LUCIO COSTA

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Paraoxonase-2 (PON2) in brain and its potential role in neuroprotection
    Lucio G Costa
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA Department of Neuroscience, University of Parma, Italy Electronic address
    Neurotoxicology 43:3-9. 2014
  2. pmc Developmental neurotoxicity: some old and new issues
    Gennaro Giordano
    Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE, Suite 100, Seattle, WA 98105, USA
    ISRN Toxicol 2012:814795. 2012
  3. pmc Neurotoxicants are in the air: convergence of human, animal, and in vitro studies on the effects of air pollution on the brain
    Lucio G Costa
    Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt, Suite no 100, Seattle, WA 98105, USA Department of Neuroscience, University of Parma, Via Volturno 39, 43100 Parma, Italy
    Biomed Res Int 2014:736385. 2014
  4. pmc Behavioral Characterization of GCLM-Knockout Mice, a Model for Enhanced Susceptibility to Oxidative Stress
    Toby B Cole
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195, USA
    J Toxicol 2011:157687. 2011
  5. pmc Modulation of paraoxonase 2 (PON2) in mouse brain by the polyphenol quercetin: a mechanism of neuroprotection?
    Lucio G Costa
    Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE, Suite 100, Seattle, WA 98105, USA
    Neurochem Res 38:1809-18. 2013
  6. doi request reprint The birth and early years of INA, the International Neurotoxicology Association
    Lucio G Costa
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA
    Neurotoxicology 36:89-103. 2013
  7. pmc Paraoxonase 1 (PON1) as a genetic determinant of susceptibility to organophosphate toxicity
    Lucio G Costa
    Dept of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA
    Toxicology 307:115-22. 2013
  8. pmc Low-level domoic acid protects mouse cerebellar granule neurons from acute neurotoxicity: role of glutathione
    Gennaro Giordano
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, USA
    Toxicol Sci 132:399-408. 2013
  9. pmc An interview with Lucio G. Costa and Michael Aschner, section editors for toxicology
    Lucio G Costa
    Department of Environmental and Occupational Health Sciences University of Washington, 4225 Roosevelt 100, Seattle, WA 98105, USA
    BMC Pharmacol Toxicol 13:16. 2012
  10. ncbi request reprint Current issues in organophosphate toxicology
    Lucio G Costa
    Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE, Suite 100 Seattle, WA 98105, USA
    Clin Chim Acta 366:1-13. 2006

Research Grants

Collaborators

Detail Information

Publications80

  1. ncbi request reprint Paraoxonase-2 (PON2) in brain and its potential role in neuroprotection
    Lucio G Costa
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA Department of Neuroscience, University of Parma, Italy Electronic address
    Neurotoxicology 43:3-9. 2014
    ..Its differential expression in males and females may explain gender differences in the incidence of various diseases, including neurodevelopmental, neurological, and neurodegenerative diseases. ..
  2. pmc Developmental neurotoxicity: some old and new issues
    Gennaro Giordano
    Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE, Suite 100, Seattle, WA 98105, USA
    ISRN Toxicol 2012:814795. 2012
    ..Guidelines for developmental neurotoxicity testing have been implemented, but there is still room for their improvement and for searching and validating alternative testing approaches...
  3. pmc Neurotoxicants are in the air: convergence of human, animal, and in vitro studies on the effects of air pollution on the brain
    Lucio G Costa
    Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt, Suite no 100, Seattle, WA 98105, USA Department of Neuroscience, University of Parma, Via Volturno 39, 43100 Parma, Italy
    Biomed Res Int 2014:736385. 2014
    ..In addition, air pollution exposure has been associated with increased expression of markers of neurodegenerative disease pathologies...
  4. pmc Behavioral Characterization of GCLM-Knockout Mice, a Model for Enhanced Susceptibility to Oxidative Stress
    Toby B Cole
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195, USA
    J Toxicol 2011:157687. 2011
    ..Results showed no differences between Gclm(-/-) and wild-type mice in any of the neurobehavioral tests. However, more subtle alterations, or changes which may appear as animals age, cannot be excluded...
  5. pmc Modulation of paraoxonase 2 (PON2) in mouse brain by the polyphenol quercetin: a mechanism of neuroprotection?
    Lucio G Costa
    Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE, Suite 100, Seattle, WA 98105, USA
    Neurochem Res 38:1809-18. 2013
    ..These findings suggest that induction of PON2 by quercetin represents an important mechanism by which this polyphenol may exert its neuroprotective action. ..
