W Coryell

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc Age of onset and the prospectively observed course of illness in bipolar disorder
    William Coryell
    Department of Psychiatry, University of Iowa, Carver College of Medicine, 500 Newton Road, Iowa City, IA 52231 1190, United States
    J Affect Disord 146:34-8. 2013
  2. pmc Effects of anxiety on the long-term course of depressive disorders
    William Coryell
    Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, University of Iowa Hospitals and Clinics, 200 Hawkins, Iowa City, IA 52242, USA
    Br J Psychiatry 200:210-5. 2012
  3. ncbi request reprint Onset of spontaneous panic attacks: a prospective study of risk factors
    William Coryell
    University of Iowa Carver College of Medicine, Department of Psychiatry, 2 205 MEB, Iowa City, IA 52242, USA
    Psychosom Med 68:754-7. 2006
  4. doi request reprint Effects of escitalopram on anxiety and respiratory responses to carbon dioxide inhalation in subjects at high risk for panic disorder: a placebo-controlled, crossover study
    William Coryell
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    J Clin Psychopharmacol 29:174-8. 2009
  5. pmc Age transitions in the course of bipolar I disorder
    W Coryell
    Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Psychol Med 39:1247-52. 2009
  6. pmc Does major depressive disorder change with age?
    W Coryell
    Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, 52242, USA
    Psychol Med 39:1689-95. 2009
  7. ncbi request reprint Clinical predictors of suicide in primary major depressive disorder
    William Coryell
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    J Clin Psychiatry 66:412-7. 2005
  8. ncbi request reprint Rapid cycling bipolar disorder: clinical characteristics and treatment options
    William Coryell
    Psychiatry Research Department, University of Iowa, Carver College of Medicine, Iowa City, Iowa 52242, USA
    CNS Drugs 19:557-69. 2005
  9. ncbi request reprint Subgenual prefrontal cortex volumes in major depressive disorder and schizophrenia: diagnostic specificity and prognostic implications
    William Coryell
    Department of Psychiatry, 2 205 MEB, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242 1000, USA
    Am J Psychiatry 162:1706-12. 2005
  10. ncbi request reprint Anxiety responses to CO2 inhalation in subjects at high-risk for panic disorder
    William Coryell
    University of Iowa Carver College of Medicine, Iowa City, USA
    J Affect Disord 92:63-70. 2006

Research Grants

  1. NIMH COLLABORATIVE DEPRESSION STUDY
    William Coryell; Fiscal Year: 2004
  2. A COLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDER
    William Coryell; Fiscal Year: 2007
  3. COLLABORATIVE DEPRESSION STUDY
    William Coryell; Fiscal Year: 2007
  4. Genetics of Early-Onset Depression
    William Coryell; Fiscal Year: 2007
  5. TRAIT MARKER FOR PANIC DISORDER
    William Coryell; Fiscal Year: 2001
  6. A COLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDER
    William Coryell; Fiscal Year: 2001

Detail Information

Publications50

  1. pmc Age of onset and the prospectively observed course of illness in bipolar disorder
    William Coryell
    Department of Psychiatry, University of Iowa, Carver College of Medicine, 500 Newton Road, Iowa City, IA 52231 1190, United States
    J Affect Disord 146:34-8. 2013
    ..To test the validity of age-of-onset grouping in bipolar disorder through the use of prospectively observed time in mood episodes...
  2. pmc Effects of anxiety on the long-term course of depressive disorders
    William Coryell
    Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, University of Iowa Hospitals and Clinics, 200 Hawkins, Iowa City, IA 52242, USA
    Br J Psychiatry 200:210-5. 2012
    ..Important questions remain as to which anxiety features are important to outcome and how sustained their prognostic effects are over time...
  3. ncbi request reprint Onset of spontaneous panic attacks: a prospective study of risk factors
    William Coryell
    University of Iowa Carver College of Medicine, Department of Psychiatry, 2 205 MEB, Iowa City, IA 52242, USA
    Psychosom Med 68:754-7. 2006
    ..An association of those features with a subsequent onset of panic attacks would compose additional evidence that they are trait markers for panic disorder...
  4. doi request reprint Effects of escitalopram on anxiety and respiratory responses to carbon dioxide inhalation in subjects at high risk for panic disorder: a placebo-controlled, crossover study
    William Coryell
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    J Clin Psychopharmacol 29:174-8. 2009
    ....
