E Courchesne

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Mapping early brain development in autism
    Eric Courchesne
    Department of Neurosciences, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Neuron 56:399-413. 2007
  2. ncbi request reprint Brainstem, cerebellar and limbic neuroanatomical abnormalities in autism
    E Courchesne
    Department of Neurosciences, School of Medicine, University of California, San Diego, CA 92093, USA
    Curr Opin Neurobiol 7:269-78. 1997
  3. ncbi request reprint Why the frontal cortex in autism might be talking only to itself: local over-connectivity but long-distance disconnection
    Eric Courchesne
    Department of Neurosciences, University of California, San Diego, CA, USA
    Curr Opin Neurobiol 15:225-30. 2005
  4. ncbi request reprint Abnormal early brain development in autism
    E Courchesne
    Department of Neuroscience, School of Medicine, University of California San Diego, La Jolla, CA 92037, USA
    Mol Psychiatry 7:S21-3. 2002
  5. doi request reprint Neuron number and size in prefrontal cortex of children with autism
    Eric Courchesne
    Department of Neuroscience, NIH UCSD Autism Center of Excellence, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    JAMA 306:2001-10. 2011
  6. ncbi request reprint Evidence of brain overgrowth in the first year of life in autism
    Eric Courchesne
    Department of Neuroscience, School of Medicine, University of California, San Diego, La Jolla, USA
    JAMA 290:337-44. 2003
  7. ncbi request reprint The autistic brain: birth through adulthood
    Eric Courchesne
    Department of Neurosciences, University of California, San Diego, California 92037, USA
    Curr Opin Neurol 17:489-96. 2004
  8. ncbi request reprint Autism at the beginning: microstructural and growth abnormalities underlying the cognitive and behavioral phenotype of autism
    Eric Courchesne
    University of California, San Diego, USA
    Dev Psychopathol 17:577-97. 2005
  9. ncbi request reprint Brain development in autism: early overgrowth followed by premature arrest of growth
    Eric Courchesne
    Center for Autism Research, Children s Hospital Research Center, La Jolla, California 92037, USA
    Ment Retard Dev Disabil Res Rev 10:106-11. 2004
  10. ncbi request reprint Brain overgrowth in autism during a critical time in development: implications for frontal pyramidal neuron and interneuron development and connectivity
    Eric Courchesne
    Department of Neurosciences, University of California, San Diego, CA, USA
    Int J Dev Neurosci 23:153-70. 2005

Detail Information

Publications64

  1. ncbi request reprint Mapping early brain development in autism
    Eric Courchesne
    Department of Neurosciences, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Neuron 56:399-413. 2007
    ..As such, autism may additionally provide unique insight into genetic and developmental processes that shape early neural wiring patterns and make possible higher-order social, emotional, and communication functions...
  2. ncbi request reprint Brainstem, cerebellar and limbic neuroanatomical abnormalities in autism
    E Courchesne
    Department of Neurosciences, School of Medicine, University of California, San Diego, CA 92093, USA
    Curr Opin Neurobiol 7:269-78. 1997
    ....
  3. ncbi request reprint Why the frontal cortex in autism might be talking only to itself: local over-connectivity but long-distance disconnection
    Eric Courchesne
    Department of Neurosciences, University of California, San Diego, CA, USA
    Curr Opin Neurobiol 15:225-30. 2005
    ....
  4. ncbi request reprint Abnormal early brain development in autism
    E Courchesne
    Department of Neuroscience, School of Medicine, University of California San Diego, La Jolla, CA 92037, USA
    Mol Psychiatry 7:S21-3. 2002
  5. doi request reprint Neuron number and size in prefrontal cortex of children with autism
    Eric Courchesne
    Department of Neuroscience, NIH UCSD Autism Center of Excellence, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    JAMA 306:2001-10. 2011
    ..Autism often involves early brain overgrowth, including the prefrontal cortex (PFC). Although prefrontal abnormality has been theorized to underlie some autistic symptoms, the cellular defects that cause abnormal overgrowth remain unknown...
