Giovanni Coppola

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc An epigenetic signature in peripheral blood associated with the haplotype on 17q21.31, a risk factor for neurodegenerative tauopathy
    Yun Li
    Department of Psychiatry and Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS Genet 10:e1004211. 2014
  2. pmc Transcriptome signature of the adult mouse choroid plexus
    Fernanda Marques
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus Gualtar, 4710 057 Braga, Portugal
    Fluids Barriers CNS 8:10. 2011
  3. pmc The choroid plexus response to a repeated peripheral inflammatory stimulus
    Fernanda Marques
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus Gualtar, 4710 057 Braga, Portugal
    BMC Neurosci 10:135. 2009
  4. doi request reprint Designing, performing, and interpreting a microarray-based gene expression study
    Giovanni Coppola
    Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, 1524 Gonda Neuroscience and Genetics Research Center, University of California Los Angeles, Los Angeles, CA, USA
    Methods Mol Biol 793:417-39. 2011
  5. pmc Functional genomic analysis of frataxin deficiency reveals tissue-specific alterations and identifies the PPARgamma pathway as a therapeutic target in Friedreich's ataxia
    Giovanni Coppola
    Department of Neurology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Hum Mol Genet 18:2452-61. 2009
  6. pmc Plasma methionine sulfoxide in persons with familial Alzheimer's disease mutations
    John M Ringman
    Mary S Easton Center for Alzheimer s Disease Research, Department of Neurology, University of California at Los Angeles, Los Angeles, CA 90095 7334, USA
    Dement Geriatr Cogn Disord 33:219-25. 2012
  7. pmc Gene expression profiling of R6/2 transgenic mice with different CAG repeat lengths reveals genes associated with disease onset and progression in Huntington's disease
    Bin Tang
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA, USA
    Neurobiol Dis 42:459-67. 2011
  8. pmc Neurodegenerative disease phenotypes in carriers of MAPT p.A152T, a risk factor for frontotemporal dementia spectrum disorders and Alzheimer disease
    Suzee E Lee
    Department of Neurology, Memory and Aging Center, University of California, San Francisco, CA Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, ON, Canada Department of Neurology and Neurosciences, Brain Dynamics Research Center, Dokuz Eylul University, Izmir, Turkey BEYINMER, Istanbul Kultur University, Istanbul, Turkey Neurology Service and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Marques de Valdecilla University Hospital, Institute for Formation and Research of the Foundation Marqués de Valdecilla IFIMAV, University of Cantabria, Cantabria, Spain Cognitive Disorders Unit, Department of Neurology, Hospital Universitario Donostia, San Sebastian, Gipuzkoa, Spain Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Area 6, Institute Carlos III, Spain Neuroscience Area, Institute Biodonostia, San Sebastian, Gipuzkoa, Spain Department of Neurology, Neurobehavior Division, University of California, Los Angeles Department of Psychiatry and Neurology, University of California, Los Angeles, CA Department of Neuroscience, Mayo Clinic, Rochester, MN Department of Medicine, Weill Medical College of Cornell University
    Alzheimer Dis Assoc Disord 27:302-9. 2013
  9. pmc Human-specific transcriptional regulation of CNS development genes by FOXP2
    Genevieve Konopka
    Program in Neurogenetics, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Nature 462:213-7. 2009
  10. pmc Progranulin mutations as risk factors for Alzheimer disease
    David C Perry
    Department of Neurology, University of California, San Francisco, CA 94158, USA
    JAMA Neurol 70:774-8. 2013

Detail Information

Publications38

  1. pmc An epigenetic signature in peripheral blood associated with the haplotype on 17q21.31, a risk factor for neurodegenerative tauopathy
    Yun Li
    Department of Psychiatry and Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS Genet 10:e1004211. 2014
    ..These data reveal that the H1 haplotype increases risk for tauopathy via differential methylation at that locus, indicating a mediating role for methylation in dementia pathophysiology...
  2. pmc Transcriptome signature of the adult mouse choroid plexus
    Fernanda Marques
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus Gualtar, 4710 057 Braga, Portugal
    Fluids Barriers CNS 8:10. 2011
    ..abstract:..
  3. pmc The choroid plexus response to a repeated peripheral inflammatory stimulus
    Fernanda Marques
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus Gualtar, 4710 057 Braga, Portugal
    BMC Neurosci 10:135. 2009
    ..As part of the barriers that separate the blood from the brain, the choroid plexus conveys inflammatory immune signals into the brain, largely through alterations in the composition of the cerebrospinal fluid...
  4. doi request reprint Designing, performing, and interpreting a microarray-based gene expression study
    Giovanni Coppola
    Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, 1524 Gonda Neuroscience and Genetics Research Center, University of California Los Angeles, Los Angeles, CA, USA
    Methods Mol Biol 793:417-39. 2011
    ..The basic analytical steps are covered, and annotated R code for the analysis of a published dataset is provided...
