MARY P CORR

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Mast cell-dependent anorexia and hypothermia induced by mucosal activation of Toll-like receptor 7
    Tomoko Hayashi
    Rebecca and John Moores Cancer Center, University of California, San Diego, La Jolla, California, CA, USA
    Am J Physiol Regul Integr Comp Physiol 295:R123-32. 2008
  2. ncbi request reprint Wnt signaling in ankylosing spondylitis
    Maripat Corr
    9500 Gilman Dr, San Diego, CA, 92131 0663, USA
    Clin Rheumatol 33:759-62. 2014
  3. pmc Interleukin 1 receptor dependence of serum transferred arthritis can be circumvented by toll-like receptor 4 signaling
    Jung Yoon Choe
    Division of Rheumatology, Allergy, and Immunology, and The Sam and Rose Stein Institute for Research on Aging, University of California, San Diego, La Jolla, CA 92093, USA
    J Exp Med 197:537-42. 2003
  4. pmc Treatment of autoimmune inflammation by a TLR7 ligand regulating the innate immune system
    Tomoko Hayashi
    Moores Cancer Center, University of California San Diego, La Jolla, CA, USA
    PLoS ONE 7:e45860. 2012
  5. doi request reprint Wnt-beta-catenin signaling in the pathogenesis of osteoarthritis
    Maripat Corr
    Department of Medicine, Division of Rheumatology, Allergy and Rheumatology, University of California at San Diego, La Jolla, CA 92093 0663, USA
    Nat Clin Pract Rheumatol 4:550-6. 2008
  6. pmc Synergistic benefit in inflammatory arthritis by targeting I kappaB kinase epsilon and interferon beta
    M Corr
    Division of Rheumatology, Allergy and Immunology, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0663, USA
    Ann Rheum Dis 68:257-63. 2009
  7. ncbi request reprint The role of FcgammaR signaling in the K/B x N serum transfer model of arthritis
    Maripat Corr
    Division of Rheumatology, Allergy, and Immunology and Sam and Rose Stein Institute for Research on Aging, University of California, San Diego, La Jolla 92093, USA
    J Immunol 169:6604-9. 2002
  8. pmc Interleukin 1 receptor antagonist mediates the beneficial effects of systemic interferon beta in mice: implications for rheumatoid arthritis
    Maripat Corr
    Correspondence to Dr Maripat Corr, Division of Rheumatology, Allergy and Immunology, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Ann Rheum Dis 70:858-63. 2011
  9. pmc Innate immunity as a hired gun: but is it rheumatoid arthritis?
    Maripat Corr
    Division of Rheumatology, Allergy, and Immunology, University of California, San Diego, La Jolla, CA 92093, USA
    J Exp Med 195:F33-5. 2002
  10. ncbi request reprint The genetics of the target tissue in rheumatoid arthritis
    Maripat Corr
    Division of Rheumatology, Allergy, and Immunology, University of California, San Diego, School of Medicine, La Jolla, California, USA
    Rheum Dis Clin North Am 28:79-94. 2002

Research Grants

  1. FRZB PROFILES AS OSTEOARTHRITIS BIOMARKERS
    MARY CORR; Fiscal Year: 2004

Collaborators

Detail Information

Publications53

  1. pmc Mast cell-dependent anorexia and hypothermia induced by mucosal activation of Toll-like receptor 7
    Tomoko Hayashi
    Rebecca and John Moores Cancer Center, University of California, San Diego, La Jolla, California, CA, USA
    Am J Physiol Regul Integr Comp Physiol 295:R123-32. 2008
    ..Our results thus suggest that tissue mast cells may play a role in the anorexia induced by mucosal activation of TLR7...
  2. ncbi request reprint Wnt signaling in ankylosing spondylitis
    Maripat Corr
    9500 Gilman Dr, San Diego, CA, 92131 0663, USA
    Clin Rheumatol 33:759-62. 2014
    ..The pathways leading to the unique pathology and bony fusion in AS are complex and the Wnt pathway might play a critical contributing role. ..