  6. doi request reprint The birth and early years of INA, the International Neurotoxicology Association
    Lucio G Costa
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA
    Neurotoxicology 36:89-103. 2013
    ..INA is registered as a scientific society in the Netherlands, and is an affiliated society of IUTOX. This paper presents a personal account of the events that led to the birth of INA, and of the first fifteen years of this association...
  7. pmc Paraoxonase 1 (PON1) as a genetic determinant of susceptibility to organophosphate toxicity
    Lucio G Costa
    Dept of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA
    Toxicology 307:115-22. 2013
    ..Evidence is slowly emerging that a low PON1 status may increase susceptibility to OP toxicity in humans. Low PON1 activity may also contribute to the developmental toxicity and neurotoxicity of OPs, as shown by animal and human studies...
  8. pmc Low-level domoic acid protects mouse cerebellar granule neurons from acute neurotoxicity: role of glutathione
    Gennaro Giordano
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, USA
    Toxicol Sci 132:399-408. 2013
    ..As Gclm (/) mice may represent a model for a common human polymorphism in GCLM, such individuals may be at particular risk for DomA-induced neurotoxicity...
  9. pmc An interview with Lucio G. Costa and Michael Aschner, section editors for toxicology
    Lucio G Costa
    Department of Environmental and Occupational Health Sciences University of Washington, 4225 Roosevelt 100, Seattle, WA 98105, USA
    BMC Pharmacol Toxicol 13:16. 2012
    ..elegans, tissue cultures and rodents) to understand the acute toxicity of manganese deposition in the brains of human neonates.In this interview we find out a little more about the key issues in the field of toxicology research...
  10. ncbi request reprint Current issues in organophosphate toxicology
    Lucio G Costa
    Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE, Suite 100 Seattle, WA 98105, USA
    Clin Chim Acta 366:1-13. 2006
    ..Continuing and recent debates, and molecular advances in these areas, and their contributions to our understanding of the toxicology of OPs are discussed...
  11. ncbi request reprint Contaminants in fish: risk-benefit considerations
    Lucio G Costa
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA
    Arh Hig Rada Toksikol 58:367-74. 2007
    ..Careful risk-benefit considerations should foster fish consumption while minimizing exposure to toxic contaminants...
  12. ncbi request reprint Modulation of paraoxonase (PON1) activity
    Lucio G Costa
    Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE, Suite 100, Seattle, WA 98105, USA
    Biochem Pharmacol 69:541-50. 2005
    ....
  13. ncbi request reprint Measurement of paraoxonase (PON1) status as a potential biomarker of susceptibility to organophosphate toxicity
    Lucio G Costa
    Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE, Suite 100 Seattle, WA 98105, USA
    Clin Chim Acta 352:37-47. 2005
    ..Documentation of exposure and of early health effects would be most relevant to increase the predictive value of the test...
  14. ncbi request reprint Signal transduction mechanisms involved in the antiproliferative effects of ethanol in glial cells
    L G Costa
    Department Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA
    Toxicol Lett 149:67-73. 2004
    ..Inhibition of astroglial cell proliferation by ethanol may contribute to the microencephaly present in most children diagnosed with the fetal alcohol syndrome...
  15. ncbi request reprint An in vitro approach to assess the toxicity of certain food contaminants: methylmercury and polychlorinated biphenyls
    Lucio G Costa
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA
    Toxicology 237:65-76. 2007
    ....
  16. pmc Developmental neurotoxicity of polybrominated diphenyl ether (PBDE) flame retardants
    Lucio G Costa
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, United States
    Neurotoxicology 28:1047-67. 2007
    ..Levels of PBDEs causing developmental neurotoxicity in animals are not much dissimilar from levels found in highly exposed infants and toddlers...
  17. ncbi request reprint Neurotoxicity of pesticides: a brief review
    Lucio G Costa
    Dept of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA
    Front Biosci 13:1240-9. 2008
    ..This brief review highlights some of the main neurotoxic pesticides, their effects, and mechanisms of action...
  18. pmc Domoic acid as a developmental neurotoxin
    Lucio G Costa
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA
    Neurotoxicology 31:409-23. 2010
    ..Given the potential higher susceptibility of the young to DomA neurotoxicity, additional studies investigating exposure to, and effects of this neurotoxin during brain development are warranted...
