MARSHALL CORSON

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi Phosphorylation of endothelial nitric oxide synthase in response to fluid shear stress
    M A Corson
    Cardiology Division, University of Washington School of Medicine, Seattle 98195, USA
    Circ Res 79:984-91. 1996
  2. ncbi Emerging inflammatory markers for assessing coronary heart disease risk
    Marshall A Corson
    University of Washington School of Medicine, Cardiology Section Chief, Harborview Medical Center, Room 2CT 64, Box 359748, 325 Ninth Avenue, Seattle, WA 98104, USA
    Curr Cardiol Rep 11:452-9. 2009
  3. ncbi Review of the evidence for the clinical utility of lipoprotein-associated phospholipase A2 as a cardiovascular risk marker
    Marshall A Corson
    Division of Cardiology, Department of Medicine, University of Washington, 325 9th Avenue, Seattle, WA 98104, USA
    Am J Cardiol 101:41F-50F. 2008
  4. ncbi Darapladib: an emerging therapy for atherosclerosis
    Marshall A Corson
    Divisions of Cardiology and Cardiovascular Research, University of Washington School of Medicine, Harborview Medical Center, Room 2EH 64, 325 9th Avenue, Seattle, WA 98104, USA
    Ther Adv Cardiovasc Dis 4:241-8. 2010
  5. ncbi Adhesion to fibronectin enhances MKP-1 activation in human endothelial cells
    F Kim
    Department of Medicine, Division of Cardiology, University of Washington, Harborview Medical Center, 325 9th Avenue, Seattle, Washington 98104, USA
    Biochem Biophys Res Commun 273:539-45. 2000
  6. ncbi TNF-alpha inhibits flow and insulin signaling leading to NO production in aortic endothelial cells
    F Kim
    Department of Medicine, Division of Cardiology, Harborview Medical Center, University of Washington, Seattle, Washington 98104, USA
    Am J Physiol Cell Physiol 280:C1057-65. 2001
  7. ncbi Identification of flow-dependent endothelial nitric-oxide synthase phosphorylation sites by mass spectrometry and regulation of phosphorylation and nitric oxide production by the phosphatidylinositol 3-kinase inhibitor LY294002
    B Gallis
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 274:30101-8. 1999
  8. ncbi Angiotensin II signal transduction in vascular smooth muscle: role of tyrosine kinases
    B C Berk
    University of Washington, Department of Medicine, Seattle 98195, USA
    Circ Res 80:607-16. 1997
  9. ncbi Increased expression of Axl tyrosine kinase after vascular injury and regulation by G protein-coupled receptor agonists in rats
    M G Melaragno
    Department of Medicine, University of Washington, Seattle, WA 98195 7710, USA
    Circ Res 83:697-704. 1998
  10. ncbi Free fatty acid impairment of nitric oxide production in endothelial cells is mediated by IKKbeta
    Francis Kim
    Department of Medicine, Division of Cardiology, University of Washington, Harborview Medical Center, Seattle, Wash 98104, USA
    Arterioscler Thromb Vasc Biol 25:989-94. 2005

