L Corey

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi In situ detection of Gag-specific CD8+ cells in the GI tract of SIV infected Rhesus macaques
    Annelie Tjernlund
    Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Retrovirology 7:12. 2010
  2. ncbi Use of "biokit HSV-2 Rapid Assay" to improve the positive predictive value of Focus HerpeSelect HSV-2 ELISA
    Rhoda Ashley Morrow
    Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA
    BMC Infect Dis 5:84. 2005
  3. ncbi Differentiation of herpes simplex virus types 1 and 2 in clinical samples by a real-time taqman PCR assay
    Lawrence Corey
    Department of Laboratory Medicine, University of Washington, Seattle, Washington 98109, USA
    J Med Virol 76:350-5. 2005
  4. ncbi Herpes simplex virus type 2 and HIV-1: the dialogue between the 2 organisms continues
    Lawrence Corey
    Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Infect Dis 195:1242-4. 2007
  5. ncbi The effects of herpes simplex virus-2 on HIV-1 acquisition and transmission: a review of two overlapping epidemics
    Lawrence Corey
    Department of Medicine, University of Washington Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Acquir Immune Defic Syndr 35:435-45. 2004
  6. ncbi Challenges in genital herpes simplex virus management
    Lawrence Corey
    Department of Laboratory Medicine, Virology Division, University of Washington, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Infect Dis 186:S29-33. 2002
  7. ncbi Once-daily valacyclovir to reduce the risk of transmission of genital herpes
    Lawrence Corey
    Department of Medicine, University of Washington, Seattle, USA
    N Engl J Med 350:11-20. 2004
  8. ncbi Prevention of herpes simplex virus type 2 transmission with antiviral therapy
    Lawrence Corey
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Herpes 11:170A-174A. 2004
  9. ncbi Frequency of symptomatic and asymptomatic herpes simplex virus type 2 reactivations among human immunodeficiency virus-infected men
    T Schacker
    Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
    J Infect Dis 178:1616-22. 1998
  10. ncbi Herpes simplex virus inhibits apoptosis through the action of two genes, Us5 and Us3
    K R Jerome
    Department of Laboratory Medicine, University of Washington, Seattle, Washington 98195, USA
    J Virol 73:8950-7. 1999

Detail Information

Publications132 found, 100 shown here

  1. ncbi In situ detection of Gag-specific CD8+ cells in the GI tract of SIV infected Rhesus macaques
    Annelie Tjernlund
    Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Retrovirology 7:12. 2010
    ..SIV and HIV predominantly replicate in lymphoid tissue, but the study of virus specific CD8+ T cells in intact lymphoid tissue is difficult, as traditional in situ tetramer staining requires fresh tissue...
  2. ncbi Use of "biokit HSV-2 Rapid Assay" to improve the positive predictive value of Focus HerpeSelect HSV-2 ELISA
    Rhoda Ashley Morrow
    Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA
    BMC Infect Dis 5:84. 2005
    ....
  3. ncbi Differentiation of herpes simplex virus types 1 and 2 in clinical samples by a real-time taqman PCR assay
    Lawrence Corey
    Department of Laboratory Medicine, University of Washington, Seattle, Washington 98109, USA
    J Med Virol 76:350-5. 2005
    ..6% of clinical samples using the new typing assay. This assay, when used in combination with the type common assay, can now accurately type almost all mucosal and visceral HSV isolates by molecular techniques...
  4. ncbi Herpes simplex virus type 2 and HIV-1: the dialogue between the 2 organisms continues
    Lawrence Corey
    Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Infect Dis 195:1242-4. 2007
  5. ncbi The effects of herpes simplex virus-2 on HIV-1 acquisition and transmission: a review of two overlapping epidemics
    Lawrence Corey
    Department of Medicine, University of Washington Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Acquir Immune Defic Syndr 35:435-45. 2004
    ....
  6. ncbi Challenges in genital herpes simplex virus management
    Lawrence Corey
    Department of Laboratory Medicine, Virology Division, University of Washington, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Infect Dis 186:S29-33. 2002
    ..Recent studies show condoms reduce transmission, providing an important tool for counseling the patient with newly diagnosed genital herpes...
  7. ncbi Once-daily valacyclovir to reduce the risk of transmission of genital herpes
    Lawrence Corey
    Department of Medicine, University of Washington, Seattle, USA
    N Engl J Med 350:11-20. 2004
    ..Nucleoside analogues against herpes simplex virus (HSV) have been shown to suppress shedding of HSV type 2 (HSV-2) on genital mucosal surfaces and may prevent sexual transmission of HSV...
  8. ncbi Prevention of herpes simplex virus type 2 transmission with antiviral therapy
    Lawrence Corey
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Herpes 11:170A-174A. 2004
    ....
  9. ncbi Frequency of symptomatic and asymptomatic herpes simplex virus type 2 reactivations among human immunodeficiency virus-infected men
    T Schacker
    Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
    J Infect Dis 178:1616-22. 1998
    ..Thus, subclinical HSV-2 reactivation is an important opportunistic infection in persons with HIV infection. Further studies are necessaryto determine the impact of subclinical HSV-2 reactivation on the natural history of HIV infection...
