Research Topics
| E CourchesneSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Mapping early brain development in autismEric Courchesne
Department of Neurosciences, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA
Neuron 56:399-413. 2007..As such, autism may additionally provide unique insight into genetic and developmental processes that shape early neural wiring patterns and make possible higher-order social, emotional, and communication functions...- Brainstem, cerebellar and limbic neuroanatomical abnormalities in autismE Courchesne
Department of Neurosciences, School of Medicine, University of California, San Diego, CA 92093, USA
Curr Opin Neurobiol 7:269-78. 1997.... - Why the frontal cortex in autism might be talking only to itself: local over-connectivity but long-distance disconnectionEric Courchesne
Department of Neurosciences, University of California, San Diego, CA, USA
Curr Opin Neurobiol 15:225-30. 2005.... - Abnormal early brain development in autismE Courchesne
Department of Neuroscience, School of Medicine, University of California-San Diego, La Jolla, CA 92037, USA
Mol Psychiatry 7:S21-3. 2002 - Neuron number and size in prefrontal cortex of children with autismEric Courchesne
Department of Neuroscience, NIH UCSD Autism Center of Excellence, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA
JAMA 306:2001-10. 2011..Autism often involves early brain overgrowth, including the prefrontal cortex (PFC). Although prefrontal abnormality has been theorized to underlie some autistic symptoms, the cellular defects that cause abnormal overgrowth remain unknown... - Evidence of brain overgrowth in the first year of life in autismEric Courchesne
Department of Neuroscience, School of Medicine, University of California, San Diego, La Jolla, USA
JAMA 290:337-44. 2003..This raises the possibility that brain overgrowth begins much earlier, perhaps before the first clinically noticeable behavioral symptoms... - The autistic brain: birth through adulthoodEric Courchesne
Department of Neurosciences, University of California, San Diego, California 92037, USA
Curr Opin Neurol 17:489-96. 2004..We discuss evidence of brain maldevelopment in the first years of life in autism and new neuroanatomical and functional evidence from later ages of development... - Autism at the beginning: microstructural and growth abnormalities underlying the cognitive and behavioral phenotype of autismEric Courchesne
University of California, San Diego, USA
Dev Psychopathol 17:577-97. 2005..and providing context-based and goal-directed feedback to lower level systems... - Brain development in autism: early overgrowth followed by premature arrest of growthEric Courchesne
Center for Autism Research, Children s Hospital Research Center, La Jolla, California 92037, USA
Ment Retard Dev Disabil Res Rev 10:106-11. 2004.... - Brain overgrowth in autism during a critical time in development: implications for frontal pyramidal neuron and interneuron development and connectivityEric Courchesne
Department of Neurosciences, University of California, San Diego, CA, USA
Int J Dev Neurosci 23:153-70. 2005..The relationship to clinical characteristics and other disorders of macrencephaly are discussed... - Unusual brain growth patterns in early life in patients with autistic disorder: an MRI studyE Courchesne
Department of Neuroscience, School of Medicine, University of California, San Diego, La Jolla, USA
Neurology 57:245-54. 2001..To quantify developmental abnormalities in cerebral and cerebellar volume in autism... - Brain growth across the life span in autism: age-specific changes in anatomical pathologyEric Courchesne
Department of Neuroscience, Autism Center of Excellence, University of California, San Diego, CA, USA
Brain Res 1380:138-45. 2011.... - Normal brain development and aging: quantitative analysis at in vivo MR imaging in healthy volunteersE Courchesne
Laboratory for Research on the Neuroscience of Autism, Children s Hospital Research Center, La Jolla, CA 92037, USA
Radiology 216:672-82. 2000..To quantitate neuroanatomic parameters in healthy volunteers and to compare the values with normative values from postmortem studies... - Brain weight in autism: normal in the majority of cases, megalencephalic in rare casesE Courchesne
Department of Neuroscience, School of Medicine, University of California, San Diego, La Jolla, USA
Neurology 52:1057-9. 1999..Brain weight is thus normal in most postmortem cases of autism. There are, however, rare cases of megalencephaly and possibly micrencephaly... - Event-related brain response abnormalities in autism: evidence for impaired cerebello-frontal spatial attention networksJ Townsend
Department of Neurosciences 0217, University of California, San Diego, La Jolla 92093 0217, USA
