S Corvera

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. pmc CD14 deficiency impacts glucose homeostasis in mice through altered adrenal tone
    James L Young
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 7:e29688. 2012
  2. pmc TGF beta receptor internalization into EEA1-enriched early endosomes: role in signaling to Smad2
    Susan Hayes
    Program in Molecular Medicine and Interdisciplinary Graduate Program, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Cell Biol 158:1239-49. 2002
  3. pmc Adipose tissue angiogenesis: impact on obesity and type-2 diabetes
    Silvia Corvera
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA Electronic address
    Biochim Biophys Acta 1842:463-72. 2014
  4. ncbi request reprint Keystone meeting summary: 'Adipogenesis, obesity, and inflammation' and 'Diabetes mellitus and the control of cellular energy metabolism, ' January 21-26, 2006, Vancouver, Canada
    Silvia Corvera
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Genes Dev 20:2193-201. 2006
  5. ncbi request reprint Signal transduction: stuck with FYVE domains
    S Corvera
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Sci STKE 2000:pe1. 2000
  6. ncbi request reprint Phosphatidylinositol 3-kinase and the control of endosome dynamics: new players defined by structural motifs
    S Corvera
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01615, USA
    Traffic 2:859-66. 2001
  7. ncbi request reprint Phosphoinositides in membrane traffic
    S Corvera
    Program in Molecular Medicine, Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Curr Opin Cell Biol 11:460-5. 1999
  8. ncbi request reprint Formation of c-Cbl.phosphatidylinositol 3-kinase complexes on lymphocyte membranes by a p56lck-independent mechanism
    D Hartley
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Biol Chem 271:21939-43. 1996
  9. ncbi request reprint The FYVE domain of early endosome antigen 1 is required for both phosphatidylinositol 3-phosphate and Rab5 binding. Critical role of this dual interaction for endosomal localization
    D C Lawe
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 275:3699-705. 2000
  10. ncbi request reprint Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction
    S Corvera
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester 01615, USA
    Trends Cell Biol 8:442-6. 1998

Research Grants

Collaborators

  • Alfonso Mora
  • S Hayes
  • Philipp E Scherer
  • Zhao Wang
  • H Stenmark
  • H Meisner
  • MITCHELL LAZAR
  • Olga Gealekman
  • Michael P Czech
  • Juerg Straubhaar
  • My Chouinard
  • James L Young
  • O Gealekman
  • Richard A Perugini
  • Vishwajeet Puri
  • Alison Burkart
  • Sarah Nicoloro
  • Leanne Wilson-Fritch
  • D Hartley
  • Anna Cerny
  • N Guseva
  • K Gurav
  • A Gusev
  • J J Dumas
  • S Malkani
  • Bruce Woda
  • C Hartigan
  • Evelyn A Kurt-Jones
  • M Thompson
  • Robert W Finberg
  • Nina Guseva
  • Kunal Gurav
  • Michael Thompson
  • Matthew Gorgoglione
  • Celia Hartigan
  • Khan Van Tran
  • Sarah Apotheker
  • D C Lawe
  • V Patki
  • S E Langille
  • Silvana Konda
  • Anil Chawla
  • Chenyi Lin
  • Sarah M C Nicoloro
  • Srijana Ranjit
  • Sarah M Nicoloro
  • John Leszyk
  • Patricia C Chui
  • E Sudharshan
  • D G Lambright
  • D Lawe
  • E Merithew
  • D Rajamani
  • D Lambright
  • R Heller-Harrison
  • M P Czech
  • J M Buxton
  • A Chawla
  • J J Holik
  • J K Klarlund

