Domenico Coppola

Summary

Affiliation: University of South Florida
Country: USA

Publications

  1. pmc Bax-interacting factor-1 expression in prostate cancer
    Domenico Coppola
    Department of Anatomic Pathology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612 9497, USA
    Clin Genitourin Cancer 6:117-21. 2008
  2. pmc Sequence, "subtle" alternative splicing and expression of the CYYR1 (cysteine/tyrosine-rich 1) mRNA in human neuroendocrine tumors
    Lorenza Vitale
    Department of Histology, Embryology and Applied Biology, University of Bologna, Bologna, Italy
    BMC Cancer 7:66. 2007
  3. pmc Microarray-based identification and RT-PCR test screening for epithelial-specific mRNAs in peripheral blood of patients with colon cancer
    Rossella Solmi
    Department of Histology, Embryology and Applied Biology, University of Bologna, Via Belmeloro 8, I 40126 Bologna, Italy
    BMC Cancer 6:250. 2006
  4. pmc IKKepsilon phosphorylation of estrogen receptor alpha Ser-167 and contribution to tamoxifen resistance in breast cancer
    Jian Ping Guo
    Department of Molecular Oncology, H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
    J Biol Chem 285:3676-84. 2010
  5. doi Expression of the antiapoptotic protein survivin in colon cancer
    Jonathan M Hernandez
    Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, FL, USA
    Clin Colorectal Cancer 10:188-93. 2011
  6. doi SLC5A8 nuclear translocation and loss of expression are associated with poor outcome in pancreatic ductal adenocarcinoma
    James Helm
    Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, FL 33612, USA
    Pancreas 41:904-9. 2012
  7. pmc Ack1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancer
    Kiran Mahajan
    Department of Drug Discovery, Moffitt Cancer Center, Tampa, Florida 33612, USA
    J Biol Chem 287:22112-22. 2012
  8. pmc ID1 facilitates the growth and metastasis of non-small cell lung cancer in response to nicotinic acetylcholine receptor and epidermal growth factor receptor signaling
    Smitha Pillai
    H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, Florida 33612, USA
    Mol Cell Biol 31:3052-67. 2011
  9. pmc ARRB1-mediated regulation of E2F target genes in nicotine-induced growth of lung tumors
    Piyali Dasgupta
    Department of Oncologic Sciences, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    J Natl Cancer Inst 103:317-33. 2011
  10. pmc Deregulation of IKBKE is associated with tumor progression, poor prognosis, and cisplatin resistance in ovarian cancer
    Jian Ping Guo
    Departments of Molecular Oncology, H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
    Am J Pathol 175:324-33. 2009

Detail Information

Publications76

  1. pmc Bax-interacting factor-1 expression in prostate cancer
    Domenico Coppola
    Department of Anatomic Pathology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612 9497, USA
    Clin Genitourin Cancer 6:117-21. 2008
    ..Loss of Bif-1 suppresses the intrinsic pathway of apoptosis and promotes tumorigenesis. We examined the expression levels of Bif-1 protein in human prostate cancer...
  2. pmc Sequence, "subtle" alternative splicing and expression of the CYYR1 (cysteine/tyrosine-rich 1) mRNA in human neuroendocrine tumors
    Lorenza Vitale
    Department of Histology, Embryology and Applied Biology, University of Bologna, Bologna, Italy
    BMC Cancer 7:66. 2007
    ..These cells may be the origin of neuroendocrine (NE) tumors. The aim of this study was to conduct an initial analysis of sequence, splicing and expression of the CYYR1 mRNA in human NE tumors...
  3. pmc Microarray-based identification and RT-PCR test screening for epithelial-specific mRNAs in peripheral blood of patients with colon cancer
    Rossella Solmi
    Department of Histology, Embryology and Applied Biology, University of Bologna, Via Belmeloro 8, I 40126 Bologna, Italy
    BMC Cancer 6:250. 2006
    ..This method seems able to reduce colorectal cancer mortality and may replace colonoscopy as the most effective means of detecting colonic lesions...