  10. ncbi Herpes simplex virus inhibits apoptosis through the action of two genes, Us5 and Us3
    K R Jerome
    Department of Laboratory Medicine, University of Washington, Seattle, Washington 98195, USA
    J Virol 73:8950-7. 1999
    ..The Us11 and Us12 genes were not necessary for protection from apoptosis induced by either stimulus. The differences between HSV-1 and HSV-2 in the ability to inhibit apoptosis may be factors in the immunobiology of HSV infections...
  11. ncbi Reactivation of genital herpes simplex virus type 2 infection in asymptomatic seropositive persons
    A Wald
    Department of Medicine, University of Washington, Seattle 98122, USA
    N Engl J Med 342:844-50. 2000
    ..Historically, it has been assumed that these persons have less frequent viral reactivation than those with symptomatic infection...
  12. ncbi Frequent genital herpes simplex virus 2 shedding in immunocompetent women. Effect of acyclovir treatment
    A Wald
    Department of Medicine, University of Washington, Seattle 98195, USA
    J Clin Invest 99:1092-7. 1997
    ..HSV-2 shedding in the genital mucosa occurs much more frequently than previously appreciated. This frequent reactivation likely plays a role in the epidemic spread of genital herpes worldwide...
  13. ncbi Acyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2
    C Celum
    Department of Global Health, University of Washington, Harborview Medical Center, 325 Ninth Ave, Box 359927, Seattle, WA 98104, USA
    N Engl J Med 362:427-39. 2010
    ..Therapy to suppress HSV-2 reduces the frequency of reactivation of HSV-2 as well as HIV-1 levels, suggesting that suppression of HSV-2 may reduce the risk of transmission of HIV-1...
  14. ncbi Long term persistence of herpes simplex virus-specific CD8+ CTL in persons with frequently recurring genital herpes
    C M Posavad
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA
    J Immunol 165:1146-52. 2000
    ..Thus, HSV recurs in the face of persistent CD8+ CTL with no evidence of clonal exhaustion or mutation of CTL epitopes as mechanisms of viral persistence...
  15. ncbi HSV and glycoprotein J inhibit caspase activation and apoptosis induced by granzyme B or Fas
    K R Jerome
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA
    J Immunol 167:3928-35. 2001
    ....
  16. ncbi Effect of conditioning regimen intensity on CMV infection in allogeneic hematopoietic cell transplantation
    Hirohisa Nakamae
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Biol Blood Marrow Transplant 15:694-703. 2009
    ..Therefore, CMV prevention strategies in NM-HCT recipients should be similar to those used in M-HCT recipients...
  17. ncbi Changes in plasma human immunodeficiency virus type 1 RNA associated with herpes simplex virus reactivation and suppression
    Timothy Schacker
    Department of Medicine, University of Minnesota, Minneapolis, 55455, USA
    J Infect Dis 186:1718-25. 2002
    ..These data indicate that frequent mucosal HSV reactivation influences HIV replication in vivo and daily HSV suppression may be important in the management of HSV-positive/HIV-positive persons...
  18. ncbi CD8 CTL from genital herpes simplex lesions: recognition of viral tegument and immediate early proteins and lysis of infected cutaneous cells
    D M Koelle
    Department of Medicine, University of Washington, Seattle, WA 98195, USA
    J Immunol 166:4049-58. 2001
    ..Tegument proteins, identified for the first time as Ags recognized by HSV-specific CD8 CTL, are rational candidate vaccine compounds...
  19. ncbi Plasma viremia in human immunodeficiency virus infection
    R W Coombs
    Department of Laboratory Medicine, University of Washington, Seattle 98105
    N Engl J Med 321:1626-31. 1989
    ..Not only whole blood but cell-free plasma from HIV-infected patients should be considered potentially infectious...
  20. ncbi Transmissible Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in saliva of men with a history of Kaposi's sarcoma
    J Vieira
    Department of Laboratory Medicine, University of Washington, Seattle 98195, USA
    J Virol 71:7083-7. 1997
    ..These results indicate that infectious KSHV can be present in saliva of patients with KS...
  21. ncbi Daily acyclovir for HIV-1 disease progression in people dually infected with HIV-1 and herpes simplex virus type 2: a randomised placebo-controlled trial
    Jairam R Lingappa
    Department of Global Health, Seattle, WA, USA
    Lancet 375:824-33. 2010
    ..Daily suppression of this herpes virus reduces plasma HIV-1 concentrations, but whether it delays HIV-1 disease progression is unknown. We investigated the effect of acyclovir on HIV-1 progression...
  22. ncbi Late cytomegalovirus disease and mortality in recipients of allogeneic hematopoietic stem cell transplants: importance of viral load and T-cell immunity
    Michael Boeckh
    Program in Infectious Diseases Immunology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Blood 101:407-14. 2003
    ..Prevention strategies should be targeted at patients in whom CMV reactivated during the first 3 months and those with poor CMV-specific immunity or low CD4 counts...
  23. ncbi Characteristics of HIV-1 discordant couples enrolled in a trial of HSV-2 suppression to reduce HIV-1 transmission: the partners study
    Jairam R Lingappa
    Department of Global Health, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 4:e5272. 2009
    ..We describe the baseline characteristics of this cohort...
  24. ncbi Persistence of HIV-1 receptor-positive cells after HSV-2 reactivation is a potential mechanism for increased HIV-1 acquisition
    Jia Zhu
    Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Nat Med 15:886-92. 2009
    ..The persistence and enrichment of HIV receptor-positive inflammatory cells in the genitalia help explain the inability of anti-HSV-2 therapy to reduce HIV acquisition...