  5. pmc Age transitions in the course of bipolar I disorder
    W Coryell
    Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Psychol Med 39:1247-52. 2009
    ....
  6. pmc Does major depressive disorder change with age?
    W Coryell
    Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, 52242, USA
    Psychol Med 39:1689-95. 2009
    ..The authors used results from a 20-year, high-intensity follow-up to measure the influence of ageing, and of age at onset, on the long-term persistence of symptoms in major depressive disorder (MDD)...
  7. ncbi request reprint Clinical predictors of suicide in primary major depressive disorder
    William Coryell
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    J Clin Psychiatry 66:412-7. 2005
    ..The following analysis takes advantage of a large cohort of depressed patients given detailed, structured interviews 2 decades ago...
  8. ncbi request reprint Rapid cycling bipolar disorder: clinical characteristics and treatment options
    William Coryell
    Psychiatry Research Department, University of Iowa, Carver College of Medicine, Iowa City, Iowa 52242, USA
    CNS Drugs 19:557-69. 2005
    ..The combination of lithium and carbamazepine, valproate or lamotrigine for maintenance has some support from controlled studies, as does the adjunctive use of olanzapine...
  9. ncbi request reprint Subgenual prefrontal cortex volumes in major depressive disorder and schizophrenia: diagnostic specificity and prognostic implications
    William Coryell
    Department of Psychiatry, 2 205 MEB, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242 1000, USA
    Am J Psychiatry 162:1706-12. 2005
    ..There are, as yet, few data to address the specificity of these abnormalities to depressive disorders or to characterize their stability over time...
  10. ncbi request reprint Anxiety responses to CO2 inhalation in subjects at high-risk for panic disorder
    William Coryell
    University of Iowa Carver College of Medicine, Iowa City, USA
    J Affect Disord 92:63-70. 2006
    ..The following was undertaken to confirm and extend these findings...
  11. pmc HPA-axis hyperactivity and mortality in psychotic depressive disorder: preliminary findings
    William Coryell
    Department of Psychiatry, University of Iowa Carver College of Medicine, 2 205 MEB, Iowa City, IA 52242, USA
    Psychoneuroendocrinology 33:654-8. 2008
    ..Among the possible mediators is the hypothalamic-pituitary-adrenal (HPA)-axis hyperactivity that characterizes many cases of relatively severe depressive disorder and severity is characteristic of psychotic depressive disorder...
  12. pmc Combined biological tests for suicide prediction
    William Coryell
    Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, 2 205 MEB, Iowa City, IA 52242 1000, USA
    Psychiatry Res 150:187-91. 2007
    ..These results indicate that, with the use of age-appropriate thresholds, serum cholesterol concentrations may be combined with DST results to provide a clinically useful estimate of suicide risk...
  13. ncbi request reprint The long-term course of rapid-cycling bipolar disorder
    William Coryell
    National Institute of Mental Health Collaborative Program on the Psychobiology of Depression Clinical Studies, National Institutes of Health, Bethesda, MD, USA
    Arch Gen Psychiatry 60:914-20. 2003
    ..To our knowledge, no prospective study has, as yet, described the course of this phenomenon beyond 5 years...
  14. doi request reprint Maintenance treatment in bipolar disorder: a reassessment of lithium as the first choice
    William Coryell
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    Bipolar Disord 11:77-83. 2009
    ..In consideration of the declining use of lithium over the past several decades, this review focuses on three topics to argue for lithium's status as first choice as the maintenance treatment of bipolar disorder...
  15. ncbi request reprint Lithium discontinuation and subsequent effectiveness
    W Coryell
    University of Iowa College of Medicine, Iowa City 52242 1000, USA
    Am J Psychiatry 155:895-8. 1998
    ..Several reports have raised concern that the discontinuation of lithium may result in treatment resistance following recurrence of affective disorder. This report explores this possibility...
  16. ncbi request reprint Persistence of depressive symptoms and cardiovascular death among patients with affective disorder
    W Coryell
    Department of Psychiatry, University of Iowa, Iowa City, USA
    Psychosom Med 61:755-61. 1999
    ....
  17. ncbi request reprint Clinical assessment of suicide risk in depressive disorder
    William H Coryell
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA
    CNS Spectr 11:455-61. 2006
    ..Observations that these measures appear to be additive, both with each other and with other clinical risk factors, indicate that a substantial improvement in the clinician's ability to assess suicide risk is possible...