  4. pmc IKKepsilon phosphorylation of estrogen receptor alpha Ser-167 and contribution to tamoxifen resistance in breast cancer
    Jian Ping Guo
    Department of Molecular Oncology, H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
    J Biol Chem 285:3676-84. 2010
    ..These data suggest that ERalpha is a bona fide substrate of IKKepsilon and IKKepsilon plays an important role in tamoxifen resistance. Thus, IKKepsilon represents a critical therapeutic target in breast cancer...
  5. doi Expression of the antiapoptotic protein survivin in colon cancer
    Jonathan M Hernandez
    Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, FL, USA
    Clin Colorectal Cancer 10:188-93. 2011
    ..We sought to evaluate survivin expression in colonic neoplasia and identify relationships with additional regulators of apoptosis...
  6. doi SLC5A8 nuclear translocation and loss of expression are associated with poor outcome in pancreatic ductal adenocarcinoma
    James Helm
    Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, FL 33612, USA
    Pancreas 41:904-9. 2012
    ..This study aimed to assess the role of SLC5A8 expression in the survival of pancreatic cancer...
  7. pmc Ack1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancer
    Kiran Mahajan
    Department of Drug Discovery, Moffitt Cancer Center, Tampa, Florida 33612, USA
    J Biol Chem 287:22112-22. 2012
    ....
  8. pmc ID1 facilitates the growth and metastasis of non-small cell lung cancer in response to nicotinic acetylcholine receptor and epidermal growth factor receptor signaling
    Smitha Pillai
    H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, Florida 33612, USA
    Mol Cell Biol 31:3052-67. 2011
    ....
  9. pmc ARRB1-mediated regulation of E2F target genes in nicotine-induced growth of lung tumors
    Piyali Dasgupta
    Department of Oncologic Sciences, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    J Natl Cancer Inst 103:317-33. 2011
    ..However, whether ARRB1 translocates to the nucleus upon nicotinic acetylcholine receptor activation and how it regulates growth of human NSCLCs are not known...
  10. pmc Deregulation of IKBKE is associated with tumor progression, poor prognosis, and cisplatin resistance in ovarian cancer
    Jian Ping Guo
    Departments of Molecular Oncology, H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
    Am J Pathol 175:324-33. 2009
    ..IKKepsilon could also serve as a prognostic marker and potential therapeutic target for this malignancy...
  11. pmc Unique ectopic lymph node-like structures present in human primary colorectal carcinoma are identified by immune gene array profiling
    Domenico Coppola
    Anatomic Pathology Division, Moffitt Cancer Center, Tampa, FL 33612 9497, USA
    Am J Pathol 179:37-45. 2011
    ....
  12. doi Histologic characteristics enhance predictive value of American Joint Committee on Cancer staging in resectable pancreas cancer
    James Helm
    Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, Florida, USA
    Cancer 115:4080-9. 2009
    ....
  13. pmc Correlation between Mcl-1 and pAKT protein expression in colorectal cancer
    Evita B Henderson-Jackson
    Departments of Oncologic Sciences Moffitt Cancer Center and Research Institute, at the University of South Florida, School of Medicine, Tampa, Florida 33612 3275, USA
    Int J Clin Exp Pathol 3:768-74. 2010
    ..008). We report the correlation of Mcl-1 protein expression with higher grade and stage in colorectal cancer. Mcl-1 correlated also with pAKT expression. We also report the up regulation of pAKT during the transition from NR to CRC...
  14. pmc MicroRNA-155 is regulated by the transforming growth factor beta/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA
    William Kong
    Departments of Molecular Oncology, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Dr, SRB3, Tampa, FL 33612, USA
    Mol Cell Biol 28:6773-84. 2008
    ..These data suggest that miR-155 may play an important role in TGF-beta-induced EMT and cell migration and invasion by targeting RhoA and indicate that it is a potential therapeutic target for breast cancer intervention...
  15. pmc MicroRNA-221/222 negatively regulates estrogen receptor alpha and is associated with tamoxifen resistance in breast cancer
    Jian Jun Zhao
    H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    J Biol Chem 283:31079-86. 2008
    ....
  16. ncbi Activation of the serine/threonine protein kinase AKT during the progression of colorectal neoplasia
    Ozlen Saglam
    Anatomic Pathology, Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center, Tampa, FL 33612 9497, USA
    Clin Colorectal Cancer 6:652-6. 2007
    ..AKT has been identified as a major regulator of cell proliferation, tumorigenesis, and apoptosis. In this study, we evaluated changes in the activity of AKT during colorectal cancer (CRC) progression...
