Research Topics
Genomes and Genes | Robert CostaSummaryAffiliation: University of Illinois at Chicago Country: USA Publications
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Publications
Transcription factors in liver development, differentiation, and regenerationRobert H Costa
Department of Biochemistry and Molecular Genetics University of Illinois at Chicago, College of Medicine, Chicago, IL 60607-7170, USA
Hepatology 38:1331-47. 2003- New and unexpected: forkhead meets ARFRobert H Costa
Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, College of Medicine, Chicago, Illinois 60607, USA
Curr Opin Genet Dev 15:42-8. 2005..Thus, the p19ARF peptide is an effective inhibitor of Foxm1b and represents a potential therapy for hepatocellular carcinoma... - Association between hepatocyte nuclear factor 6 (HNF-6) and FoxA2 DNA binding domains stimulates FoxA2 transcriptional activity but inhibits HNF-6 DNA bindingFrancisco M Rausa
Department of Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60607, USA
Mol Cell Biol 23:437-49. 2003..This is the first reported example of a liver-enriched transcription factor (HNF-6) functioning as a coactivator protein to potentiate the transcriptional activity of another liver factor, FoxA2... - The forkhead box m1 transcription factor is essential for embryonic development of pulmonary vasculatureIl Man Kim
Department of Medicine and Committee on Developmental Biology, The University of Chicago, Chicago, IL 60637, USA
J Biol Chem 280:22278-86. 2005..In summary, development of mouse lungs depends on the Foxm1 transcription factor, which regulates expression of genes essential for mesenchyme proliferation, extracellular matrix remodeling, and vasculogenesis... - Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressorVladimir V Kalinichenko
University of Illinois at Chicago, College of Medicine, Department of Biochemistry and Molecular Genetics, Chicago, Illinois 60607, USA
Genes Dev 18:830-50. 2004..Our studies demonstrate that the Foxm1b transcription factor is required for proliferative expansion during tumor progression and constitutes a potential new target for therapy of human HCC tumors... - Sustained hepatic expression of FoxM1B in transgenic mice has minimal effects on hepatocellular carcinoma development but increases cell proliferation rates in preneoplastic and early neoplastic lesionsOlga A Kalinina
Department of Oral Medicine and Diagnostic Sciences and the Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, IL 60612, USA
Oncogene 22:6266-76. 2003..This suggests that the artificial enrichment of FoxM1B in the liver, which has been suggested as a gene therapy protocol for liver dysfunction with aging, may not be tumorigenic in that organ... - Rapid hepatocyte nuclear translocation of the Forkhead Box M1B (FoxM1B) transcription factor caused a transient increase in size of regenerating transgenic hepatocytesXinhe Wang
Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, College of Medicine, 900 South Ashland Ave, Chicago, IL 60607 7170, USA
Gene Expr 11:149-62. 2003.... - Stability of the hepatocyte nuclear factor 6 transcription factor requires acetylation by the CREB-binding protein coactivatorFrancisco M Rausa
Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, College of Medicine, Chicago, Illinois 60607, USA
J Biol Chem 279:43070-6. 2004.... - Forkhead box M1B transcriptional activity requires binding of Cdk-cyclin complexes for phosphorylation-dependent recruitment of p300/CBP coactivatorsMichael L Major
Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60607, USA
Mol Cell Biol 24:2649-61. 2004.... - The mouse Forkhead Box m1 transcription factor is essential for hepatoblast mitosis and development of intrahepatic bile ducts and vessels during liver morphogenesisKatherine Krupczak-Hollis
Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607 7170, USA
Dev Biol 276:74-88. 2004.... - Haploinsufficiency of the mouse Forkhead Box f1 gene causes defects in gall bladder developmentVladimir V Kalinichenko
Department of Molecular Genetics, University of Illinois at Chicago, College of Medicine, Chicago, Illinois 60607 7170, USA