  3. pmc Interleukin 1 receptor dependence of serum transferred arthritis can be circumvented by toll-like receptor 4 signaling
    Jung Yoon Choe
    Division of Rheumatology, Allergy, and Immunology, and The Sam and Rose Stein Institute for Research on Aging, University of California, San Diego, La Jolla, CA 92093, USA
    J Exp Med 197:537-42. 2003
    ..These results suggest that innate immune functions via TLR-4 might perpetuate inflammatory mechanisms and bypass the need for IL-1 in chronic joint inflammation...
  4. pmc Treatment of autoimmune inflammation by a TLR7 ligand regulating the innate immune system
    Tomoko Hayashi
    Moores Cancer Center, University of California San Diego, La Jolla, CA, USA
    PLoS ONE 7:e45860. 2012
    ..This treatment strategy might be a new modality to treat T cell mediated autoimmune diseases...
  5. doi request reprint Wnt-beta-catenin signaling in the pathogenesis of osteoarthritis
    Maripat Corr
    Department of Medicine, Division of Rheumatology, Allergy and Rheumatology, University of California at San Diego, La Jolla, CA 92093 0663, USA
    Nat Clin Pract Rheumatol 4:550-6. 2008
    ..Hence, the sum of local and systemic factors contributes to the outcome of the Wnt-frizzled pathways. Further investigation is needed to fully define the role of Wnt signaling in OA...
  6. pmc Synergistic benefit in inflammatory arthritis by targeting I kappaB kinase epsilon and interferon beta
    M Corr
    Division of Rheumatology, Allergy and Immunology, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0663, USA
    Ann Rheum Dis 68:257-63. 2009
    ..We examined the role of IKKepsilon in arthritis and its ability to enhance the therapeutic response to systemic interferon (IFN) beta therapy in passive murine K/BxN arthritis...
  7. ncbi request reprint The role of FcgammaR signaling in the K/B x N serum transfer model of arthritis
    Maripat Corr
    Division of Rheumatology, Allergy, and Immunology and Sam and Rose Stein Institute for Research on Aging, University of California, San Diego, La Jolla 92093, USA
    J Immunol 169:6604-9. 2002
    ....
  8. pmc Interleukin 1 receptor antagonist mediates the beneficial effects of systemic interferon beta in mice: implications for rheumatoid arthritis
    Maripat Corr
    Correspondence to Dr Maripat Corr, Division of Rheumatology, Allergy and Immunology, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Ann Rheum Dis 70:858-63. 2011
    ..To explain this paradox, the authors evaluated the mechanism of IFNβ benefit in passive K/BxN arthritis and the effect of IFNβ treatment on RA synovium...
  9. pmc Innate immunity as a hired gun: but is it rheumatoid arthritis?
    Maripat Corr
    Division of Rheumatology, Allergy, and Immunology, University of California, San Diego, La Jolla, CA 92093, USA
    J Exp Med 195:F33-5. 2002
  10. ncbi request reprint The genetics of the target tissue in rheumatoid arthritis
    Maripat Corr
    Division of Rheumatology, Allergy, and Immunology, University of California, San Diego, School of Medicine, La Jolla, California, USA
    Rheum Dis Clin North Am 28:79-94. 2002
    ..Further studies of large populations are likely to segregate out factors affecting specific ethnic, clinical, and genetic subgroups...
  11. ncbi request reprint In vivo priming by DNA injection occurs predominantly by antigen transfer
    M Corr
    Department of Medicine, The Sam and Rose Stein Institute for Research on Aging, University of California at San Diego, La Jolla 92093, USA
    J Immunol 163:4721-7. 1999
    ..These in vivo studies are the first to define the role of transfected nonlymphoid cells in generating Ag for presentation by bone marrow-derived APCs after needle injection with plasmid DNA...
  12. ncbi request reprint A subset of Toll-like receptor ligands induces cross-presentation by bone marrow-derived dendritic cells
    Sandip K Datta
    Department of Medicine and The Sam and Rose Stein Institute for Research on Aging, University of California, La Jolla, CA 92093, USA
    J Immunol 170:4102-10. 2003
    ..In contrast to presentation of Ag to CD4(+) T cells by immature DCs, TLR-induced cross-presentation is mediated by mature DCs, is independent of endosomal acidification, and relies on cytosolic Ag processing machinery...
