Research Topics
| Jack R CorneliusSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
Evaluation of cognitive behavioral therapy/motivational enhancement therapy (CBT/MET) in a treatment trial of comorbid MDD/AUD adolescentsJack R Cornelius
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Addict Behav 36:843-8. 2011....- Cannabis withdrawal is common among treatment-seeking adolescents with cannabis dependence and major depression, and is associated with rapid relapse to dependenceJack R Cornelius
Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, PAARC Suite, Pittsburgh, PA 15213, USA
Addict Behav 33:1500-5. 2008..These findings suggest that cannabis withdrawal should be included as a diagnosis in the upcoming DSM-V, and should be listed in the upcoming criteria list for the DSM-V diagnostic category of cannabis dependence... - Premature mortality among males with substance use disordersJack R Cornelius
Center for Education and Drug Abuse Research CEDAR, University of Pittsburgh, 3811 O Hara Street, PAARC Suite, Pittsburgh, PA 15213, USA
Addict Behav 33:156-60. 2008..The objective of this study was to assess whether the presence of SUD or ASP is associated with early mortality among males (fathers) in a predominantly community sample, using a 15-year prospective longitudinal study design... - Husbands' SUD is associated with higher levels of co-occurring but not non-co-occurring psychiatric disorders among their wivesJack R Cornelius
Center for Education and Drug Abuse Research CEDAR, University of Pittsburgh, Pittsburgh, PA 15213, USA
Addict Behav 33:1231-4. 2008..We hypothesized that the presence of SUDs among males would be associated with a higher level of SUDs, of co-occurring psychiatric disorders, and of non-co-occurring psychiatric disorders in their wives... - Double-blind placebo-controlled trial of fluoxetine in adolescents with comorbid major depression and an alcohol use disorderJack R Cornelius
University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh PA 15213, USA
Addict Behav 34:905-9. 2009..We hypothesized that fluoxetine would demonstrate efficacy versus placebo for the treatment of both the depressive symptoms and the drinking of comorbid MDD/AUD adolescents... - PTSD contributes to teen and young adult cannabis use disordersJack R Cornelius
Center for Education and Drug Abuse Research, University of Pittsburgh, 3811 O Hara Street, PAARC Suite, Pittsburgh, PA 15213, USA
Addict Behav 35:91-4. 2010..This study addresses the effect of PTSD on CUD among teenagers transitioning to young adulthood... - Amygdala reactivity is inversely related to level of cannabis use in individuals with comorbid cannabis dependence and major depressionJack R Cornelius
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, United States
Addict Behav 35:644-6. 2010..70, df = 5, p < 0.05, two-tailed). These findings are consistent with the reports by Phan et al. (2008) and Hariri et al. (2009) suggesting that cannabinoids have an inhibitory effect on threat-related amygdala reactivity... - Double-blind fluoxetine trial in comorbid MDD-CUD youth and young adultsJack R Cornelius
Department of Psychiatry, University of Pittsburgh School of Medicine, PAARC Suite, Pittsburgh, PA 15213, USA
Drug Alcohol Depend 112:39-45. 2010..We hypothesized that fluoxetine would demonstrate efficacy versus placebo for the treatment of the depressive symptoms and the cannabis use of adolescents and young adults with comorbid MDD/CUD... 
