Robert Cousins

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. Cousins R, Blanchard R, Popp M, Liu L, Cao J, Moore J, et al. A global view of the selectivity of zinc deprivation and excess on genes expressed in human THP-1 mononuclear cells. Proc Natl Acad Sci U S A. 2003;100:6952-7 pubmed
    ..Categorization by function revealed numerous genes needed for host defense were among those identified as zinc responsive, including cytokine receptors and genes associated with amplification of the Th1 immune response. ..
  2. Cousins R. Driving Along the Zinc Road. Annu Rev Nutr. 2016;36:1-15 pubmed publisher
    ..As the time of this writing, I maintain an active laboratory. ..
  3. Troche C, Aydemir T, Cousins R. Zinc transporter Slc39a14 regulates inflammatory signaling associated with hypertrophic adiposity. Am J Physiol Endocrinol Metab. 2016;310:E258-68 pubmed publisher
    ..To our knowledge, this is the first investigation into the mechanistic role of ZIP14 in adipose tissue regulation and metabolism. ..
  4. Cousins R, Blanchard R, Moore J, Cui L, Green C, Liuzzi J, et al. Regulation of zinc metabolism and genomic outcomes. J Nutr. 2003;133:1521S-6S pubmed publisher
    ..Collectively, these findings provide a genomic footprint upon which to address the biological and clinical significance of zinc and new avenues for status assessment. ..
  5. Guthrie G, Aydemir T, Troche C, Martin A, Chang S, Cousins R. Influence of ZIP14 (slc39A14) on intestinal zinc processing and barrier function. Am J Physiol Gastrointest Liver Physiol. 2015;308:G171-8 pubmed publisher
    ..In conclusion, ZIP14 is a basolaterally localized protein in enterocytes and is involved in endosomal trafficking of zinc and is necessary for proper maintenance of intestinal tight junctions. ..
  6. Wessels I, Cousins R. Zinc dyshomeostasis during polymicrobial sepsis in mice involves zinc transporter Zip14 and can be overcome by zinc supplementation. Am J Physiol Gastrointest Liver Physiol. 2015;309:G768-78 pubmed publisher
    ..The results are promising for the use of zinc and its transporters as targets for future sepsis therapy. ..
  7. Kim M, Aydemir T, Cousins R. Dietary Zinc Regulates Apoptosis through the Phosphorylated Eukaryotic Initiation Factor 2?/Activating Transcription Factor-4/C/EBP-Homologous Protein Pathway during Pharmacologically Induced Endoplasmic Reticulum Stress in Livers of Mice. J Nutr. 2016;146:2180-2186 pubmed
  8. Aydemir T, Troche C, Kim J, Kim M, Teran O, Leeuwenburgh C, et al. Aging amplifies multiple phenotypic defects in mice with zinc transporter Zip14 (Slc39a14) deletion. Exp Gerontol. 2016;85:88-94 pubmed publisher
    ..These results demonstrate that the inflammation-responsive zinc transporter ZIP14 has phenotypic effects that are amplified with aging. ..
  9. Aydemir T, Troche C, Kim M, Cousins R. Hepatic ZIP14-mediated Zinc Transport Contributes to Endosomal Insulin Receptor Trafficking and Glucose Metabolism. J Biol Chem. 2016;291:23939-23951 pubmed
    ..Therefore, modulation of ZIP14 transport activity presents a new target for management of diabetes and other glucose-related disorders. ..

More Information

Publications11

  1. Aydemir T, Kim M, Kim J, Colon Perez L, Banan G, Mareci T, et al. Metal Transporter Zip14 (Slc39a14) Deletion in Mice Increases Manganese Deposition and Produces Neurotoxic Signatures and Diminished Motor Activity. J Neurosci. 2017;37:5996-6006 pubmed publisher
    ..Humans with altered ZIP14 function would lack this gatekeeper function of ZIP14 and therefore would be prone to manganese-related neurological diseases. ..
  2. Kim M, Aydemir T, Kim J, Cousins R. Hepatic ZIP14-mediated zinc transport is required for adaptation to endoplasmic reticulum stress. Proc Natl Acad Sci U S A. 2017;114:E5805-E5814 pubmed publisher
    ..These results show the importance of zinc trafficking and functional ZIP14 transporter activity for adaptation to ER stress associated with chronic metabolic disorders. ..