J Biol Chem 277:12369-74. 2002.... - Adenovirus-mediated increase in HNF-3beta or HNF-3alpha shows differences in levels of liver glycogen and gene expressionYongjun Tan
University of Illinois at Chicago, College of Medicine, Department of Molecular Genetics, Chicago, IL 60607-7170, USA
Hepatology 35:30-9. 2002.... - Structure of the hepatocyte nuclear factor 6alpha and its interaction with DNAWanyun Sheng
Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60607, USA
J Biol Chem 279:33928-36. 2004..The structure implies that this sequence has to undergo structural changes when it interacts with CREB-binding protein... - Increased hepatic Forkhead Box M1B (FoxM1B) levels in old-aged mice stimulated liver regeneration through diminished p27Kip1 protein levels and increased Cdc25B expressionXinhe Wang
Department of Molecular Genetics, University of Illinois at Chicago, College of Medicine and Dentistry, 60607, USA
J Biol Chem 277:44310-6. 2002.... - FoxM1 regulates growth factor-induced expression of kinase-interacting stathmin (KIS) to promote cell cycle progressionVladimir Petrovic
Department of Biochemistry and Molecular Genetics, University of Illinois College of Medicine, 900 S Ashland Avenue, Chicago, IL 60607, USA
J Biol Chem 283:453-60. 2008..Furthermore, we show that KIS is a direct transcriptional target of FoxM1. Thus FoxM1 promotes cell cycle progression by down-regulating p27(Kip1) through multiple mechanisms... - Increased expression of hepatocyte nuclear factor 6 stimulates hepatocyte proliferation during mouse liver regenerationYongjun Tan
Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago College of Medicine, Chicago, Illinois 60607 7170, USA
Gastroenterology 130:1283-300. 2006..Here, we examined whether increased levels of HNF6 stimulate hepatocyte proliferation during mouse liver regeneration... - Growth hormone stimulates proliferation of old-aged regenerating liver through forkhead box m1bKatherine Krupczak-Hollis
Department of Molecular Genetics, University of Illinois at Chicago College of Medicine, Chicago, IL 60607 7170, USA
Hepatology 38:1552-62. 2003..In conclusion, our old-aged liver regeneration studies show that increased Foxm1b levels are essential for GH to stimulate hepatocyte proliferation, thus providing a mechanism for GH action in the elderly... - Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligaseI Ching Wang
Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, College of Medicine, 60607 7170, USA
Mol Cell Biol 25:10875-94. 2005..Taken together, these results demonstrate that FoxM1 regulates transcription of cell cycle genes critical for progression into S-phase and mitosis... - Elevated hepatocyte levels of the Forkhead box A2 (HNF-3beta) transcription factor cause postnatal steatosis and mitochondrial damageDouglas E Hughes
University of Illinois at Chicago, College of Medicine, Department of Molecular Genetics, Chicago, IL 60607 7170, USA
Hepatology 37:1414-24. 2003.... - Maintaining HNF6 expression prevents AdHNF3beta-mediated decrease in hepatic levels of Glut-2 and glycogenYongjun Tan
Department of Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607-7170, USA
Hepatology 35:790-8. 2002..In conclusion, these studies show that the hepatic Glut-2 promoter is a direct target for HNF-6 transcriptional activation... - Fusion of lung lobes and vessels in mouse embryos heterozygous for the forkhead box f1 targeted alleleLorena Lim
Department of Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60607 7170, USA
Am J Physiol Lung Cell Mol Physiol 282:L1012-22. 2002.... - The Forkhead Box m1b transcription factor is essential for hepatocyte DNA replication and mitosis during mouse liver regenerationXinhe Wang
Department of Molecular Genetics, University of Illinois College of Medicine, 900 South Ashland Avenue, Chicago, IL 60607, USA
Proc Natl Acad Sci U S A 99:16881-6. 2002..Our present study shows that the mammalian Foxm1b transcription factor regulates expression of cell cycle proteins essential for hepatocyte entry into DNA replication and mitosis... - Ubiquitous expression of the forkhead box M1B transgene accelerates proliferation of distinct pulmonary cell types following lung injuryVladimir V Kalinichenko