  13. pmc IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis
    Christoph J Binder
    Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, La Jolla 92093 0682, USA
    J Clin Invest 114:427-37. 2004
    ..Thus, IL-5 links adaptive and natural immunity specific to epitopes of OxLDL and protects from atherosclerosis, in part by stimulating the expansion of atheroprotective natural IgM specific for OxLDL...
  14. pmc Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans
    Meng Yun Chou
    Department of Medicine, UCSD, La Jolla, California 92093, USA
    J Clin Invest 119:1335-49. 2009
    ..These findings provide novel insights into the functions of NAbs in mediating host homeostasis and into their roles in health and diseases, such as chronic inflammatory diseases and atherosclerosis...
  15. pmc Caspase 1-independent activation of interleukin-1beta in neutrophil-predominant inflammation
    Monica Guma
    University of California at San Diego, La Jolla
    Arthritis Rheum 60:3642-50. 2009
    ..This study was undertaken to examine the potential contributions of each of these proteases in experimental models of inflammatory arthritis...
  16. pmc Gadd45beta deficiency in rheumatoid arthritis: enhanced synovitis through JNK signaling
    Camilla I Svensson
    University of California San Diego School of Medicine, La Jolla, CA 92093, USA
    Arthritis Rheum 60:3229-40. 2009
    ..This study was carried out to evaluate whether low Gadd45beta expression in RA enhances JNK activation and overproduction of MMPs in RA, and whether Gadd45beta deficiency increases arthritis severity in passive K/BxN murine arthritis...
  17. pmc Intravesical Toll-like receptor 7 agonist R-837: optimization of its formulation in an orthotopic mouse model of bladder cancer
    Tomoko Hayashi
    Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093 0820, USA
    Int J Urol 17:483-90. 2010
    ..To study the immune response caused by the intravesical administration of the immunomodulator R-837 in various formulations and to estimate its therapeutic potential for bladder cancer...
  18. pmc In vivo efficacy of a phosphodiester TLR-9 aptamer and its beneficial effect in a pulmonary anthrax infection model
    Christina C N Wu
    Department of Medicine, Rebecca and John Moores UCSD Cancer Center, University of California San Diego, La Jolla, CA 92093 0820, USA
    Cell Immunol 251:78-85. 2008
    ..Hence, the transient effects from a PO TLR-9 agonist may be beneficial for protection in a bacterial bioterrorism attack, by delaying the onset of systemic infection without the induction of a cytokine syndrome...
  19. pmc Kinetic analysis of synovial signalling and gene expression in animal models of arthritis
    Akihisa Fukushima
    Division of Rheumatology, Allergy and Immunology, University of California, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093 0656, USA
    Ann Rheum Dis 69:918-23. 2010
    ..Animal models of arthritis are frequently used to evaluate novel therapeutic agents. However, their ability to predict responses in humans is variable...
  20. pmc Repression of beta-catenin function in malignant cells by nonsteroidal antiinflammatory drugs
    Desheng Lu
    Rebecca and John Moores Cancer Center, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 102:18567-71. 2005
    ..Repression of beta-catenin-dependent transcription by NSAIDs is thus indirect and depends on the coexpression of other nuclear receptors...
  21. ncbi request reprint Fcgamma receptor type IIIA polymorphisms influence treatment outcomes in patients with inflammatory arthritis treated with tumor necrosis factor alpha-blocking agents
    Zuhre Tutuncu
    Division of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla 92093 0943, USA
    Arthritis Rheum 52:2693-6. 2005
    ....
  22. ncbi request reprint The role of natural antibodies in atherogenesis
    Christoph J Binder
    Department of Medicine, University of California, San Diego, La Jolla, CA, USA
    J Lipid Res 46:1353-63. 2005
    ..This review will focus on these recent findings and discuss the emerging evidence for an important role of natural antibodies in atherogenesis...
  23. ncbi request reprint Selection of oligonucleotide aptamers with enhanced uptake and activation of human leukemia B cells
    Christina C N Wu
    Division of Rheumatology Allergy and Immunology, Department of Medicine, Sam and Rose Stein Institute for Research on Aging, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0663, USA
    Hum Gene Ther 14:849-60. 2003
    ..Together, these findings suggest that the sequence compositions in R-aptamers that promote multimerization and contain optimal ISS CpG motifs facilitate the delivery of ISS-ODN to CLL cells and enhance the activation of these cells...