  19. pmc Pharmacological and dietary modulators of paraoxonase 1 (PON1) activity and expression: the hunt goes on
    Lucio G Costa
    Dept of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE, Seattle, WA 98105, USA
    Biochem Pharmacol 81:337-44. 2011
    ....
  20. pmc Is decabromodiphenyl ether (BDE-209) a developmental neurotoxicant?
    Lucio G Costa
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA
    Neurotoxicology 32:9-24. 2011
    ....
  21. doi request reprint In vitro neurotoxicology: an introduction
    Lucio G Costa
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA
    Methods Mol Biol 758:1-9. 2011
    ....
  22. pmc Developmental neuropathology of environmental agents
    Lucio G Costa
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, USA
    Annu Rev Pharmacol Toxicol 44:87-110. 2004
    ..Additionally, the issue of silent neurotoxicity, i.e., persistent morphological and/or biochemical injury that remains clinically unapparent until later in life, is discussed...
  23. ncbi request reprint Signal transduction in environmental neurotoxicity
    L G Costa
    Department of Environmental Health, University of Washington, Seattle 98105, USA
    Annu Rev Pharmacol Toxicol 38:21-43. 1998
    ..The possible causal relationship of such cellular and molecular interactions with known signs and symptoms of neurotoxicity are highlighted...
  24. ncbi request reprint Paraoxonase (PON 1) as a biomarker of susceptibility for organophosphate toxicity
    Lucio G Costa
    Department of Environmental Health, University of Washington, Seattle, Washington 98105 6099, USA
    Biomarkers 8:1-12. 2003
    ..Low PON1 activity may also contribute to the higher sensitivity of newborns to OP toxicity...
  25. ncbi request reprint Functional genomic of the paraoxonase (PON1) polymorphisms: effects on pesticide sensitivity, cardiovascular disease, and drug metabolism
    Lucio G Costa
    Department of Environmental Health, University of Washington, Seattle, Washington 98195, USA
    Annu Rev Med 54:371-92. 2003
    ..A more recent area of investigation, the role of PON1 in drug metabolism, is also discussed. We emphasize the importance of considering both PON1 isoforms and PON1 levels in disease/sensitivity association studies...
  26. ncbi request reprint Polymorphisms of paraoxonase (PON1) and their significance in clinical toxicology of organophosphates
    Lucio G Costa
    Department of Environmental Health, University of Washington, Seattle, Washington 98105 6099, USA
    J Toxicol Clin Toxicol 41:37-45. 2003
    ....
  27. ncbi request reprint Modulation of DNA synthesis by muscarinic cholinergic receptors
    L G Costa
    Department of Environmental Health, University of Washington, Seattle, USA
    Growth Factors 18:227-36. 2001
    ..The ability of acetylcholine to modulate DNA synthesis through muscarinic receptors may be relevant in the context of brain development and neoplastic growth...
  28. ncbi request reprint Intracellular signal transduction pathways as targets for neurotoxicants
    L G Costa
    Department of Environmental Health, University of Washington, 4225 Roosevelt 100, Seattle, WA 98105, USA
    Toxicology 160:19-26. 2001
    ....
  29. ncbi request reprint The emerging field of ecogenetics
    L G Costa
    Department of Environmental Health, University of Washington, Seattle 98105 6099, USA
    Neurotoxicology 21:85-9. 2000
    ..Furthermore, issues related to the functional significance of genetic polymorphisms, their interaction/combination, and ethical and societal considerations, are briefly addressed...
  30. ncbi request reprint Biochemical and molecular neurotoxicology: relevance to biomarker development, neurotoxicity testing and risk assessment
    L G Costa
    Department of Environmental Health, University of Washington, Seattle 98105 6099, USA
    Toxicol Lett 102:417-21. 1998
    ..The utilization of such information in the area of biomarkers of exposure and effects, and of in vitro testing is presented. Additionally, mechanistic issues related to genetic polymorphisms and risk assessment are discussed...
  31. ncbi request reprint Inhibition of muscarinic receptor-induced proliferation of astroglial cells by ethanol: mechanisms and implications for the fetal alcohol syndrome
    Lucio G Costa
    Department of Environmental Health, University of Washington, Seattle, WA, USA
    Neurotoxicology 23:685-91. 2002
    ..Inhibition of astroglial proliferation by ethanol may contribute to the microencephaly seen in FAS...
