Robert Cousins

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. pmc Zinc transporter ZIP14 functions in hepatic zinc, iron and glucose homeostasis during the innate immune response (endotoxemia)
    Tolunay Beker Aydemir
    Food Science and Human Nutrition Department and Center for Nutritional Sciences, College of Agricultural and Life Sciences, University of Florida, Gainesville, FL, USA
    PLoS ONE 7:e48679. 2012
  2. pmc MTF-1-mediated repression of the zinc transporter Zip10 is alleviated by zinc restriction
    Louis A Lichten
    Center for Nutritional Sciences, Food Science and Human Nutrition Department, College of Agricultural and Life Sciences, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 6:e21526. 2011
  3. pmc Plenary Lecture 2: Transcription factors, regulatory elements and nutrient-gene communication
    Robert J Cousins
    Center for Nutritional Sciences, Food Science and Human Nutrition Department, College of Agricultural and Life Sciences and Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, Florida, USA
    Proc Nutr Soc 69:91-4. 2010
  4. ncbi request reprint Mammalian zinc transport, trafficking, and signals
    Robert J Cousins
    Nutritional Genomics Laboratory, Food Science and Human Nutrition Department, Center for Nutritional Sciences, University of Florida, Gainesville, Florida 32611 0370, USA
    J Biol Chem 281:24085-9. 2006
  5. pmc A global view of the selectivity of zinc deprivation and excess on genes expressed in human THP-1 mononuclear cells
    Robert J Cousins
    Nutritional Genomics Laboratory, Food Science and Human Nutrition Department, Center for Nutritional Sciences, and Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, FL 32611 0370, USA
    Proc Natl Acad Sci U S A 100:6952-7. 2003
  6. ncbi request reprint Regulation of zinc metabolism and genomic outcomes
    Robert J Cousins
    Nutritional Genomics Laboratory, Food Science and Human Nutrition, Department for Nutritional Sciences, University of Florida, Gainesville, FL 32611 0370, USA
    J Nutr 133:1521S-6S. 2003
  7. ncbi request reprint Mammalian zinc transporters
    Juan P Liuzzi
    Nutrition Genomics Laboratory and Center for Nutritional Sciences, University of Florida, Gainesville, Florida, 32611 0370, USA
    Annu Rev Nutr 24:151-72. 2004
  8. pmc Responsive transporter genes within the murine intestinal-pancreatic axis form a basis of zinc homeostasis
    Juan P Liuzzi
    Nutritional Genomics Laboratory, Center for Nutritional Sciences, and Small Animal Clinical Sciences Department, University of Florida, Gainesville, FL 32611, USA
    Proc Natl Acad Sci U S A 101:14355-60. 2004
  9. pmc STAT5-glucocorticoid receptor interaction and MTF-1 regulate the expression of ZnT2 (Slc30a2) in pancreatic acinar cells
    Liang Guo
    Nutritional Genomics Laboratory, Food Science and Human Nutrition Department, Center for Nutritional Sciences, University of Florida, Gainesville, FL 32611 0370, USA
    Proc Natl Acad Sci U S A 107:2818-23. 2010
  10. ncbi request reprint Mammalian zinc transporters: nutritional and physiologic regulation
    Louis A Lichten
    Nutritional Genomics Laboratory, Food Science and Human Nutrition Department and Center for Nutritional Sciences, University of Florida, Gainesville, FL 32611 2710, USA
    Annu Rev Nutr 29:153-76. 2009