Department of Molecular Genetics, University of Illinois at Chicago, College of Medicine, Chicago, Illinois 60607 7170, USA
J Biol Chem 278:37888-94. 2003..Taken together, these results suggest that increasing FoxM1B levels is an effective means to stimulate cellular proliferation during aging and in lung diseases such as emphysema... - Foxf1 +/- mice exhibit defective stellate cell activation and abnormal liver regeneration following CCl4 injuryVladimir V Kalinichenko
Department of Molecular Genetics, College of Medicine, University of Illinois at Chicago, 60607, USA
Hepatology 37:107-17. 2003..In conclusion, Foxf1 +/- mice exhibited abnormal liver repair, diminished activation of hepatic stellate cells, and increased pericentral hepatic apoptosis following CCl(4) injury... - Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genesYongjun Tan
Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607, USA
Mol Cell Biol 27:1007-16. 2007..These results identify a novel role for FoxM1 in the transcriptional response during DNA damage/checkpoint signaling and show a novel mechanism by which Chk2 protein regulates expression of DNA repair enzymes... - A conserved phosphorylation site within the forkhead domain of FoxM1B is required for its activation by cyclin-CDK1Yi Ju Chen
Department of Biochemistry and Molecular Genetics, University of Illinois, College of Medicine, Chicago, Illinois 60607, USA
J Biol Chem 284:30695-707. 2009.... - Endothelial cell-restricted disruption of FoxM1 impairs endothelial repair following LPS-induced vascular injuryYou Yang Zhao
Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois 60612, USA
J Clin Invest 116:2333-43. 2006..These data suggest that impairment in FoxM1 activation may be an important determinant of the persistent vascular barrier leakiness and edema formation associated with inflammatory diseases... - Foxf1 haploinsufficiency reduces Notch-2 signaling during mouse lung developmentVladimir V Kalinichenko
Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois, Chicago, IL 60607 7170, USA
Am J Physiol Lung Cell Mol Physiol 286:L521-30. 2004..Foxf1 haploinsufficiency disrupted pulmonary expression of genes in the Notch-2-signaling pathway and resulted in abnormal development of lung microvasculature... - ARF directly binds DP1: interaction with DP1 coincides with the G1 arrest function of ARFAbhishek Datta
Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, 900 S Ashland Ave, Chicago, IL 60607, USA
Mol Cell Biol 25:8024-36. 2005..Also, the interaction between ARF and DP1 is enhanced during oncogenic stress and "culture shock." Taken together, our results show that DP1 is a critical direct target of ARF... - Wild-type levels of the mouse Forkhead Box f1 gene are essential for lung repairVladimir V Kalinichenko
Department of Molecular Genetics, College of Medicine, University of Illinois at Chicago, 60607 7170, USA
Am J Physiol Lung Cell Mol Physiol 282:L1253-65. 2002..Collectively, our data suggest that sustained expression of Foxf1 is essential for normal lung repair and endothelial cell survival in response to pulmonary cell injury... - A cell-penetrating ARF peptide inhibitor of FoxM1 in mouse hepatocellular carcinoma treatmentGalina A Gusarova
Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, College of Medicine, Chicago, Illinois 60607 7170, USA
J Clin Invest 117:99-111. 2007..These studies indicate that ARF peptide treatment is an effective therapeutic approach to limit proliferation and induce apoptosis of liver cancer cells in vivo... - Diminished hepatic expression of the HNF-6 transcription factor during bile duct obstructionAi Xuan L Holterman
Department of Surgery, Division of Pediatric Surgery, University of Illinois at Chicago, 60607 7170, USA
Hepatology 35:1392-9. 2002..In conclusion, we propose a biologic role for diminished HNF-6 protein levels in bile duct disease... - FoxM1 regulates transcription of JNK1 to promote the G1/S transition and tumor cell invasivenessI Ching Wang
Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, 900 S Ashland Avenue, Chicago, IL 60607, USA
J Biol Chem 283:20770-8. 2008..Taken together, these findings identify JNK1 as a critical transcriptional target of FoxM1 that contributes to FoxM1-regulated cell cycle progression, tumor cell migration, invasiveness, and anchorage-independent growth... - FoxM1, a critical regulator of oxidative stress during oncogenesisHyun Jung Park
Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA
EMBO J 28:2908-18. 2009..Together, our results identify FoxM1 as a key regulator of ROS in dividing cells, and provide insights into the mechanism how tumour cells use FoxM1 to control oxidative stress to escape premature senescence and apoptosis... - The Forkhead Box m1 transcription factor stimulates the proliferation of tumor cells during development of lung cancerIl Man Kim
Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
Cancer Res 66:2153-61. 2006..Foxm1-depleted A549 cells exhibit reduced expression of cell cycle-promoting cyclin A2 and cyclin B1 genes. These data show that Foxm1 stimulates the proliferation of tumor cells during progression of NSCLC... - Identification of a chemical inhibitor of the oncogenic transcription factor forkhead box M1Senthil K Radhakrishnan
Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
Cancer Res 66:9731-5. 2006..Taken together, our data suggest that FoxM1 inhibitor Siomycin A could represent a useful starting point for the development of anticancer therapeutics... - The forkhead box M1 transcription factor contributes to the development and growth of mouse colorectal cancerYuichi Yoshida
Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, College of Medicine, Chicago, Illinois, USA
Gastroenterology 132:1420-31. 2007..In this study, we used Forkhead Box m1b (Foxm1b) transgenic mice and conditional Foxm1 knock-out mice to examine the role of Foxm1 in colon cancer development and proliferation... - On the epigenetic regulation of the human reelin promoterYing Chen
Psychiatric Institute, Department of Psychiatry, 1601 West Taylor Street, M C 912, College of Medicine, University of Illinois, Chicago, IL 60612, USA
Nucleic Acids Res 30:2930-9. 2002..Our data also raise the interesting possibility that the down-regulation of reelin expression documented in psychiatric patients might be the consequence of inappropriate promoter hypermethylation... - In vivo regulation of murine CYP7A1 by HNF-6: a novel mechanism for diminished CYP7A1 expression in biliary obstructionMinhua Wang
Department of Surgery, University of Illinois at Chicago College of Medicine, Chicago, IL 60612, USA
Hepatology 40:600-8. 2004.... - Anaphase-promoting complex/cyclosome-CDH1-mediated proteolysis of the forkhead box M1 transcription factor is critical for regulated entry into S phaseHyun Jung Park
Department of Biochemistry and Molecular Genetics M C 669, University of Illinois at Chicago, College of Medicine, 900 S Ashland Ave, MBRB Rm 2302, Chicago, IL 60607 7170, USA
Mol Cell Biol 28:5162-71. 2008..Together, our observations show that FoxM1 is one of the targets of Cdh1 in late M or early G(1) phase and that its proteolysis is important for regulated entry into S phase... - The forkhead box F1 transcription factor is expressed in brain and head mesenchyme during mouse embryonic developmentVladimir V Kalinichenko
Department of Molecular Genetics M C 669, University of Illinois at Chicago, College of Medicine, 900 South Ashland Avenue, Chicago, IL 60607 7170, USA
Gene Expr Patterns 3:153-8. 2003.... - C/EBPalpha and HNF6 protein complex formation stimulates HNF6-dependent transcription by CBP coactivator recruitment in HepG2 cellsYuichi Yoshida
Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, College of Medicine, Chicago, IL 60607-7170, USA
Hepatology 43:276-86. 2006.... - Increased levels of the FoxM1 transcription factor accelerate development and progression of prostate carcinomas in both TRAMP and LADY transgenic miceTanya V Kalin
Department of Biochemistry and Molecular Genetics and Toxicology Research Laboratory, Department of Pharmacology, College of Medicine, University of Illinois at Chicago, 900 South Ashland Avenue, Chicago, IL 60607, USA
