Timothy T Cornell

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Clinical implications and molecular mechanisms of immunoparalysis after cardiopulmonary bypass
    Timothy T Cornell
    Division of Critical Care Medicine, C S Mott Children s Hospital, F 6882, 1500 East Medical Center Dr, Ann Arbor, MI 48109 0243, USA
    J Thorac Cardiovasc Surg 143:1160-1166.e1. 2012
  2. pmc Mitogen-activated protein kinase phosphatase 2, MKP-2, regulates early inflammation in acute lung injury
    Timothy T Cornell
    Division of Pediatric Critical Care Medicine, Dept of Pediatrics and Communicable Diseases, Univ of Michigan Medical School, C S Mott Children s Hospital, Ann Arbor, MI 48109 0243, USA
    Am J Physiol Lung Cell Mol Physiol 303:L251-8. 2012
  3. pmc Ceramide-dependent PP2A regulation of TNFalpha-induced IL-8 production in respiratory epithelial cells
    Timothy T Cornell
    Division of Pediatric Critical Care Medicine, C S Mott Children s Hospital, Ann Arbor, MI 48109 0243, USA
    Am J Physiol Lung Cell Mol Physiol 296:L849-56. 2009
  4. pmc Mitogen-activated protein kinase phosphatase 2 regulates the inflammatory response in sepsis
    Timothy T Cornell
    Division of Pediatric Critical Care Medicine, Department of Pediatrics and Communicable Diseases, University of Michigan School of Medicine, and CS Mott Children s Hospital, Ann Arbor, Michigan 48109 0243, USA
    Infect Immun 78:2868-76. 2010
  5. pmc Fluid overload and fluid removal in pediatric patients on extracorporeal membrane oxygenation requiring continuous renal replacement therapy
    David T Selewski
    Division of Nephrology, Department of Pediatrics and Communicable Diseases, C S Mott Children s Hospital, University of Michigan, Ann Arbor, MI, USA
    Crit Care Med 40:2694-9. 2012
  6. doi request reprint Surface-micromachined microfiltration membranes for efficient isolation and functional immunophenotyping of subpopulations of immune cells
    Weiqiang Chen
    Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA
    Adv Healthc Mater 2:965-75. 2013
  7. pmc An integrated microfluidic platform for in situ cellular cytokine secretion immunophenotyping
    Nien Tsu Huang
    Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA
    Lab Chip 12:4093-101. 2012
  8. pmc Weight-based determination of fluid overload status and mortality in pediatric intensive care unit patients requiring continuous renal replacement therapy
    David T Selewski
    Division of Nephrology, Department of Pediatrics and Communicable Diseases, C S Mott Children s Hospital, University of Michigan, Ann Arbor, MI, USA
    Intensive Care Med 37:1166-73. 2011
  9. pmc Mechanisms and regulation of the gene-expression response to sepsis
    Timothy T Cornell
    Division of Critical Care Medicine, C S Mott Children s Hospital, University of Michigan, Ann Arbor, MI, USA
    Pediatrics 125:1248-58. 2010
  10. pmc Challenges during repeat extracorporeal life support in a patient with pulmonary alveolar proteinosis
    Hemanth Lingadevaru
    Pediatric Critical Care Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    ASAIO J 57:473-4. 2011