Detail Information

Publications19

  1. pmc CD14 deficiency impacts glucose homeostasis in mice through altered adrenal tone
    James L Young
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 7:e29688. 2012
    ..These results point out a previously unappreciated crosstalk between innate immune- and sympathoadrenal- systems, which exerts a major long-term effect on glucose homeostasis...
  2. pmc TGF beta receptor internalization into EEA1-enriched early endosomes: role in signaling to Smad2
    Susan Hayes
    Program in Molecular Medicine and Interdisciplinary Graduate Program, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Cell Biol 158:1239-49. 2002
    ..These results indicate that traffic of the TGF beta receptor into the endosome enables TGF beta signaling, revealing a novel function for the endosome as a compartment specialized for the amplification of certain extracellular signals...
  3. pmc Adipose tissue angiogenesis: impact on obesity and type-2 diabetes
    Silvia Corvera
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA Electronic address
    Biochim Biophys Acta 1842:463-72. 2014
    ..This article is part of a Special Issue entitled: Modulation of Adipose Tissue in Health and Disease. ..
  4. ncbi request reprint Keystone meeting summary: 'Adipogenesis, obesity, and inflammation' and 'Diabetes mellitus and the control of cellular energy metabolism, ' January 21-26, 2006, Vancouver, Canada
    Silvia Corvera
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Genes Dev 20:2193-201. 2006
    ....
  5. ncbi request reprint Signal transduction: stuck with FYVE domains
    S Corvera
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Sci STKE 2000:pe1. 2000
    ..The Perspective also addresses how proteins with FYVE domains and protein internalization are involved in signal transduction...
  6. ncbi request reprint Phosphatidylinositol 3-kinase and the control of endosome dynamics: new players defined by structural motifs
    S Corvera
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01615, USA
    Traffic 2:859-66. 2001
    ....
  7. ncbi request reprint Phosphoinositides in membrane traffic
    S Corvera
    Program in Molecular Medicine, Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Curr Opin Cell Biol 11:460-5. 1999
    ..A novel phosphoinositide appears to regulate effectors involved in the formation of multivesicular endosomes...
  8. ncbi request reprint Formation of c-Cbl.phosphatidylinositol 3-kinase complexes on lymphocyte membranes by a p56lck-independent mechanism
    D Hartley
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Biol Chem 271:21939-43. 1996
    ..PI 3-kinase complexes occur upstream or independently of mitogenic signal transduction pathways in T cells...
  9. ncbi request reprint The FYVE domain of early endosome antigen 1 is required for both phosphatidylinositol 3-phosphate and Rab5 binding. Critical role of this dual interaction for endosomal localization
    D C Lawe
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 275:3699-705. 2000
    ..Thus, the levels of Rab5 are rate-limiting for the recruitment of EEA1 to endosome membranes. PtdIns3P may play a role in modulating the Rab5 EEA1 interaction...
  10. ncbi request reprint Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction
    S Corvera
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester 01615, USA
    Trends Cell Biol 8:442-6. 1998
    ..This review discusses how the recent identification of proteins that interact directly with 3'-polyphosphoinositides has revealed novel potential interconnections between these fundamental cellular processes...
  11. ncbi request reprint Multivalent endosome targeting by homodimeric EEA1
    J J Dumas
    Program in Molecular Medicine and Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Cell 8:947-58. 2001
    ..A unique mode of membrane engagement deduced from the quaternary structure of the C-terminal region provides insight into the structural basis of endosome tethering...
  12. ncbi request reprint ADP-ribosylation factor 6 as a target of guanine nucleotide exchange factor GRP1
    S E Langille
    Program in Molecular Medicine, Worcester, Massachusetts 01605, USA
    J Biol Chem 274:27099-104. 1999
    ..Further, co-localization of GRP1 with ARF6, combined with its demonstrated ability to activate ARF6, suggests a physiological role for GRP1 in regulating ARF6 functions...
  13. ncbi request reprint Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl
    D Hartley
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester 01655, USA
    J Biol Chem 270:18260-3. 1995
    ..Thus, these results show important functional differences between the alpha and beta isoforms of p85 in vivo and point to c-cbl as a potentially important mediator of some of the functions of PI-3 kinase in intact cells...
  14. pmc Effect of rosiglitazone on capillary density and angiogenesis in adipose tissue of normoglycaemic humans in a randomised controlled trial
    O Gealekman
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01615, USA
    Diabetologia 55:2794-9. 2012
    ..This study aimed to determine whether the insulin-sensitising peroxisome proliferator-activated receptor ╬│ (PPAR╬│) activator rosiglitazone affects adipose tissue vascularisation in normal humans...
  15. ncbi request reprint Insulin stimulates the assembly of cytosolic clathrin onto adipocyte plasma membranes
    S Corvera
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester 01655
    J Biol Chem 265:2413-6. 1990
    ..These results suggest that insulin induces an increase in the assembly of cytosolic clathrin onto the plasma membrane in conjunction with its ability to increase the concentration of receptors on the cell surface...
  16. pmc Depot-specific differences and insufficient subcutaneous adipose tissue angiogenesis in human obesity
    Olga Gealekman
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01615, USA
    Circulation 123:186-94. 2011
    ..The objective of this study was to measure angiogenesis in visceral and subcutaneous adipose tissue and to establish whether there is a relationship between obesity, metabolic status, and the angiogenic properties of these depots...
  17. pmc Cidea is associated with lipid droplets and insulin sensitivity in humans
    Vishwajeet Puri
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 105:7833-8. 2008
    ..The data support a model whereby failure of this pathway results in ectopic lipid accumulation, insulin resistance, and its associated comorbidities in humans...
  18. pmc Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone
    Leanne Wilson-Fritch
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, 01601, USA
    J Clin Invest 114:1281-9. 2004
    ....
  19. pmc Enhanced angiogenesis in obesity and in response to PPARgamma activators through adipocyte VEGF and ANGPTL4 production
    Olga Gealekman
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Am J Physiol Endocrinol Metab 295:E1056-64. 2008
    ..Thus, the interplay between VEGF and ANGPTL4 could lead to a net expansion of the adipose tissue capillary network, required for adipose tissue growth, in response to PPARgamma activators...