Research Grants

  1. ZINC AND THE SYNTHESIS OF ZINC BINDING PROTEINS
    Robert Cousins; Fiscal Year: 2007
  2. ZINC AND THE SYNTHESIS OF ZINC BINDING PROTEINS
    Robert Cousins; Fiscal Year: 2007
  3. ZINC AND THE SYNTHESIS OF ZINC BINDING PROTEINS
    Robert Cousins; Fiscal Year: 2006
  4. ZINC AND THE SYNTHESIS OF ZINC BINDING PROTEINS
    Robert Cousins; Fiscal Year: 2004
  5. ZINC AND THE SYNTHESIS OF ZINC BINDING PROTEINS
    Robert Cousins; Fiscal Year: 2004
  6. ZINC AND THE SYNTHESIS OF ZINC BINDING PROTEINS
    Robert Cousins; Fiscal Year: 2003
  7. ZINC AND THE SYNTHESIS OF ZINC BINDING PROTEINS
    Robert Cousins; Fiscal Year: 2002
  8. ZINC AND THE SYNTHESIS OF ZINC BINDING PROTEINS
    Robert Cousins; Fiscal Year: 2001
  9. ZINC AND THE SYNTHESIS OF ZINC BINDING PROTEINS
    Robert Cousins; Fiscal Year: 1991
  10. ZINC AND THE SYNTHESIS OF ZINC BINDING PROTEINS
    Robert Cousins; Fiscal Year: 2001