Collaborators

Detail Information

Publications11

  1. pmc Clinical implications and molecular mechanisms of immunoparalysis after cardiopulmonary bypass
    Timothy T Cornell
    Division of Critical Care Medicine, C S Mott Children s Hospital, F 6882, 1500 East Medical Center Dr, Ann Arbor, MI 48109 0243, USA
    J Thorac Cardiovasc Surg 143:1160-1166.e1. 2012
    ..We assessed the impact of CPB on histone methylation as a potential mechanism for altering gene expression necessary for the immune system's capacity to defend against infections...
  2. pmc Mitogen-activated protein kinase phosphatase 2, MKP-2, regulates early inflammation in acute lung injury
    Timothy T Cornell
    Division of Pediatric Critical Care Medicine, Dept of Pediatrics and Communicable Diseases, Univ of Michigan Medical School, C S Mott Children s Hospital, Ann Arbor, MI 48109 0243, USA
    Am J Physiol Lung Cell Mol Physiol 303:L251-8. 2012
    ..These data suggest that altering MKP-2 activity may have therapeutic potential to reduce lung inflammation in ALI without impacting pathogen clearance...
  3. pmc Ceramide-dependent PP2A regulation of TNFalpha-induced IL-8 production in respiratory epithelial cells
    Timothy T Cornell
    Division of Pediatric Critical Care Medicine, C S Mott Children s Hospital, Ann Arbor, MI 48109 0243, USA
    Am J Physiol Lung Cell Mol Physiol 296:L849-56. 2009
    ..In summary, our data suggest that in respiratory epithelium, TNFalpha induces ceramide accumulation, resulting in subsequent activation of PP2A, which targets those kinases responsible for transcriptional activation of IL-8...
  4. pmc Mitogen-activated protein kinase phosphatase 2 regulates the inflammatory response in sepsis
    Timothy T Cornell
    Division of Pediatric Critical Care Medicine, Department of Pediatrics and Communicable Diseases, University of Michigan School of Medicine, and CS Mott Children s Hospital, Ann Arbor, Michigan 48109 0243, USA
    Infect Immun 78:2868-76. 2010
    ..These data support a mechanism by which MKP-2 targets ERK deactivation, thereby decreasing MKP-1 and thus removing the negative inhibition of MKP-1 on cytokine production...
  5. pmc Fluid overload and fluid removal in pediatric patients on extracorporeal membrane oxygenation requiring continuous renal replacement therapy
    David T Selewski
    Division of Nephrology, Department of Pediatrics and Communicable Diseases, C S Mott Children s Hospital, University of Michigan, Ann Arbor, MI, USA
    Crit Care Med 40:2694-9. 2012
    ....
  6. doi request reprint Surface-micromachined microfiltration membranes for efficient isolation and functional immunophenotyping of subpopulations of immune cells
    Weiqiang Chen
    Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA
    Adv Healthc Mater 2:965-75. 2013
    ....
  7. pmc An integrated microfluidic platform for in situ cellular cytokine secretion immunophenotyping
    Nien Tsu Huang
    Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA
    Lab Chip 12:4093-101. 2012
    ....
  8. pmc Weight-based determination of fluid overload status and mortality in pediatric intensive care unit patients requiring continuous renal replacement therapy
    David T Selewski
    Division of Nephrology, Department of Pediatrics and Communicable Diseases, C S Mott Children s Hospital, University of Michigan, Ann Arbor, MI, USA
    Intensive Care Med 37:1166-73. 2011
    ..We hypothesized that a weight-based definition of FO at CRRT initiation would correlate with the fluid balance method and prove predictive of outcome...
  9. pmc Mechanisms and regulation of the gene-expression response to sepsis
    Timothy T Cornell
    Division of Critical Care Medicine, C S Mott Children s Hospital, University of Michigan, Ann Arbor, MI, USA
    Pediatrics 125:1248-58. 2010
    ..We anticipate that emerging data from genetic, genomic, and other translation studies in pediatric sepsis will advance our biological understanding of this response and undoubtedly identify targets for newer therapies...
  10. pmc Challenges during repeat extracorporeal life support in a patient with pulmonary alveolar proteinosis
    Hemanth Lingadevaru
    Pediatric Critical Care Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    ASAIO J 57:473-4. 2011
    ..Our case illustrates standard cannulation may not be possible for children requiring a second ECLS course and the importance of considering alternative modes of cannulation and ECLS support when conventional methods are not possible...
  11. ncbi request reprint Epstein-Barr virus-induced hemophagocytic lymphohistiocytosis and X-linked lymphoproliferative disease: a mimicker of sepsis in the pediatric intensive care unit
    Matthew Mischler
    Division of Pediatric Critical Care Medicine, C S Mott Children s Hospital, University of Michigan, Ann Arbor, Michigan 48109, USA
    Pediatrics 119:e1212-8. 2007
    ....