Affiliation: University of California
- Smoked cannabis for spasticity in multiple sclerosis: a randomized, placebo-controlled trialJody Corey-Bloom
Department of Neurosciences, University of California, San Diego, La Jolla, Calif, USA
CMAJ 184:1143-50. 2012..Spasticity is a common and poorly controlled symptom of multiple sclerosis. Our objective was to determine the short-term effect of smoked cannabis on this symptom...
- Treatment trials in aging and mild cognitive impairmentJody Corey-Bloom
Shiley Marcos Alzheimer Disease Research Center, University of California, San Diego, 8950 Villa La Jolla Drive Suite C129, La Jolla, CA, 92037, USA
Curr Top Behav Neurosci 10:347-56. 2012....
- Basal ganglia atrophy in prodromal Huntington's disease is detectable over one year using automated segmentationD S Adnan Majid
Department of Psychology, University of California, San Diego, San Diego, California 92093 0841, USA
Mov Disord 26:2544-51. 2011..This underscores the utility of this automatic image segmentation and longitudinal nonlinear registration method for upcoming studies of preHD and other neurodegenerative disorders...
- Sustained use of CPAP slows deterioration of cognition, sleep, and mood in patients with Alzheimer's disease and obstructive sleep apnea: a preliminary studyJana R Cooke
Department of Medicine, University of California, San Diego, CA, USA
J Clin Sleep Med 5:305-9. 2009..Continuous positive airway pressure (CPAP) has recently been shown to have beneficial effects on cognition in AD. Little attention has focused on the long-term benefits of CPAP in these patients...
- Automated structural imaging analysis detects premanifest Huntington's disease neurodegeneration within 1 yearD S Adnan Majid
Department of Psychology, University of California, San Diego UCSD, San Diego, California, USA
Mov Disord 26:1481-8. 2011..This MRI biomarker approach could be used to evaluate neuroprotection in preHD...
- Effect of light on agitation in institutionalized patients with severe Alzheimer diseaseSonia Ancoli-Israel
Department of Psychiatry, University of California, San Diego, Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA
Am J Geriatr Psychiatry 11:194-203. 2003..The authors expand on an earlier pilot study by evaluating the effect of bright light therapy on agitated behavior in a large sample of patients with severe dementia...
- Changes on brief cognitive instruments over time in Parkinson's diseaseSTEPHANIE LESSIG
Department of Neurosciences, University of California San Diego, San Diego, California, USA
Mov Disord 27:1125-8. 2012..This suggests that the MoCA may be more sensitive for detecting early cognitive change in PD, but that the MMSE, and not the MoCA, may be better for tracking cognitive decline...
- Neuropsychological deficits associated with Alzheimer's disease in the very-old: discrepancies in raw vs. standardized scoresMark W Bondi
VA San Diego Healthcare System, San Diego, California 92161, USA
J Int Neuropsychol Soc 9:783-95. 2003..These data suggest that the profile of neuropsychological deficits associated with AD in the Very-Old lacks the disproportionate saliency of episodic memory and executive function deficits typical of the Young-Old...
- Stability of resting fMRI interregional correlations analyzed in subject-native space: a one-year longitudinal study in healthy adults and premanifest Huntington's diseaseTyler M Seibert
Department of Bioengineering, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0949, USA
Neuroimage 59:2452-63. 2012..Within the premanifest Huntington's group, though, there was evidence that decreased striatal functional correlations might be associated with disease severity, as gauged by estimated years to symptom onset or by striatal volume...
- Cognitive and functional decline in Huntington's disease: dementia criteria revisitedGuerry M Peavy
Department of Neurosciences, University of California, San Diego, California, USA
Mov Disord 25:1163-9. 2010....
- Profile of hippocampal volumes and stroke risk varies by neuropsychological definition of mild cognitive impairmentAmy J Jak
Research Service, VA San Diego Healthcare System, San Diego, CA 92161, USA
J Int Neuropsychol Soc 15:890-7. 2009....
