Research Topics
Species | Jean Philippe CoudercSummaryAffiliation: University of Rochester Country: USA Publications
Research Grants
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Detail Information
Publications
Changes in deceleration capacity of heart rate and heart rate variability induced by ambient air pollution in individuals with coronary artery diseaseAlexandra Schneider
Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany
Part Fibre Toxicol 7:29. 2010..The study assessed the association between deceleration capacity (DC) as well as heart rate variability (HRV) and ambient particulate matter (PM) in patients with coronary artery disease (CAD)...- Highly automated QT measurement techniques in 7 thorough QT studies implemented under ICH E14 guidelinesJean Philippe Couderc
Heart Research Follow Up Program, Cardiology Department, University of Rochester Medical Center, Rochester, NY 14642, USA
Ann Noninvasive Electrocardiol 16:13-24. 2011..1 ± 0.1 ms (P = 0.7). Also, the time course of the moxifloxacin-induced QTc prolongation adjusted for placebo was not statistically different between measurements methods... 
A scientific repository to support the research and development of technologies related to quantitative electrocardiography: the Telemetric and Holter ECG Warehouse (THEW)Jean Philippe Couderc
Center for Quantitative Electrocardiography and Cardiac Safety, University of Rochester Medical Center, Rochester, NY 14618, USA
Cardiol J 17:416-9. 2010..In this paper, we present briefly the content and the current research triggered by this initiative...
Baseline values and sotalol-induced changes of ventricular repolarization duration, heterogeneity, and instability in patients with a history of drug-induced torsades de pointesJean Philippe Couderc
Heart Research Follow Up Program, Cardiology Department, University of Rochester Medical Center, Rochester, NY 14642, USA
J Clin Pharmacol 49:6-16. 2009....- Investigating the effect of sotalol on the repolarization intervals in healthy young individualsJean Philippe Couderc
Heart Research Follow Up Program, Cardiology Department, University of Rochester, Rochester, NY, USA
J Electrocardiol 41:595-602. 2008..In a group of healthy individuals exposed to sotalol, we compared their drug-induced changes to the drug-induced prolongations of the QTc, QTc apex and T-peak to T-end intervals... - Improving the detection of subtle I(Kr)-inhibition: assessing electrocardiographic abnormalities of repolarization induced by moxifloxacinJean Philippe Couderc
Heart Research Follow Up Program, Cardiology Department, University of Rochester Medical Center, Rochester, New York, USA
Drug Saf 31:249-60. 2008.... - Impaired T-amplitude adaptation to heart rate characterizes I(Kr) inhibition in the congenital and acquired forms of the long QT syndromeJean Philippe Couderc
Heart Research Follow Up Program, Cardiology Department, University of Rochester Medical Center, Rochester, New York, USA
J Cardiovasc Electrophysiol 18:1299-305. 2007..In the search for alternative markers, we investigated the T-amplitude and QT interval adaptation to heart rate (HR) in patients with the congenital long QT syndrome (LQTS) and individuals with sotalol-induced QT prolongation... - Repolarization variability in the risk stratification of MADIT II patientsJean Philippe Couderc
Heart Research Follow Up Program, Cardiology, University of Rochester Medical Center, Rochester, NY 14642, USA
Europace 9:717-23. 2007.... - Identification of sotalol-induced changes in repolarization with T wave area-based repolarization duration parametersJean Philippe Couderc
Cardiology Unit, Heart Research Follow Up Program, University of Rochester, NY 14642, USA
J Electrocardiol 36:115-20. 2003..In conclusion, morphological parameters of T wave are able to identify the changes in repolarization interval induced by sotalol. These parameters are more stable and thus more reliable than the traditional QT interval measurements... - A quantitative assessment of T-wave morphology in LQT1, LQT2, and healthy individuals based on Holter recording technologyMartino Vaglio
Heart Research Follow Up Program, University of Rochester Medical Center, Rochester, New York, USA
Heart Rhythm 5:11-8. 2008..The clinical course and the precipitating risk factors in the congenital long QT syndrome (LQTS) are genotype specific... - T-wave morphology abnormalities in benign, potent, and arrhythmogenic I(kr) inhibitionJean Philippe Couderc
Heart Research Follow Up Program, Cardiology Department, University of Rochester Medical Center, Rochester, New York, USA
Heart Rhythm 8:1036-43. 2011..There is a consensus on the limited value of the QTc interval prolongation as a surrogate marker of drug cardiotoxicity and as a risk stratifier in inherited long QT syndrome (LQTS) patients... - Improving the precision of QT measurementsBorje Darpo
iCardiac Technologies, 150 Allen Creek Rd, Rochester, NY 14618, USA
Cardiol J 18:401-10. 2011.... - Effects of on-road highway aerosol exposures on autonomic responses in aged, spontaneously hypertensive ratsAlison Elder
Department of Environmental Medicine, University of Rochester, Rochester, New York, USA
Inhal Toxicol 19:1-12. 2007..These findings show that environmental exposure concentrations of mixed traffic-related UFP/gas-phase emissions can affect the autonomic nervous system... - Genotype- and Sex-Specific QT-RR Relationship in the Type-1 Long-QT SyndromeJean Philippe Couderc