  24. ncbi request reprint Regulation of fibronectin and metalloproteinase expression by Wnt signaling in rheumatoid arthritis synoviocytes
    Malini Sen
    Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0663, USA
    Arthritis Rheum 46:2867-77. 2002
    ..The purpose of the present experiments was to determine the role of Wnt-1-like molecules in the expression of matrix proteins by RA FLS and to ascertain the effects of Wnt antagonists on RA FLS function and survival...
  25. ncbi request reprint Necessity of oligonucleotide aggregation for toll-like receptor 9 activation
    Christina C N Wu
    Division of Rheumatology Allergy and Immunology, Department of Medicine and The Sam and Rose Stein Institute for Research on Aging, University of California San Diego, La Jolla, California 92093 0663, USA
    J Biol Chem 279:33071-8. 2004
    ..These findings suggest that an optimal TLR9 agonist needs to contain a spatially distinct multimerization domain and a receptor binding CpG domain. This concept may prove useful for the design of new TLR9-modulating agents...
  26. ncbi request reprint Common mechanisms in immune-mediated inflammatory disease
    Gary S Firestein
    Division of Rheumatology, Allergy, and Immunology, Department of Medicine, University of California at San Diego, San Diego, California, USA
    J Rheumatol Suppl 73:8-13; discussion 29-30. 2005
    ..Understanding the autoimmune and inflammatory pathways implicated in disease has led to targeted drug development and improved clinical outcomes...
  27. pmc The R-enantiomer of the nonsteroidal antiinflammatory drug etodolac binds retinoid X receptor and induces tumor-selective apoptosis
    Siva Kumar Kolluri
    The Burnham Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 102:2525-30. 2005
    ..These results document that pharmacologic antagonism of RXRalpha transactivation is achievable and can have profound inhibitory effects in cancer development...
  28. pmc Regulation of dendritic cells and macrophages by an anti-apoptotic cell natural antibody that suppresses TLR responses and inhibits inflammatory arthritis
    Yifang Chen
    Laboratory of B Cell Immunobiology, University of California, San Diego, La Jolla, CA 92093, USA
    J Immunol 183:1346-59. 2009
    ..These studies identify and characterize a previously unknown regulatory circuit by which a NAb product of innate-like B cells aids homeostasis by control of fundamental inflammatory pathways...
  29. pmc Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells
    Kazumichi Abe
    Department of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 104:17022-7. 2007
    ..These data highlight a novel role of cDCs in the regulation of other innate immune cells and position them as major players in acute colonic inflammation...
  30. ncbi request reprint Rheumatoid arthritis. Introduction
    Maripat Corr
    Department of Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, CA 92093, USA
    Springer Semin Immunopathol 25:1-2. 2003
  31. pmc Mitogen-activated protein kinase kinase 3 is a pivotal pathway regulating p38 activation in inflammatory arthritis
    Tomoyuki Inoue
    Division of Rheumatology, Allergy, and Immunology, University of California at San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093 0656, USA
    Proc Natl Acad Sci U S A 103:5484-9. 2006
    ..Therefore, selective MKK3 deficiency can suppress inflammatory arthritis and cytokine production while Toll-like receptor 4-mediated host defense remains intact...
  32. pmc Synthesis and immunological characterization of toll-like receptor 7 agonistic conjugates
    Michael Chan
    Moores Cancer Center and Department of Medicine, University of California, San Diego, La Jolla, CA92093 0820, USA
    Bioconjug Chem 20:1194-200. 2009
    ..These data show that the immunostimulatory activity of a TLR7 ligand can be amplified and focused by conjugation, thus broadening the potential therapeutic application of these agents...
  33. pmc Platelet-derived growth factor and transforming growth factor beta synergistically potentiate inflammatory mediator synthesis by fibroblast-like synoviocytes
    Sanna Rosengren
    Division of Rheumatology, Allergy and Immunology, University of California at San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093 0656, USA
    Arthritis Res Ther 12:R65. 2010
    ....