  6. ncbi request reprint Evidence of brain overgrowth in the first year of life in autism
    Eric Courchesne
    Department of Neuroscience, School of Medicine, University of California, San Diego, La Jolla, USA
    JAMA 290:337-44. 2003
    ..This raises the possibility that brain overgrowth begins much earlier, perhaps before the first clinically noticeable behavioral symptoms...
  7. ncbi request reprint The autistic brain: birth through adulthood
    Eric Courchesne
    Department of Neurosciences, University of California, San Diego, California 92037, USA
    Curr Opin Neurol 17:489-96. 2004
    ..We discuss evidence of brain maldevelopment in the first years of life in autism and new neuroanatomical and functional evidence from later ages of development...
  8. ncbi request reprint Autism at the beginning: microstructural and growth abnormalities underlying the cognitive and behavioral phenotype of autism
    Eric Courchesne
    University of California, San Diego, USA
    Dev Psychopathol 17:577-97. 2005
    ..and providing context-based and goal-directed feedback to lower level systems...
  9. ncbi request reprint Brain development in autism: early overgrowth followed by premature arrest of growth
    Eric Courchesne
    Center for Autism Research, Children s Hospital Research Center, La Jolla, California 92037, USA
    Ment Retard Dev Disabil Res Rev 10:106-11. 2004
    ....
  10. ncbi request reprint Brain overgrowth in autism during a critical time in development: implications for frontal pyramidal neuron and interneuron development and connectivity
    Eric Courchesne
    Department of Neurosciences, University of California, San Diego, CA, USA
    Int J Dev Neurosci 23:153-70. 2005
    ..The relationship to clinical characteristics and other disorders of macrencephaly are discussed...
  11. ncbi request reprint Unusual brain growth patterns in early life in patients with autistic disorder: an MRI study
    E Courchesne
    Department of Neuroscience, School of Medicine, University of California, San Diego, La Jolla, USA
    Neurology 57:245-54. 2001
    ..To quantify developmental abnormalities in cerebral and cerebellar volume in autism...
  12. doi request reprint Brain growth across the life span in autism: age-specific changes in anatomical pathology
    Eric Courchesne
    Department of Neuroscience, Autism Center of Excellence, University of California, San Diego, CA, USA
    Brain Res 1380:138-45. 2011
    ....
  13. ncbi request reprint Normal brain development and aging: quantitative analysis at in vivo MR imaging in healthy volunteers
    E Courchesne
    Laboratory for Research on the Neuroscience of Autism, Children s Hospital Research Center, La Jolla, CA 92037, USA
    Radiology 216:672-82. 2000
    ..To quantitate neuroanatomic parameters in healthy volunteers and to compare the values with normative values from postmortem studies...
  14. ncbi request reprint Brain weight in autism: normal in the majority of cases, megalencephalic in rare cases
    E Courchesne
    Department of Neuroscience, School of Medicine, University of California, San Diego, La Jolla, USA
    Neurology 52:1057-9. 1999
    ..Brain weight is thus normal in most postmortem cases of autism. There are, however, rare cases of megalencephaly and possibly micrencephaly...
  15. ncbi request reprint Event-related brain response abnormalities in autism: evidence for impaired cerebello-frontal spatial attention networks
    J Townsend
    Department of Neurosciences 0217, University of California, San Diego, La Jolla 92093 0217, USA
    Brain Res Cogn Brain Res 11:127-45. 2001
    ..The electrophysiological abnormalities reported here index spatial attention deficits in autism that may reflect cerebellar influence on both frontal and parietal spatial attention function...
  16. ncbi request reprint Removal of eye activity artifacts from visual event-related potentials in normal and clinical subjects
    T P Jung
    University of California, San Diego, La Jolla, CA 92093, USA
    Clin Neurophysiol 111:1745-58. 2000
    ..Often, all epochs contaminated by large eye artifacts are rejected as unusable, though this may prove unacceptable when blinks and eye movements occur frequently...
