LES COSTELLO

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi request reprint Direct effect of zinc on mitochondrial apoptogenesis in prostate cells
    Pei Feng
    Greenebaum Cancer Center and Department of OCBS, Dental School, University of Maryland, Baltimore, Maryland, USA
    Prostate 52:311-8. 2002
  2. pmc Zinc is decreased in prostate cancer: an established relationship of prostate cancer!
    Leslie C Costello
    Department of Oncology and Diagnostic Sciences, Dental School, University of Maryland, 650 West Baltimore Street, Baltimore, MD 21201, USA
    J Biol Inorg Chem 16:3-8. 2011
  3. pmc Human prostate cancer ZIP1/zinc/citrate genetic/metabolic relationship in the TRAMP prostate cancer animal model
    Leslie C Costello
    Department of Oncology and Diagnostic Sciences, Dental School and Greenebaum Cancer Center, University of Maryland, Baltimore, MD, USA
    Cancer Biol Ther 12:1078-84. 2011
  4. pmc Evidence for changes in RREB-1, ZIP3, and Zinc in the early development of pancreatic adenocarcinoma
    Leslie C Costello
    Department of Oncology and Diagnostic Sciences, University of Maryland Dental School, 650 West Baltimore Street, Baltimore, MD 21201, USA
    J Gastrointest Cancer 43:570-8. 2012
  5. doi request reprint The genetic/metabolic transformation concept of carcinogenesis
    Leslie C Costello
    Department of Oncology and Diagnostic Sciences, University of Maryland, Baltimore, MD 21201, USA
    Cancer Metastasis Rev 31:123-30. 2012
  6. pmc The involvement of Bax in zinc-induced mitochondrial apoptogenesis in malignant prostate cells
    Pei Feng
    Department of Biomedical Sciences Dental School and The Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland, USA
    Mol Cancer 7:25. 2008
  7. pmc hZip2 and hZip3 zinc transporters are down regulated in human prostate adenocarcinomatous glands
    Mohamed M Desouki
    Dept of Pathology and Lab Medicine, Medical University of South Carolina, Charleston, SC, USA
    Mol Cancer 6:37. 2007
  8. pmc Mitochondrial aconitase and citrate metabolism in malignant and nonmalignant human prostate tissues
    Keshav K Singh
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Mol Cancer 5:14. 2006
  9. pmc hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer
    Renty B Franklin
    Department of Biomedical Sciences, Dental School, University of Maryland, Baltimore, MD, USA
    Mol Cancer 4:32. 2005
  10. pmc EAAC1 is expressed in rat and human prostate epithelial cells; functions as a high-affinity L-aspartate transporter; and is regulated by prolactin and testosterone
    Renty B Franklin
    Department of Biomedical Sciences Dental School, University of Maryland, Baltimore, Maryland, USA
    BMC Biochem 7:10. 2006

Research Grants

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Direct effect of zinc on mitochondrial apoptogenesis in prostate cells
    Pei Feng
    Greenebaum Cancer Center and Department of OCBS, Dental School, University of Maryland, Baltimore, Maryland, USA
    Prostate 52:311-8. 2002
    ..The apoptotic effect is due to zinc induction of mitochondrial apoptogenesis. We now report additional studies that corroborate this effect of zinc and provide insight into the mechanism of this unique effect...
  2. pmc Zinc is decreased in prostate cancer: an established relationship of prostate cancer!
    Leslie C Costello
    Department of Oncology and Diagnostic Sciences, Dental School, University of Maryland, 650 West Baltimore Street, Baltimore, MD 21201, USA
    J Biol Inorg Chem 16:3-8. 2011
    ..This leads to misinformation and misinterpretations regarding clinical, experimental, and epidemiological issues that do not serve the best interests of the scientific, medical, and public communities...
  3. pmc Human prostate cancer ZIP1/zinc/citrate genetic/metabolic relationship in the TRAMP prostate cancer animal model
    Leslie C Costello
    Department of Oncology and Diagnostic Sciences, Dental School and Greenebaum Cancer Center, University of Maryland, Baltimore, MD, USA
    Cancer Biol Ther 12:1078-84. 2011
    ..It now appears that the TRAMP model will be suitable for studies relating to the implications and role of zinc- and citrate-related metabolism in the development and progression of human prostate cancer...