  34. pmc Role of MAPK kinase 6 in arthritis: distinct mechanism of action in inflammation and cytokine expression
    Toshio Yoshizawa
    Division of Rheumatology, Allergy and Immunology, University of California San Diego, School of Medicine, La Jolla, CA 92093, USA
    J Immunol 183:1360-7. 2009
    ..Although MKK3 and MKK6 activate the p38 pathway, they regulate distinct subsets of proinflammatory cytokines. MKK6 appears mainly to facilitate p38 and MK2 colocalization in the nucleus rather than to phosphorylate p38...
  35. pmc Activation of the Wnt signaling pathway in chronic lymphocytic leukemia
    Desheng Lu
    Rebecca and John Moores UCSD Cancer Center, University of California at San Diego, La Jolla, CA 92093 0663, USA
    Proc Natl Acad Sci U S A 101:3118-23. 2004
    ..Taken together, these results indicate that Wnt signaling genes are overexpressed and are active in CLL. Uncontrolled Wnt signaling may contribute to the defect in apoptosis that characterizes this malignancy...
  36. pmc TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis in mice
    Jose M Gonzalez-Navajas
    Department of Medicine, UCSD, La Jolla, California, USA
    J Clin Invest 120:570-81. 2010
    ..Our data therefore reveal a tonic inhibitory role for TLR4 signaling on subsequent TCR-dependent CD4+ T cell responses...
  37. pmc Nrf2 responses and the therapeutic selectivity of electrophilic compounds in chronic lymphocytic leukemia
    Raymond P Wu
    Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 107:7479-84. 2010
    ..These experiments document the presence of Nrf2 signaling in human CLL and suggest that altered Nrf2 responses may contribute to the observed selective cytotoxicity of electrophilic compounds in this disease...
  38. ncbi request reprint Regulation of arthritis by p53: critical role of adaptive immunity
    Egle Simelyte
    University of California, San Diego, School of Medicine, La Jolla, CA, USA
    Arthritis Rheum 52:1876-84. 2005
    ..To determine if adaptive immune responses or synovial effector functions are responsible for this effect, passive models of arthritis were studied in p53 wild-type and knockout mice...
  39. ncbi request reprint Quinolinium salt as a potent inhibitor of lymphocyte apoptosis
    Sylvie D Barchéchath
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093 0663, USA
    Bioorg Med Chem Lett 15:1785-8. 2005
    ..013 microM, which was at least 300-fold more potent than the reference compound pifithrin-alpha...
  40. ncbi request reprint Cutting Edge: Bim is required for superantigen-mediated B cell death
    Carl S Goodyear
    Rheumatic Diseases Core Center, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    J Immunol 178:2636-40. 2007
    ..These studies characterize a BCR-dependent negative clonal selection pathway that has been co-opted by a common bacterial pathogen to induce selective defects in host immune defenses...
  41. ncbi request reprint Induction of a homeostatic circuit in lung tissue by microbial compounds
    Kenji Takabayshi
    Department of Medicine, University of California, San Diego, La Jolla, 92093, USA
    Immunity 24:475-87. 2006
    ....
  42. ncbi request reprint Inhibitors of apoptosis in lymphocytes: synthesis and biological evaluation of compounds related to pifithrin-alpha
    Sylvie D Barchéchath
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093 0663, USA
    J Med Chem 48:6409-22. 2005
    ..35 microM. Also, 60 provided significant protection against gamma-irradiation-induced apoptosis, as expected. Compounds 19 and 60 may be promising for potential clinical development...
  43. ncbi request reprint Wnt and frizzled receptors as potential targets for immunotherapy in head and neck squamous cell carcinomas
    Chae Seo Rhee
    Department of Medicine and The Sam and Rose Stein Institute for Research on Aging, University of California San Diego, La Jolla, California, CA 92093 0663, USA
    Oncogene 21:6598-605. 2002
    ..Hence, the Wnt and Fz receptors may be possible targets for immunotherapy therapy of this common cancer...
  44. ncbi request reprint HIF-1alpha is essential for myeloid cell-mediated inflammation
    Thorsten Cramer
    Molecular Biology Section, Division of Biological Sciences, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Cell 112:645-57. 2003
    ..This role for HIF-1alpha demonstrates its direct regulation of survival and function in the inflammatory microenvironment...