  18. ncbi request reprint The prospectively observed course of illness among depressed patients who commit suicide
    William Coryell
    Department of Psychiatry, University of Iowa, Iowa City 52242 1000, USA
    Acta Psychiatr Scand 105:218-23. 2002
    ..These analyses were conducted to describe the course of illness among patients with major affective disorders who commit suicide...
  19. pmc Anxiety and outcome in bipolar disorder
    William Coryell
    Department of Psychiatry, University of Iowa Hospitals and Clinics, Iowa City, 52242, USA
    Am J Psychiatry 166:1238-43. 2009
    ..The authors sought to identify the anxiety features most predictive of subsequent affective morbidity and to evaluate the persistence of the prognostic relationship...
  20. ncbi request reprint The significance of psychotic features in manic episodes: a report from the NIMH collaborative study
    W Coryell
    University of Iowa College of Medicine, Psychiatry Research, 2-205 MEB, Iowa City, IA 52242-1000, USA
    J Affect Disord 67:79-88. 2001
    ..Psychotic features are much less predictive of future psychosis when they occur within a manic syndrome than when they occur within a depressive syndrome...
  21. ncbi request reprint Lithium and suicidal behavior in major affective disorder: a case-control study
    W Coryell
    Department of Psychiatry, University of Iowa, Iowa City, 52242-1000, USA
    Acta Psychiatr Scand 104:193-7. 2001
    ..Other existing datasets should be explored with this design to establish whether lithium does, or does not, offer special protection against suicide...
  22. ncbi request reprint The dexamethasone suppression test and suicide prediction
    W Coryell
    Department of Psychiatry, University of Iowa College of Medicine, Iowa City, IA 52242-1000, USA
    Am J Psychiatry 158:748-53. 2001
    ..Research on the pathophysiology of suicidal behavior in major depressive disorder should emphasize the HPA axis and its interplay with the serotonin system...
  23. ncbi request reprint Aberrant respiratory sensitivity to CO(2) as a trait of familial panic disorder
    W Coryell
    Department of Psychiatry, University of Iowa College of Medicine, Iowa City, Iowa 52242 1000, USA
    Biol Psychiatry 49:582-7. 2001
    ..This study sought to determine whether a heightened sensitivity to CO(2) manifests specifically in respiratory changes...
  24. ncbi request reprint The heritability of schizophrenia and schizoaffective disorder. A family study
    W Coryell
    Department of Psychiatry, University of Iowa, Iowa City 52242
    Arch Gen Psychiatry 45:323-7. 1988
    ....
  25. doi request reprint Genome-wide association study of recurrent early-onset major depressive disorder
    J Shi
    Department of Psychiatry, Stanford University, Stanford, CA, USA
    Mol Psychiatry 16:193-201. 2011
    ..Larger samples will be required to confirm the hypothesis of association between MDD (and particularly the recurrent early-onset subtype) and common SNPs...
  26. doi request reprint Residual symptom recovery from major affective episodes in bipolar disorders and rapid episode relapse/recurrence
    Lewis L Judd
    Department of Psychiatry, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0603, USA
    Arch Gen Psychiatry 65:386-94. 2008
    ..Both bipolar disorder type I and type II are characterized by frequent affective episode relapse and/or recurrence. An increasingly important goal of therapy is reducing chronicity by preventing or delaying additional episodes...
  27. doi request reprint Family-based association of YWHAH in psychotic bipolar disorder
    Deepak Grover
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    Am J Med Genet B Neuropsychiatr Genet 150:977-83. 2009
    ....
  28. ncbi request reprint Relationship of electroconvulsive therapy to course in affective illness: a collaborative study
    G winokur
    Department of Psychiatry, University of Iowa College of Medicine, Psychiatric Hospital, Iowa City 52242
    Eur Arch Psychiatry Clin Neurosci 240:54-9. 1990
    ..The findings suggest the need for long-term studies following ECT on clinical and biological variables...
  29. doi request reprint Family-based association of FKBP5 in bipolar disorder
    V L Willour
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Mol Psychiatry 14:261-8. 2009
    ..Ongoing whole-genome association studies in bipolar disorder and major depression should further clarify the role of FKBP5 and other HPA genes in these illnesses...