Center for Quantitative Electrocardiography and Cardiac Safety, Heart Research Follow Up Program, University of Rochester Medical Center, NY J P C, X X, A J M, W Z
J Am Heart Assoc 1:e000570. 2012..We hypothesize that the impaired response to increases in heart rate leads to abnormal QT-RR dynamic profiles and is responsible for the increased cardiac risk for these patients... - Assessment of the stability of the individual-based correction of QT interval for heart rateJean Philippe Couderc
Heart Research Follow Up Program, Cardiology Department, University of Rochester, Rochester, New York 14642, USA
Ann Noninvasive Electrocardiol 10:25-34. 2005..In this study, we propose guidelines to ensure appropriate use of the regression technique for heart rate correction of QT intervals... - Repolarization morphology in adult LQT2 carriers with borderline prolonged QTc intervalJean-Philippe Couderc
Heart Research Follow-up Program, University of Rochester Medical Center, Rochester, New York
Heart Rhythm 3:1460-6. 2006..CONCLUSION: Abnormal T-wave morphology is a phenotypic expression of LQT2, and its quantification could be used to identify patients with suspected LQTS who do not have overt QTc prolongation (QTc >470)... - ECG parameters and exposure to carbon ultrafine particles in young healthy subjectsWojciech Zareba
Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
Inhal Toxicol 21:223-33. 2009..However, trends are observed indicating that some subjects might be susceptible to air pollution, with a response involving autonomic modulation of the heart and repolarization of the ventricular myocardium... - Cardiac regulation and electrocardiographic factors contributing to the measurement of repolarization variabilityJean Philippe Couderc
Heart Research Follow Up Program, Department of Cardiology, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
J Electrocardiol 42:494-9. 2009..We will discuss these factors and provocatively describe why they should be cautiously considered to avoid erroneous measurements of repolarization instability... - Temporal complexity of repolarization and mortality in patients with implantable cardioverter defibrillatorsJuha S Perkiomaki
Cardiology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
Pacing Clin Electrophysiol 26:1931-6. 2003..None of the repolarization variability parameters independently predicted death/appropriate ICD shocks. Increased temporal complexity of repolarization (RTmax-ApEn) independently predicts mortality in ICD patients... - The telemetric and Holter ECG warehouse initiative (THEW): a data repository for the design, implementation and validation of ECG-related technologiesJean Philippe Couderc
Center for Quantitative Electrocardiography and Cardiac Safety, University of Rochester Medical Center, Rochester, NY 14618, USA
Conf Proc IEEE Eng Med Biol Soc 2010:6252-5. 2010..We believe that sharing data reinforces open scientific inquiry. It encourages diversity of analysis and opinion while promoting new research and facilitating the education of new researchers... - Short and long QT syndromes: does QT length really matter?Jean Philippe Couderc
Center for Quantitative Electrocardiography and Cardiac Safety, Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
J Electrocardiol 43:396-9. 2010..In this review, we discuss these mechanisms and provocatively question the role of the QT interval duration as a surrogate marker of increased risk for arrhythmia in both the LQTS and the SQTS... - Measurement and regulation of cardiac ventricular repolarization: from the QT interval to repolarization morphologyJean Philippe Couderc
Heart Research Follow Up Program, Cardiology Department, Box 653, University of Rochester Medical Center, 601 Elmwood Avenue, University of Rochester, Rochester, NY 14642, USA
Philos Trans A Math Phys Eng Sci 367:1283-99. 2009..Several modelling techniques and measurement methods will be presented and their role within the arena of cardiac safety will be discussed... - Measure of the QT-RR dynamic coupling in patients with the long QT syndromeJosef Halamek
Institute of Scientific Instruments, AS CR, Brno, Czech Republic
Ann Noninvasive Electrocardiol 17:323-30. 2012..The patients with the long QT syndrome type-1 (LQT-1) have an impaired adaptation of the QT interval to heart rate changes. Yet, the description of the dynamic QT-RR coupling in genotyped LQT-1 has never been thoroughly investigated... - A unique digital electrocardiographic repository for the development of quantitative electrocardiography and cardiac safety: the Telemetric and Holter ECG Warehouse (THEW)Jean Philippe Couderc
Center for Quantitative Electrocardiography and Cardiac Safety, University of Rochester Medical Center, Rochester, NY, USA
J Electrocardiol 43:595-600. 2010..The THEW hosts unique datasets from clinical trials and drug safety studies that, so far, were not available...
Research Grants
- Interest of IKr-related Abnormalities of ECGs to Improve Drug-safety EvaluationJean Philippe Couderc; Fiscal Year: 2007..The important parameters will be used to discriminate patient carriers and non-carriers of a LQT2 mutation of the long QT syndrome that also involve the same ion channel affected by the drug moxifloxacin. ..