Brain Res Cogn Brain Res 11:127-45. 2001..The electrophysiological abnormalities reported here index spatial attention deficits in autism that may reflect cerebellar influence on both frontal and parietal spatial attention function... - Removal of eye activity artifacts from visual event-related potentials in normal and clinical subjectsT P Jung
University of California, San Diego, La Jolla, CA 92093, USA
Clin Neurophysiol 111:1745-58. 2000..Often, all epochs contaminated by large eye artifacts are rejected as unusable, though this may prove unacceptable when blinks and eye movements occur frequently... - Functionally independent components of early event-related potentials in a visual spatial attention taskS Makeig
Naval Health Research Center, San Diego, CA 92186 5122, USA
Philos Trans R Soc Lond B Biol Sci 354:1135-44. 1999.... - Analysis and visualization of single-trial event-related potentialsT P Jung
Institute for Neural Computation, University of California San Diego, La Jolla, California 92093 0523, USA
Hum Brain Mapp 14:166-85. 2001..Applying ICA and ERP image visualization to the analysis of sets of single trials from event-related EEG (or MEG) experiments can increase the information available from ERP (or ERF) data... - Abnormal activity patterns in premotor cortex during sequence learning in autistic patientsRalph Axel Müller
Department of Psychology, San Diego State University, San Diego, California, USA
Biol Psychiatry 56:323-32. 2004..Studies in healthy adults suggest reduced premotor and increased prefrontal activity during advanced learning stages. We examined hemodynamic changes during visuomotor learning in autistic patients... - Relationship between head circumference and brain volume in healthy normal toddlers, children, and adultsH H Bartholomeusz
Center for Autism Research, Children's Hospital of San Diego, La Jolla, CA 92037, USA
Neuropediatrics 33:239-41. 2002.... - Abnormal variability and distribution of functional maps in autism: an FMRI study of visuomotor learningRalph Axel Müller
Department of Psychology, San Diego State University, Childrens Hospital Reserch Children, La Jolla, California 92120, USA
Am J Psychiatry 160:1847-62. 2003..The authors examined whether such abnormalities generalize to multimodal processing (visually driven motor sequence learning)... - Longitudinal magnetic resonance imaging study of cortical development through early childhood in autismCynthia M Schumann
Autism Center of Excellence, Department of Neurosciences, Center for Human Development, and Departments of Psychiatry and Radiology, University of California, San Diego, La Jolla, California 92093, USA
J Neurosci 30:4419-27. 2010.... - Differential effects of developmental cerebellar abnormality on cognitive and motor functions in the cerebellum: an fMRI study of autismGreg Allen
Laboratory for Research on the Neuroscience of Autism, San Diego Children's Hospital Research Center, La Jolla, CA 92037, USA
Am J Psychiatry 160:262-73. 2003..CONCLUSIONS: These findings shed new light on the cerebellar role in attention deficits in autism and suggest that developmental cerebellar abnormality has differential functional implications for cognitive and motor systems... - Activity and functional connectivity of inferior frontal cortex associated with response conflictNobuko Kemmotsu
Brain Development Imaging Laboratory, Department of Psychology, San Diego State University, 6363 Alvarado Ct, 225 E, San Diego, CA 92120-1863, USA
Brain Res Cogn Brain Res 24:335-42. 2005..We conclude that bilateral inferior frontal cortex is involved in response suppression associated with interference in the counting Stroop task... - Inverse correlation between frontal lobe and cerebellum sizes in children with autismR A Carper
Department of Neuroscience, School of Medicine, University of California, San Diego, USA
Brain 123:836-44. 2000..This evidence of concurrent structural abnormalities in both the frontal lobe and the cerebellum has important implications for understanding the development and persistence of the autistic disorder... - Atypical [corrected] participation of visual cortex during word processing in autism: an fMRI study of semantic decisionMichael S Gaffrey
Brain Development Imaging Laboratory, Department of Psychology, San Diego State University, San Diego, CA 92120, USA
Neuropsychologia 45:1672-84. 2007.... - Functional abnormalities of the default network during self- and other-reflection in autismDaniel P Kennedy
Department of Neurosciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0662, USA
Soc Cogn Affect Neurosci 3:177-90. 2008..Overall, these results provide a more detailed view of default network functionality and abnormality in autism... - Evidence for a cerebellar role in reduced exploration and stereotyped behavior in autismK Pierce
Department of Neurosciences, School of Medicine, University of California, 8110 La Jolla Shores Drive, La Jolla, CA 92037, USA