Collaborators

Detail Information

Publications21

  1. pmc Zinc transporter ZIP14 functions in hepatic zinc, iron and glucose homeostasis during the innate immune response (endotoxemia)
    Tolunay Beker Aydemir
    Food Science and Human Nutrition Department and Center for Nutritional Sciences, College of Agricultural and Life Sciences, University of Florida, Gainesville, FL, USA
    PLoS ONE 7:e48679. 2012
    ..Our data show the role of ZIP14 in the hepatocyte is multi-functional since zinc and iron trafficking are altered in the Zip14(-/-) mice and their phenotype shows defects in glucose homeostasis...
  2. pmc MTF-1-mediated repression of the zinc transporter Zip10 is alleviated by zinc restriction
    Louis A Lichten
    Center for Nutritional Sciences, Food Science and Human Nutrition Department, College of Agricultural and Life Sciences, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 6:e21526. 2011
    ..ZIP10 may have roles in control of zinc homeostasis in specific sites particularly those of the brain and liver. Within that context ZIP10 may act as an important survival mechanism during periods of zinc inadequacy...
  3. pmc Plenary Lecture 2: Transcription factors, regulatory elements and nutrient-gene communication
    Robert J Cousins
    Center for Nutritional Sciences, Food Science and Human Nutrition Department, College of Agricultural and Life Sciences and Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, Florida, USA
    Proc Nutr Soc 69:91-4. 2010
    ..This process in turn influences signalling molecules that regulate gene expression. The examples provided in the present review point to a new level of complexity in understanding nutrient-gene communication...
  4. ncbi request reprint Mammalian zinc transport, trafficking, and signals
    Robert J Cousins
    Nutritional Genomics Laboratory, Food Science and Human Nutrition Department, Center for Nutritional Sciences, University of Florida, Gainesville, Florida 32611 0370, USA
    J Biol Chem 281:24085-9. 2006
  5. pmc A global view of the selectivity of zinc deprivation and excess on genes expressed in human THP-1 mononuclear cells
    Robert J Cousins
    Nutritional Genomics Laboratory, Food Science and Human Nutrition Department, Center for Nutritional Sciences, and Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, FL 32611 0370, USA
    Proc Natl Acad Sci U S A 100:6952-7. 2003
    ..Categorization by function revealed numerous genes needed for host defense were among those identified as zinc responsive, including cytokine receptors and genes associated with amplification of the Th1 immune response...
  6. ncbi request reprint Regulation of zinc metabolism and genomic outcomes
    Robert J Cousins
    Nutritional Genomics Laboratory, Food Science and Human Nutrition, Department for Nutritional Sciences, University of Florida, Gainesville, FL 32611 0370, USA
    J Nutr 133:1521S-6S. 2003
    ..Collectively, these findings provide a genomic footprint upon which to address the biological and clinical significance of zinc and new avenues for status assessment...
  7. ncbi request reprint Mammalian zinc transporters
    Juan P Liuzzi
    Nutrition Genomics Laboratory and Center for Nutritional Sciences, University of Florida, Gainesville, Florida, 32611 0370, USA
    Annu Rev Nutr 24:151-72. 2004
    ..Both the ZnT and Zip transporter families exhibit unique tissue-specific expression, differential responsiveness to dietary zinc deficiency and excess, and differential responsiveness to physiologic stimuli via hormones and cytokines...
  8. pmc Responsive transporter genes within the murine intestinal-pancreatic axis form a basis of zinc homeostasis
    Juan P Liuzzi
    Nutritional Genomics Laboratory, Center for Nutritional Sciences, and Small Animal Clinical Sciences Department, University of Florida, Gainesville, FL 32611, USA
    Proc Natl Acad Sci U S A 101:14355-60. 2004
    ..The results show that Zn transporter expression in the intestinal-pancreatic axis is a component of the homeostatic regulation of this micronutrient...
  9. pmc STAT5-glucocorticoid receptor interaction and MTF-1 regulate the expression of ZnT2 (Slc30a2) in pancreatic acinar cells
    Liang Guo
    Nutritional Genomics Laboratory, Food Science and Human Nutrition Department, Center for Nutritional Sciences, University of Florida, Gainesville, FL 32611 0370, USA
    Proc Natl Acad Sci U S A 107:2818-23. 2010
    ..The ZnT2 transporter appears to function in a physiologically responsive manner involving entero-pancreatic zinc trafficking...
  10. ncbi request reprint Mammalian zinc transporters: nutritional and physiologic regulation
    Louis A Lichten
    Nutritional Genomics Laboratory, Food Science and Human Nutrition Department and Center for Nutritional Sciences, University of Florida, Gainesville, FL 32611 2710, USA
    Annu Rev Nutr 29:153-76. 2009
    ..Other salient findings are the involvement of ZnT2 in lactation, ZIP14 in the hypozincemia of inflammation, ZIP6, ZIP7, and ZIP10 in metastatic breast cancer, and ZnT8 in insulin processing and as an autoantigen in diabetes...
  11. pmc Dietary zinc modulates gene expression in murine thymus: results from a comprehensive differential display screening
    J Bernadette Moore