  17. pmc Functionally independent components of early event-related potentials in a visual spatial attention task
    S Makeig
    Naval Health Research Center, San Diego, CA 92186 5122, USA
    Philos Trans R Soc Lond B Biol Sci 354:1135-44. 1999
    ....
  18. ncbi request reprint Analysis and visualization of single-trial event-related potentials
    T P Jung
    Institute for Neural Computation, University of California San Diego, La Jolla, California 92093 0523, USA
    Hum Brain Mapp 14:166-85. 2001
    ..Applying ICA and ERP image visualization to the analysis of sets of single trials from event-related EEG (or MEG) experiments can increase the information available from ERP (or ERF) data...
  19. ncbi request reprint Abnormal activity patterns in premotor cortex during sequence learning in autistic patients
    Ralph Axel Müller
    Department of Psychology, San Diego State University, San Diego, California, USA
    Biol Psychiatry 56:323-32. 2004
    ..Studies in healthy adults suggest reduced premotor and increased prefrontal activity during advanced learning stages. We examined hemodynamic changes during visuomotor learning in autistic patients...
  20. ncbi request reprint Relationship between head circumference and brain volume in healthy normal toddlers, children, and adults
    H H Bartholomeusz
    Center for Autism Research, Children s Hospital of San Diego, La Jolla, CA 92037, USA
    Neuropediatrics 33:239-41. 2002
    ..To quantify the relationship between brain volume and head circumference from early childhood to adulthood, and quantify how this relationship changes with age...
  21. ncbi request reprint Abnormal variability and distribution of functional maps in autism: an FMRI study of visuomotor learning
    Ralph Axel Müller
    Department of Psychology, San Diego State University, Childrens Hospital Reserch Children, La Jolla, California 92120, USA
    Am J Psychiatry 160:1847-62. 2003
    ..The authors examined whether such abnormalities generalize to multimodal processing (visually driven motor sequence learning)...
  22. pmc Longitudinal magnetic resonance imaging study of cortical development through early childhood in autism
    Cynthia M Schumann
    Autism Center of Excellence, Department of Neurosciences, Center for Human Development, and Departments of Psychiatry and Radiology, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 30:4419-27. 2010
    ....
  23. ncbi request reprint Differential effects of developmental cerebellar abnormality on cognitive and motor functions in the cerebellum: an fMRI study of autism
    Greg Allen
    Laboratory for Research on the Neuroscience of Autism, San Diego Children s Hospital Research Center, La Jolla, CA 92037, USA
    Am J Psychiatry 160:262-73. 2003
    ..The aim of the present study was to examine how such pathology ultimately impacts cognitive and motor function within the cerebellum...
  24. ncbi request reprint Activity and functional connectivity of inferior frontal cortex associated with response conflict
    Nobuko Kemmotsu
    Brain Development Imaging Laboratory, Department of Psychology, San Diego State University, 6363 Alvarado Ct, 225 E, San Diego, CA 92120 1863, USA
    Brain Res Cogn Brain Res 24:335-42. 2005
    ..We conclude that bilateral inferior frontal cortex is involved in response suppression associated with interference in the counting Stroop task...
  25. ncbi request reprint Inverse correlation between frontal lobe and cerebellum sizes in children with autism
    R A Carper
    Department of Neuroscience, School of Medicine, University of California, San Diego, USA
    Brain 123:836-44. 2000
    ..This evidence of concurrent structural abnormalities in both the frontal lobe and the cerebellum has important implications for understanding the development and persistence of the autistic disorder...
  26. ncbi request reprint Atypical patterns of cerebral motor activation in autism: a functional magnetic resonance study
    R A Muller
    Laboratory for the Neuroscience of Autism, Children s Hospital Research Center, 8110 La Jolla Shores Sr 200, La Jolla, CA 92037, USA
    Biol Psychiatry 49:665-76. 2001
    ..Early neurodevelopmental pathogenesis in autism potentially affects emerging functional maps, but little imaging evidence is available...
