S J Corey
Affiliation: University of Pittsburgh
- Requirement of Src kinase Lyn for induction of DNA synthesis by granulocyte colony-stimulating factorS J Corey
Division of Hematology Oncology, Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Biol Chem 273:3230-5. 1998..These studies show that the absence of Lyn results in the loss of mitogenic signaling in the G-CSF signaling pathway and that activation of Jak1 or Jak2 is not sufficient to cause mitogenesis...
- Suppression of apoptosis and granulocyte colony-stimulating factor-induced differentiation by an oncogenic form of CblS Sinha
Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Exp Hematol 29:746-55. 2001..v-Cbl-expressing 32Dcl3 cells were resistant to differentiation. v-Cbl suppresses apoptosis and differentiation, possibly through enhancement of Lyn, Syk, and PI3'-kinase activities and Bcl-2...
- Interaction between growth arrest-DNA damage protein 34 and Src kinase Lyn negatively regulates genotoxic apoptosisA V Grishin
Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA 15213, USA
Proc Natl Acad Sci U S A 98:10172-7. 2001..In contrast, pretreatment of cells with the Src-specific tyrosine kinase inhibitor PP1 strengthened promotion of apoptosis by GADD34. We propose that Lyn regulates the proapoptotic function of GADD34 by binding and phosphorylating it...
- Engagement of the B-cell antigen receptor activates STAT through Lyn in a Jak-independent pathwayL Wang
Division of Pediatrics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Oncogene 26:2851-9. 2007..In an electrophoretic mobility shift assay, BCR stimulation led to enhanced DNA binding of the STAT3 in DT40, but not in the Lyn-null cells. We conclude that BCR engagement activates the STAT pathway via Lyn, independent of JAK...
- Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinasesS J Corey
Department of Pediatrics, University of Pittsburgh School of Medicine, PA
Proc Natl Acad Sci U S A 91:4683-7. 1994..Their sequential recruitment into the G-CSFR signaling complex demonstrates the coordinated involvement of two PTKs with a member of the hematopoietic/cytokine receptor superfamily...
- Signaling via Src family kinases is required for normal internalization of the receptor c-KitV C Broudy
Divisions of Hematology, Department of Medicine, University of Washington, Seattle, WA, USA
Blood 94:1979-86. 1999..These results indicate that Src family kinases play a role in ligand-induced trafficking of c-Kit...