  32. doi request reprint Manganese inhibits the ability of astrocytes to promote neuronal differentiation
    Gennaro Giordano
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA
    Toxicol Appl Pharmacol 240:226-35. 2009
    ..These results indicate that Mn, by targeting astrocytes, affects their ability to promote neuronal differentiation by a mechanism which is likely to involve oxidative stress...
  33. pmc Ethanol inhibits muscarinic receptor-induced axonal growth in rat hippocampal neurons
    Kathryn L VanDeMark
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA
    Alcohol Clin Exp Res 33:1945-55. 2009
    ..This study investigated the effect of ethanol on the differentiation of rat hippocampal pyramidal neurons induced by carbachol as a possible mechanism involved in the developmental neurotoxicity of ethanol...
  34. ncbi request reprint 5' and 3' region variability in the dopamine transporter gene (SLC6A3), pesticide exposure and Parkinson's disease risk: a hypothesis-generating study
    Samir N P Kelada
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA
    Hum Mol Genet 15:3055-62. 2006
    ..66 (95% CI: 1.73-18.53). Thus, allelic variants in SLC6A3, which affect gene expression, are associated with PD in this population and may interact with occupational pesticide exposure to increase PD risk...
  35. pmc The activation of M1 muscarinic receptor signaling induces neuronal differentiation in pyramidal hippocampal neurons
    Kathryn L VanDeMark
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA
    J Pharmacol Exp Ther 329:532-42. 2009
    ..Together, these results show that cholinergic stimulation of prenatal hippocampal pyramidal neurons accelerates axonal growth through the induction of Ca(2+) mobilization and the activation of PKC and especially of ERK1/2...
  36. pmc Paraoxonase 1 (PON1) modulates the toxicity of mixed organophosphorus compounds
    Karen L Jansen
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195, USA
    Toxicol Appl Pharmacol 236:142-53. 2009
    ..Potentiation by PO was equivalent among all four genotypes. These results indicate that PON1 status can have a major influence on CaE-mediated detoxication of OP compounds...
  37. ncbi request reprint Organophosphorus insecticides chlorpyrifos and diazinon and oxidative stress in neuronal cells in a genetic model of glutathione deficiency
    Gennaro Giordano
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA
    Toxicol Appl Pharmacol 219:181-9. 2007
    ..These studies indicate that cytotoxicity of OPs involves generation of reactive oxygen species and is modulated by intracellular GSH, and suggest that it may involve disturbances in intracellular homeostasis of calcium...
  38. ncbi request reprint Review of the toxicology of chlorpyrifos with an emphasis on human exposure and neurodevelopment
    David L Eaton
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, USA
    Crit Rev Toxicol 38:1-125. 2008
    ....
  39. pmc Neurotoxicity of a polybrominated diphenyl ether mixture (DE-71) in mouse neurons and astrocytes is modulated by intracellular glutathione levels
    Gennaro Giordano
    Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE, Seattle, WA 98105, USA
    Toxicol Appl Pharmacol 232:161-8. 2008
    ..These findings suggest that the developmental neurotoxicity of PBDE may involve oxidative stress, and that individual with genetic polymorphisms leading to lower GSH levels may be more susceptible to their adverse effects...
  40. ncbi request reprint Inorganic lead activates the mitogen-activated protein kinase kinase-mitogen-activated protein kinase-p90(RSK) signaling pathway in human astrocytoma cells via a protein kinase C-dependent mechanism
    Hailing Lu
    Department of Environmental, University of Washington, Seattle, Washington 98105, USA
    J Pharmacol Exp Ther 300:818-23. 2002
    ..Stimulation of DNA synthesis by lead in astrocytoma cells may be of interest in light of the observed association between exposure to lead and an increased risk of astrocytomas...
  41. pmc Shotgun proteomics implicates extracellular matrix proteins and protease systems in neuronal development induced by astrocyte cholinergic stimulation
    Nadia H Moore
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, USA
    J Neurochem 108:891-908. 2009
    ....
  42. ncbi request reprint Pharmacogenomic considerations of the paraoxonase polymorphisms
    Clement E Furlong
    Department of genome Services, University of Washington, Seattle, WA 98195, USA
    Pharmacogenomics 3:341-8. 2002
    ....