  30. ncbi request reprint A prospective investigation of the natural history of the long-term weekly symptomatic status of bipolar II disorder
    Lewis L Judd
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0603, USA
    Arch Gen Psychiatry 60:261-9. 2003
    ..This is the first prospective longitudinal study, to our knowledge, of the natural history of the weekly symptomatic status of bipolar II disorder (BP-II)...
  31. pmc Challenges assessing clinical endpoints in early Huntington disease
    Jane S Paulsen
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242 1000, USA
    Mov Disord 25:2595-603. 2010
    ..We conclude that future clinical trials designed for very early disease will require the development of new and more sensitive measures of real-life function...
  32. ncbi request reprint Psychosocial disability and work role function compared across the long-term course of bipolar I, bipolar II and unipolar major depressive disorders
    Lewis L Judd
    Department of Psychiatry, University of California at San Diego, La Jolla, CA 92093 0603, USA
    J Affect Disord 108:49-58. 2008
    ....
  33. ncbi request reprint Hyperactivity of the hypothalamic-pituitary-adrenal axis and mortality in major depressive disorder
    William Coryell
    Department of Psychiatry, University of Iowa, Roy J and Lucille A Carver College of Medicine, Iowa City, IA 52242 1000, USA
    Psychiatry Res 142:99-104. 2006
    ..Because nearly all previous reports of DST results and suicide described depressed inpatients, it is possible that the DST is a useful predictor only within this population...
  34. ncbi request reprint Psychosocial disability in the course of bipolar I and II disorders: a prospective, comparative, longitudinal study
    Lewis L Judd
    Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0603, USA
    Arch Gen Psychiatry 62:1322-30. 2005
    ..Evidence of psychosocial disability in bipolar disorder is based primarily on bipolar I disorder (BP-I) and does not relate disability to affective symptom severity and polarity or to bipolar II disorder (BP-II)...
  35. ncbi request reprint DSM-III personality disorder diagnoses in a nonpatient sample. Demographic correlates and comorbidity
    M Zimmerman
    Department of Psychiatry, University of Iowa College of Medicine, Iowa City 52242
    Arch Gen Psychiatry 46:682-9. 1989
    ..The demographic correlates and frequency of Axis I disorders in individuals with each specific PD were examined, and all but histrionic and passive-aggressive PDs had distinctive profiles...
  36. ncbi request reprint Loci on chromosomes 6q and 6p interact to increase susceptibility to bipolar affective disorder in the national institute of mental health genetics initiative pedigrees
    Thomas G Schulze
    Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Program, Bethesda, USA
    Biol Psychiatry 56:18-23. 2004
    ....
  37. ncbi request reprint Comorbid major depression and panic disorder: significance of temporal sequencing to familial transmission
    Lilian Dindo
    Psychiatry Research, Department of Psychiatry, College of Medicine, University of Iowa, MEB 2 202, Iowa City, IA 52242 1000, USA
    J Affect Disord 82:119-23. 2004
    ..Our aim was to determine if the risk for depression in a proband is influenced by the temporal sequence of comorbid PD and major depression in an affected family member...
  38. pmc Two variants in Ankyrin 3 (ANK3) are independent genetic risk factors for bipolar disorder
    T G Schulze
    Unit on the Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892 3719, USA
    Mol Psychiatry 14:487-91. 2009
    ..Further analysis suggested that each marker contributed independently to BD, with no significant marker x marker interaction. Our findings strongly support ANK3 as a BD susceptibility gene and suggest true allelic heterogeneity...
  39. pmc Genome-wide linkage and follow-up association study of postpartum mood symptoms
    Pamela Belmonte Mahon
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA
    Am J Psychiatry 166:1229-37. 2009
    ..The authors then fine-mapped their best linkage regions, assessing single nucleotide polymorphisms (SNPs) for genetic association with postpartum symptoms...
  40. doi request reprint Genome-wide parametric linkage analyses of 644 bipolar pedigrees suggest susceptibility loci at chromosomes 16 and 20
    Jessica Ross
    Department of Psychiatry, University of California, San Francisco, CA 94132 0984, USA
    Psychiatr Genet 18:191-8. 2008
    ..Our aim is to map chromosomal regions that harbor loci that increase susceptibility to bipolar disorder...