  17. doi RUNX1T1: a novel predictor of liver metastasis in primary pancreatic endocrine neoplasms
    Aejaz Nasir
    Department of Pathology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA
    Pancreas 40:627-33. 2011
    ....
  18. ncbi P53 enhances ascorbyl stearate-induced G2/M arrest of human ovarian cancer cells
    K Akhilender Naidu
    Division of Anatomic Pathology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    Anticancer Res 27:3927-34. 2007
    ..We have previously demonstrated that Asc-S inhibits ovarian carcinoma cell proliferation through modulation of the cell cycle. This study was designed to further elucidate the mechanisms underlying such regulation...
  19. pmc Ack1 tyrosine kinase activation correlates with pancreatic cancer progression
    Kiran Mahajan
    Department of Drug Discovery, Moffitt Cancer Center, Tampa, Florida 33612, USA
    Am J Pathol 180:1386-93. 2012
    ..Collectively, our data indicate that activated Ack1 could be a prognostic marker for ascertaining early or advanced pancreatic cancer. Thus, Ack1 inhibitors hold promise for therapeutic intervention to inhibit pancreatic tumor growth...
  20. doi Complementary strand microRNAs mediate acquisition of metastatic potential in colonic adenocarcinoma
    Dung Tsa Chen
    Department of Biomedical Informatics, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA
    J Gastrointest Surg 16:905-12; discussion 912-3. 2012
    ..However, little is known about the genome-wide alterations in miRNA expression during the neoplastic progression of primary colorectal cancers...
  21. pmc SirT1 is an inhibitor of proliferation and tumor formation in colon cancer
    Neha Kabra
    Molecular Oncology Program, Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    J Biol Chem 284:18210-7. 2009
    ..These results suggest a rationale for the use of SirT1 activators and inhibitors in the prevention and treatment of colon cancer...
  22. pmc MicroRNA-155 regulates cell survival, growth, and chemosensitivity by targeting FOXO3a in breast cancer
    William Kong
    Department of Molecular Oncology, H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
    J Biol Chem 285:17869-79. 2010
    ..In conclusion, our study reveals a molecular link between miR-155 and FOXO3a and presents evidence that miR-155 is a critical therapeutic target in breast cancer...
  23. pmc Nicotine promotes tumor growth and metastasis in mouse models of lung cancer
    Rebecca Davis
    Department of Oncologic Sciences, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
    PLoS ONE 4:e7524. 2009
    ..This effect was observed when nicotine was administered through intraperitoneal injections, or through over-the-counter transdermal patches...
  24. pmc Down-regulation of Bax-interacting factor-1 in colorectal adenocarcinoma
    Domenico Coppola
    Department of Anatomic Pathology, H Lee Moffitt Cancer Center, Tampa, Florida 33612 9497, USA
    Cancer 113:2665-70. 2008
    ..Loss of Bif-1 suppresses programmed cell death and promotes tumorigenesis. The connection of Bif-1 to colorectal cancer remains to be evaluated...
  25. pmc Prognostic and predictive value of a malignancy-risk gene signature in early-stage non-small cell lung cancer
    Dung Tsa Chen
    Department of Biostatistics, Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    J Natl Cancer Inst 103:1859-70. 2011
    ..We hypothesized that the malignancy-risk gene signature has prognostic and predictive value for early-stage non-small cell lung cancer (NSCLC) patients...
  26. pmc Vitamin E δ-tocotrienol induces p27(Kip1)-dependent cell-cycle arrest in pancreatic cancer cells via an E2F-1-dependent mechanism
    Pamela J Hodul
    Department of Gastrointestinal Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
    PLoS ONE 8:e52526. 2013
    ....
  27. pmc IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformation
    Jian Ping Guo
    Department of Molecular Oncology, H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
    J Biol Chem 286:37389-98. 2011
    ..Our data also suggest that Akt inhibitors targeting the PH domain have no effect on the tumors in which hyperactive Akt resulted from elevated IKBKE...