Research Grants

  1. REGULATION OF ENDOTHELIAL NO SYNTHASE BY PHOSPHORYLATION
    MARSHALL CORSON; Fiscal Year: 2003

Detail Information

Publications13

  1. ncbi Phosphorylation of endothelial nitric oxide synthase in response to fluid shear stress
    M A Corson
    Cardiology Division, University of Washington School of Medicine, Seattle 98195, USA
    Circ Res 79:984-91. 1996
    ....
  2. ncbi Emerging inflammatory markers for assessing coronary heart disease risk
    Marshall A Corson
    University of Washington School of Medicine, Cardiology Section Chief, Harborview Medical Center, Room 2CT 64, Box 359748, 325 Ninth Avenue, Seattle, WA 98104, USA
    Curr Cardiol Rep 11:452-9. 2009
    ....
  3. ncbi Review of the evidence for the clinical utility of lipoprotein-associated phospholipase A2 as a cardiovascular risk marker
    Marshall A Corson
    Division of Cardiology, Department of Medicine, University of Washington, 325 9th Avenue, Seattle, WA 98104, USA
    Am J Cardiol 101:41F-50F. 2008
    ..Ultimately, Lp-PLA(2) may also be classified as a risk factor, but this should not detract from its utility today as a risk marker...
  4. ncbi Darapladib: an emerging therapy for atherosclerosis
    Marshall A Corson
    Divisions of Cardiology and Cardiovascular Research, University of Washington School of Medicine, Harborview Medical Center, Room 2EH 64, 325 9th Avenue, Seattle, WA 98104, USA
    Ther Adv Cardiovasc Dis 4:241-8. 2010
    ..When completed, these trials should provide important insights into the utility of darapladib to reduce myocardial infarction, stroke and cardiovascular death...
  5. ncbi Adhesion to fibronectin enhances MKP-1 activation in human endothelial cells
    F Kim
    Department of Medicine, Division of Cardiology, University of Washington, Harborview Medical Center, 325 9th Avenue, Seattle, Washington 98104, USA
    Biochem Biophys Res Commun 273:539-45. 2000
    ..Regulation of MKP-1 by MAPK likely represents an important negative-feedback mechanism...
  6. ncbi TNF-alpha inhibits flow and insulin signaling leading to NO production in aortic endothelial cells
    F Kim
    Department of Medicine, Division of Cardiology, Harborview Medical Center, University of Washington, Seattle, Washington 98104, USA
    Am J Physiol Cell Physiol 280:C1057-65. 2001
    ..This study suggests one potential mechanism for the development of endothelial dysfunction in disease states with alterations in insulin regulation and increased TNF-alpha levels...
  7. ncbi Identification of flow-dependent endothelial nitric-oxide synthase phosphorylation sites by mass spectrometry and regulation of phosphorylation and nitric oxide production by the phosphatidylinositol 3-kinase inhibitor LY294002
    B Gallis
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 274:30101-8. 1999
    ..Finally, PKB phosphorylated eNOS in vitro at the same site phosphorylated in the cell and increased eNOS enzymatic activity by 15-20-fold...
  8. ncbi Angiotensin II signal transduction in vascular smooth muscle: role of tyrosine kinases
    B C Berk
    University of Washington, Department of Medicine, Seattle 98195, USA
    Circ Res 80:607-16. 1997
    ..Thus, understanding angiotensin II-stimulated signaling events, especially those related to tyrosine kinase activity, may form the basis for the development of new therapies for cardiovascular diseases...
  9. ncbi Increased expression of Axl tyrosine kinase after vascular injury and regulation by G protein-coupled receptor agonists in rats
    M G Melaragno
    Department of Medicine, University of Washington, Seattle, WA 98195 7710, USA
    Circ Res 83:697-704. 1998
    ..Our results implicate Axl as a potential mediator of vascular smooth muscle migration and proliferation caused by vascular injury and G protein-coupled receptor agonists...
  10. ncbi Free fatty acid impairment of nitric oxide production in endothelial cells is mediated by IKKbeta
    Francis Kim
    Department of Medicine, Division of Cardiology, University of Washington, Harborview Medical Center, Seattle, Wash 98104, USA
    Arterioscler Thromb Vasc Biol 25:989-94. 2005
    ..Insulin receptor substrate-1 (IRS-1) regulation is critical for activation of endothelial nitric oxide synthase (eNOS) in response to stimulation by insulin or fluid shear stress...
  11. ncbi Activation of IKKbeta by glucose is necessary and sufficient to impair insulin signaling and nitric oxide production in endothelial cells
    Francis Kim
    Department of Medicine, Harborview Medical Center, University of Washington, Box 359748, Seattle, WA 98104, USA
    J Mol Cell Cardiol 39:327-34. 2005
    ..These data demonstrate that activation of IKKbeta plays a critical and novel role to mediate the deleterious effects of high glucose on endothelial cell function...
  12. ncbi Consensus panel recommendation for incorporating lipoprotein-associated phospholipase A2 testing into cardiovascular disease risk assessment guidelines
    Michael H Davidson
    Preventive Cardiology Center, Pritzker School of Medicine, University of Chicago, 515 North State Street, Chicago, IL 60610, USA
    Am J Cardiol 101:51F-57F. 2008
    ..However, at this time Lp-PLA(2) cannot be recommended as a target of therapy...
  13. ncbi Immunocytochemical detection of phosphatidylinositol 3-kinase activation by insulin and leptin
    Kevin D Niswender
    Division of Metabolism, Endocrinology and Nutrition, Seattle, Washington, USA
    J Histochem Cytochem 51:275-83. 2003
    ..We conclude that immunocytochemical PIP3 staining can detect changes in PI3K activation induced by insulin and leptin in cell culture and intact liver...

Research Grants4

  1. REGULATION OF ENDOTHELIAL NO SYNTHASE BY PHOSPHORYLATION
    MARSHALL CORSON; Fiscal Year: 2003
    ..To determine the mechanotransducers of fluid shear stress to eNOS phosphorylation. Aim 4. To elucidate the regulatory role of eNOS phosphorylation in regenerating endothelial cells in culture and in denuded rat aorta. ..