  27. pmc Atypical [corrected] participation of visual cortex during word processing in autism: an fMRI study of semantic decision
    Michael S Gaffrey
    Brain Development Imaging Laboratory, Department of Psychology, San Diego State University, San Diego, CA 92120, USA
    Neuropsychologia 45:1672-84. 2007
    ....
  28. pmc Functional abnormalities of the default network during self- and other-reflection in autism
    Daniel P Kennedy
    Department of Neurosciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0662, USA
    Soc Cogn Affect Neurosci 3:177-90. 2008
    ..Overall, these results provide a more detailed view of default network functionality and abnormality in autism...
  29. ncbi request reprint Evidence for a cerebellar role in reduced exploration and stereotyped behavior in autism
    K Pierce
    Department of Neurosciences, School of Medicine, University of California, 8110 La Jolla Shores Drive, La Jolla, CA 92037, USA
    Biol Psychiatry 49:655-64. 2001
    ..Our findings represent the first documented link between the restricted range of interests and stereotyped behaviors pathognomonic of autism and particular neuroanatomic sites...
  30. ncbi request reprint Face processing occurs outside the fusiform 'face area' in autism: evidence from functional MRI
    K Pierce
    Department of Neurosciences, University of California, San Diego, USA
    Brain 124:2059-73. 2001
    ....
  31. doi request reprint Functional neuroimaging of speech perception during a pivotal period in language acquisition
    Elizabeth Redcay
    Department of Psychology, University of California, San Diego, USA
    Dev Sci 11:237-52. 2008
    ..These findings are consistent with the interactive specialization hypothesis, which proposes that cognitive abilities develop from the interaction of brain regions that include and extend beyond those used in the adult brain...
  32. ncbi request reprint When is the brain enlarged in autism? A meta-analysis of all brain size reports
    Elizabeth Redcay
    Department of Psychology, University of California, San Diego, USA
    Biol Psychiatry 58:1-9. 2005
    ..These conflicting results may be due to a lack of accounting for age-related changes in brain enlargement, use of small sample sizes, or differences in data acquisition methods...
  33. pmc Amygdala enlargement in toddlers with autism related to severity of social and communication impairments
    Cynthia Mills Schumann
    Department of Neurosciences, Autism Center of Excellence, University of California, San Diego, La Jolla, CA 92037, USA
    Biol Psychiatry 66:942-9. 2009
    ....
  34. pmc Deviant functional magnetic resonance imaging patterns of brain activity to speech in 2-3-year-old children with autism spectrum disorder
    Elizabeth Redcay
    Department of Psychology, University of California, San Diego, California, USA
    Biol Psychiatry 64:589-98. 2008
    ..A failure to develop normal language is one of the most common first signs that a toddler might be at risk for autism. Currently the neural bases underlying this failure to develop language are unknown...
  35. pmc Failing to deactivate: resting functional abnormalities in autism
    Daniel P Kennedy
    Department of Neurosciences, and Psychology, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 103:8275-80. 2006
    ..We speculate that the lack of deactivation in the autism group is indicative of abnormal internally directed processes at rest, which may be an important contribution to the social and emotional deficits of autism...
  36. pmc Abnormalities on the neurological examination and EEG in young children with pervasive developmental disorders
    Natacha Akshoomoff
    Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA
    J Autism Dev Disord 37:887-93. 2007
    ..Results also indicate that EEG abnormalities are common in this young population but clinical seizures are rare, confirming other studies...
  37. ncbi request reprint fMRI during natural sleep as a method to study brain function during early childhood
    Elizabeth Redcay
    Department of Psychology, University of California, San Diego, La Jolla, CA 92037, USA
    Neuroimage 38:696-707. 2007
    ..We conclude that the use of sleep fMRI may be a valuable tool for examining functional brain organization in young children...