  25. ncbi Continued evolution of HIV-1 circulating in blood monocytes with antiretroviral therapy: genetic analysis of HIV-1 in monocytes and CD4+ T cells of patients with discontinued therapy
    Nick Llewellyn
    Department of Laboratory Medicine, University of Washington School of Medicine, Washington, USA
    J Leukoc Biol 80:1118-26. 2006
    ..These results suggest that ART inhibits HIV-1 replication in CD4+ T cells more than in blood monocytes and that better treatments to combat HIV-1 in monocytes/macrophages may be needed for a more complete suppression of HIV replication...
  26. ncbi Association between culturable human immunodeficiency virus type 1 (HIV-1) in semen and HIV-1 RNA levels in semen and blood: evidence for compartmentalization of HIV-1 between semen and blood
    R W Coombs
    Department of Laboratory Medicine, University of Washington, School of Medicine, Seattle 98195 7110, USA
    J Infect Dis 177:320-30. 1998
    ....
  27. ncbi Cytomegalovirus (CMV) DNA load in plasma for the diagnosis of CMV disease before engraftment in hematopoietic stem-cell transplant recipients
    A P Limaye
    Departments of Laboratory Medicine and Medicine, University of Washington, Seattle, WA 98195 7110, USA
    J Infect Dis 183:377-82. 2001
    ..5x107] vs. <50 [range, <50-350] CMV DNA copies/mL plasma, respectively; P<.001). Quantitative PCR for CMV DNA in plasma appears to be useful for the identification of HSCT recipients at risk for CMV disease before engraftment...
  28. ncbi Emergence of ganciclovir-resistant cytomegalovirus disease among recipients of solid-organ transplants
    A P Limaye
    Department of Laboratory Medicine, University of Washington, Seattle 98195 7110, USA
    Lancet 356:645-9. 2000
    ..We retrospectively assessed the occurrence of ganciclovir-resistant cytomegalovirus disease among transplant recipients who had received oral ganciclovir prophylaxis and highly potent immunosuppression...
  29. ncbi Functional properties and epitope characteristics of T-cells recognizing natural HIV-1 variants
    U Malhotra
    Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Vaccine 27:6678-87. 2009
    ..However, cost-effective design of peptide and sequence based vaccine immunogens that provide maximal coverage of circulating sequences may be achieved through emphasis on virus domains likely to be T-cell targets...
  30. ncbi Clearance of HSV-2 from recurrent genital lesions correlates with infiltration of HSV-specific cytotoxic T lymphocytes
    D M Koelle
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Clin Invest 101:1500-8. 1998
    ..The phenotypes of cells with HSV-specific cytotoxic responses varied between patients, having CD4+ and CD8+ components. Immunotherapeutic approaches to HSV should be directed at improving in vivo cytolytic activity to HSV...
  31. ncbi Detection of Epstein-Barr virus DNA in sera from transplant recipients with lymphoproliferative disorders
    A P Limaye
    Department of Laboratory Medicine and Medicine Infectious Diseases, University of Washington, Seattle, USA
    J Clin Microbiol 37:1113-6. 1999
    ..Further studies to define the role of such assays in evaluating solid-organ transplant patients at risk for PTLD are warranted...
  32. ncbi Vitamin A supplementation and genital shedding of herpes simplex virus among HIV-1-infected women: a randomized clinical trial
    Jared M Baeten
    Department of Epidemiology, University of Washington, Seattle, Washington 98104 2499, USA
    J Infect Dis 189:1466-71. 2004
    ..Vitamin A supplementation is unlikely to decrease HSV shedding and infectivity...
  33. ncbi Virus population homogenization following acute human immunodeficiency virus type 1 infection
    Gerald H Learn
    Department of Microbiology, University of Washington, Seattle, Washington 98195, USA
    J Virol 76:11953-9. 2002
    ..This early selective process focuses on viral properties within Env but not Gag p17. Hence, the viral homogeneity observed early in HIV-1 infection results from a selective process that occurs during the establishment of infection...
  34. ncbi HIV-specific cytotoxic T lymphocytes traffic to lymph nodes and localize at sites of HIV replication and cell death
    S J Brodie
    Department of Laboratory Medicine, University of Washington, Seattle, Washington 98195, USA
    J Clin Invest 105:1407-17. 2000
    ..Moreover, these studies provide a methodology that will facilitate studies of both the magnitude and functional phenotype of Ag-specific CD8(+) T cells in vivo...
  35. ncbi Protection against human immunodeficiency virus type 1 infection in persons with repeated exposure: evidence for T cell immunity in the absence of inherited CCR5 coreceptor defects
    W C Goh
    Division of Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    J Infect Dis 179:548-57. 1999
    ....
  36. ncbi Effect of condoms on reducing the transmission of herpes simplex virus type 2 from men to women
    A Wald
    University of Washington, Virology Research Clinic, 1001 Broadway, Suite 320, Seattle, WA 98122, USA
    JAMA 285:3100-6. 2001
    ..Herpes simplex virus type 2 (HSV-2) is one of the most common sexually transmitted infections in the United States. No prospective study has shown the ability of condoms to reduce transmission of HSV-2...