Research Grants19

  1. PI-3 kinase effectors in insulin-responsive systems
    Silvia Corvera; Fiscal Year: 2010
    ..4) Define the mechanism of action of WDFY2 by identifying proteins that specifically interact with its WD-40 motifs using proteomic and 2-hybrid approaches. ..
  2. PI-3 kinase effectors in insulin-responsive systems
    Silvia Corvera; Fiscal Year: 2009
    ..4) Define the mechanism of action of WDFY2 by identifying proteins that specifically interact with its WD-40 motifs using proteomic and 2-hybrid approaches. ..
  3. PI-3 kinase effectors in insulin-responsive systems
    Silvia Corvera; Fiscal Year: 2007
    ..4) Define the mechanism of action of WDFY2 by identifying proteins that specifically interact with its WD-40 motifs using proteomic and 2-hybrid approaches. ..
  4. Diabetes Mellitus and the Control of Energy Metabolism
    Silvia Corvera; Fiscal Year: 2005
    ..Collaborative efforts between investigators in these areas and those involved in chemistry and therapeutics are envisioned to result from this meeting. ..
  5. PI 3-kinase Effectors in Insulin Responsive Systems
    Silvia Corvera; Fiscal Year: 2005
    ..To test the hypothesis that signal transduction to nuclear import requires endosomal localization, we will study two paradigms; the TGFbeta to Smad2 pathway, and the insulin to p42/44 MAP kinase pathway. ..
  6. PI 3-kinase Effectors in Insulin Responsive Systems
    Silvia Corvera; Fiscal Year: 2004
    ..To test the hypothesis that signal transduction to nuclear import requires endosomal localization, we will study two paradigms; the TGFbeta to Smad2 pathway, and the insulin to p42/44 MAP kinase pathway. ..
  7. Novel Imaging Technologies applied to Insulin Action
    Silvia Corvera; Fiscal Year: 2004
    ..SPECIFIC AIM 4: To test the hypothesis that insulin stimulates budding of GLUT4 vesicles from the juxtanuclear region by imaging at higher spatial and temporal resolution. ..
  8. PI 3-kinase Effectors in Insulin Responsive Systems
    Silvia Corvera; Fiscal Year: 2003
    ..To test the hypothesis that signal transduction to nuclear import requires endosomal localization, we will study two paradigms; the TGFbeta to Smad2 pathway, and the insulin to p42/44 MAP kinase pathway. ..
  9. Novel Imaging Technologies applied to Insulin Action
    Silvia Corvera; Fiscal Year: 2003
    ..SPECIFIC AIM 4: To test the hypothesis that insulin stimulates budding of GLUT4 vesicles from the juxtanuclear region by imaging at higher spatial and temporal resolution. ..
  10. PI 3-kinase Effectors in Insulin Responsive Systems
    Silvia Corvera; Fiscal Year: 2002
    ..To test the hypothesis that signal transduction to nuclear import requires endosomal localization, we will study two paradigms; the TGFbeta to Smad2 pathway, and the insulin to p42/44 MAP kinase pathway. ..
  11. Novel Imaging Technologies applied to Insulin Action
    Silvia Corvera; Fiscal Year: 2002
    ..SPECIFIC AIM 4: To test the hypothesis that insulin stimulates budding of GLUT4 vesicles from the juxtanuclear region by imaging at higher spatial and temporal resolution. ..
  12. PI3 KINASE EFFECTORS IN INSULIN RESPONSIVE SYSTEMS
    Silvia Corvera; Fiscal Year: 2001
    ..3) To characterize the structure and general function of accessory peptides that have been found to interact with EEA1. 4) To determine which of the known PI-3 kinases present in mammalian cells is relevant for EEA1 function. ..
  13. Novel Imaging Technologies applied to Insulin Action
    Silvia Corvera; Fiscal Year: 2001
    ..SPECIFIC AIM 4: To test the hypothesis that insulin stimulates budding of GLUT4 vesicles from the juxtanuclear region by imaging at higher spatial and temporal resolution. ..
  14. PI3 KINASE EFFECTORS IN INSULIN RESPONSIVE SYSTEMS
    Silvia Corvera; Fiscal Year: 2000
    ..3) To characterize the structure and general function of accessory peptides that have been found to interact with EEA1. 4) To determine which of the known PI-3 kinases present in mammalian cells is relevant for EEA1 function. ..
  15. PI3 KINASE EFFECTORS IN INSULIN RESPONSIVE SYSTEMS
    Silvia Corvera; Fiscal Year: 1999
    ..3) To characterize the structure and general function of accessory peptides that have been found to interact with EEA1. 4) To determine which of the known PI-3 kinases present in mammalian cells is relevant for EEA1 function. ..
  16. PI-3 kinase effectors in insulin-responsive systems
    Silvia Corvera; Fiscal Year: 2010
    ..4) Define the mechanism of action of WDFY2 by identifying proteins that specifically interact with its WD-40 motifs using proteomic and 2-hybrid approaches. ..