Biol Psychiatry 49:655-64. 2001..Our findings represent the first documented link between the restricted range of interests and stereotyped behaviors pathognomonic of autism and particular neuroanatomic sites... - Face processing occurs outside the fusiform 'face area' in autism: evidence from functional MRIK Pierce
Department of Neurosciences, University of California, San Diego, USA
Brain 124:2059-73. 2001.... - Functional neuroimaging of speech perception during a pivotal period in language acquisitionElizabeth Redcay
Department of Psychology, University of California, San Diego, USA
Dev Sci 11:237-52. 2008..These findings are consistent with the interactive specialization hypothesis, which proposes that cognitive abilities develop from the interaction of brain regions that include and extend beyond those used in the adult brain... - When is the brain enlarged in autism? A meta-analysis of all brain size reportsElizabeth Redcay
Department of Psychology, University of California, San Diego, USA
Biol Psychiatry 58:1-9. 2005..These conflicting results may be due to a lack of accounting for age-related changes in brain enlargement, use of small sample sizes, or differences in data acquisition methods... - Amygdala enlargement in toddlers with autism related to severity of social and communication impairmentsCynthia Mills Schumann
Department of Neurosciences, Autism Center of Excellence, University of California, San Diego, La Jolla, CA 92037, USA
Biol Psychiatry 66:942-9. 2009.... - Deviant functional magnetic resonance imaging patterns of brain activity to speech in 2-3-year-old children with autism spectrum disorderElizabeth Redcay
Department of Psychology, University of California, San Diego, California, USA
Biol Psychiatry 64:589-98. 2008..A failure to develop normal language is one of the most common first signs that a toddler might be at risk for autism. Currently the neural bases underlying this failure to develop language are unknown... - Failing to deactivate: resting functional abnormalities in autismDaniel P Kennedy
Department of Neurosciences, and Psychology, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 103:8275-80. 2006..We speculate that the lack of deactivation in the autism group is indicative of abnormal internally directed processes at rest, which may be an important contribution to the social and emotional deficits of autism... - Abnormalities on the neurological examination and EEG in young children with pervasive developmental disordersNatacha Akshoomoff
Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA
J Autism Dev Disord 37:887-93. 2007..Results also indicate that EEG abnormalities are common in this young population but clinical seizures are rare, confirming other studies... - fMRI during natural sleep as a method to study brain function during early childhoodElizabeth Redcay
Department of Psychology, University of California, San Diego, La Jolla, CA 92037, USA
Neuroimage 38:696-707. 2007..We conclude that the use of sleep fMRI may be a valuable tool for examining functional brain organization in young children... - MRI neuroanatomy in young girls with autism: a preliminary studyCinnamon S Bloss
San Diego State University and University of California, San Diego Joint Doctoral Program in Clinical Psychology, USA
J Am Acad Child Adolesc Psychiatry 46:515-23. 2007..To test the hypothesis that young girls and boys with autism exhibit different profiles of neuroanatomical abnormality relative to each other and relative to typically developing children... - The intrinsic functional organization of the brain is altered in autismDaniel P Kennedy
Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093 0662, USA
Neuroimage 39:1877-85. 2008..These results also highlight the usefulness of resting fcMRI for studying the brain in neuropsychiatric and neurodevelopmental disorders... - Auditory spatial localization and attention deficits in autistic adultsWolfgang A Teder-Sälejärvi
Department of Neurosciences 0608, School of Medicine, 9500 Gilman Drive, University of California, San Diego, La Jolla, CA 92093 0608, USA
Brain Res Cogn Brain Res 23:221-34. 2005..These findings point to a fundamental deficit in the spatial focusing of auditory attention in autism, which may be a factor that impedes social interactions and sensory-guided behavior, particularly in noisy environments... - The neurobiological basis of autism from a developmental perspectiveNatacha Akshoomoff
Laboratory for Research on the Neuroscience of Autism, Children s Hospital Research Center, La Jolla, CA 92037, USA
Dev Psychopathol 14:613-34. 2002..We discuss how these recent advances have led us to develop a growth dysregulation hypothesis of autism. Finally, we discuss how this hypothesis may lead to new innovations in autism research... - Functional MRI of motor sequence acquisition: effects of learning stage and performanceRalph Axel Müller