  28. ncbi Palladin is a marker of liver metastasis in primary pancreatic endocrine carcinomas
    Evita B Henderson-Jackson
    Department of Pathology, Moffitt Cancer Center and Research Institute, Tampa, Florida, USA
    Anticancer Res 31:2957-62. 2011
    ..Palladin is a metastasis-associated gene regulating cell motility. The expression of palladin protein in pancreatic neuroendocrine tumors (PET) and carcinomas (PECA) is not known...
  29. doi Increased cyclin D3 expression significantly correlates with p27 nuclear positivity in gastrointestinal stromal tumors
    Nicole Draper
    Department of Pathology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612 9497, USA
    Hum Pathol 39:1784-91. 2008
    ..We report a direct correlation between cyclin D3 and p27 expression in gastrointestinal stromal tumors. Additional alterations in cyclin D1, Ki-67, and retinoblastoma protein expression indicate a disregulated cell cycle in these tumors...
  30. doi First-line chemotherapy with capecitabine and temozolomide in patients with metastatic pancreatic endocrine carcinomas
    Jonathan R Strosberg
    Department of Gastrointestinal Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    Cancer 117:268-75. 2011
    ..The authors retrospectively evaluated the efficacy of capecitabine and temozolomide in 30 patients with metastatic pancreatic endocrine carcinomas to assess response rate, progression free survival (PFS), and overall survival (OS)...
  31. doi Effect of Ack1 tyrosine kinase inhibitor on ligand-independent androgen receptor activity
    Kiran Mahajan
    Drug Discovery Department, Moffitt Cancer Center, Tampa, Florida 33612, USA
    Prostate 70:1274-85. 2010
    ..However, whether a small molecule inhibitor that can mitigate Ack1 activation is sufficient to abrogate AR activity on AR regulated promoters in androgen-depleted environment is not known...
  32. pmc Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis
    Yoshinori Takahashi
    H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive Tampa, FL 33612, USA
    Nat Cell Biol 9:1142-51. 2007
    ..Moreover, knockout of Bif-1 significantly enhances the development of spontaneous tumours in mice. These findings suggest that Bif-1 joins the UVRAG-Beclin 1 complex as a potential activator of autophagy and tumour suppressor...
  33. pmc EGFR/Src/Akt signaling modulates Sox2 expression and self-renewal of stem-like side-population cells in non-small cell lung cancer
    Sandeep Singh
    Department of Tumor Biology, H, Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL, 33612, USA
    Mol Cancer 11:73. 2012
    ..Further, we investigated if the self-renewal of SP cells is dependent on EGFR mediated signaling...
  34. doi Prognostic validity of the American Joint Committee on Cancer staging classification for midgut neuroendocrine tumors
    Jonathan R Strosberg
    Department of GI Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    J Clin Oncol 31:420-5. 2013
    ..This classification has not been validated in a population consisting solely of midgut NETs. The purpose of this study was to test the prognostic validity of the classification in such a population...
  35. pmc The ATDC (TRIM29) protein binds p53 and antagonizes p53-mediated functions
    Zhigang Yuan
    H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Mol Cell Biol 30:3004-15. 2010
    ..Together, these results provide novel mechanistic insights into the function of ATDC and offer an explanation for how ATDC promotes cancer cell proliferation...
  36. doi IκB Kinase ε expression in pancreatic ductal adenocarcinoma
    Anna Cheng
    Anatomic Pathology, Moffitt Cancer Center, Tampa, FL 33612, USA
    Am J Clin Pathol 136:60-6. 2011
    ..In addition, IKKε could serve as a prognostic marker and potential therapeutic target for PDA intervention...
  37. ncbi Activation of the serine/threonine protein kinase Akt during the progression of Barrett neoplasia
    Elizabeth Sagatys
    Division of Anatomic Pathology, Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center, Tampa, FL 33612 9497, USA
    Hum Pathol 38:1526-31. 2007
    ....
  38. ncbi Elucidation of a protein signature discriminating six common types of adenocarcinoma
    Gregory C Bloom
    Biostatistics Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Int J Cancer 120:769-75. 2007
    ....
  39. doi MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN
    Hua Yang
    Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    Cancer Res 68:425-33. 2008
    ..These findings indicate that deregulation of miRNAs is a recurrent event in human ovarian cancer and that miR-214 induces cell survival and cisplatin resistance primarily through targeting the PTEN/Akt pathway...