  41. ncbi request reprint Long-term symptomatic status of bipolar I vs. bipolar II disorders
    Lewis L Judd
    National Institute of Mental Health Collaborative Program on the Psychobiology of Depression Clinical Studies, San Diego, La Jolla, CA, USA
    Int J Neuropsychopharmacol 6:127-37. 2003
    ..However the genetic variation underlying such a putative spectrum remains to be clarified...
  42. doi request reprint Familial aggregation of postpartum mood symptoms in bipolar disorder pedigrees
    Jennifer L Payne
    Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    Bipolar Disord 10:38-44. 2008
    ..We sought to determine if postpartum mood symptoms and depressive episodes exhibit familial aggregation in bipolar I pedigrees...
  43. pmc CAG-repeat length and the age of onset in Huntington disease (HD): a review and validation study of statistical approaches
    Douglas R Langbehn
    Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242 1000, USA
    Am J Med Genet B Neuropsychiatr Genet 153:397-408. 2010
    ..The Langbehn et al. model appears accurate enough to have substantial utility in various research contexts. We also emphasize remaining caveats, many of which are relevant for any direct application to genetic counseling...
  44. ncbi request reprint Is perinatal depression familial?
    Kathleen Murphy-Eberenz
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 3309, USA
    J Affect Disord 90:49-55. 2006
    ....
  45. ncbi request reprint Unipolar mania over the course of a 20-year follow-up study
    David A Solomon
    NIMH Collaborative Program on the Psychobiology of Depression Clinical Studies, at Mood Disorders Program, Department of Psychiatry, Rhode Island Hospital, 593 Eddy Street, Providence RI 02903 4970, USA
    Am J Psychiatry 160:2049-51. 2003
    ..Using data from a longitudinal study of the mood disorders, the investigators address the phenomenon of unipolar mania...
  46. pmc Rostral anterior cingulate cortex volume correlates with depressed mood in normal healthy children
    Aaron D Boes
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA
    Biol Psychiatry 63:391-7. 2008
    ....
  47. ncbi request reprint Association of an exonic LDHA polymorphism with altered respiratory response in probands at high risk for panic disorder
    Robert A Philibert
    Department of Psychiatry, The University of Iowa, Iowa City, Iowa 52242 1000, USA
    Am J Med Genet B Neuropsychiatr Genet 117:11-7. 2003
    ....
  48. ncbi request reprint Bupropion in the treatment of pathological gambling: a randomized, double-blind, placebo-controlled, flexible-dose study
    Donald W Black
    Department of Psychiatry, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, IA 52242, USA
    J Clin Psychopharmacol 27:143-50. 2007
    ..The high placebo response rate and the high noncompletion rate each reflect the challenge inherent in treating persons with PG...
  49. pmc Cholesterol and suicide attempts: a prospective study of depressed inpatients
    Jess G Fiedorowicz
    Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, University of Iowa Hospitals and Clinics, 200 Hawkins Drive W279 GH, Iowa City, IA 52242, USA
    Psychiatry Res 152:11-20. 2007
    ..The results from this prospective dataset do not support an association between low cholesterol and subsequent suicide attempts despite replicating the retrospective findings of previous case-control and cross-sectional studies...
  50. ncbi request reprint Illness prediction in psychiatry
    Christopher P Szabo
    Acta Psychiatr Scand 109:323-4. 2004

Research Grants28

  1. NIMH COLLABORATIVE DEPRESSION STUDY
    William Coryell; Fiscal Year: 2004
    ....
  2. A COLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDER
    William Coryell; Fiscal Year: 2007
    ..Analysis of the existing sib pair families plus this large set of cases and controls should permit the confirmation of several vulnerability genes during this grant period. ..
  3. COLLABORATIVE DEPRESSION STUDY
    William Coryell; Fiscal Year: 2007
    ....
  4. Genetics of Early-Onset Depression
    William Coryell; Fiscal Year: 2007
    ..abstract_text> ..
  5. TRAIT MARKER FOR PANIC DISORDER
    William Coryell; Fiscal Year: 2001
    ..If the study's predictions are sustained, subsequent efforts will be directed toward lengthening the follow-up period and toward an eventual, ten-year diagnostic reassessment. ..
  6. A COLLABORATIVE GENOMIC STUDY OF BIPOLAR DISORDER
    William Coryell; Fiscal Year: 2001
    ..Genotypes will be shared with a consortium of investigators studying linkage in bipolar illness. Cell lines and interview data will be made freely available to the scientific community. ..