  5. pmc Functional genomic analysis of frataxin deficiency reveals tissue-specific alterations and identifies the PPARgamma pathway as a therapeutic target in Friedreich's ataxia
    Giovanni Coppola
    Department of Neurology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Hum Mol Genet 18:2452-61. 2009
    ..Finally, we show that genetic modulation of the PPARgamma pathway affects frataxin levels in vitro, supporting PPARgamma as a novel therapeutic target in FRDA...
  6. pmc Plasma methionine sulfoxide in persons with familial Alzheimer's disease mutations
    John M Ringman
    Mary S Easton Center for Alzheimer s Disease Research, Department of Neurology, University of California at Los Angeles, Los Angeles, CA 90095 7334, USA
    Dement Geriatr Cogn Disord 33:219-25. 2012
    ..We asked if consequently, oxidation of methionine residues to methionine sulfoxide (MetO) was increased in plasma proteins of persons carrying familial AD (FAD) mutations...
  7. pmc Gene expression profiling of R6/2 transgenic mice with different CAG repeat lengths reveals genes associated with disease onset and progression in Huntington's disease
    Bin Tang
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA, USA
    Neurobiol Dis 42:459-67. 2011
    ..Such genes may represent novel therapeutic avenues to decrease htt aggregate toxicity and cell death in HD patients, with Lrsam1 being a promising, novel candidate disease modifier...
  8. pmc Neurodegenerative disease phenotypes in carriers of MAPT p.A152T, a risk factor for frontotemporal dementia spectrum disorders and Alzheimer disease
    Suzee E Lee
    Department of Neurology, Memory and Aging Center, University of California, San Francisco, CA Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, ON, Canada Department of Neurology and Neurosciences, Brain Dynamics Research Center, Dokuz Eylul University, Izmir, Turkey BEYINMER, Istanbul Kultur University, Istanbul, Turkey Neurology Service and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Marques de Valdecilla University Hospital, Institute for Formation and Research of the Foundation Marqués de Valdecilla IFIMAV, University of Cantabria, Cantabria, Spain Cognitive Disorders Unit, Department of Neurology, Hospital Universitario Donostia, San Sebastian, Gipuzkoa, Spain Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Area 6, Institute Carlos III, Spain Neuroscience Area, Institute Biodonostia, San Sebastian, Gipuzkoa, Spain Department of Neurology, Neurobehavior Division, University of California, Los Angeles Department of Psychiatry and Neurology, University of California, Los Angeles, CA Department of Neuroscience, Mayo Clinic, Rochester, MN Department of Medicine, Weill Medical College of Cornell University
    Alzheimer Dis Assoc Disord 27:302-9. 2013
    ..These data warrant larger studies with clinicopathologic correlation to elucidate the influence of this genetic variant on neurodegenerative disease. ..
  9. pmc Human-specific transcriptional regulation of CNS development genes by FOXP2
    Genevieve Konopka
    Program in Neurogenetics, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Nature 462:213-7. 2009
    ..Because FOXP2 has an important role in speech and language in humans, the identified targets may have a critical function in the development and evolution of language circuitry in humans...
  10. pmc Progranulin mutations as risk factors for Alzheimer disease
    David C Perry
    Department of Neurology, University of California, San Francisco, CA 94158, USA
    JAMA Neurol 70:774-8. 2013
    ..We describe 2 patients with progranulin gene mutations and evidence of Alzheimer disease (AD) pathology. We also conducted a literature review...
  11. pmc Functional genomic analyses identify pathways dysregulated by progranulin deficiency, implicating Wnt signaling
    Ezra Y Rosen
    Interdepartmental Program for Neuroscience, University of California Los Angeles, Los Angeles, CA 90095, USA
    Neuron 71:1030-42. 2011
    ..Together, these in vitro and in vivo data point to an adaptive role for altered Wnt signaling in GRN deficiency-mediated FTD, representing a potential therapeutic target...
  12. pmc Induced pluripotent stem cell models of progranulin-deficient frontotemporal dementia uncover specific reversible neuronal defects
    Sandra Almeida
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell Rep 2:789-98. 2012
    ..Our findings identify cell-autonomous, reversible defects in patient neurons with PGRN deficiency, and provide a compelling model for studying PGRN-dependent pathogenic mechanisms and testing potential therapies...
  13. pmc Mutations in SLC20A2 are a major cause of familial idiopathic basal ganglia calcification
    Sandy Chan Hsu
    Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    Neurogenetics 14:11-22. 2013
    ..Non-perfect segregation patterns of predicted deleterious variants highlight the challenges of phenotypic assessment in this condition with highly variable clinical presentation...
