PEGGY COTTER

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Phosphorelay control of virulence gene expression in Bordetella
    Peggy A Cotter
    Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106 9610, USA
    Trends Microbiol 11:367-73. 2003
  2. ncbi request reprint c-di-GMP-mediated regulation of virulence and biofilm formation
    Peggy A Cotter
    Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106 9610, USA
    Curr Opin Microbiol 10:17-23. 2007
  3. pmc Type VI secretion: not just for pathogenesis anymore
    Andrea J Jani
    Biomolecular Science and Engineering Program, University of California, Santa Barbara, Santa Barbara, CA 93106, USA
    Cell Host Microbe 8:2-6. 2010
  4. pmc Characterization of the filamentous hemagglutinin-like protein FhaS in Bordetella bronchiseptica
    Steven M Julio
    Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106 9610, USA
    Infect Immun 73:4960-71. 2005
  5. pmc Natural-host animal models indicate functional interchangeability between the filamentous haemagglutinins of Bordetella pertussis and Bordetella bronchiseptica and reveal a role for the mature C-terminal domain, but not the RGD motif, during infection
    Steven M Julio
    Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106 9610, USA
    Mol Microbiol 71:1574-90. 2009
  6. pmc Autoregulation is essential for precise temporal and steady-state regulation by the Bordetella BvgAS phosphorelay
    Corinne L Williams
    Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA 93106 9610, USA
    J Bacteriol 189:1974-82. 2007
  7. ncbi request reprint Topology and maturation of filamentous haemagglutinin suggest a new model for two-partner secretion
    Joseph Mazar
    Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106 9610, USA
    Mol Microbiol 62:641-54. 2006
  8. ncbi request reprint Role of BvgA phosphorylation and DNA binding affinity in control of Bvg-mediated phenotypic phase transition in Bordetella pertussis
    Allison M Jones
    Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA 93109 9610, USA
    Mol Microbiol 58:700-13. 2005
  9. ncbi request reprint BvgA functions as both an activator and a repressor to control Bvg phase expression of bipA in Bordetella pertussis
    Corinne L Williams
    Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106 9610, USA
    Mol Microbiol 56:175-88. 2005
  10. pmc Bordetella filamentous hemagglutinin plays a critical role in immunomodulation, suggesting a mechanism for host specificity
    Carol S Inatsuka
    Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA 93106 9610, USA
    Proc Natl Acad Sci U S A 102:18578-83. 2005

Research Grants

  1. GENETIC ANALYSIS OF BORDETELLA PAHTOGENESIS
    PEGGY COTTER; Fiscal Year: 2003
  2. Genetic Analysis of Bordetella Pathogenesis
    PEGGY COTTER; Fiscal Year: 2007
  3. Genetic Analysis of Bordetella Pathogenesis
    PEGGY COTTER; Fiscal Year: 2009