  38. ncbi request reprint MRI neuroanatomy in young girls with autism: a preliminary study
    Cinnamon S Bloss
    San Diego State University and University of California, San Diego Joint Doctoral Program in Clinical Psychology, USA
    J Am Acad Child Adolesc Psychiatry 46:515-23. 2007
    ..To test the hypothesis that young girls and boys with autism exhibit different profiles of neuroanatomical abnormality relative to each other and relative to typically developing children...
  39. ncbi request reprint The intrinsic functional organization of the brain is altered in autism
    Daniel P Kennedy
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093 0662, USA
    Neuroimage 39:1877-85. 2008
    ..These results also highlight the usefulness of resting fcMRI for studying the brain in neuropsychiatric and neurodevelopmental disorders...
  40. ncbi request reprint Auditory spatial localization and attention deficits in autistic adults
    Wolfgang A Teder-Sälejärvi
    Department of Neurosciences 0608, School of Medicine, 9500 Gilman Drive, University of California, San Diego, La Jolla, CA 92093 0608, USA
    Brain Res Cogn Brain Res 23:221-34. 2005
    ..These findings point to a fundamental deficit in the spatial focusing of auditory attention in autism, which may be a factor that impedes social interactions and sensory-guided behavior, particularly in noisy environments...
  41. ncbi request reprint The neurobiological basis of autism from a developmental perspective
    Natacha Akshoomoff
    Laboratory for Research on the Neuroscience of Autism, Children s Hospital Research Center, La Jolla, CA 92037, USA
    Dev Psychopathol 14:613-34. 2002
    ..We discuss how these recent advances have led us to develop a growth dysregulation hypothesis of autism. Finally, we discuss how this hypothesis may lead to new innovations in autism research...
  42. ncbi request reprint Functional MRI of motor sequence acquisition: effects of learning stage and performance
    Ralph Axel Müller
    Department of Psychology, San Diego State University, MC1863, 6363 Alvarado Ct 200, San Diego, CA 92120, USA
    Brain Res Cogn Brain Res 14:277-93. 2002
    ....
  43. ncbi request reprint Cerebellar abnormalities in infants and toddlers with Williams syndrome
    Wendy Jones
    Laboratory for Cognitive Neuroscience, The Salk Institute for Biological Studies, LaJolla, CA 92037, USA
    Dev Med Child Neurol 44:688-94. 2002
    ..Our results are discussed relative to the cognitive delays observed in Williams syndrome versus other disorders such as autism, leading us to suggest that the cerebellum may play a role in cognition...
  44. ncbi request reprint Outcome classification of preschool children with autism spectrum disorders using MRI brain measures
    Natacha Akshoomoff
    Children s Hospital Research Center, La Jolla, CA 92037, USA
    J Am Acad Child Adolesc Psychiatry 43:349-57. 2004
    ....
  45. pmc Electroencephalographic brain dynamics following manually responded visual targets
    Scott Makeig
    Swartz Center for Computational Neuroscience, Institute for Neural Computation, University of California at San Diego, La Jolla, USA
    PLoS Biol 2:e176. 2004
    ....
  46. ncbi request reprint The functional neuroanatomy of spatial attention in autism spectrum disorder
    Frank Haist
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0959, USA
    Dev Neuropsychol 27:425-58. 2005
    ..This article also describes a method for reducing the contribution of physical eye movements to the blood-oxygenation level dependent activity in studies of ASD...
  47. ncbi request reprint The brain response to personally familiar faces in autism: findings of fusiform activity and beyond
    Karen Pierce
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA
    Brain 127:2703-16. 2004
    ..Therefore, dysfunction in the FFA found in other studies of autism may reflect defects in systems that modulate the FFA, rather than the FFA itself...
  48. ncbi request reprint Localized enlargement of the frontal cortex in early autism
    Ruth A Carper
    Center for Autism Research, Children s Hospital Research Center, and Neurosciences Department, University of California at San Diego, San Diego, California, USA
    Biol Psychiatry 57:126-33. 2005
    ..It is not yet clear to what extent the frontal lobe is affected; that is, whether all regions of frontal cortex show the same signs of structural maldevelopment...