Alcohol use disorder symptoms and risk-taking behavior as predictors of alcohol-related medical events among young adults treated in emergency departmentsThomas M Kelly
Pittsburgh Adolescent Alcohol Research Center, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Addict Behav 30:1674-89. 2005..Studies of alcohol-positive patients in emergency departments are not clear on the relationship between alcohol use disorder (AUD) symptoms and risk for injury...- Major depression associated with earlier alcohol relapse in treated teens with AUDJack R Cornelius
Department of Psychiatry, Western Psychiatric Institute, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Addict Behav 29:1035-8. 2004..27, df=1, P=.039). These results suggest that the comorbid presence of MDD is associated with an earlier relapse to alcohol use among adolescents with an AUD... - Acute phase and five-year follow-up study of fluoxetine in adolescents with major depression and a comorbid substance use disorder: a reviewJack R Cornelius
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PAARC Suite, Pittsburgh, PA 15213, USA
Addict Behav 30:1824-33. 2005..However, the long-term clinical course for the Major Depression of that comorbid adolescent population is surprisingly poor... - Patient characteristics and treatment implications of marijuana abuse among bipolar alcoholics: results from a double blind, placebo-controlled studyIhsan M Salloum
Western Psychiatric Institute and Clinic of the University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Addict Behav 30:1702-8. 2005..The aim of this study was to characterize bipolar alcoholic patients with comorbid marijuana abuse and test the impact of marijuana abuse on alcohol and mood outcome of patients with bipolar disorder and comorbid alcohol dependence... - General-medical conditions in older patients with serious mental illnessAmy M Kilbourne
VA Pittsburgh Center for Health Equity Research and Promotion 151 C, University Drive C, Pittsburgh, PA 15240, USA
Am J Geriatr Psychiatry 13:250-4. 2005..The burden of medical comorbidities was compared between older (> or =60 years) and younger patients with serious mental illness... - Fluoxetine in adolescents with comorbid major depression and an alcohol use disorder: a 3-year follow-up studyJack R Cornelius
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, PAARC Suite, Pittsburgh, PA 15213, USA
Addict Behav 30:807-14. 2005..The high rate of MDD at follow-up suggests that longer term antidepressant medication treatment may be needed for at least some comorbid adolescents... - Psychiatric disorders among older adolescents treated in emergency departments on weekends: a comparison with a matched community sampleThomas M Kelly
Pittsburgh Adolescent Alcohol Research Center, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, Pennsylvania 15213, USA
J Stud Alcohol 64:616-22. 2003.... - Treatment of co-occurring alcohol, drug, and psychiatric disordersJack R Cornelius
School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213-2593, USA
Recent Dev Alcohol 17:349-65. 2005..This chapter also identifies gaps in knowledge regarding the treatment of comorbid adolescents, and outlines directions for future research in this field... - Efficacy of valproate maintenance in patients with bipolar disorder and alcoholism: a double-blind placebo-controlled studyIhsan M Salloum
Western Psychiatric Institute and Clinic of the University of Pittsburgh Medical Center and School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15213, USA
Arch Gen Psychiatry 62:37-45. 2005..Patients with comorbid substance abuse disorders often are excluded from clinical trials. Thus, treatments targeting this high-risk clinical population are lacking... - Divalproex utility in bipolar disorder with co-occurring cocaine dependence: a pilot studyIhsan M Salloum
Western Psychiatric Institute and Clinic of the University of Pittsburgh Medical Center, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Addict Behav 32:410-5. 2007..The aim of this open-label pilot study was to evaluate the utility of divalproex in decreasing cocaine use and stabilizing mood symptoms among patients with bipolar disorder with comorbid cocaine dependence... - Brief screens for detecting alcohol use disorder among 18-20 year old young adults in emergency departments: Comparing AUDIT-C, CRAFFT, RAPS4-QF, FAST, RUFT-Cut, and DSM-IV 2-Item ScaleThomas M Kelly
Pittsburgh Adolescent Alcohol Research Center, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, United States
Addict Behav 34:668-74. 2009..This study compared six of the briefest screening instruments for detecting DSM-IV-defined Alcohol Use Disorder (AUD) among older adolescents treated in Emergency Departments (ED)... - Dental abnormalities in children of fathers with substance use disordersJack R Cornelius
School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Addict Behav 29:979-82. 2004..The data from this study provide evidence that paternal SUDs (HAR vs. LAR status) is associated with poor dental condition, poor oral hygiene, a greater need for dental treatment, and inadequate levels of dental treatment utilization... - Greater prevalence of proposed DSM-5 nicotine use disorder compared to DSM-IV nicotine dependence in treated adolescents and young adultsTammy Chung
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA, USA
Addiction 107:810-8. 2012..The impact of the proposed changes on nicotine disorder prevalence and the concurrent validity of diagnostic criteria were examined... - Joint trajectory analysis of treated adolescents' alcohol use and symptoms over 1 yearTammy Chung
University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, Pittsburgh Adolescent Alcohol Research Center, Pittsburgh, PA 15213, USA
Addict Behav 30:1690-701. 2005.... - Neurobehavioral disinhibition in childhood predicts early age at onset of substance use disorderRalph E Tarter
University of Pittsburgh, Department of Pharmaceutical Sciences, Pittsburgh, PA 15261, USA
Am J Psychiatry 160:1078-85. 2003.... 