  37. ncbi Herpes simplex virus shedding and plasma human immunodeficiency virus RNA levels in coinfected women
    M Augenbraun
    Department of Medicine, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
    Clin Infect Dis 33:885-90. 2001
    ..74). In women who shed HSV, as evaluated by detection of virus, plasma HIV RNA load did not fluctuate with HSV shedding...
  38. ncbi Comparison of assays to detect cytomegalovirus shedding in the semen of HIV-infected men
    C Diamond
    University of Washington School of Public Health, Seattle, WA, USA
    J Virol Methods 90:185-91. 2000
    ..28, CI: 2.30-7.95). CMV shedding was associated with decreased CD4+ cell counts in peripheral blood (P=0.05). It is concluded that the PCR assay provided the greatest sensitivity among the three detection methods...
  39. ncbi Quantitation of BK virus load in serum for the diagnosis of BK virus-associated nephropathy in renal transplant recipients
    A P Limaye
    Department of Laboratory Medicine, University of Washington, Seattle, USA
    J Infect Dis 183:1669-72. 2001
    ..It is concluded that quantitative PCR for BK virus DNA in serum is useful both for identifying transplant recipients at risk for BK virus nephropathy and for monitoring the response to therapy...
  40. ncbi Preinfection human immunodeficiency virus (HIV)-specific cytotoxic T lymphocytes failed to prevent HIV type 1 infection from strains genetically unrelated to viruses in long-term exposed partners
    Yi Liu
    Department of Microbiology, University of Washington, Seattle, WA 98109, USA
    J Virol 83:10821-9. 2009
    ....
  41. ncbi Reduced levels of neutralizing antibodies to Kaposi sarcoma-associated herpesvirus in persons with a history of Kaposi sarcoma
    Louise E Kimball
    Department of Pathobiology, University of Washington, and Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, 98109, USA
    J Infect Dis 189:2016-22. 2004
    ..The data from the present study suggest that NAb may play a role in the control of KSHV infection and the prevention of progression of KSHV infection to KS...
  42. ncbi Mucosal host immune response predicts the severity and duration of herpes simplex virus-2 genital tract shedding episodes
    Joshua T Schiffer
    Department of Medicine, Laboratory Medicine, Global Health Medicine, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 107:18973-8. 2010
    ..The model suggests that the rate of containment of infected cells by the peripheral mucosal immune system is the major driver of duration and severity of HSV-2 reactivation in the immunocompetent host...
  43. ncbi Immune reconstitution to cytomegalovirus after allogeneic hematopoietic stem cell transplantation: impact of host factors, drug therapy, and subclinical reactivation
    Morgan Hakki
    Fred Hutchinson Cancer Research Center, and the University of Washington, Seattle, USA
    Blood 102:3060-7. 2003
    ..Subclinical CMV reactivation while on ganciclovir appears to be a potent stimulator of T-cell function. These findings have implications for vaccination and adoptive-immunotherapy strategies in this population...
  44. ncbi Invasive aspergillosis in allogeneic stem cell transplant recipients: changes in epidemiology and risk factors
    Kieren A Marr
    Fred Hutchinson Cancer Research Center Programs in Infectious Diseases and Long term Follow up, Seattle, WA 98109, USA
    Blood 100:4358-66. 2002
    ....
  45. ncbi Rapidly cleared episodes of oral and anogenital herpes simplex virus shedding in HIV-infected adults
    Karen E Mark
    Department of Medicine, University of Washington, Seattle, WA, USA
    J Acquir Immune Defic Syndr 54:482-8. 2010
    ..To determine whether rapidly cleared episodes of herpes simplex virus (HSV) reactivation occur in HIV-infected adults...
  46. ncbi Sensitive method for detection of human herpesviruses 6 and 7 in saliva collected in field studies
    D M Zerr
    Department of Pediatrics, University of Washington, Seattle, USA
    J Clin Microbiol 38:1981-3. 2000
    ..The sensitivity and specificity of this method even after prolonged drying of the specimens compared favorably to those of our traditional method of collecting and assaying saliva...
  47. ncbi Impact of unrelated donor status on the incidence and outcome of cytomegalovirus infections after non-myeloablative allogeneic stem cell transplantation
    Christian Junghanss
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA
    Br J Haematol 123:662-70. 2003
    ....
  48. ncbi Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: a prospective cohort analysis
    Deborah Donnell
    Statistical Center for HIV AIDS Research and Prevention and the Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Lancet 375:2092-8. 2010
    ..Initiation of antiretroviral therapy (ART) reduces plasma HIV-1 concentrations. We aimed to assess the effect of ART use by patients infected with HIV-1 on risk of transmission to their uninfected partners...
  49. ncbi Optimization of quantitative detection of cytomegalovirus DNA in plasma by real-time PCR
    Michael Boeckh
    Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, Washington 98109 1024, USA
    J Clin Microbiol 42:1142-8. 2004
    ..Thus, primer optimization and improved DNA extraction techniques resulted in a plasma-based PCR assay that is significantly more sensitive than pp65 antigenemia and blood cultures for detection of CMV in blood specimens...