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Phosphorelay control of virulence gene expression in Bordetella
    Peggy A Cotter
    Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106 9610, USA
    Trends Microbiol 11:367-73. 2003
  2. ncbi request reprint c-di-GMP-mediated regulation of virulence and biofilm formation
    Peggy A Cotter
    Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106 9610, USA
    Curr Opin Microbiol 10:17-23. 2007
    ....
  3. pmc Type VI secretion: not just for pathogenesis anymore
    Andrea J Jani
    Biomolecular Science and Engineering Program, University of California, Santa Barbara, Santa Barbara, CA 93106, USA
    Cell Host Microbe 8:2-6. 2010
    ....
  4. pmc Characterization of the filamentous hemagglutinin-like protein FhaS in Bordetella bronchiseptica
    Steven M Julio
    Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106 9610, USA
    Infect Immun 73:4960-71. 2005
    ..parapertussis(hu) most likely acquired its fhaS allele from B. pertussis horizontally, suggesting fhaS may contribute to host-species specificity...
  5. pmc Natural-host animal models indicate functional interchangeability between the filamentous haemagglutinins of Bordetella pertussis and Bordetella bronchiseptica and reveal a role for the mature C-terminal domain, but not the RGD motif, during infection
    Steven M Julio
    Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106 9610, USA
    Mol Microbiol 71:1574-90. 2009
    ..We could not, however, detect a role for the RGD in any of these processes...
  6. pmc Autoregulation is essential for precise temporal and steady-state regulation by the Bordetella BvgAS phosphorelay
    Corinne L Williams
    Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA 93106 9610, USA
    J Bacteriol 189:1974-82. 2007
    ..In addition, considered in relation to BvgA and BvgS activities demonstrated in vitro, our results provide insight into how BvgA and BvgS function mechanistically...
  7. ncbi request reprint Topology and maturation of filamentous haemagglutinin suggest a new model for two-partner secretion
    Joseph Mazar
    Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106 9610, USA
    Mol Microbiol 62:641-54. 2006
    ..This model provides an explanation for the energetics of export of globular protein domains across membranes in the absence of ATP and it suggests a new mechanism for the control of protein folding...
  8. ncbi request reprint Role of BvgA phosphorylation and DNA binding affinity in control of Bvg-mediated phenotypic phase transition in Bordetella pertussis
    Allison M Jones
    Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA 93109 9610, USA
    Mol Microbiol 58:700-13. 2005
    ....
  9. ncbi request reprint BvgA functions as both an activator and a repressor to control Bvg phase expression of bipA in Bordetella pertussis
    Corinne L Williams
    Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106 9610, USA
    Mol Microbiol 56:175-88. 2005
    ....
  10. pmc Bordetella filamentous hemagglutinin plays a critical role in immunomodulation, suggesting a mechanism for host specificity
    Carol S Inatsuka
    Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA 93106 9610, USA
    Proc Natl Acad Sci U S A 102:18578-83. 2005
    ..These results indicate a critical role for FHA in B. bronchiseptica-mediated immunomodulation, and they suggest a role for FHA in host specificity...
  11. pmc Serendipitous discovery of an immunoglobulin-binding autotransporter in Bordetella species
    Corinne L Williams
    Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, CA 93106 9610, USA
    Infect Immun 76:2966-77. 2008
    ..bronchiseptica. Taken together, our data suggest that BatB played an important role in the evolution of virulence and host specificity among the mammalian-adapted bordetellae...
  12. pmc Pertactin is required for Bordetella species to resist neutrophil-mediated clearance
    Carol S Inatsuka
    Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, Santa Barbara, California 93106 9610, USA
    Infect Immun 78:2901-9. 2010
    ....
  13. ncbi request reprint Reverse transcriptase-mediated tropism switching in Bordetella bacteriophage
    Minghsun Liu
    Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Science 295:2091-4. 2002
    ..This cassette-based mechanism is capable of providing a vast repertoire of potential ligand-receptor interactions...
  14. ncbi request reprint New insight into the molecular mechanisms of two-partner secretion
    Joseph Mazar
    Department of Molecular, Cellular and Developmental Biology, University of California Santa Barbara, Santa Barbara, CA 93106 9610, USA
    Trends Microbiol 15:508-15. 2007
    ..Evidence for secretion-dependent folding of mature exoproteins has also been obtained. Together, these findings provide a deeper understanding of the molecular mechanisms underlying these simple but elegant secretion systems...
  15. pmc Comparative phenotypic analysis of the Bordetella parapertussis isolate chosen for genomic sequencing
    Ulrich Heininger
    Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles School of Medicine, University of California Los Angeles, Los Angeles, California 90095 1747, USA
    Infect Immun 70:3777-84. 2002
    ..pertussis (by lack of motility and cytotoxicity to a macrophage-like cell line). These results begin to provide phenotypes that can be related to genetic differences identified in the genomic sequences of bordetellae...
  16. pmc Evaluation of the role of the Bvg intermediate phase in Bordetella pertussis during experimental respiratory infection
    Nuria Vergara-Irigaray
    Departamento de Microbiologia y Parasitologia, Universidad de Navarra, Apartado 177, 31080 Pamplona, Spain
    Infect Immun 73:748-60. 2005
    ..Finally, even though B. pertussis expresses in vitro the Bvg(i) phase at the human nasal temperature, anti-BipA antibodies were undetectable in a large collection of sera from pertussis patients...
  17. pmc Microbial pathogenesis: mechanisms of infectious disease
    Vern B Carruthers
    Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA
    Cell Host Microbe 2:214-9. 2007
    ..Here, we review the presented research that highlights this theme, including studies of both short-term and long-term interactions between microbes and their hosts...

Research Grants8

  1. GENETIC ANALYSIS OF BORDETELLA PAHTOGENESIS
    PEGGY COTTER; Fiscal Year: 2003
    ..The Principal Investigator plans to investigate a recently discovered Bvg intermediate phase gene and test the hypothesis that this phase is essential for transmission. ..
  2. Genetic Analysis of Bordetella Pathogenesis
    PEGGY COTTER; Fiscal Year: 2007
    ....
  3. Genetic Analysis of Bordetella Pathogenesis
    PEGGY COTTER; Fiscal Year: 2009
    ....