S J Corey

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Requirement of Src kinase Lyn for induction of DNA synthesis by granulocyte colony-stimulating factor
    S J Corey
    Division of Hematology Oncology, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 273:3230-5. 1998
  2. ncbi request reprint Suppression of apoptosis and granulocyte colony-stimulating factor-induced differentiation by an oncogenic form of Cbl
    S Sinha
    Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Exp Hematol 29:746-55. 2001
  3. pmc Interaction between growth arrest-DNA damage protein 34 and Src kinase Lyn negatively regulates genotoxic apoptosis
    A V Grishin
    Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Proc Natl Acad Sci U S A 98:10172-7. 2001
  4. ncbi request reprint Engagement of the B-cell antigen receptor activates STAT through Lyn in a Jak-independent pathway
    L Wang
    Division of Pediatrics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 26:2851-9. 2007
  5. pmc Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases
    S J Corey
    Department of Pediatrics, University of Pittsburgh School of Medicine, PA
    Proc Natl Acad Sci U S A 91:4683-7. 1994
  6. ncbi request reprint Signaling via Src family kinases is required for normal internalization of the receptor c-Kit
    V C Broudy
    Divisions of Hematology, Department of Medicine, University of Washington, Seattle, WA, USA
    Blood 94:1979-86. 1999

Collaborators

Detail Information

Publications6

  1. ncbi request reprint Requirement of Src kinase Lyn for induction of DNA synthesis by granulocyte colony-stimulating factor
    S J Corey
    Division of Hematology Oncology, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 273:3230-5. 1998
    ..These studies show that the absence of Lyn results in the loss of mitogenic signaling in the G-CSF signaling pathway and that activation of Jak1 or Jak2 is not sufficient to cause mitogenesis...
  2. ncbi request reprint Suppression of apoptosis and granulocyte colony-stimulating factor-induced differentiation by an oncogenic form of Cbl
    S Sinha
    Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Exp Hematol 29:746-55. 2001
    ..v-Cbl-expressing 32Dcl3 cells were resistant to differentiation. v-Cbl suppresses apoptosis and differentiation, possibly through enhancement of Lyn, Syk, and PI3'-kinase activities and Bcl-2...
  3. pmc Interaction between growth arrest-DNA damage protein 34 and Src kinase Lyn negatively regulates genotoxic apoptosis
    A V Grishin
    Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Proc Natl Acad Sci U S A 98:10172-7. 2001
    ..In contrast, pretreatment of cells with the Src-specific tyrosine kinase inhibitor PP1 strengthened promotion of apoptosis by GADD34. We propose that Lyn regulates the proapoptotic function of GADD34 by binding and phosphorylating it...
  4. ncbi request reprint Engagement of the B-cell antigen receptor activates STAT through Lyn in a Jak-independent pathway
    L Wang
    Division of Pediatrics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 26:2851-9. 2007
    ..In an electrophoretic mobility shift assay, BCR stimulation led to enhanced DNA binding of the STAT3 in DT40, but not in the Lyn-null cells. We conclude that BCR engagement activates the STAT pathway via Lyn, independent of JAK...
  5. pmc Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases
    S J Corey
    Department of Pediatrics, University of Pittsburgh School of Medicine, PA
    Proc Natl Acad Sci U S A 91:4683-7. 1994
    ..Their sequential recruitment into the G-CSFR signaling complex demonstrates the coordinated involvement of two PTKs with a member of the hematopoietic/cytokine receptor superfamily...
  6. ncbi request reprint Signaling via Src family kinases is required for normal internalization of the receptor c-Kit
    V C Broudy
    Divisions of Hematology, Department of Medicine, University of Washington, Seattle, WA, USA
    Blood 94:1979-86. 1999
    ..These results indicate that Src family kinases play a role in ligand-induced trafficking of c-Kit...