  45. pmc ERK activation drives intestinal tumorigenesis in Apc(min/+) mice
    Sung Hee Lee
    Department of Medicine, University of California, San Diego, La Jolla, California, USA
    Nat Med 16:665-70. 2010
    ..Our data reveal a new facet of oncogene-environment interaction, in which microflora-induced TLR activation regulates oncogene expression and related IEC tumor growth in a susceptible host...
  46. pmc Prevention of autoimmune disease by induction of tolerance to Toll-like receptor 7
    Tomoko Hayashi
    Moores Cancer Center, and Department Medicine, University California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 106:2764-9. 2009
    ..These findings suggest that induction of TLR7 tolerance might be a new therapeutic approach to subdue inflammation in autoimmune diseases...
  47. pmc Targeting the Wnt signaling pathway to augment bone formation
    Mohammad Shahnazari
    Department of Medicine, UC Davis Medical Center, 4800 Second Avenue, Suite 2600, Sacramento, CA 95817, USA
    Curr Osteoporos Rep 6:142-8. 2008
    ..In this article, we briefly describe the Wnt signaling elements, their characterized role in bone, and summarize the current knowledge on the potential to enhance bone formation through the manipulation of Wnt signaling antagonists...
  48. ncbi request reprint Wnt signaling antagonists are potential prognostic biomarkers for the progression of radiographic hip osteoarthritis in elderly Caucasian women
    Nancy E Lane
    University of California, Davis, Sacramento, CA 95817, USA
    Arthritis Rheum 56:3319-25. 2007
    ..To determine whether serum levels of 2 Wnt signaling antagonists, Frizzled-related protein (FRP) and Dkk-1, are associated with the development and progression of radiographic hip osteoarthritis (RHOA)...
  49. ncbi request reprint The KRN mouse model of inflammatory arthritis
    Diego Kyburz
    Department of Rheumatology, University Hospital of Zurich, Gloriastrasse 25, 8091, Zurich, Switzerland
    Springer Semin Immunopathol 25:79-90. 2003
    ..Because of the reliable and robust induction of joint inflammation by serum transfer this new disease model has been and will be a valuable means to address the as-yet-unanswered key questions related to the development of arthritis...
  50. ncbi request reprint Inhibition of HER-kinase activation prevents ERK-mediated degradation of PPARgamma
    Michael Hedvat
    Louis Warschaw Prostate Cancer Center, Cedars Sinai Medical Center, 8631 West Third Street, Suite 1001E, Los Angeles, CA 90048, USA
    Cancer Cell 5:565-74. 2004
    ..This study introduces a novel concept of an in vivo crosstalk between the HER-kinase axis and PPARgamma pathways, ultimately leading to negative regulation of PPARgamma activity and tumor growth inhibition...
  51. ncbi request reprint IFN-alpha beta promote priming of antigen-specific CD8+ and CD4+ T lymphocytes by immunostimulatory DNA-based vaccines
    Hearn Jay Cho
    Division of Hematology Medical Oncology, Department of Medicine, New York Presbyterian Hospital and Cornell Medical Center, 525 East 68th Street, New York, NY 10021
    J Immunol 168:4907-13. 2002
    ..Coordinated regulation of B7 costimulation and TAP-dependent cross-presentation results in priming of Ag-specific CD8(+) CTL, whereas CD40, B7, and IL-12 costimulation is required for priming of CD4(+) Th cells by ISS-based vaccines...
  52. pmc Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females
    John Loughlin
    Institute of Musculoskeletal Sciences, Botnar Research Centre, Nuffield Orthopaedic Centre, University of Oxford, Oxford OX1 7LD, United Kingdom
    Proc Natl Acad Sci U S A 101:9757-62. 2004
    ..Hence, functional polymorphisms within FRZB confer susceptibility for hip OA in females and implicate the wnt signaling pathway in the pathogenesis of this disease...
  53. ncbi request reprint The tolls of arthritis
    Maripat Corr
    Arthritis Rheum 52:2233-6. 2005

Research Grants1

  1. FRZB PROFILES AS OSTEOARTHRITIS BIOMARKERS
    MARY CORR; Fiscal Year: 2004
    ..The results of these studies will both contribute to, and will utilize, the resources of the OA biomarker consortium. ..