  50. ncbi BK DNA viral load in plasma: evidence for an association with hemorrhagic cystitis in allogeneic hematopoietic cell transplant recipients
    Veronique Erard
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Program in Infectious Diseases, 1100 Fairview Ave North D3-100, PO Box 19024, Seattle, WA 98109-1024, USA
    Blood 106:1130-2. 2005
    ..BK virus seems to play a role in the development of HC and quantitative detection of BK DNA in plasma appears to be a marker of BK virus disease in HCT recipients...
  51. ncbi Antiretroviral therapy for HIV-1 vaccine efficacy trial participants who seroconvert
    H Nina Kim
    Departments of Medicine, University of Washington, Seattle, WA, USA
    Vaccine 24:532-9. 2006
    ..A standardized HAART protocol for HIV-1 vaccine efficacy trial participants who become HIV-infected is essential to the evaluation of CTL-based HIV-1 vaccines on the natural history of HIV-1 infection...
  52. ncbi Effect of maternal herpes simplex virus (HSV) serostatus and HSV type on risk of neonatal herpes
    Elizabeth L Brown
    Department of Epidemiology, University of Washington, Seattle, WA 98122, USA, and Department of Pediatrics, Karolinska University Hospital, Stockholm, Sweden
    Acta Obstet Gynecol Scand 86:523-9. 2007
    ..We have conducted pooled analyses of data from 3 cohorts to evaluate the effects of maternal HSV serostatus and HSV type on risk of neonatal HSV acquisition and severity...
  53. ncbi An update on short-course episodic and prevention therapies for herpes genitalis
    Lawrence Corey
    Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Herpes 14:5A-11A. 2007
    ..Suppressive antiviral therapy has been shown to decrease the risk of HSV transmission in heterosexual couples. New approaches to the prevention of HSV infection, including vaccines and topical microbicides, are under investigation...
  54. ncbi A double-blind, randomized, placebo-controlled trial of acyclovir in late pregnancy for the reduction of herpes simplex virus shedding and cesarean delivery
    D Heather Watts
    Department of Obstetrics and Gynecology, University of Washington, Seattle, USA
    Am J Obstet Gynecol 188:836-43. 2003
    ..Neonatal outcomes were similar between groups. CONCLUSION: Acyclovir significantly reduced, but did not eliminate, herpes simplex virus lesions and detection in late pregnancy...
  55. ncbi Role for HLA class II molecules in HIV-1 suppression and cellular immunity following antiretroviral treatment
    U Malhotra
    Program in Infectious Diseases, Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, D3-100, Seattle, WA 98109, USA
    J Clin Invest 107:505-17. 2001
    ..Eliciting responses to the promiscuous epitope region may be beneficial in vaccine strategies...
  56. ncbi Effect of combination antiretroviral therapy on T-cell immunity in acute human immunodeficiency virus type 1 infection
    U Malhotra
    Department of Medicine, University of Washington, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    J Infect Dis 181:121-31. 2000
    ..The amplified HIV-1-specific T-cell responses may help maintain cytotoxic activities...
  57. ncbi Phase 1 evaluation of the respiratory syncytial virus-specific monoclonal antibody palivizumab in recipients of hematopoietic stem cell transplants
    M Boeckh
    Program in Infectious Diseases, Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA 98109, USA
    J Infect Dis 184:350-4. 2001
    ..Thus, palivizumab appears to be safe and well tolerated in HSCT recipients...
  58. ncbi Use of long-term suppressive acyclovir after hematopoietic stem-cell transplantation: impact on herpes simplex virus (HSV) disease and drug-resistant HSV disease
    Veronique Erard
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    J Infect Dis 196:266-70. 2007
    ..2% [95% CI, 0%-0.8%]; P=.006), and in 0 patients in cohort 3 (cohort 2 vs. cohort 3, P=.3). Long-term use of suppressive prophylactic ACV appears to prevent the emergence of drug-resistant HSV disease in HCT...
  59. ncbi Overlapping reactivations of herpes simplex virus type 2 in the genital and perianal mucosa
    Sunitha Tata
    Vaccine and Infectious Disease Institute, University of Washington, Seattle, USA
    J Infect Dis 201:499-504. 2010
    ..Genital shedding of herpes simplex virus (HSV) type 2 occurs frequently. Anatomic patterns of genital HSV-2 reactivation have not been intensively studied...
  60. ncbi Evidence for limited genetic compartmentalization of HIV-1 between lung and blood
    Laura Heath
    Department of Microbiology, University of Washington, Seattle, WA, USA
    PLoS ONE 4:e6949. 2009
    ..The unique environment of the lung, rich in alveolar macrophages and with specialized local immune responses, may contribute to differential evolution or selection of HIV-1...
  61. ncbi Clinical correlates of herpes simplex virus viremia among hospitalized adults
    William R Berrington
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Clin Infect Dis 49:1295-301. 2009
    ..Quantification of herpes simplex virus (HSV) DNA in the peripheral blood is often used to evaluate patients suspected of having disseminated HSV infection. Few studies have examined the clinical correlates of HSV viremia among adults...
  62. ncbi Clinical presentation and outcome of epidemic Kaposi sarcoma in Ugandan children
    Soren Gantt
    Seattle Children s Hospital, Seattle, WA, USA
    Pediatr Blood Cancer 54:670-4. 2010
    ..Kaposi sarcoma (KS) is one of the most common pediatric cancers in sub-Saharan Africa. Few data are available about the clinical presentation or response to treatment of children with epidemic (HIV-associated) KS...
