changes in gene expression were detected in livers of patients with metastatic colorectal cancer. The newly identified role of TIMP-1 to create a prometastatic niche may also explain the TIMP-1 paradoxon... - Genetic and cellular mechanisms of oncogenesisLisa M Coussens
Curr Opin Genet Dev 18:1-2. 2008