  43. pmc Modulation of neuritogenesis by astrocyte muscarinic receptors
    Marina Guizzetti
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, USA
    J Biol Chem 283:31884-97. 2008
    ..Taken together, these results demonstrate that cholinergic muscarinic stimulation of astrocytes induces the release of permissive factors that accelerate neuronal development...
  44. doi request reprint Sonic hedgehog in Smith-Lemli-Opitz syndrome and tumor development
    Marina Guizzetti
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA
    J Pediatr Hematol Oncol 30:641-2. 2008
  45. pmc Ethanol inhibits neuritogenesis induced by astrocyte muscarinic receptors
    Marina Guizzetti
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA
    Glia 58:1395-406. 2010
    ..This study identifies a potential novel mechanism involved in the developmental effects of ethanol mediated by the interaction of ethanol with cell signaling in astrocytes, leading to an impairment in neuron-astrocyte communication...
  46. ncbi request reprint Effect of ethanol on protein kinase Czeta and p70S6 kinase activation by carbachol: a possible mechanism for ethanol-induced inhibition of glial cell proliferation
    Marina Guizzetti
    Department of Environmental Health, University of Washington, 4229 Roosevelt Way NE 100, Seattle, WA 98105, USA
    J Neurochem 82:38-46. 2002
    ..These results indicate that activation of the PKCzeta--> p70S6K pathway by M3 mAChRs may play a role in the increased DNA synthesis and may represent a target for ethanol-induced inhibition of astroglial cell proliferation...
  47. ncbi request reprint Gender difference in the interaction of smoking and monoamine oxidase B intron 13 genotype in Parkinson's disease
    Samir N Kelada
    Department of Environmental Health, University of Washington, Seattle 98195, USA
    Neurotoxicology 23:515-9. 2002
    ..These results suggest that a strong gender difference exists with respect to the modifying effect of MAO-B genotype on the smoking association with PD...
  48. pmc Comparative cytotoxicity and intracellular accumulation of five polybrominated diphenyl ether congeners in mouse cerebellar granule neurons
    Suping C Huang
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, USA
    Toxicol Sci 114:124-32. 2010
    ....
  49. pmc The toxicity of mixtures of specific organophosphate compounds is modulated by paraoxonase 1 status
    Toby B Cole
    Department of Medicine and Genome Sciences, University of Washington, Seattle, WA, USA
    Adv Exp Med Biol 660:47-60. 2010
    ..PON1 status can also impact the capacity to metabolize drugs or other CaE substrates following insecticide exposure...
  50. ncbi request reprint Role of paraoxonase (PON1) status in pesticide sensitivity: genetic and temporal determinants
    Clement E Furlong
    Genome Sciences and Medicine, Division of Medical Genetics, University of Washington, Box 357720, Seattle, WA 98195 7720, USA
    Neurotoxicology 26:651-9. 2005
    ..Our studies indicate that children less than 2 years old, especially those homozygous for PON1Q192, would be predicted to be particularly susceptible to CPO toxicity...
  51. ncbi request reprint Genotype combinations for monoamine oxidase-B intron 13 polymorphism and dopamine D2 receptor TaqIB polymorphism are associated with ever-smoking status among men
    Paola Costa-Mallen
    Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE, 100, Seattle, WA 98105, USA
    Neurosci Lett 385:158-62. 2005
    ..These results demonstrate that particular combinations of genotypes for MAO-B and DRD2 genes are associated with significantly higher risk for smoking behavior in men, but not in women...
  52. ncbi request reprint Toxicity of chlorpyrifos and chlorpyrifos oxon in a transgenic mouse model of the human paraoxonase (PON1) Q192R polymorphism
    Toby B Cole
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98195 7720, USA
    Pharmacogenet Genomics 15:589-98. 2005
    ..The current study examined the relevance of these observations for in-vivo exposures to chlorpyrifos and chlorpyrifos oxon...
  53. ncbi request reprint Dopamine transporter (SLC6A3) 5' region haplotypes significantly affect transcriptional activity in vitro but are not associated with Parkinson's disease
    Samir N Kelada
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, USA
    Pharmacogenet Genomics 15:659-68. 2005
    ..In addition, our findings provide further evidence supporting an association of PD with the VNTR polymorphism...
  54. ncbi request reprint Effect of organophosphorus insecticides and their metabolites on astroglial cell proliferation
    Marina Guizzetti
    Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way N E 100, Seattle, WA 98105, USA
    Toxicology 215:182-90. 2005
    ....