Cannabis withdrawal predicts severity of cannabis involvement at 1-year follow-up among treated adolescentsTammy Chung
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Addiction 103:787-99. 2008..This study contrasted the concurrent and predictive validity of three operational definitions of cannabis withdrawal in a sample of treated adolescents...- Substance use disorder trajectory classes: diachronic integration of onset age, severity, and courseDuncan B Clark
Center for Education and Drug Abuse Research, University of Pittsburgh, and Western Psychiatric Institute and Clinic, PA 15213, USA
Addict Behav 31:995-1009. 2006..This article illustrates the utilization of SAS-TRAJ mixture modeling to characterize variations in SUD symptom trajectories to define phenotypes... - Clinical practices in the pharmacological treatment of comorbid psychopathology in adolescents with alcohol use disordersDuncan B Clark
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara Street, Pittsburgh, PA 15213, USA
J Subst Abuse Treat 25:293-5. 2003..The treatment setting did not significantly influence antidepressant prescribing practices. The common and increasing use of psychiatric medications in this population emphasizes the urgent need for empirically based clinical guidelines... - Reductions in and relations between "craving" and drinking in a prospective, open-label trial of ondansetron in adolescents with alcohol dependenceMichael A Dawes
START Center, Division of Alcohol and Drug Addiction, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, The South Texas Addiction Research and Technology Center, San Antonio, TX 78229 3900, USA
Addict Behav 30:1630-7. 2005..These preliminary results suggest that the A-OCDS can be useful as an outcome measure in clinical studies of adolescents with alcohol dependence... - Fluoxetine in depressed AUD adolescents: a 1-year follow-up evaluationJack R Cornelius
Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania, USA
J Child Adolesc Psychopharmacol 14:33-8. 2004..1998) and the significant levels of drinking of our comorbid adolescents suggest that longer term treatment may be needed for at least some adolescents with major depressive disorder and alcohol use disorder... - Psychiatric disorders and attempted suicide among adolescents with substance use disordersThomas M Kelly
Pittsburgh Adolescent Alcohol Research Center, School of Medicine, University of Pittsburgh, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Drug Alcohol Depend 73:87-97. 2004..To determine the effects of psychiatric disorders on attempted suicide among adolescents with substance use disorders (SUD)... - Brief assessment of readiness to change tobacco use in treated youthTammy Chung
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15213, USA
J Subst Abuse Treat 41:137-47. 2011..Results support the clinical utility of the Ruler and motivation to abstain as brief measures of readiness to change, and perceived difficulty to abstain as a tool to aid adolescent tobacco cessation... - Early age of first sexual intercourse and affiliation with deviant peers predict development of SUD: a prospective longitudinal studyJack R Cornelius
Center for Education and Drug Abuse Research CEDAR, University of Pittsburgh, 3811 O Hara Street, PAARC Suite, Pittsburgh, PA 15213, USA
Addict Behav 32:850-4. 2007..The objective of this study was to assess whether early onset of sexual intercourse and affiliation with deviant peers serve as predictors of the development of SUD, using a prospective longitudinal study design... - Predicting risky drinking outcomes longitudinally: what kind of advance notice can we get?Robert A Zucker
Department of Psychiatry, University of Michigan Addiction Research Center, Ann Arbor, Michigan 48105, USA
Alcohol Clin Exp Res 30:243-52. 2006..Finally, Robert Zucker examines the degree to which the core symposium questions are answered and comments on next step research and clinical practice changes that are called for by these findings... - Multidimensional assessment of nicotine dependence in adolescentsDuncan B Clark
Department of Psychiatry, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Drug Alcohol Depend 77:235-42. 2005..The findings suggest that the NDSS has acceptable psychometric properties when applied to adolescents, complementing smoking rate and FTND in a multidimensional smoking assessment... - Adolescent alcohol use disorders predict adult borderline personalityDawn L Thatcher