  63. ncbi Respiratory virus infection among hematopoietic cell transplant recipients: evidence for asymptomatic parainfluenza virus infection
    Angela J Peck
    Department of Pediatrics, Children s Hospital and Regional Medical Center and University of Washington, Seattle, WA, USA
    Blood 110:1681-8. 2007
    ..004). Subclinical infection with PIV may help explain why infection-control programs that emphasize symptoms are effective against RSV and influenza but often not against PIV...
  64. ncbi Incidence and outcome of cytomegalovirus infections following nonmyeloablative compared with myeloablative allogeneic stem cell transplantation, a matched control study
    Christian Junghanss
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109-1024, USA
    Blood 99:1978-85. 2002
    ..Therefore, nonmyeloablative HSCT patients should receive CMV surveillance beyond day 100 and pre-emptive ganciclovir treatment similar to that of myeloablative HSCT patients...
  65. ncbi Human herpesvirus 8: seroprevalence and correlates in prostitutes in Mombasa, Kenya
    Ludo Lavreys
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    J Infect Dis 187:359-63. 2003
    ..These results suggest that heterosexual transmission may contribute to acquisition of HHV-8 infections in this African population of prostitutes...
  66. ncbi Expression of cutaneous lymphocyte-associated antigen by CD8(+) T cells specific for a skin-tropic virus
    David M Koelle
    Department of Medicine, Department of Laboratory Medicine, and Department of Pathobiology, University of Washington, Seattle, Washington 98104, USA
    J Clin Invest 110:537-48. 2002
    ..The evaluation of vaccines for skin and mucosal pathogens should include study of the induction of appropriate tissue-specific homing molecules...
  67. ncbi Transferred herpes simplex virus immunity after stem-cell transplantation: clinical implications
    W Garrett Nichols
    Program in Infectious Diseases, Fred Hutchinson Cancer Research Center, University of Washington, 1100 Fairview Avenue N, D3 100, Seattle, WA 98109 4417, USA
    J Infect Dis 187:801-8. 2003
    ..Serological testing of donors can identify patients who are at highest risk for HSV-related morbidity, for whom prolonged prophylaxis or donor vaccination (once available) could be considered...
  68. ncbi Selection for human immunodeficiency virus type 1 recombinants in a patient with rapid progression to AIDS
    Shan-Lu Liu
    Department of Microbiology, University of Washington, Seattle, Washington 98195, USA
    J Virol 76:10674-84. 2002
    ....
  69. ncbi Safety and immunogenicity of a high-titered canarypox vaccine in combination with rgp120 in a diverse population of HIV-1-uninfected adults: AIDS Vaccine Evaluation Group Protocol 022A
    Kalpana Gupta
    Department of Medicine, University of Washington, Seattle, Washington, USA
    J Acquir Immune Defic Syndr 29:254-61. 2002
    ..This high-titered preparation of ALVAC-HIV vCP205 in combination with gp120 was safe and immunogenic in a diverse group of HIV-1-seronegative volunteers...
  70. ncbi Adenovirus infection in hematopoietic stem cell transplantation: effect of ganciclovir and impact on survival
    Benedetto Bruno
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA
    Biol Blood Marrow Transplant 9:341-52. 2003
    ..Ganciclovir, given for CMV prevention, may have a protective effect. Controlled treatment and prevention studies are warranted...
  71. ncbi Are there benefits to starting antiretroviral therapy during primary HIV infection? Conclusions from the Seattle Primary Infection Cohort vary by control group
    J D Stekler
    Department of Medicine, University of Washington, Seattle, WA, USA
    Int J STD AIDS 23:201-6. 2012
    ..Randomized trials are needed to address benefits of cART during PHI...
  72. ncbi Safety and pharmacokinetics of aciclovir in women following release from a silicone elastomer vaginal ring
    M J Keller
    Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Antimicrob Chemother 67:2005-12. 2012
    ..Intravaginal ring (IVR) delivery of aciclovir may provide pre-exposure prophylaxis against HSV acquisition...
  73. ncbi Comparison of Western blot (immunoblot) and glycoprotein G-specific immunodot enzyme assay for detecting antibodies to herpes simplex virus types 1 and 2 in human sera
    R L Ashley
    Department of Laboratory Medicine, University of Washington, Seattle 98105
    J Clin Microbiol 26:662-7. 1988
    ..WBA was more sensitive than IEA in detecting seroconversion following primary HSV-1 genital herpes, although both assays may miss persons undergoing early seroconversion to HSV-2...
  74. ncbi A randomized, double-blind, phase I/II trial of tumor necrosis factor and interferon-gamma for treatment of AIDS-related complex (Protocol 025 from the AIDS Clinical Trials Group)
    J M Agosti
    Department of Medicine, University of Washington, Seattle
    AIDS Res Hum Retroviruses 8:581-7. 1992
    ..These cytokines alone do not appear to be of benefit, nor do they appear to hasten the progression of HIV infection...
  75. ncbi Antigen-specific T cells localize to the uterine cervix in women with genital herpes simplex virus type 2 infection
    D M Koelle
    Allergy and Infectious Diseases, Harborview Medical Center, Seattle, WA 98104, USA
    J Infect Dis 182:662-70. 2000
    ..This local response may possibly assist in limiting the clinical consequences of secondary HSV-2 infection, whether due to endogenous reactivation or exogenous reinfection...
