S Corvera

Summary

Affiliation: University of Massachusetts Medical Center
Country: USA

Publications

  1. ncbi request reprint Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction
    S Corvera
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester 01615, USA
    Trends Cell Biol 8:442-6. 1998
  2. ncbi request reprint The FYVE domain of early endosome antigen 1 is required for both phosphatidylinositol 3-phosphate and Rab5 binding. Critical role of this dual interaction for endosomal localization
    D C Lawe
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 275:3699-705. 2000
  3. ncbi request reprint Formation of c-Cbl.phosphatidylinositol 3-kinase complexes on lymphocyte membranes by a p56lck-independent mechanism
    D Hartley
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Biol Chem 271:21939-43. 1996
  4. ncbi request reprint Signal transduction: stuck with FYVE domains
    S Corvera
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Sci STKE 2000:pe1. 2000
  5. ncbi request reprint Phosphatidylinositol 3-kinase and the control of endosome dynamics: new players defined by structural motifs
    S Corvera
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01615, USA
    Traffic 2:859-66. 2001
  6. ncbi request reprint Multivalent endosome targeting by homodimeric EEA1
    J J Dumas
    Program in Molecular Medicine and Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Cell 8:947-58. 2001
  7. ncbi request reprint ADP-ribosylation factor 6 as a target of guanine nucleotide exchange factor GRP1
    S E Langille
    Program in Molecular Medicine, Worcester, Massachusetts 01605, USA
    J Biol Chem 274:27099-104. 1999
  8. ncbi request reprint Phosphoinositides in membrane traffic
    S Corvera
    Program in Molecular Medicine, Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Curr Opin Cell Biol 11:460-5. 1999
  9. ncbi request reprint Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl
    D Hartley
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester 01655, USA
    J Biol Chem 270:18260-3. 1995
  10. ncbi request reprint Insulin stimulates the assembly of cytosolic clathrin onto adipocyte plasma membranes
    S Corvera
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester 01655
    J Biol Chem 265:2413-6. 1990

Collaborators

  • H Stenmark
  • H Meisner
  • D Hartley
  • J J Dumas
  • D C Lawe
  • V Patki
  • S E Langille
  • E Sudharshan
  • D G Lambright
  • S Hayes
  • E Merithew
  • D Rajamani
  • D Lawe
  • D Lambright
  • R Heller-Harrison
  • M P Czech
  • J M Buxton
  • A Chawla
  • J J Holik
  • J K Klarlund

Detail Information

Publications10

  1. ncbi request reprint Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction
    S Corvera
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester 01615, USA
    Trends Cell Biol 8:442-6. 1998
    ..This review discusses how the recent identification of proteins that interact directly with 3'-polyphosphoinositides has revealed novel potential interconnections between these fundamental cellular processes...
  2. ncbi request reprint The FYVE domain of early endosome antigen 1 is required for both phosphatidylinositol 3-phosphate and Rab5 binding. Critical role of this dual interaction for endosomal localization
    D C Lawe
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 275:3699-705. 2000
    ..Thus, the levels of Rab5 are rate-limiting for the recruitment of EEA1 to endosome membranes. PtdIns3P may play a role in modulating the Rab5 EEA1 interaction...
  3. ncbi request reprint Formation of c-Cbl.phosphatidylinositol 3-kinase complexes on lymphocyte membranes by a p56lck-independent mechanism
    D Hartley
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Biol Chem 271:21939-43. 1996
    ..PI 3-kinase complexes occur upstream or independently of mitogenic signal transduction pathways in T cells...
  4. ncbi request reprint Signal transduction: stuck with FYVE domains
    S Corvera
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Sci STKE 2000:pe1. 2000
    ..The Perspective also addresses how proteins with FYVE domains and protein internalization are involved in signal transduction...
  5. ncbi request reprint Phosphatidylinositol 3-kinase and the control of endosome dynamics: new players defined by structural motifs
    S Corvera
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01615, USA
    Traffic 2:859-66. 2001
    ....
  6. ncbi request reprint Multivalent endosome targeting by homodimeric EEA1
    J J Dumas
    Program in Molecular Medicine and Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Cell 8:947-58. 2001
    ..A unique mode of membrane engagement deduced from the quaternary structure of the C-terminal region provides insight into the structural basis of endosome tethering...
  7. ncbi request reprint ADP-ribosylation factor 6 as a target of guanine nucleotide exchange factor GRP1
    S E Langille
    Program in Molecular Medicine, Worcester, Massachusetts 01605, USA
    J Biol Chem 274:27099-104. 1999
    ..Further, co-localization of GRP1 with ARF6, combined with its demonstrated ability to activate ARF6, suggests a physiological role for GRP1 in regulating ARF6 functions...
  8. ncbi request reprint Phosphoinositides in membrane traffic
    S Corvera
    Program in Molecular Medicine, Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Curr Opin Cell Biol 11:460-5. 1999
    ..A novel phosphoinositide appears to regulate effectors involved in the formation of multivesicular endosomes...
  9. ncbi request reprint Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl
    D Hartley
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester 01655, USA
    J Biol Chem 270:18260-3. 1995
    ..Thus, these results show important functional differences between the alpha and beta isoforms of p85 in vivo and point to c-cbl as a potentially important mediator of some of the functions of PI-3 kinase in intact cells...
  10. ncbi request reprint Insulin stimulates the assembly of cytosolic clathrin onto adipocyte plasma membranes
    S Corvera
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester 01655
    J Biol Chem 265:2413-6. 1990
    ..These results suggest that insulin induces an increase in the assembly of cytosolic clathrin onto the plasma membrane in conjunction with its ability to increase the concentration of receptors on the cell surface...