Alberto C S Costa

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi Behavioral validation of the Ts65Dn mouse model for Down syndrome of a genetic background free of the retinal degeneration mutation Pde6b(rd1)
    Alberto C S Costa
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
    Behav Brain Res 206:52-62. 2010
  2. ncbi Acute injections of the NMDA receptor antagonist memantine rescue performance deficits of the Ts65Dn mouse model of Down syndrome on a fear conditioning test
    Alberto C S Costa
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
    Neuropsychopharmacology 33:1624-32. 2008
  3. ncbi Hypothermic responses to 8-OH-DPAT in the Ts65Dn mouse model of Down syndrome
    Melissa R Stasko
    Eleanor Roosevelt Institute, University of Denver, Denver, Colorado 80206, USA
    Neuroreport 17:837-41. 2006
  4. ncbi Experimental parameters affecting the Morris water maze performance of a mouse model of Down syndrome
    Melissa R Stasko
    Eleanor Roosevelt Institute at the University of Denver, 1899 Gaylord Street, Denver, CO 80206, USA
    Behav Brain Res 154:1-17. 2004
  5. ncbi Gait dynamics in trisomic mice: quantitative neurological traits of Down syndrome
    Thomas G Hampton
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Physiol Behav 82:381-9. 2004
  6. ncbi The mouse model of Down syndrome Ts65Dn presents visual deficits as assessed by pattern visual evoked potentials
    Jonah Jacob Scott-McKean
    Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    Invest Ophthalmol Vis Sci 51:3300-8. 2010
  7. ncbi The proteins of human chromosome 21
    Katheleen Gardiner
    Eleanor Roosevelt Institute, University of Denver, 1899 Gaylord Street, Denver, Colorado 80206, USA
    Am J Med Genet C Semin Med Genet 142:196-205. 2006
  8. ncbi G-protein-gated potassium (GIRK) channels containing the GIRK2 subunit are control hubs for pharmacologically induced hypothermic responses
    Alberto C S Costa
    Eleanor Roosevelt Institute, University of Denver, Denver, Colorado 80206, USA
    J Neurosci 25:7801-4. 2005
  9. ncbi On the promise of pharmacotherapies targeted at cognitive and neurodegenerative components of Down syndrome
    Alberto C S Costa
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University of Colorado Denver Anschutz Medical Campus, Aurora, CO 80045, USA
    Dev Neurosci 33:414-27. 2011
  10. ncbi Deficits in hippocampal CA1 LTP induced by TBS but not HFS in the Ts65Dn mouse: a model of Down syndrome
    Alberto C S Costa
    Eleanor Roosevelt Institute, University of Denver, 1899 Gaylord Street, Denver, CO 80206, USA
    Neurosci Lett 382:317-22. 2005

Research Grants

  1. SYNAPTIC PLASTICITY IN MOUSE MODELS FOR DOWN SYNDROME
    Alberto Costa; Fiscal Year: 2002
  2. MOUSE MODELS AND PHARMACOTHERAPIES FOR DOWN SYNDROME
    Alberto Costa; Fiscal Year: 2003