Pittsburgh Adolescent Alcohol Research Center PAARC, Department of Psychiatry, University of Pittsburgh Medical Center, USA
Addict Behav 30:1709-24. 2005..This study investigated adolescent alcohol use disorders (AUDs) and other characteristics as predictors of adult borderline personality disorder (BPD) symptoms... - Predictors of problem drinking among older adolescent emergency department patientsThomas M Kelly
Pittsburgh Adolescent Alcohol Research Center (PAARC, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213, USA
J Emerg Med 27:209-18. 2004.... - Physical and sexual abuse, depression and alcohol use disorders in adolescents: onsets and outcomesDuncan B Clark
Department of Psychiatry and Pharmaceutical Sciences, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Drug Alcohol Depend 69:51-60. 2003..These results indicate that MDD among adolescents with AUD may be partly attributable to PS Abuse... - Rapid relapse generally follows treatment for substance use disorders among adolescentsJack R Cornelius
Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Addict Behav 28:381-6. 2003..1993). In J. S. Baer, G. A. Marlatt, & R. J. McMahon (Eds.), Addictive behaviors across the life span (pp. 160-183). London: SAGE.] in showing that most adolescents relapse quickly following treatment for substance use disorders... - Quality of care for substance use disorders in patients with serious mental illnessAmy M Kilbourne
VA Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA
J Subst Abuse Treat 30:73-7. 2006..9%, 63.2%, and 62.2%, respectively; chi(2) = 72.25, df = 2, p <. 001). Greater efforts are needed to diagnose and treat SUDs in patients with serious mental illness, particularly for those with bipolar disorder... - Burden of general medical conditions among individuals with bipolar disorderAmy M Kilbourne
VA Pittsburgh Healthcare System, University of Pittsburgh, Pittsburgh, PA 15240, USA
Bipolar Disord 6:368-73. 2004..We determined the prevalence of general medical conditions in a population-based sample of patients diagnosed with bipolar disorder in the Veterans Administration (VA)... - Adolescents' alcohol and drug use trajectories in the year following treatmentTammy Chung
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara Street, Pittsburgh, Pennsylvania 15213, USA
J Stud Alcohol 65:105-14. 2004..This study characterized treated teens' short-term alcohol and other drug use trajectories over 1-year follow-up... - Childhood risk categories for adolescent substance involvement: a general liability typologyDuncan B Clark
Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Drug Alcohol Depend 77:13-21. 2005..The findings indicate that these five risk categories constitute general liability classes for adolescent substance involvement, and may identify homogeneous groups of children requiring distinct preventive interventions... - Child neglect and oral health problems in offspring of substance-abusing fathersAda C Mezzich
Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA
Am J Addict 16:397-402. 2007.... - Interventions in suicidal alcoholicsJack R Cornelius
University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Alcohol Clin Exp Res 28:89S-96S. 2004..Appropriate hospitalization, discharge, and family involvement are discussed. Finally, gaps in knowledge are identified with a focus on priorities and directions for future research... - Alcohol and psychiatric comorbidityJack R Cornelius
Pittsburgh Adolescent Alcohol Research Center, Center for Education and Drug Abuse Research, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Recent Dev Alcohol 16:361-74. 2003..However, controlled treatment studies involving alcoholics with other comorbid disorders are almost totally lacking. Consequently, to date, no empirically proven treatment exists for most of these comorbid disorders... - Adolescent-onset substance use disorders predict young adult mortalityDuncan B Clark
Pittsburgh Adolescent Alcohol Research Center, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