- Difficulty modifying a sustained motor response in prodromal Huntington's diseaseLaura Mickes
Department of Psychology, University of California, San Diego, La Jolla, CA 92093 0109, USA
J Clin Exp Neuropsychol 35:35-40. 2013..Our results show that motor slowing is evident prior to the clinical diagnosis of Huntington's disease and may reflect difficulty in modifying a sustained motor program...
- A comparison of two brief screening measures of cognitive impairment in Huntington's diseaseLaura Mickes
Department of Psychology, University of California, San Diego, La Jolla, California 92093 0109, USA
Mov Disord 25:2229-33. 2010..e., visuospatial abilities) revealed that the MoCA achieved higher sensitivity without sacrificing specificity in many domains relative to the MMSE...
- Evaluating imaging biomarkers for neurodegeneration in pre-symptomatic Huntington's disease using machine learning techniquesAngela Rizk-Jackson
Department of Neuroscience, University of California Los Angeles, Los Angeles, CA, USA
Neuroimage 56:788-96. 2011..We have shown that several neuroimaging measures contain multivariate patterns of information that are useful for the development of disease-state biomarkers for HD...
- Continuous positive airway pressure deepens sleep in patients with Alzheimer's disease and obstructive sleep apneaJana R Cooke
Department of Medicine, University of California San Diego, La Jolla, CA 92093 0733, USA
Sleep Med 10:1101-6. 2009..Patients with Alzheimer's disease (AD) and obstructive sleep apnea (OSA) experience disrupted sleep. This study examined the effect of continuous positive airway pressure (CPAP) on sleep parameters in AD patients with OSA...
- The contribution of cognition and spasticity to driving performance in multiple sclerosisThomas D Marcotte
Department of Psychiatry, University of California, San Diego, CA 92119, USA
Arch Phys Med Rehabil 89:1753-8. 2008..To examine the independent and combined impact of cognitive dysfunction and spasticity on driving tasks involving high cognitive workload and lower-limb mobility in persons with multiple sclerosis (MS)...
- Recall discriminability: utility of a new CVLT-II measure in the differential diagnosis of dementiaDean C Delis
Psychology Service, Veterans Affairs San Diego Healthcare System, San Diego, California 92161, USA
J Int Neuropsychol Soc 11:708-15. 2005..Implications of these results for clinical practice and theories of memory disorder in dementia are discussed...
- The ABC of Alzheimer's disease: cognitive changes and their management in Alzheimer's disease and related dementiasJody Corey-Bloom
Neurology Service, UCSD School of Medicine, San Diego, California 92161, USA
Int Psychogeriatr 14:51-75. 2002..The benefits of long-term treatment on symptomatic improvement in cognition and further potential disease-modifying effects are highlighted...
- Differential cross-sectional and longitudinal impact of APOE genotype on hippocampal volumes in nondemented older adultsAmy J Jak
Veteran s Medical Research Foundation, San Diego, CA 92161, USA
Dement Geriatr Cogn Disord 23:382-9. 2007..Because of conflicting findings across studies, we sought to better determine the relationship between apolipoprotein E (APOE) genotype, hippocampal volume, and cognitive performance in nondemented older adults...
- Impaired postural stability as a marker of premanifest Huntington's diseaseDanielle Salomonczyk
Department of Psychology, San Diego State University, San Diego, California 92120, USA
Mov Disord 25:2428-33. 2010..The findings suggest that the SOT may be a highly sensitive indicator of early motor impairment and subsequent phenoconversion to manifest HD in preHD...
- Cognitive performance on the mini-mental state examination and the montreal cognitive assessment across the healthy adult lifespanShea Gluhm
Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA
Cogn Behav Neurol 26:1-5. 2013..We sought to compare age-related performance on the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) across the adult lifespan in an asymptomatic, presumably normal, sample...
- Increased light exposure consolidates sleep and strengthens circadian rhythms in severe Alzheimer's disease patientsSonia Ancoli-Israel
Department of Psychiatry 116A, University of California, Veterans Affairs San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
Behav Sleep Med 1:22-36. 2003..It would behoove nursing homes to consider increasing ambient light in multipurpose rooms where patients often spend much of their days...