    Nutritional Genomics Laboratory, Food Science and Human Nutrition Department and Center for Nutritional Sciences, University of Florida, Gainesville, FL 32611 0370, USA
    Proc Natl Acad Sci U S A 100:3883-8. 2003
    ..Several genes involved in T cell development were identified as regulated by zinc and will be targets to evaluate the effects of zinc on immune function...
  12. pmc Kr├╝ppel-like factor 4 regulates adaptive expression of the zinc transporter Zip4 in mouse small intestine
    Juan P Liuzzi
    Center for Nutritional Sciences and Food Science and Human Nutrition Department, University of Florida, Gainesville, FL 32611, USA
    Am J Physiol Gastrointest Liver Physiol 296:G517-23. 2009
    ..These data from experiments with mice and murine IECs demonstrate that KLF4 is induced during zinc restriction and is a transcription factor involved in adaptive regulation of the zinc transporter ZIP4...
  13. pmc Zinc transporters ZnT1 (Slc30a1), Zip8 (Slc39a8), and Zip10 (Slc39a10) in mouse red blood cells are differentially regulated during erythroid development and by dietary zinc deficiency
    Moon Suhn Ryu
    Food Science and Human Nutrition Department, Center for Nutritional Sciences, University of Florida, Gainesville, FL 32611 0370, USA
    J Nutr 138:2076-83. 2008
    ..Collectively, these data suggest that the zinc transporters ZnT1, Zip8, and Zip10 are important for zinc homeostasis in erythrocytes and that ZnT1 and Zip10 respond to the dietary zinc supply...
  14. pmc Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cells
    Juan P Liuzzi
    Nutritional Genomics Laboratory, Food Science and Human Nutrition Department, Center for Nutritional Sciences, University of Florida, Gainesville, FL 32611 0370, USA
    Proc Natl Acad Sci U S A 103:13612-7. 2006
    ..Because NTBI is commonly found in plasma of patients with hemochromatosis and transfusional iron overload, Zip14-mediated NTBI uptake may contribute to the hepatic iron loading that characterizes these diseases...
  15. pmc Zinc supplementation of young men alters metallothionein, zinc transporter, and cytokine gene expression in leukocyte populations
    Tolunay Beker Aydemir
    Nutritional Genomics Laboratory, Food Science and Human Nutrition Department, Center for Nutritional Sciences, University of Florida, Gainesville, FL 32611 0370, USA
    Proc Natl Acad Sci U S A 103:1699-704. 2006
    ..The results obtained also show that zinc supplementation of human subjects programs specific leukocytic subsets to show enhanced cytokine expression upon activation by stimulators of immunity...
  16. ncbi request reprint Overexpression of CRIP in transgenic mice alters cytokine patterns and the immune response
    Lorraine Lanningham-Foster
    Food Science and Human Nutrition Department, Center for Nutritional Sciences, University of Florida, Gainesville, Florida 32611, USA
    Am J Physiol Endocrinol Metab 282:E1197-203. 2002
    ..The observed responses to overexpression of the CRIP gene are consistent with a role for this LIM protein in a cellular pathway that produces an imbalance in cytokine pattern favoring Th2 cytokines...
  17. ncbi request reprint Zinc transporters 1, 2 and 4 are differentially expressed and localized in rats during pregnancy and lactation
    Juan P Liuzzi
    Food Science and Human Nutrition Department, University of Florida, Gainesville, FL, USA
    J Nutr 133:342-51. 2003
    ..These results support a role for these transporters in maintaining an adequate zinc supply derived from the maternal diet for zinc acquisition and use by the fetus and neonate...
  18. pmc Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response
    Juan P Liuzzi
    Nutritional Genomics Laboratory, Center for Nutritional Sciences, University of Florida, Gainesville, FL 32611, USA
    Proc Natl Acad Sci U S A 102:6843-8. 2005
    ....
  19. pmc Interleukin-1beta contributes via nitric oxide to the upregulation and functional activity of the zinc transporter Zip14 (Slc39a14) in murine hepatocytes
    Louis A Lichten
    Food Science and Human Nutrition Department, Center for Nutritional Sciences, University of Florida, Gainesville, FL 32611 0370, USA
    Am J Physiol Gastrointest Liver Physiol 296:G860-7. 2009
    ..These data suggest that signaling pathways activated by NO are factors in the upregulation of Zip14, which in turn mediates hepatic zinc accumulation and hypozincemia during inflammation and sepsis...
  20. pmc Zinc transporter ZIP8 (SLC39A8) and zinc influence IFN-gamma expression in activated human T cells
    Tolunay B Aydemir
    Center for Nutritional Sciences, College of Agricultural and Life Sciences, University of Florida, Gainesville, FL 32611, USA
    J Leukoc Biol 86:337-48. 2009
    ..ZIP8, through control of zinc transport from the lysosome, may provide a secondary level of IFN-gamma regulation in T cells...
  21. ncbi request reprint The permissive effect of zinc deficiency on uroguanylin and inducible nitric oxide synthase gene upregulation in rat intestine induced by interleukin 1alpha is rapidly reversed by zinc repletion
    Li Cui
    Food Science and Human Nutrition Department and Center for Nutritional Sciences, University of Florida, Gainesville 32611 0370, USA
    J Nutr 133:51-6. 2003
    ..Dysregulation of both genes may contribute to the severity of zinc-responsive diarrheal disease and intestinal inflammatory disease...