  14. pmc New genes and new insights from old genes: update on Alzheimer disease
    John M Ringman
    Easton Center for Alzheimer s Disease Research at UCLA, 10911 Weyburn Ave, 200, Los Angeles, CA 90095 7226, USA
    Continuum (Minneap Minn) 19:358-71. 2013
    ..This article discusses the current status of knowledge regarding the genetic basis of Alzheimer disease (AD) with a focus on clinically relevant aspects...
  15. pmc Regional brain volume differences in symptomatic and presymptomatic carriers of familial Alzheimer's disease mutations
    Grace J Lee
    Mary S Easton Center for Alzheimer s Disease Research, Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7226, USA
    J Neurol Neurosurg Psychiatry 84:154-62. 2013
    ..Using tensor-based morphometry (TBM), we examined brain volume differences between presymptomatic and symptomatic FAD mutation carriers and non-carrier (NC) relatives...
  16. pmc A gene expression phenotype in lymphocytes from Friedreich ataxia patients
    Giovanni Coppola
    Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Ann Neurol 70:790-804. 2011
    ..Peripheral biomarkers related to disease status would be extremely valuable for assessing drug efficacy and could provide new pathophysiological insights...
  17. pmc Genomic profiles of damage and protection in human intracerebral hemorrhage
    S Thomas Carmichael
    Department of Neurology, Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    J Cereb Blood Flow Metab 28:1860-75. 2008
    ..These inflammatory and anti-inflammatory networks interact at several key points in neutrophil signaling, apoptotic cell death, and protease responses, and indicate that secondary damage in ICH activates opposing molecular systems...
  18. pmc Greater medial temporal hypometabolism and lower cortical amyloid burden in ApoE4-positive AD patients
    Manja Lehmann
    Department of Neurology, Memory and Aging Center, University of California, San Francisco, California, USA
    J Neurol Neurosurg Psychiatry 85:266-73. 2014
    ..We aimed to assess the relationship between amyloid deposition, glucose metabolism and ApoE4 genotype in a clinically heterogeneous population of AD patients...
  19. pmc Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases
    Giovanni Coppola
    Department of Neurology, University of California, Los Angeles, CA, USA
    Hum Mol Genet 21:3500-12. 2012
    ....
  20. pmc In vivo cell-autonomous transcriptional abnormalities revealed in mice expressing mutant huntingtin in striatal but not cortical neurons
    Elizabeth A Thomas
    Department of Molecular Biology, Scripps Research Institute, La Jolla, CA, USA
    Hum Mol Genet 20:1049-60. 2011
    ..Overall, HD-induced dysregulation of the striatal transcriptome can be largely attributed to intrinsic effects of mutant Htt, in the absence of expression in cortical neurons...
  21. pmc Cerebrospinal fluid neurofilament concentration reflects disease severity in frontotemporal degeneration
    Carole S Scherling
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA
    Ann Neurol 75:116-26. 2014
    ..Cerebrospinal fluid (CSF) neurofilament light chain (NfL) concentration is elevated in neurological disorders, including frontotemporal degeneration (FTD). We investigated the clinical correlates of elevated CSF NfL levels in FTD...
  22. pmc Gene expression study on peripheral blood identifies progranulin mutations
    Giovanni Coppola
    Department of Neurology, Program in Neurogenetics, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Ann Neurol 64:92-6. 2008
    ..This proof-of-principle report supports the use of gene quantification as diagnostic screen for PGRN mutations and suggests a potential role for progranulin in Alzheimer's disease...
  23. pmc Mutations in rare ataxia genes are uncommon causes of sporadic cerebellar ataxia
    Brent L Fogel
    Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
    Mov Disord 27:442-6. 2012
    ..Rare genetic ataxias, reported only in specific populations or families, may contribute to a percentage of sporadic ataxia...
  24. pmc Familial cortical myoclonus with a mutation in NOL3
    Jonathan F Russell
    Department of Neurology, School of Medicine, University of California at San Francisco, San Francisco, CA 94158, USA
    Ann Neurol 72:175-83. 2012
    ..We identified a family suffering from adult onset, cortical myoclonus without associated seizures. We performed clinical, electrophysiological, and genetic studies to define this phenotype...
  25. pmc Microarrays and the microscope: balancing throughput with resolution
    Giovanni Coppola
    Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    J Physiol 575:353-9. 2006
    ..Here we review representative examples of currently available methods that allow high resolution and specificity in brain microarray studies, while maintaining the goal of comprehensive, high-throughput analysis...