Collaborators

Detail Information

Publications14

  1. ncbi Behavioral validation of the Ts65Dn mouse model for Down syndrome of a genetic background free of the retinal degeneration mutation Pde6b(rd1)
    Alberto C S Costa
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
    Behav Brain Res 206:52-62. 2010
    ..Except for very subtle differences on water maze performance, we found no significant differences between Ts65Dn mice on the two backgrounds in the measures assessed...
  2. ncbi Acute injections of the NMDA receptor antagonist memantine rescue performance deficits of the Ts65Dn mouse model of Down syndrome on a fear conditioning test
    Alberto C S Costa
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
    Neuropsychopharmacology 33:1624-32. 2008
    ..These results are very promising from a potential therapeutic perspective, given memantine's current status as a Food and Drug Administration (FDA)-approved drug...
  3. ncbi Hypothermic responses to 8-OH-DPAT in the Ts65Dn mouse model of Down syndrome
    Melissa R Stasko
    Eleanor Roosevelt Institute, University of Denver, Denver, Colorado 80206, USA
    Neuroreport 17:837-41. 2006
    ..This finding may be relevant to the understanding of previously reported differences in serotoninergic neurotransmission in persons with Down syndrome...
  4. ncbi Experimental parameters affecting the Morris water maze performance of a mouse model of Down syndrome
    Melissa R Stasko
    Eleanor Roosevelt Institute at the University of Denver, 1899 Gaylord Street, Denver, CO 80206, USA
    Behav Brain Res 154:1-17. 2004
    ..More studies are needed to tease out further the potential effects of confounding factors on the performance of Ts65Dn mice...
  5. ncbi Gait dynamics in trisomic mice: quantitative neurological traits of Down syndrome
    Thomas G Hampton
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Physiol Behav 82:381-9. 2004
    ..This technique may provide opportunities for testing the efficacy of therapies for motor dysfunction in persons with DS...
  6. ncbi The mouse model of Down syndrome Ts65Dn presents visual deficits as assessed by pattern visual evoked potentials
    Jonah Jacob Scott-McKean
    Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    Invest Ophthalmol Vis Sci 51:3300-8. 2010
    ..Quantitative information was generated about visual function in the Ts65Dn mouse by investigating their visual capabilities by means of electroretinography (ERG) and patterned visual evoked potentials (pVEPs)...
  7. ncbi The proteins of human chromosome 21
    Katheleen Gardiner
    Eleanor Roosevelt Institute, University of Denver, 1899 Gaylord Street, Denver, Colorado 80206, USA
    Am J Med Genet C Semin Med Genet 142:196-205. 2006
    ....
  8. ncbi G-protein-gated potassium (GIRK) channels containing the GIRK2 subunit are control hubs for pharmacologically induced hypothermic responses
    Alberto C S Costa
    Eleanor Roosevelt Institute, University of Denver, Denver, Colorado 80206, USA
    J Neurosci 25:7801-4. 2005
    ..These channels also are involved in the alcohol-induced hypothermic response. These results have implications for the understanding of pharmacologically induced hypothermia and thermoregulatory mechanisms...
  9. ncbi On the promise of pharmacotherapies targeted at cognitive and neurodegenerative components of Down syndrome
    Alberto C S Costa
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University of Colorado Denver Anschutz Medical Campus, Aurora, CO 80045, USA
    Dev Neurosci 33:414-27. 2011
    ..The design and current status of this clinical trial will be discussed, which will be followed by some speculation on the potential impact of this and future clinical trials in the field of DS...
  10. ncbi Deficits in hippocampal CA1 LTP induced by TBS but not HFS in the Ts65Dn mouse: a model of Down syndrome
    Alberto C S Costa
    Eleanor Roosevelt Institute, University of Denver, 1899 Gaylord Street, Denver, CO 80206, USA
    Neurosci Lett 382:317-22. 2005
    ..However, future experiments to examine the state of hippocampus CA1 GABAergic inhibition in Ts65Dn mice will be necessary to further explore these hypotheses...
  11. ncbi An assessment of the vestibulo-ocular reflex (VOR) in persons with Down syndrome
    Alberto C S Costa
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University of Colorado Denver School of Medicine, 12700 East 19th Avenue, Campus Box C 237, Aurora, CO 80045, USA
    Exp Brain Res 214:199-213. 2011
    ..These findings may have implications to the understanding of the neurological basis of the motor dysfunction that affects performance in many practical tasks persons with DS encounter in their everyday lives...
  12. ncbi An assessment of optokinetic nystagmus (OKN) in persons with Down syndrome
    Alberto C S Costa
    Division of Clinical Pharmacology and Toxicology, Department of Medicine, University of Colorado Denver School of Medicine, 12700 East 19th Avenue, Campus Box C 237, Aurora, CO 80045, USA
    Exp Brain Res 214:381-91. 2011
    ..These findings may have implications to the understanding of the neurological basis of the motor dysfunction that affects performance in many practical tasks persons with DS encounter in their everyday lives...
  13. ncbi Fluoxetine rescues deficient neurogenesis in hippocampus of the Ts65Dn mouse model for Down syndrome
    Sarah Clark
    Department of Pharmacology and Exp. Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201-1509, USA
    Exp Neurol 200:256-61. 2006
    ....
  14. ncbi Down syndrome and genetics - a case of linked histories
    David Patterson
    Eleanor Roosevelt Institute, Department of Biological Sciences, University of Denver, Colorado 80206, USA
    Nat Rev Genet 6:137-47. 2005

Research Grants2

  1. SYNAPTIC PLASTICITY IN MOUSE MODELS FOR DOWN SYNDROME
    Alberto Costa; Fiscal Year: 2002
    ....
  2. MOUSE MODELS AND PHARMACOTHERAPIES FOR DOWN SYNDROME
    Alberto Costa; Fiscal Year: 2003
    ....