  4. pmc Evidence for changes in RREB-1, ZIP3, and Zinc in the early development of pancreatic adenocarcinoma
    Leslie C Costello
    Department of Oncology and Diagnostic Sciences, University of Maryland Dental School, 650 West Baltimore Street, Baltimore, MD 21201, USA
    J Gastrointest Cancer 43:570-8. 2012
    ..This study was conducted to establish the changes in zinc, ZIP3 zinc transporter, and Ras-responsive element-binding protein 1 (RREB-1) transcription factor as early events in the development of malignancy...
  5. doi request reprint The genetic/metabolic transformation concept of carcinogenesis
    Leslie C Costello
    Department of Oncology and Diagnostic Sciences, University of Maryland, Baltimore, MD 21201, USA
    Cancer Metastasis Rev 31:123-30. 2012
    ....
  6. pmc The involvement of Bax in zinc-induced mitochondrial apoptogenesis in malignant prostate cells
    Pei Feng
    Department of Biomedical Sciences Dental School and The Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland, USA
    Mol Cancer 7:25. 2008
    ..The present report provides for the first time information that implicates Bax in the zinc induction of mitochondrial apoptogenesis...
  7. pmc hZip2 and hZip3 zinc transporters are down regulated in human prostate adenocarcinomatous glands
    Mohamed M Desouki
    Dept of Pathology and Lab Medicine, Medical University of South Carolina, Charleston, SC, USA
    Mol Cancer 6:37. 2007
    ..Zip2 and Zip3 relative protein levels were determined by immunohistochemistry analysis of human prostate tissue sections...
  8. pmc Mitochondrial aconitase and citrate metabolism in malignant and nonmalignant human prostate tissues
    Keshav K Singh
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Mol Cancer 5:14. 2006
    ..To address this issue, the in situ level of m-aconitase enzyme was determined by immunohistochemical analysis of prostate cancer tissue sections and malignant prostate cell lines...
  9. pmc hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer
    Renty B Franklin
    Department of Biomedical Sciences, Dental School, University of Maryland, Baltimore, MD, USA
    Mol Cancer 4:32. 2005
    ..hZIP1 expression was also determined in malignant prostate cell lines...
  10. pmc EAAC1 is expressed in rat and human prostate epithelial cells; functions as a high-affinity L-aspartate transporter; and is regulated by prolactin and testosterone
    Renty B Franklin
    Department of Biomedical Sciences Dental School, University of Maryland, Baltimore, Maryland, USA
    BMC Biochem 7:10. 2006
    ..The present report is concerned with the identification of this putative L-aspartate transporter in rat and human prostate cells...
  11. pmc Evidence for operation of the direct zinc ligand exchange mechanism for trafficking, transport, and reactivity of zinc in mammalian cells
    Leslie C Costello
    Department of Oncology and Diagnostic Sciences, Dental School, University of Maryland, Baltimore, MD 21201, USA
    J Inorg Biochem 105:589-99. 2011
    ....
  12. pmc Cytotoxic/tumor suppressor role of zinc for the treatment of cancer: an enigma and an opportunity
    Leslie C Costello
    Department of Oncology and Diagnostic Sciences, Dental School, University of Maryland, Baltimore, MA 21201, USA
    Expert Rev Anticancer Ther 12:121-8. 2012
    ..Important areas of research are identified as being essential for the successful application of zinc cytotoxicity/tumor suppression actions for the treatment of specific cancers...
  13. doi request reprint The effect of contemporary education and training of biomedical scientists on present and future medical research
    Leslie C Costello
    Division of Oncology Dental School and The Greenebaum Cancer Center, University of Maryland, Baltimore, MD 21201, USA
    Acad Med 84:459-63. 2009
    ..This article is intended to expose these issues and to stimulate a serious discussion and assessment of contemporary graduate training as it relates to the biomedical research and issues of today and of the future...
  14. pmc Tumor cell metabolism: the marriage of molecular genetics and proteomics with cellular intermediary metabolism; proceed with caution!