  55. ncbi request reprint Characterization of the in vitro transcriptional activity of polymorphic alleles of the human monoamine oxidase-B gene
    Paola Costa-Mallen
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, 98105, USA
    Neurosci Lett 383:171-5. 2005
    ..Allele G of intron 13 had significantly higher activity than allele A in both cell lines. These results indicate transcriptional activity differences between MAO-B variant alleles that are naturally occurring in the population...
  56. ncbi request reprint In vivo ethanol decreases phosphorylated MAPK and p70S6 kinase in the developing rat brain
    Ryozo Tsuji
    Department of Environmental Health, University of Washington, 4225 Roosevelt Way NE, 100 Seattle, WA 98105 6099, USA
    Neuroreport 14:1395-9. 2003
    ..These results suggest that phosphorylation of MAPK and p70S6 kinase may represent relevant targets for the developmental neurotoxicity of ethanol, and may be involved in microencephaly...
  57. ncbi request reprint Ethanol induces cholesterol efflux and up-regulates ATP-binding cassette cholesterol transporters in fetal astrocytes
    Marina Guizzetti
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, USA
    J Biol Chem 282:18740-9. 2007
    ..Ethanol did not affect cholesterol synthesis and reduced the levels of intracellular cholesterol in rat astrocytes. Retinoic acid, which induces teratogenic effects similarly to ethanol, also caused up-regulation of ABCA1 and ABCG1...
  58. ncbi request reprint Ethanol inhibits muscarinic receptor-mediated DNA synthesis and signal transduction in human fetal astrocytes
    Marina Guizzetti
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA
    Neurosci Lett 344:68-70. 2003
    ....
  59. ncbi request reprint Role of phospholipase D signaling in ethanol-induced inhibition of carbachol-stimulated DNA synthesis of 1321N1 astrocytoma cells
    Marina Guizzetti
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, USA
    J Neurochem 90:646-53. 2004
    ..Moreover, the effect of ethanol on carbachol-induced proliferation appears to be mediated, at least in part, by its ability to interact with PLD leading to a decreased synthesis of PA...
  60. ncbi request reprint DNA sequence analysis of monoamine oxidase B gene coding and promoter regions in Parkinson's disease cases and unrelated controls
    Paola Costa-Mallen
    Department of Environmental and Occupational Health Sciences, School of Public Health and Community Medicine, University of Washington, Seattle, Washington 98195 6099, USA
    Mov Disord 19:76-83. 2004
    ..No commonly occurring (>10%) polymorphisms were found in the exons or the intronic sequences flanking the exons, although several rare variants were detected in the coding and promoter regions...
  61. ncbi request reprint Disruption of cholesterol homeostasis in the developing brain as a potential mechanism contributing to the developmental neurotoxicity of ethanol: an hypothesis
    Marina Guizzetti
    Department of Environmental and Occupational Health Sciences, School of Public Health and Community Medicine, Toxicology Program, University of Washington, Seattle, WA 98105, USA
    Med Hypotheses 64:563-7. 2005
    ....
  62. ncbi request reprint Glutathione levels modulate domoic acid induced apoptosis in mouse cerebellar granule cells
    Gennaro Giordano
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA
    Toxicol Sci 100:433-44. 2007
    ..These results indicate that low concentrations of domoic acid cause apoptotic neuronal cell death mediated by oxidative stress...
  63. ncbi request reprint Paraoxonase 1 (PON1) status and risk of insecticide exposure
    Clement E Furlong
    Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA 98195 7720, USA
    J Biochem Mol Toxicol 19:182-3. 2005
  64. ncbi request reprint Developmental neurotoxicity of toluene: in vivo and in vitro effects on astroglial cells
    Mark Burry
    Toxicology Program, University of Washington, Seattle, WA 98105, USA
    Dev Neurosci 25:14-9. 2003
    ..These results indicate that toluene does not cause selective microencephaly; however, it affects brain weight, and appears to target developing astrocytes, possibly by inhibiting their proliferation...
  65. pmc Mouse cerebellar astrocytes protect cerebellar granule neurons against toxicity of the polybrominated diphenyl ether (PBDE) mixture DE-71
    Gennaro Giordano
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA
    Neurotoxicology 30:326-9. 2009
    ..Since several polymorphisms, including some in the Gclm gene, cause very low levels of GSH, it may be speculated that such individuals might display a higher susceptibility to the neurotoxic effects of PBDEs...