  76. ncbi Risk factors for repeatedly reactive HIV-1 EIA and indeterminate western blots. A population-based case-control study
    C L Celum
    Department of Medicine, University of Washington, Seattle
    Arch Intern Med 154:1129-37. 1994
    ..This case-control study assessed risk factors for IWB results, including early HIV infection, other retroviral infection, autoantibodies, and other medical conditions...
  77. ncbi Serial in vivo passage of HIV-1 infection in Macaca nemestrina
    M B Agy
    Regional Primate Research Center, University of Washington, Seattle 98195, USA
    Virology 238:336-43. 1997
    ..Whether such containment is a function of the host's immune response or a virus cell incompatibility remains to be determined...
  78. ncbi Prolonged fluconazole prophylaxis is associated with persistent protection against candidiasis-related death in allogeneic marrow transplant recipients: long-term follow-up of a randomized, placebo-controlled trial
    K A Marr
    Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, WA 98109 1024, USA
    Blood 96:2055-61. 2000
    ....
  79. ncbi Diagnostic accuracy of an allele-specific reverse transcriptase-PCR assay targeting the H275Y oseltamivir resistant mutation in 2009 pandemic influenza A/H1N1 virus
    C Renaud
    Fred Hutchinson Cancer Research Center, Seattle, WA, United States
    J Clin Virol 49:21-5. 2010
    ..Oseltamivir resistant 2009 pandemic influenza A/H1N1 viruses (pH1N1) are emerging and rapid molecular assays identifying these strains are needed for clinical management...
  80. ncbi Phase I study of a herpes simplex virus type 2 (HSV-2) DNA vaccine administered to healthy, HSV-2-seronegative adults by a needle-free injection system
    Ashok Cattamanchi
    Department of Medicine, University of Washington, Seattle, WA 98109, USA
    Clin Vaccine Immunol 15:1638-43. 2008
    ..A DNA-based vaccination strategy against HSV-2 appears to be safe and may generate a vaccine-specific cellular immune response, but high vaccine doses are likely needed to elicit an immune response in most vaccinees...
  81. ncbi Isolation of herpes simplex virus from the genital tract during symptomatic recurrence on the buttocks
    Katrina Kerkering
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    Obstet Gynecol 108:947-52. 2006
    ..Patients with buttock herpes recurrences should be instructed about the risk of genital shedding during such recurrences. LEVEL OF EVIDENCE: II-2...
  82. ncbi Env length and N-linked glycosylation following transmission of human immunodeficiency virus Type 1 subtype B viruses
    Yi Liu
    Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195 8070, USA
    Virology 374:229-33. 2008
    ....
  83. ncbi Rapid detection directly from patient serum samples of human cytomegalovirus UL97 mutations conferring ganciclovir resistance
    Jared Castor
    Department of Laboratory Medicine, University of Washington Medical Center, Seattle, Washington 98195, USA
    J Clin Microbiol 45:2681-3. 2007
    ..An evaluation of 120 sequential samples submitted for clinical testing revealed a variety of silent and amino acid mutations...
  84. ncbi Phase 2 study of an HIV-1 canarypox vaccine (vCP1452) alone and in combination with rgp120: negative results fail to trigger a phase 3 correlates trial
    Nina D Russell
    Program in Infectious Diseases, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    J Acquir Immune Defic Syndr 44:203-12. 2007
    ..We conducted a phase 2 trial to determine if a canarypox vaccine candidate (vCP1452) administered with rgp120 subunit protein would "qualify" for a trial to define a correlate of efficacy...
  85. ncbi Blood monocytes harbor HIV type 1 strains with diversified phenotypes including macrophage-specific CCR5 virus
    Younong Xu
    Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, Washington 98195 8070, USA
    J Infect Dis 197:309-18. 2008
    ..However, the biological function of monocyte-derived HIV-1 remains unclear...
  86. ncbi Virus-specific CD8+ T cells accumulate near sensory nerve endings in genital skin during subclinical HSV-2 reactivation
    Jia Zhu
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA
    J Exp Med 204:595-603. 2007
    ..These findings indicate that the frequency and clinical course of HSV-2 reactivation in humans is influenced by virus-specific CD8(+) T cells that persist in peripheral mucosa and genital skin after resolution of herpes lesions...
  87. ncbi Male genital tract compartmentalization of human immunodeficiency virus type 1 (HIV)
    Kurt Diem
    Department of Laboratory Medicine, University of Washington, Seattle, Washington 98195, USA
    AIDS Res Hum Retroviruses 24:561-71. 2008
    ..As such, our study findings are important for understanding the long-term response to antiretroviral therapy, the design of vaccines, and the sexual transmission of HIV...
  88. ncbi Maternal herpes simplex virus antibody avidity and risk of neonatal herpes
    Elizabeth L Brown
    Department of Epidemiology, University of Washington, Seattle, WA 98122, USA
    Am J Obstet Gynecol 195:115-20. 2006
    ..Among women with herpes simplex virus antibody at delivery, low antibody avidity was associated with herpes simplex virus transmission to the neonate and may be a useful marker for recent seroconversion...
  89. ncbi Early induction and maintenance of Env-specific T-helper cells following human immunodeficiency virus type 1 infection
    Uma Malhotra
    Program in Infectious Diseases, Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
    J Virol 77:2663-74. 2003
    ..The inability to detect Env-specific Th responses over time and despite antiretroviral therapy may reflect low frequencies and impaired proliferative capacity, and viral escape is not necessary for this to occur...