Department of Psychology, San Diego State University, MC1863, 6363 Alvarado Ct 200, San Diego, CA 92120, USA
Brain Res Cogn Brain Res 14:277-93. 2002.... - Cerebellar abnormalities in infants and toddlers with Williams syndromeWendy Jones
Laboratory for Cognitive Neuroscience, The Salk Institute for Biological Studies, LaJolla, CA 92037, USA
Dev Med Child Neurol 44:688-94. 2002..Our results are discussed relative to the cognitive delays observed in Williams syndrome versus other disorders such as autism, leading us to suggest that the cerebellum may play a role in cognition... - Outcome classification of preschool children with autism spectrum disorders using MRI brain measuresNatacha Akshoomoff
Children s Hospital Research Center, La Jolla, CA 92037, USA
J Am Acad Child Adolesc Psychiatry 43:349-57. 2004.... - Electroencephalographic brain dynamics following manually responded visual targetsScott Makeig
Swartz Center for Computational Neuroscience, Institute for Neural Computation, University of California at San Diego, La Jolla, USA
PLoS Biol 2:e176. 2004.... - The functional neuroanatomy of spatial attention in autism spectrum disorderFrank Haist
Department of Psychiatry, University of California, San Diego, La Jolla 92093 0959, USA
Dev Neuropsychol 27:425-58. 2005..This article also describes a method for reducing the contribution of physical eye movements to the blood-oxygenation level dependent activity in studies of ASD... - The brain response to personally familiar faces in autism: findings of fusiform activity and beyondKaren Pierce
Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA
Brain 127:2703-16. 2004..Therefore, dysfunction in the FFA found in other studies of autism may reflect defects in systems that modulate the FFA, rather than the FFA itself... - Localized enlargement of the frontal cortex in early autismRuth A Carper
Center for Autism Research, Children s Hospital Research Center, and Neurosciences Department, University of California at San Diego, San Diego, California, USA
Biol Psychiatry 57:126-33. 2005..It is not yet clear to what extent the frontal lobe is affected; that is, whether all regions of frontal cortex show the same signs of structural maldevelopment... - Attention function and dysfunction in autismG Allen
Department of Psychology, San Diego State University, Department of Psychiatry, School of Medicine, University of California, San Diego, USA
Front Biosci 6:D105-19. 2001..The present review will explore this pattern of attentional strengths and weaknesses and the neural defects that underlie them... - Microglial activation and increased microglial density observed in the dorsolateral prefrontal cortex in autismJohn T Morgan
Department of Neuroscience, School of Medicine, University of California, San Diego, La Jolla, CA 95817, USA
Biol Psychiatry 68:368-76. 2010..However, it is unknown whether microglial somal volume or density are altered in the cortex and whether any alteration is associated with age or other potential covariates... - No reduction of spindle neuron number in frontoinsular cortex in autismDaniel P Kennedy
Department of Neurosciences, University of California, San Diego, and Center for Autism Research, Children s Hospital Research Center, La Jolla, CA 92093 0662, USA
Brain Cogn 64:124-9. 2007..Future postmortem studies with larger sample sizes will likely be critical in elucidating the spared and defective neural systems underlying the autistic phenotype... - Cerebral lobes in autism: early hyperplasia and abnormal age effectsRuth A Carper
Laboratory for Research on the Neuroscience of Autism, Children's Hospital Research Center, San Diego, California, USA
Neuroimage 16:1038-51. 2002..For instance, possible influences of neurotrophic factors, or of abnormal afferent activity from other affected brain regions are considered... - Prenatal, perinatal, and neonatal factors in autism, pervasive developmental disorder-not otherwise specified, and the general populationN Juul-Dam
School of Medicine, University of California, San Diego, La Jolla, California, USA
Pediatrics 107:E63. 2001..This may, in turn, help to determine the reliability of a diagnosis of autism in younger children, leading to earlier intervention and assistance for an improved outcome in long-term functionality and quality of life... - Broca's area and the discrimination of frequency transitions: a functional MRI studyR A Muller
Laboratory for the Neuroscience of Autism, Children s Hospital Research Center, La Jolla, California 92037, USA
Brain Lang 76:70-6. 2001..Our findings are consistent with a participation of Broca's area in nonlinguistic processes besides its known roles in semantic, syntactic, and phonological functions... - Regional size reduction in the human corpus callosum following pre- and perinatal brain injuryP Moses
Department of Cognitive Science, University of California, San Diego, La Jolla, CA 92093, USA