  66. ncbi request reprint Expression of human paraoxonase (PON1) during development
    Toby B Cole
    Departments of Environmental Health, University of Washington, Seattle 98195 7720, USA
    Pharmacogenetics 13:357-64. 2003
    ..Since PON1 levels are important in determining resistance to specific organophosphorus compounds, the time course of appearance of PON1 in newborns is of great interest...
  67. doi request reprint Effects of postnatal ethanol exposure at different developmental phases on neurotrophic factors and phosphorylated proteins on signal transductions in rat brain
    Ryozo Tsuji
    Environmental Health Science Laboratory, Sumitomo Chemical Co Ltd, 3 1 98 Kasugade naka, Osaka 554 8559, Japan
    Neurotoxicol Teratol 30:228-36. 2008
    ..These findings suggest that GDNF and the phosphorylation of Akt play a possible key role in the ethanol-induced developmental neurotoxicity...
  68. ncbi request reprint Effects of postnatal ethanol exposure on neurotrophic factors and signal transduction pathways in rat brain
    Vittorio Fattori
    Environmental Health Science Laboratory, Sumitomo Chemical Co Ltd, 3 1 98 Kasugade naka, Konohana ku, Osaka 554 8558, Japan
    J Appl Toxicol 28:370-6. 2008
    ..These results suggest that BDNF and its related signal pathways involving Akt, MAPK and p70S6K are potential targets of ethanol-induced developmental neurotoxicity...
  69. ncbi request reprint Differential in vitro neurotoxicity of the flame retardant PBDE-99 and of the PCB Aroclor 1254 in human astrocytoma cells
    Federica Madia
    Department of Pharmacology of Natural Substances and General Physiology, University of Rome La Sapienza, Italy
    Toxicol Lett 154:11-21. 2004
    ..These results suggest that PBDE-99 and Aroclor 1254 exert differential cytotoxic effects on human astroglial cells...
  70. ncbi request reprint Activation of NMDA receptors induces protein kinase A-mediated phosphorylation and degradation of matrin 3. Blocking these effects prevents NMDA-induced neuronal death
    Gennaro Giordano
    Laboratory of Neurobiology, Fundacion Valenciana de Investigaciones Biomedicas, Valencia, Spain
    J Neurochem 94:808-18. 2005
    ....
  71. ncbi request reprint Chronic exposure to ammonia induces isoform-selective alterations in the intracellular distribution and NMDA receptor-mediated translocation of protein kinase C in cerebellar neurons in culture
    Gennaro Giordano
    Laboratory of Neurobiology, Fundacion Valenciana de Investigaciones Biomédicas Valencia, Spain
    J Neurochem 92:143-57. 2005
    ..Chronic hyperammonemia reduces Ca+2-mediated but not diacylglycerol-mediated translocation of PKC isoforms induced by NMDA...
  72. ncbi request reprint Effects of perinatal exposure to a polybrominated diphenyl ether (PBDE 99) on mouse neurobehavioural development
    Igor Branchi
    Department of Pharmacology of Natural Substances and General Physiology, University of Rome La Sapienza, Italy
    Neurotoxicology 23:375-84. 2002
    ..The possibility of exposure of neonates to PBDEs warrants further studies to characterise their developmental neurotoxicity...
  73. ncbi request reprint Paraoxonase (PON1): from toxicology to cardiovascular medicine
    Lucio G Costa
    Dept of Human Anatomy, Pharmacology and Forensic Science, University of Parma Medical School, Parma, Italy
    Acta Biomed 76:50-7. 2005
    ....
  74. ncbi request reprint Polybrominated diphenyl ethers: neurobehavioral effects following developmental exposure
    Igor Branchi
    Section of Behavioural Pathophysiology, Laboratorio di Fisiopatologia, Istituto Superiore di Sanita, Rome, Italy
    Neurotoxicology 24:449-62. 2003
    ....
  75. ncbi request reprint Early developmental exposure to BDE 99 or Aroclor 1254 affects neurobehavioural profile: interference from the administration route
    Igor Branchi
    Istituto Superiore di Sanita, Section of Behavioural Neuroscience, Department of Cell Biology and Neuroscience, Viale Regina Elena 299, 00161 Rome, Italy
    Neurotoxicology 26:183-92. 2005
    ....