    Leslie C Costello
    Department of Biomedical Sciences, Dental School, and the Greenebaum Cancer Center, University of Maryland, 650 West Baltimore Street, Baltimore, MD 21201, USA
    Mol Cancer 5:59. 2006
    ..The appropriate marriage of molecular genetics/proteomics with the regulation of cellular intermediary metabolism will provide new revelations and understanding of malignancy that could not be achieved in earlier generations...
  15. pmc Prostatic fluid electrolyte composition for the screening of prostate cancer: a potential solution to a major problem
    L C Costello
    Department of Biomedical Sciences, University of Maryland, Baltimore, MD 21201, USA
    Prostate Cancer Prostatic Dis 12:17-24. 2009
    ..Further exploration and development of citrate, zinc and other electrolytes as prostatic fluid biomarkers are urgently needed to address this critical prostate cancer issue...
  16. pmc The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots
    Leslie C Costello
    Department of Biomedical Sciences, Dental School, University of Maryland, Baltimore, Maryland, USA
    Mol Cancer 5:17. 2006
    ..The evidence for a concept of zinc as a tumor suppressor agent and Zip1 zinc transporter as a tumor-suppressor gene is described...
  17. doi request reprint Perspective: is NIH funding the "best science by the best scientists"? A critique of the NIH R01 research grant review policies
    Leslie C Costello
    Division of Oncology Dental School and Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland 21201, USA
    Acad Med 85:775-9. 2010
    ..The NIH should eliminate all directives that prevent R01 grants from being awarded solely to the highest-quality research. This is in the best interest of the biomedical community and the health and welfare of the public at large...
  18. pmc Decreased zinc and downregulation of ZIP3 zinc uptake transporter in the development of pancreatic adenocarcinoma
    Leslie C Costello
    Department of Oncology and Diagnostic Sciences, The University of Maryland, Baltimore, USA
    Cancer Biol Ther 12:297-303. 2011
    ....
  19. ncbi request reprint Kinetic identification of a mitochondrial zinc uptake transport process in prostate cells
    Zhixin Guan
    Molecular and Cell Biology Section, Department of Biomedical Sciences, Dental School, University of Maryland, 666 West Baltimore Street, Baltimore, MD 21201, USA
    J Inorg Biochem 97:199-206. 2003
    ..The uniquely high accumulation of mitochondrial zinc in prostate cells appears to be due to their high cytosolic level of zinc-transportable ligands, particularly Zn-Cit...
  20. pmc The important role of the apoptotic effects of zinc in the development of cancers
    Renty B Franklin
    Division of Oncology Dental School and Greenebaum Cancer Center, University of Maryland Baltimore, 650 West Baltimore Street, Baltimore, Maryland 21201, USA
    J Cell Biochem 106:750-7. 2009
    ..Thus one must be mindful of the experimental conditions under which zinc effects are investigated relative to the physiological and pathological conditions of cellular zinc distribution and concentrations that can exist in situ...
  21. doi request reprint Ras responsive element binding protein-1 (RREB-1) down-regulates hZIP1 expression in prostate cancer cells
    Beatrice C Milon
    Department of Oncology and Diagnostic Sciences, Dental School, Greenebaum Cancer Center, University of Maryland Baltimore, Baltimore, MD 21201, USA
    Prostate 70:288-96. 2010
    ..However, the mechanism of hZIP1 down-regulation is not known. We have hypothesized that hZIP1 is down-regulated through transcriptional regulation...
  22. ncbi request reprint Effect of zinc on prostatic tumorigenicity in nude mice
    Pei Feng
    Department of Biomedical Sciences, University of Maryland Dental School, Baltimore, Maryland 21201, USA
    Ann N Y Acad Sci 1010:316-20. 2003
    ..The inhibitory effect of zinc appears to result from zinc-induced apoptosis by regulation of mitochondrial membrane permeability-related Bax/Bcl-2 proteins...