J Adolesc Health 42:637-9. 2008..Adolescent SUDs, as well as gender, ethnic group, hazardous substance use, and drug trafficking, predicted these deaths. Among African American males with SUDs, 23% died by age 25... - Characteristics and consequences of heroin use among older adults in the United States: a review of the literature, treatment implications, and recommendations for further researchDaniel Rosen
School of Social Work, University of Pittsburgh, Pittsburgh, PA 15260, USA
Addict Behav 36:279-85. 2011.... - Impact of concurrent alcohol misuse on symptom presentation of acute mania at initial evaluationIhsan M Salloum
Center for Psychiatric and Chemical Dependency Services, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213, USA
Bipolar Disord 4:418-21. 2002..The aim of this study was to evaluate the impact of current alcohol misuse on symptom presentation of acute mania... - Limitations in the assessment of DSM-IV cannabis tolerance as an indicator of dependence in adolescentsTammy Chung
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15213, USA
Exp Clin Psychopharmacol 12:136-46. 2004..Results suggest limitations of the DSM-IV and change-based operational definition of tolerance in adolescents... - A prospective, open-label trial of ondansetron in adolescents with alcohol dependenceMichael A Dawes
START Center, Division of Alcohol and Drug Addiction, Department of Psychiatry, The University of Texas Health Science Center at San Antonio UTHSCSA, 3939 Medical Drive, Suite 100, San Antonio, TX 78229 3900, USA
Addict Behav 30:1077-85. 2005..Findings of decreased drinking underscore the need for future double-blind, placebo-controlled studies in this adolescent population... - Psychiatric and substance use disorders as risk factors for attempted suicide among adolescents: a case control studyThomas M Kelly
Western Psychiatric Institute and Clinic, Pittsburgh Adolescent Alcohol Research Center, University of Pittsburgh Medical School, PA 15213, USA
Suicide Life Threat Behav 32:301-12. 2002..Evaluation of these particular comorbid conditions should be part of the adolescent suicide risk assessment... - Antenatal risk factors associated with postpartum comorbid alcohol use and depressive symptomatologyGregory G Homish
Research Institute on Addictions, University at Buffalo, State University of New York, Buffalo, New York 14203 1016, USA
Alcohol Clin Exp Res 28:1242-8. 2004..The goal of this work was to identify prenatal factors (at each trimester) that predicted postpartum comorbid depressive symptoms and alcohol use in women... - Nonproblem drinking outcomes in adolescents treated for alcohol use disordersStephen A Maisto
Exp Clin Psychopharmacol 10:324-31. 2002..The results suggest alternative views of treatment goals, relapse, and treatment outcome in adolescents... - Illicit drug use and marital satisfactionGregory G Homish
Department of Health Behavior, The State University of New York at Buffalo, Buffalo, NY 14214 8028, USA
Addict Behav 33:279-91. 2008..Over the first four years of marriage, couples in each group experienced significant declines in marital satisfaction... - Predictors of marijuana use among married couples: the influence of one's spouseGregory G Homish
Research Institute on Addictions, University at Buffalo, The State University of New York, 1021 Main Street, Buffalo, NY 14203 1016, USA
Drug Alcohol Depend 91:121-8. 2007..After considering the impact of time and individual risk factors, a spouse's use of marijuana prior to marriage was a strong predictor of increased risk for marijuana use during the first four years of marriage... - Treatment studies involving adolescents with drug and alcohol disordersJack R Cornelius
Addict Behav 30:1627-9. 2005 - Alcohol relapse as a function of relapse definition in a clinical sample of adolescentsStephen A Maisto
Department of Psychology, Syracuse University, 430 Huntington Hall, Syracuse, NY 13244, USA
Addict Behav 28:449-59. 2003..Suggestions for the extensions of this investigation in future research are provided... - Factor structure of the SOCRATES in a clinical sample of adolescentsStephen A Maisto
Department of Psychology, Syracuse University, New York 13244, USA
Psychol Addict Behav 17:98-107. 2003..The results were interpreted as supporting the use of the SOCRATES with clinical samples of adolescents...