Research Grants20

  1. ZINC AND THE SYNTHESIS OF ZINC BINDING PROTEINS
    Robert Cousins; Fiscal Year: 2007
    ..Extensive use will be made of transporter localization using immunohistochemistry and immunocytochemistry and zinc fluorophores as visualized by fluorescence microscopy. ..
  2. ZINC AND THE SYNTHESIS OF ZINC BINDING PROTEINS
    Robert Cousins; Fiscal Year: 2007
    ..Extensive use will be made of transporter localization using immunohistochemistry and immunocytochemistry and zinc fluorophores as visualized by fluorescence microscopy. ..
  3. ZINC AND THE SYNTHESIS OF ZINC BINDING PROTEINS
    Robert Cousins; Fiscal Year: 2006
    ..Extensive use will be made of transporter localization using immunohistochemistry and immunocytochemistry and zinc fluorophores as visualized by fluorescence microscopy. ..
  4. ZINC AND THE SYNTHESIS OF ZINC BINDING PROTEINS
    Robert Cousins; Fiscal Year: 2004
    ..These studies will be expanded, using the murine Zn deficiency model, to identify Zn regulated genes in spleen and pancreas using cDNA array analysis. ..
  5. ZINC AND THE SYNTHESIS OF ZINC BINDING PROTEINS
    Robert Cousins; Fiscal Year: 2004
    ..These studies will be expanded, using the murine Zn deficiency model, to identify Zn regulated genes in spleen and pancreas using cDNA array analysis. ..
  6. ZINC AND THE SYNTHESIS OF ZINC BINDING PROTEINS
    Robert Cousins; Fiscal Year: 2003
    ..These studies will be expanded, using the murine Zn deficiency model, to identify Zn regulated genes in spleen and pancreas using cDNA array analysis. ..
  7. ZINC AND THE SYNTHESIS OF ZINC BINDING PROTEINS
    Robert Cousins; Fiscal Year: 2002
    ..These studies will be expanded, using the murine Zn deficiency model, to identify Zn regulated genes in spleen and pancreas using cDNA array analysis. ..
  8. ZINC AND THE SYNTHESIS OF ZINC BINDING PROTEINS
    Robert Cousins; Fiscal Year: 2001
    ..These studies will be expanded, using the murine Zn deficiency model, to identify Zn regulated genes in spleen and pancreas using cDNA array analysis. ..
  9. ZINC AND THE SYNTHESIS OF ZINC BINDING PROTEINS
    Robert Cousins; Fiscal Year: 1991
    ..The relationship of liver zinc metabolism and metallothionein induction to fructose 1,6-bisphosphatase activity will be examined...
  10. ZINC AND THE SYNTHESIS OF ZINC BINDING PROTEINS
    Robert Cousins; Fiscal Year: 2001
    ..These studies will be expanded, using the murine Zn deficiency model, to identify Zn regulated genes in spleen and pancreas using cDNA array analysis. ..
  11. ZINC AND THE SYNTHESIS OF ZINC BINDING PROTEINS
    Robert Cousins; Fiscal Year: 2009
    ..Extensive use will be made of transporter localization using immunohistochemistry and immunocytochemistry and zinc fluorophores as visualized by fluorescence microscopy. ..
  12. ZINC AND THE SYNTHESIS OF ZINC BINDING PROTEINS
    Robert Cousins; Fiscal Year: 2005
    ..Extensive use will be made of transporter localization using immunohistochemistry and immunocytochemistry and zinc fluorophores as visualized by fluorescence microscopy. ..
  13. ZINC AND THE SYNTHESIS OF ZINC BINDING PROTEINS
    Robert Cousins; Fiscal Year: 2000
    ..These studies will be expanded, using the murine Zn deficiency model, to identify Zn regulated genes in spleen and pancreas using cDNA array analysis. ..
  14. ZINC AND THE SYNTHESIS OF ZINC BINDING PROTEINS
    Robert Cousins; Fiscal Year: 2006
    ..Extensive use will be made of transporter localization using immunohistochemistry and immunocytochemistry and zinc fluorophores as visualized by fluorescence microscopy. ..
  15. ZINC AND THE SYNTHESIS OF ZINC BINDING PROTEINS
    Robert Cousins; Fiscal Year: 1990
    ..The relationship of liver zinc metabolism and metallothionein induction to fructose 1,6-bisphosphatase activity will be examined...