  76. ncbi request reprint Characterization of the effect of Epilobium extracts on human cell proliferation
    Annabella Vitalone
    Department of Pharmacology of Natural Substances and General Physiology, University of Rome La Sapienza, Piazzale Aldo Moro 5, IT 00185 Rome, Italy
    Pharmacology 69:79-87. 2003
    ..The difference observed between extracts from the same species underscores the importance of determination and standardization of active ingredients in phytotherapeutic agents...
  77. ncbi request reprint In vitro assessment of mutagenicity and clastogenicity of BDE-99, a pentabrominated diphenyl ether flame retardant
    Maria G Evandri
    Department of Pharmacology of Natural Substances and General Physiology, University of Rome La Sapienza, Rome, Italy
    Environ Mol Mutagen 42:85-90. 2003
    ..cepa. In conclusion, BDE-99 was not mutagenic in S. typhimurium or E. coli, or clastogenic in A. cepa; however, the possibility that PBDEs might act through an epigenetic mechanism cannot be excluded...
  78. doi request reprint Application of in vitro neurotoxicity testing for regulatory purposes: Symposium III summary and research needs
    Anna K Bal-Price
    European Centre for the Validation of Alternative Methods ECVAM, Institute of Health and Consumer Protection, European Commission Joint Research Centre, Ispra Va, Italy
    Neurotoxicology 29:520-31. 2008
    ....
  79. ncbi request reprint Extracts of various species of Epilobium inhibit proliferation of human prostate cells
    Annabella Vitalone
    Dept of Pharmacology of Natural Substances and General Physiology, University of Roma La Sapienza, Rome, Italy
    J Pharm Pharmacol 55:683-90. 2003
    ..This study provides some initial biological plausibility for the use of Epilobium extracts in benign prostatic hyperplasia...
  80. ncbi request reprint Correspondence re: Navas-Acien et al., Interactive effect of chemical substances and occupational electromagnetic field exposure on the risk of gliomas and meningiomas in Swedish men. 11:1678-1683, 2002
    Lucio G Costa
    Cancer Epidemiol Biomarkers Prev 12:950. 2003

Research Grants19

  1. Developmental neurotoxicity of ethanol
    LUCIO COSTA; Fiscal Year: 2009
    ..Altogether, these studies are aimed at elucidating novel aspects of the communication between astrocytes and neurons and at characterizing new mechanisms involved in the developmental neurotoxicity of ethanol. ..
  2. Developmental neurotoxicity of ethanol
    LUCIO COSTA; Fiscal Year: 2009
    ..Altogether, these studies are aimed at elucidating novel aspects of the communication between astrocytes and neurons and at characterizing new mechanisms involved in the developmental neurotoxicity of ethanol. ..
  3. Developmental neurotoxicity of ethanol
    LUCIO COSTA; Fiscal Year: 2007
    ..Altogether, these studies are aimed at elucidating novel aspects of the communication between astrocytes and neurons and at characterizing new mechanisms involved in the developmental neurotoxicity of ethanol. ..
  4. ETHANOL AND PHOSPHOINOSITIDES DURING BRAIN DEVELOPMENT
    LUCIO COSTA; Fiscal Year: 2000
    ..2. To investigate the molecular pathways involved in the observed inhibition by ethanol of the mitogenic action of acetylcholine in astrocytes. ..
  5. ETHANOL AND PHOSPHOINOSITIDES DURING BRAIN DEVELOPMENT
    LUCIO COSTA; Fiscal Year: 1993
    ....
  6. ETHANOL AND PHOSPHOINOSITIDES DURING BRAIN DEVELOPMENT
    LUCIO COSTA; Fiscal Year: 1991
    ....
  7. ETHANOL AND PHOSPHOINOSITIDES DURING BRAIN DEVELOPMENT
    LUCIO COSTA; Fiscal Year: 1999
    ..2. To investigate the molecular pathways involved in the observed inhibition by ethanol of the mitogenic action of acetylcholine in astrocytes. ..
  8. ETHANOL AND PHOSPHOINOSITIDES DURING BRAIN DEVELOPMENT
    LUCIO COSTA; Fiscal Year: 1992
    ....
  9. Developmental neurotoxicity of ethanol
    Lucio G Costa; Fiscal Year: 2010
    ..Altogether, these studies are aimed at elucidating novel aspects of the communication between astrocytes and neurons and at characterizing new mechanisms involved in the developmental neurotoxicity of ethanol. ..