  26. pmc Novel roles for osteopontin and clusterin in peripheral motor and sensory axon regeneration
    Megan C Wright
    Departments of Neurology, Neuroscience, and Orthopedics, The Johns Hopkins School of Medicine, Baltimore, Maryland 21287, and Departments of Neurology and Psychiatry, University of California, Los Angeles, Los Angeles, California 90095
    J Neurosci 34:1689-700. 2014
    ..Together, these studies suggest unique roles for SC-derived OPN and CLU in regeneration of peripheral motor and sensory axons. ..
  27. pmc Frontotemporal dementia due to C9ORF72 mutations: clinical and imaging features
    Sharon J Sha
    Department of Neurology, University of California, San Francisco, USA
    Neurology 79:1002-11. 2012
    ..To describe the phenotype of patients with C9FTD/ALS (C9ORF72) hexanucleotide repeat expansion...
  28. pmc Cerebrospinal fluid biomarkers and proximity to diagnosis in preclinical familial Alzheimer's disease
    John M Ringman
    Mary S Easton Center for Alzheimer s Disease Research at UCLA, Los Angeles, Calif, USA
    Dement Geriatr Cogn Disord 33:1-5. 2012
    ..Changes in cerebrospinal fluid (CSF) levels of 42-amino-acid β-amyloid (Aβ(42)), total tau protein (t-tau) and phosphorylated tau at residue 181 (p-tau(181)) during this state are incompletely characterized...
  29. pmc Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors
    Mary E Hamby
    Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095 1763, USA
    J Neurosci 32:14489-510. 2012
    ....
  30. pmc An age-related sprouting transcriptome provides molecular control of axonal sprouting after stroke
    Songlin Li
    Department of Neurology, David Geffen School of Medicine at University of California, Los Angeles, California, USA
    Nat Neurosci 13:1496-504. 2010
    ..This neuronal growth program may provide new therapeutic targets and suggest mechanisms for age-related differences in functional recovery...
  31. pmc Epigenetics of Alzheimer's disease and frontotemporal dementia
    Chendhore S Veerappan
    Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA
    Neurotherapeutics 10:709-21. 2013
    ....
  32. pmc Network organization of the huntingtin proteomic interactome in mammalian brain
    Dyna I Shirasaki
    Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA
    Neuron 75:41-57. 2012
    ....
  33. pmc Disruption of astrocyte STAT3 signaling decreases mitochondrial function and increases oxidative stress in vitro
    Theodore A Sarafian
    Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 5:e9532. 2010
    ..We have recently shown that STAT3 is an important regulator of astrocyte reactivity after spinal cord injury in vivo[1]...
  34. ncbi request reprint Technology Insight: querying the genome with microarrays--progress and hope for neurological disease
    Giovanni Coppola
    Neurogenetics Program, Center for Autism Research, University of California Los Angeles, CA 90095, USA
    Nat Clin Pract Neurol 2:147-58. 2006
    ..Numerous clinical and preclinical applications are likely to dominate the ambitious microarray agenda within the next decade...
  35. pmc Identification of the transcriptional targets of FOXP2, a gene linked to speech and language, in developing human brain
    Elizabeth Spiteri
    Program in Neurogenetics, Department of Neurology, University of California Los Angeles, Los Angeles, CA 90095, USA
    Am J Hum Genet 81:1144-57. 2007
    ....
  36. pmc A shift to organismal stress resistance in programmed cell death mutants
    Meredith E Judy
    Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, California, United States of America Department of Biochemistry, University of California San Francisco, San Francisco, California, United States of America
    PLoS Genet 9:e1003714. 2013
    ..While the mechanism is not entirely clear, it is intriguing that animals lacking the ability to efficiently and correctly remove dying cells should switch to a more global animal-wide system of stress resistance. ..
  37. pmc Younger age of dementia diagnosis in a Hispanic population in southern California
    L Jaime Fitten
    Easton Center for Alzheimer Disease Research, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA Greater Los Angeles Veterans Affairs Healthcare System, Sepulveda Ambulatory Care Center, US Department of Veterans Affairs, Los Angeles, CA, USA Department of Psychiatry Olive View, UCLA Medical Center, Los Angeles, CA, USA Department of Psychiatry and Biobehavioral Sciences, School of Medicine, UCLA, Los Angeles, CA, USA
    Int J Geriatr Psychiatry 29:586-93. 2014
    ..We performed a cross-sectional study to examine clinical and sociodemographic variables associated with age of dementia diagnosis in older Hispanics and White, non-Hispanics in southern California...
  38. pmc Gene expression profiling in frataxin deficient mice: microarray evidence for significant expression changes without detectable neurodegeneration
    Giovanni Coppola
    Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine UCLA, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Neurobiol Dis 22:302-11. 2006
    ..The identification of a core set of genes changing early in the FRDA pathogenesis can be a useful tool in both clarifying the disease process and in evaluating new therapeutic strategies...