  49. ncbi request reprint Attention function and dysfunction in autism
    G Allen
    Department of Psychology, San Diego State University, Department of Psychiatry, School of Medicine, University of California, San Diego, USA
    Front Biosci 6:D105-19. 2001
    ..The present review will explore this pattern of attentional strengths and weaknesses and the neural defects that underlie them...
  50. doi request reprint Microglial activation and increased microglial density observed in the dorsolateral prefrontal cortex in autism
    John T Morgan
    Department of Neuroscience, School of Medicine, University of California, San Diego, La Jolla, CA 95817, USA
    Biol Psychiatry 68:368-76. 2010
    ..However, it is unknown whether microglial somal volume or density are altered in the cortex and whether any alteration is associated with age or other potential covariates...
  51. ncbi request reprint No reduction of spindle neuron number in frontoinsular cortex in autism
    Daniel P Kennedy
    Department of Neurosciences, University of California, San Diego, and Center for Autism Research, Children s Hospital Research Center, La Jolla, CA 92093 0662, USA
    Brain Cogn 64:124-9. 2007
    ..Future postmortem studies with larger sample sizes will likely be critical in elucidating the spared and defective neural systems underlying the autistic phenotype...
  52. ncbi request reprint Cerebral lobes in autism: early hyperplasia and abnormal age effects
    Ruth A Carper
    Laboratory for Research on the Neuroscience of Autism, Children s Hospital Research Center, San Diego, California, USA
    Neuroimage 16:1038-51. 2002
    ..For instance, possible influences of neurotrophic factors, or of abnormal afferent activity from other affected brain regions are considered...
  53. ncbi request reprint Prenatal, perinatal, and neonatal factors in autism, pervasive developmental disorder-not otherwise specified, and the general population
    N Juul-Dam
    School of Medicine, University of California, San Diego, La Jolla, California, USA
    Pediatrics 107:E63. 2001
    ..This may, in turn, help to determine the reliability of a diagnosis of autism in younger children, leading to earlier intervention and assistance for an improved outcome in long-term functionality and quality of life...
  54. ncbi request reprint Broca's area and the discrimination of frequency transitions: a functional MRI study
    R A Muller
    Laboratory for the Neuroscience of Autism, Children s Hospital Research Center, La Jolla, California 92037, USA
    Brain Lang 76:70-6. 2001
    ..Our findings are consistent with a participation of Broca's area in nonlinguistic processes besides its known roles in semantic, syntactic, and phonological functions...
  55. ncbi request reprint Regional size reduction in the human corpus callosum following pre- and perinatal brain injury
    P Moses
    Department of Cognitive Science, University of California, San Diego, La Jolla, CA 92093, USA
    Cereb Cortex 10:1200-10. 2000
    ..This cortical-callosal pattern coincides with adult and nonhuman primate mappings. Callosal thinning despite the early onset of the lesions suggests limits to developmental neuroplasticity...
  56. ncbi request reprint Dynamic brain sources of visual evoked responses
    S Makeig
    Computational Neurobiology Laboratory and, The Howard Hughes Medical Institute, The Salk Institute, 10010 North Torrey Pines Road, San Diego, CA 92037, USA
    Science 295:690-4. 2002
    ..Scalp topographies of these components were consistent with their generation in compact cortical domains...
  57. ncbi request reprint Linguistic theory and neuroimaging evidence: an fMRI study of Broca's area in lexical semantics
    Ralph Axel Müller
    Department of Psychology, San Diego State University, MC 1863, San Diego, CA 92120, USA
    Neuropsychologia 41:1199-207. 2003
    ..Findings of lexico-semantic as well as syntactic processing in the inferior frontal lobe may be accounted for in terms of working memory demands...
  58. ncbi request reprint The developmental neurobiology of autism spectrum disorder
    Emanuel DiCicco-Bloom
    Department of Neuroscience, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
    J Neurosci 26:6897-906. 2006
  59. pmc Atypical functional lateralization of language in autism spectrum disorders
    Natalia M Kleinhans
    Department of Radiology, University of Washington, Seattle, WA 98195, USA
    Brain Res 1221:115-25. 2008
    ..Abnormal functional organization may contribute to the language impairment seen in ASD...