Cancer Res 66:1712-20. 2006..Our results suggest that the FoxM1 transcription factor regulates development and proliferation of prostate tumors, and that FoxM1 is a novel target for prostate cancer treatment... - Functional polymorphism of the Anpep gene increases promoter activity in the Dahl salt-resistant ratKumar Kotlo
Department of Medicine, University of Illinois at Chicago, 840 S Wood St, Chicago, IL 60612
Hypertension 49:467-72. 2007..These results highlight a possible association of the Anpep gene with hypertension in Dahl rat and raise the prospect that increased Anpep may play a mechanistic role in adaptation to high salt... - Transplanted hepatocytes over-expressing FoxM1B efficiently repopulate chronically injured mouse liver independent of donor ageNicolas Brezillon
Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
Mol Ther 15:1710-5. 2007..In conclusion, our results point to the potential use of FoxM1B expression in hepatocyte-based therapy protocols in diseases where host hepatocytes are chronically injured, especially if donor hepatocytes come from old livers... - The FoxM1 transcription factor is required to maintain pancreatic beta-cell massHongjie Zhang
Departments of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
Mol Endocrinol 20:1853-66. 2006..These results suggest that mechanisms regulating embryonic beta-cell proliferation differ from those used postnatally to maintain the differentiated cell population... - Myocardium defects and ventricular hypoplasia in mice homozygous null for the Forkhead Box M1 transcription factorSneha Ramakrishna
Department of Medicine, University of Chicago, Chicago, Illinois
Dev Dyn 236:1000-13. 2007..Foxm1 regulates expression of genes essential for the proliferation of cardiomyocytes during heart development... - Functional characterization of evolutionarily conserved DNA regions in forkhead box f1 gene locusIl Man Kim
Department of Medicine, The University of Chicago, Illinois 60637, USA
J Biol Chem 280:37908-16. 2005..3-kb Foxf1 promoter in cotransfection assays. These studies demonstrated that the conserved Foxf1 3'RE region is essential for proper tissue-specific regulation of the Foxf1 promoter region during mouse embryogenesis... - Hepatocyte nuclear factor 3beta inhibits hepatitis B virus replication in vivoKrista E Banks
Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
J Virol 76:12974-80. 2002..This suggests that altering the activity of this transcription factor in vivo in chronic HBV carriers might be therapeutically beneficial... - FoxM1 dances with mitosisRobert H Costa
Nat Cell Biol 7:108-10. 2005 - Robert H. Costa: 1957-2006Pradip Raychaudhuri
Hepatology 44:1364. 2006 - The CAR nuclear receptor and hepatocyte proliferationRobert H Costa
Hepatology 42:1004-8. 2005
Research Grants
- REGULATION OF TRANSTHYRETIN IN THE LIVERRobert Costa; Fiscal Year: 2002..Analysis of the phenotypes in these mice may provide information regarding human birth defects and liver disease resulting from altered expression of differentiating transcription factors. ..
- FoxM1B in Preventing Age-Related Proliferation DefectsRobert Costa; Fiscal Year: 2002..A long-term goal of these studies ti examine whether Rosa26-FoxM1B transgenic mice display sustained cellular proliferation during aging and exhibit life span extension. ..
- FoxM1B Protein in Stimulating Proliferation during AgingRobert Costa; Fiscal Year: 2003....
- HEPATOCYTE NUCLEAR FACTORS IN LIVER REGENERATIONRobert Costa; Fiscal Year: 2003..An understanding of transcriptional mechanisms which mediate liver regeneration may allow us to identify regulatory pathways that are potentially disrupted during liver fibrosis and cirrhosis. ..
- Hepatocyte Nuclear Factors in Regenerating LiverRobert Costa; Fiscal Year: 2005....
- REGULATION OF TRANSTHYRETIN IN THE LIVERRobert Costa; Fiscal Year: 1993..These studies will strengthen our understanding of the molecular basis controlling tissue-specific gene transcription...
- REGULATION OF TRANSTHYRETIN IN THE LIVERRobert Costa; Fiscal Year: 2005..abstract_text> ..