  90. ncbi Subclinical viremia increases risk for chronic allograft injury in pediatric renal transplantation
    Jodi M Smith
    Department of Pediatrics, University of Washington, Seattle, Washington, USA
    J Am Soc Nephrol 21:1579-86. 2010
    ..Taken together, these results demonstrate an association between subclinical CMV and EBV infections, which occur despite standard antiviral prophylaxis, and chronic allograft injury in pediatric renal transplant recipients...
  91. ncbi A humanized non-FcR-binding anti-CD3 antibody, visilizumab, for treatment of steroid-refractory acute graft-versus-host disease
    Paul A Carpenter
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, USA
    Blood 99:2712-9. 2002
    ..Visilizumab is well tolerated and has activity in advanced GVHD. A phase 2 study incorporating preemptive therapy for PTLD is warranted to determine the efficacy of visilizumab in GVHD...
  92. ncbi Polyamides reveal a role for repression in latency within resting T cells of HIV-infected donors
    Loyda Ylisastigui
    University of Texas Southwestern Medical Center at Dallas, Department of Medicine, Division of Infectious Diseases, Dallas, Texas 75390-9113, USA
    J Infect Dis 190:1429-37. 2004
    ..CONCLUSIONS: We identify histone deacetylation as a mechanism that can dampen viral expression in infected, activated CD4+ T cells and establish a persistent, quiescent reservoir of HIV infection...
  93. ncbi Correlates of human herpesvirus-8 seropositivity among U.S. military members recently infected with human immunodeficiency virus
    Nancy F Crum
    Department of Medicine, Infectious Diseases Division, Naval Medical Center San Diego, San Diego, California 92134 1005, USA
    Sex Transm Dis 30:713-8. 2003
    ..Human herpesvirus 8 (HHV-8), the cause of Kaposi's sarcoma, is common among HIV-infected persons. The exact route of transmission of HHV-8 in various populations is still debated...
  94. ncbi HHV-8 infection: a model for reactivation and transmission
    Lawrence Corey
    Department of Medicine, Laboratory Medicine and Epidemiology, University of Washington, Seattle, WA, USA
    Rev Med Virol 12:47-63. 2002
    ..Hopefully continued study will address many of the critical questions that exist today regarding how this infection is transmitted and acquired...
  95. ncbi CD27 expression promotes long-term survival of functional effector-memory CD8+ cytotoxic T lymphocytes in HIV-infected patients
    Adrian F Ochsenbein
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    J Exp Med 200:1407-17. 2004
    ..Our findings suggest that the CD27-CD70 interaction in HIV infection may provide CD27(+) CD8(+) T cells with a survival advantage and compensate for limiting or absent CD4(+) T help to maintain the CD8 response...
  96. ncbi Acyclovir sensitivity of sequential herpes simplex virus type 2 isolates from the genital mucosa of immunocompetent women
    Rachna Gupta
    Department of Medicine, University of Washington, Seattle, USA
    J Infect Dis 192:1102-7. 2005
    ..To understand the frequency and clinical significance of acyclovir-resistant isolates, we evaluated the in vitro acyclovir sensitivities of sequential isolates from 34 immunocompetent women...
  97. ncbi Evasion of the mucosal innate immune system by herpes simplex virus type 2
    Tao Peng
    Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    J Virol 83:12559-68. 2009
    ..HSV-2's blockade of the innate immune system's production of type I IFN may be a major factor in allowing the virus to break through host mucosal defenses...
  98. ncbi Comprehensive analysis of human immunodeficiency virus type 1 (HIV-1)-specific gamma interferon-secreting CD8+ T cells in primary HIV-1 infection
    Jianhong Cao
    Program in Infectious Diseases, Clinical Research Division, Fred Hutchinson Cancer Research Center and Department of Medicine, University of Washington, Seattle, Washington 98109, USA
    J Virol 77:6867-78. 2003
    ..Many novel epitopes, particularly directed to Nef, Tat, and Env, and frequently with unique HLA restrictions, merit further consideration in vaccine design...
  99. ncbi Diversity of the CD8+ T-cell response to herpes simplex virus type 2 proteins among persons with genital herpes
    Nancy Hosken
    Department of Laboratory Medicine, University of Washington, Seattle, WA 98109, USA
    J Virol 80:5509-15. 2006
    ..Whether this variability in the CD8(+) T-cell response within individuals is associated with the frequency of viral reactivation warrants further study...
  100. ncbi Compartmentalization of human immunodeficiency virus type 1 between blood monocytes and CD4+ T cells during infection
    Jennifer A Fulcher
    Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, WA 98195-8070, USA
    J Virol 78:7883-93. 2004
    ....
  101. ncbi Treatment of primary human immunodeficiency virus type 1 infection with potent antiretroviral therapy reduces frequency of rapid progression to AIDS
    M M Berrey
    Department of Medicine, University of Washington, Seattle, WA, USA
    J Infect Dis 183:1466-75. 2001
    ..Combination antiretroviral therapy during primary HIV-1 infection demonstrated a decreased frequency of minor opportunistic infections, mucocutaneous disorders, and respiratory infections and reduced progression to AIDS...