Cereb Cortex 10:1200-10. 2000..This cortical-callosal pattern coincides with adult and nonhuman primate mappings. Callosal thinning despite the early onset of the lesions suggests limits to developmental neuroplasticity... - Dynamic brain sources of visual evoked responsesS Makeig
Computational Neurobiology Laboratory and, The Howard Hughes Medical Institute, The Salk Institute, 10010 North Torrey Pines Road, San Diego, CA 92037, USA
Science 295:690-4. 2002..Scalp topographies of these components were consistent with their generation in compact cortical domains... - Linguistic theory and neuroimaging evidence: an fMRI study of Broca's area in lexical semanticsRalph Axel Müller
Department of Psychology, San Diego State University, MC 1863, San Diego, CA 92120, USA
Neuropsychologia 41:1199-207. 2003..Findings of lexico-semantic as well as syntactic processing in the inferior frontal lobe may be accounted for in terms of working memory demands... - The developmental neurobiology of autism spectrum disorderEmanuel DiCicco-Bloom
Department of Neuroscience, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
J Neurosci 26:6897-906. 2006 - Atypical functional lateralization of language in autism spectrum disordersNatalia M Kleinhans
Department of Radiology, University of Washington, Seattle, WA 98195, USA
Brain Res 1221:115-25. 2008..Abnormal functional organization may contribute to the language impairment seen in ASD... - Offering to share: how to put heads together in autism neuroimagingMatthew K Belmonte
Department of Human Development, Cornell University, Martha Van Rensselaer Hall, Ithaca, NY 14853 4401, USA
J Autism Dev Disord 38:2-13. 2008..A theme in these requirements is the need to preserve creative approaches and risk-taking within individual laboratories at the same time as common standards are provided for these laboratories to build on... - Cerebellar function in autism: functional magnetic resonance image activation during a simple motor taskGreg Allen
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Biol Psychiatry 56:269-78. 2004..This neurofunctional deficit might be a key contributor to the development of certain diagnostic features of autism (e.g., impaired communication and social interaction, restricted interests, and stereotyped behaviors)... - N-acetyl aspartate in autism spectrum disorders: regional effects and relationship to fMRI activationNatalia M Kleinhans
Department of Radiology, University of Washington, Box 357115, Seattle, WA 98195, USA
Brain Res 1162:85-97. 2007..Furthermore, this study provided the first direct evidence of the relationship between abnormal functional activation in prefrontal cortex and neuronal dysfunction in ASD... - Transmission disequilibrium studies of the serotonin 5-HT2A receptor gene (HTR2A) in autismJeremy Veenstra-Vanderweele
Laboratory of Developmental Neuroscience, Child and Adolescent Psychiatry, Department of Psychiatry, University of Chicago, Chicago, Illinois 60637, USA
Am J Med Genet 114:277-83. 2002..No evidence was found for unequal transmission of haplotypes; however, power analysis reveals low power to detect a parent-of-origin effect in this sample size... - Mutation screening and transmission disequilibrium study of ATP10C in autismSoo-Jeong Kim
Laboratory of Developmental Neuroscience, Child and Adolescent Psychiatry, Department of Psychiatry MC3077, University of Chicago, Chicago, Illinois 60637, USA
Am J Med Genet 114:137-43. 2002....
Research Grants
- MRL Neuroanatomy in Autism: From Infancy to ChildhooodEric Courchesne; Fiscal Year: 2005..Results from the proposed research will provide knowledge of the developmental anatomic phenotype in autism. ..
- Biomarkers of Autism at 12 months: From Brain Overgrowth to GenesEric Courchesne; Fiscal Year: 2007..Each infant will be studied at intervals longitudinally and a final best estimate diagnosis made at 36 months providing a final step for group assignment for statistical ..
- ANATOMY AND FUNCTION CORRELATES OF COGNITION IN AUTISMEric Courchesne; Fiscal Year: 2006..We hypothesize that cerebellar and cerebral cortices will show abnormal fragmentation of functional specialization in autism. ..
- fMRI Studies of Neural Dysfunction in Autistic ToddlersEric Courchesne; Fiscal Year: 2007....
- fMRI Studies of Neural Dysfunction in Autistic ToddlersEric Courchesne; Fiscal Year: 2009....
- BRAIN BEHAVIOR CORRELATES OF ATTENTION DEFICIT IN AUTISMEric Courchesne; Fiscal Year: 1999..The completion of this study will further their long-term objective of elucidating the anatomical substrate of neurofunctional deficits in autism. ..
- AUTISM--MR NEUROANATOMIC ABNORMALITIESEric Courchesne; Fiscal Year: 2001..The completion of this study will further our long-term objective of elucidating the neuroanatomical substrate of infantile autism. ..
- fMRI Studies of Neural Dysfunction in Autistic ToddlersEric Courchesne; Fiscal Year: 2010....