  60. pmc Offering to share: how to put heads together in autism neuroimaging
    Matthew K Belmonte
    Department of Human Development, Cornell University, Martha Van Rensselaer Hall, Ithaca, NY 14853 4401, USA
    J Autism Dev Disord 38:2-13. 2008
    ..A theme in these requirements is the need to preserve creative approaches and risk-taking within individual laboratories at the same time as common standards are provided for these laboratories to build on...
  61. ncbi request reprint Cerebellar function in autism: functional magnetic resonance image activation during a simple motor task
    Greg Allen
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Biol Psychiatry 56:269-78. 2004
    ..The purpose of the present investigation was to examine activation in the cerebella of autistic patients and normal control subjects performing this motor task...
  62. pmc N-acetyl aspartate in autism spectrum disorders: regional effects and relationship to fMRI activation
    Natalia M Kleinhans
    Department of Radiology, University of Washington, Box 357115, Seattle, WA 98195, USA
    Brain Res 1162:85-97. 2007
    ..Furthermore, this study provided the first direct evidence of the relationship between abnormal functional activation in prefrontal cortex and neuronal dysfunction in ASD...
  63. ncbi request reprint Transmission disequilibrium studies of the serotonin 5-HT2A receptor gene (HTR2A) in autism
    Jeremy Veenstra-Vanderweele
    Laboratory of Developmental Neuroscience, Child and Adolescent Psychiatry, Department of Psychiatry, University of Chicago, Chicago, Illinois 60637, USA
    Am J Med Genet 114:277-83. 2002
    ..No evidence was found for unequal transmission of haplotypes; however, power analysis reveals low power to detect a parent-of-origin effect in this sample size...
  64. ncbi request reprint Mutation screening and transmission disequilibrium study of ATP10C in autism
    Soo Jeong Kim
    Laboratory of Developmental Neuroscience, Child and Adolescent Psychiatry, Department of Psychiatry MC3077, University of Chicago, Chicago, Illinois 60637, USA
    Am J Med Genet 114:137-43. 2002
    ....

Research Grants24

  1. MRL Neuroanatomy in Autism: From Infancy to Childhoood
    Eric Courchesne; Fiscal Year: 2005
    ..Results from the proposed research will provide knowledge of the developmental anatomic phenotype in autism. ..
  2. Biomarkers of Autism at 12 months: From Brain Overgrowth to Genes
    Eric Courchesne; Fiscal Year: 2007
    ..Each infant will be studied at intervals longitudinally and a final best estimate diagnosis made at 36 months providing a final step for group assignment for statistical ..
  3. ANATOMY AND FUNCTION CORRELATES OF COGNITION IN AUTISM
    Eric Courchesne; Fiscal Year: 2006
    ..We hypothesize that cerebellar and cerebral cortices will show abnormal fragmentation of functional specialization in autism. ..
  4. fMRI Studies of Neural Dysfunction in Autistic Toddlers
    Eric Courchesne; Fiscal Year: 2007
    ....
  5. fMRI Studies of Neural Dysfunction in Autistic Toddlers
    Eric Courchesne; Fiscal Year: 2009
    ....
  6. BRAIN BEHAVIOR CORRELATES OF ATTENTION DEFICIT IN AUTISM
    Eric Courchesne; Fiscal Year: 1999
    ..The completion of this study will further their long-term objective of elucidating the anatomical substrate of neurofunctional deficits in autism. ..
  7. AUTISM--MR NEUROANATOMIC ABNORMALITIES
    Eric Courchesne; Fiscal Year: 2001
    ..The completion of this study will further our long-term objective of elucidating the neuroanatomical substrate of infantile autism. ..
  8. fMRI Studies of Neural Dysfunction in Autistic Toddlers
    Eric Courchesne; Fiscal Year: 2010
    ....