  23. ncbi request reprint Metallothionein can function as a chaperone for zinc uptake transport into prostate and liver mitochondria
    Leslie C Costello
    Department of Biomedical Sciences, Dental School, University of Maryland, 666 West Baltimore Street, Baltimore, MD 21201, USA
    J Inorg Biochem 98:664-6. 2004
    ..However, in liver and perhaps other cells, Zn(7)-MT is probably important in the cytosolic trafficking of zinc to the mitochondria for the uptake of zinc into the mitochondrial matrix by the putative zinc uptake transporter...
  24. ncbi request reprint Zinc and zinc transporters in normal prostate and the pathogenesis of prostate cancer
    Renty B Franklin
    Department of Biomedical Sciences, Dental School, University of Maryland, Baltimore, MD 21201, USA
    Front Biosci 10:2230-9. 2005
    ....
  25. ncbi request reprint Zinc and prostate cancer: a critical scientific, medical, and public interest issue (United States)
    Leslie C Costello
    Department of Biomedical Sciences, Dental School, University of Maryland, 666 W Baltimore St, Baltimore, MD 21201, USA
    Cancer Causes Control 16:901-15. 2005
    ....
  26. pmc Zinc as an anti-tumor agent in prostate cancer and in other cancers
    Renty B Franklin
    Department of Biomedical Sciences, University of Maryland Baltimore, Dental School, 650 West Baltimore Street, Baltimore, MD 21201, USA
    Arch Biochem Biophys 463:211-7. 2007
    ..Therefore we regard ZIP1 as a tumor suppressor gene in prostate cancer. In addition to prostate cells, similar tumor suppressor effects of zinc have been identified in several other types of tumors...
  27. ncbi request reprint Characterization of the mitochondrial aconitase promoter and the identification of transcription factor binding
    Ziqiang Yu
    Department of Biomedical Sciences, Dental School, University of Maryland, Baltimore, Maryland 21201, USA
    Prostate 66:1061-9. 2006
    ..Mitochondrial (m) aconitase plays an important role in the unique pathway of citrate accumulation in prostate epithelial cells through its limited activity. In the current study, we characterized the human m-aconitase gene promoter...
  28. ncbi request reprint Histidine residues in the region between transmembrane domains III and IV of hZip1 are required for zinc transport across the plasma membrane in PC-3 cells
    Beatrice Milon
    Department of Biomedical Sciences, Dental School, University of Maryland, Baltimore, MD 21201, USA
    Biochim Biophys Acta 1758:1696-701. 2006
    ..In addition, two histidine residues in transmembrane domains IV and V are also important in the zinc transport function. The results support an intermolecular exchange mechanism of zinc transport...
  29. ncbi request reprint 'Why do tumour cells glycolyse?': from glycolysis through citrate to lipogenesis
    Leslie C Costello
    Department of Biomedical Sciences, Dental School University of Maryland, Baltimore, USA
    Mol Cell Biochem 280:1-8. 2005
    ..We express our appreciation to the many pioneering and contemporary researchers whose studies provide much of the basis for this presentation...
  30. ncbi request reprint Re: Zinc supplement use and risk of prostate cancer
    Leslie C Costello
    J Natl Cancer Inst 96:239-40; author reply 240-1. 2004
  31. ncbi request reprint Re: Silvano Gallus, Roberto Foschi, Eva Negri et al. Dietary zinc and prostate cancer risk: a case-control study from Italy. Eur urol 2007;52:1052-7
    Leslie C Costello
    Eur Urol 52:1262-3; author reply 1263-4. 2007

Research Grants10

  1. HORMONAL AND ZINC REGULATION OF PROSTATE M ACONITASE
    LES COSTELLO; Fiscal Year: 2004
    ..This information will provide new approaches to the diagnosis, prevention, and treatment of PCa. ..
  2. HORMONAL AND ZINC REGULATION OF PROSTATE M-ACONITASE
    LES COSTELLO; Fiscal Year: 1999
    ..This information will provide new insights into the pathogenesis of PCa and the malignant process and will provide new approaches to the diagnosis, prevention, and treatment of PCa. ..
  3. UNIQUE ASPARTATE TRANSPORT IN PROSTATE
    LES COSTELLO; Fiscal Year: 2004
    ..abstract_text> ..