  40. pmc DNA methylation profiling across the spectrum of HPV-associated anal squamous neoplasia
    Jonathan M Hernandez
    Department of Gastrointestinal Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
    PLoS ONE 7:e50533. 2012
    ..We sought to characterize broad methylation profiles across the spectrum of anal squamous neoplasia...
  41. doi A phase II study of RO4929097 in metastatic colorectal cancer
    Jonathan R Strosberg
    Dept of GI Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, United States
    Eur J Cancer 48:997-1003. 2012
    ..RO4929097 is a selective inhibitor of γ-secretase. We tested the activity of RO4929097 in patients with metastatic, refractory colorectal cancer...
  42. pmc Vitamin E delta-tocotrienol levels in tumor and pancreatic tissue of mice after oral administration
    Kazim Husain
    Department of Gastrointestinal Oncology and Drug Discovery, Moffitt Cancer Center, Department of Oncological Sciences University of South Florida, Tampa, FL 33612, USA
    Pharmacology 83:157-63. 2009
    ..Our data suggest that bioactive levels of delta-tocotrienol can be achieved in the pancreas following oral administration and supports its clinical investigation in pancreatic cancer...
  43. pmc Regulation of MDMX expression by mitogenic signaling
    Daniele M Gilkes
    H Lee Moffitt Cancer Center, MRC3057A, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Mol Cell Biol 28:1999-2010. 2008
    ..Therefore, MDMX expression is regulated by mitogenic signaling pathways. This mechanism may protect normal proliferating cells from p53 but also hamper p53 response during tumor development...
  44. doi Phase I pharmacokinetic and pharmacodynamic study of triciribine phosphate monohydrate, a small-molecule inhibitor of AKT phosphorylation, in adult subjects with solid tumors containing activated AKT
    Christopher R Garrett
    Department of Experimental Therapeutics, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612 9497, USA
    Invest New Drugs 29:1381-9. 2011
    ..AKT is an intracellular protein that, when activated, leads to cellular division; it is dysregulated in a large number of malignancies, and constitutively activating AKT mutations are present in a minority of cancers...
  45. pmc Protein expressions and genetic variations of SLC5A8 in prostate cancer risk and aggressiveness
    Hui Yi Lin
    Department of Biostatistics, H Lee Moffitt Cancer Center, Tampa, FL, USA
    Urology 78:971.e1-9. 2011
    ..Previous studies have suggested that SLC5A8 might function as a tumor suppressor gene, whose silencing by epigenetic changes might contribute to carcinogenesis...
  46. ncbi Inhibiting angiogenesis and tumorigenesis by a synthetic molecule that blocks binding of both VEGF and PDGF to their receptors
    Jiazhi Sun
    Drug Discovery Program, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, MRC DRDIS, Tampa, FL 33612, USA
    Oncogene 24:4701-9. 2005
    ..Finally, treatment of mice with GFB-204 suppresses human tumor growth and angiogenesis. Thus, inhibition of VEGF and PDGF receptor binding with a synthetic molecule results in potent inhibition of angiogenesis and tumorigenesis...
  47. doi Correlation between grade and prognosis in metastatic gastroenteropancreatic neuroendocrine tumors
    Jonathan Strosberg
    H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Hum Pathol 40:1262-8. 2009
    ..Both mitotic rates and Ki-67 indexes are inversely associated with survival and can be analyzed independently for assignment of grade...
  48. doi Purified human chorionic gonadotropin induces apoptosis in breast cancer
    Dayami Lopez
    Don and Erika Wallace Comprehensive Breast Program, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, WCB 2, Tampa, FL 33612 9416, USA
    Mol Cancer Ther 7:2837-44. 2008
    ..Preoperative apoptotic induction by factors such as purified hCG may improve local control or work synergistically with neoadjuvant chemotherapy to improve complete pathologic response of locally advanced breast cancer...
  49. ncbi Uncertainty in the utility of immunohistochemistry in mismatch repair protein expression in epithelial ovarian cancer
    Domenico Coppola
    Department of Anatomic Pathology, H Lee Moffitt Cancer Center, Tampa, FL, USA
    Anticancer Res 32:4963-9. 2012
    ..We evaluated MMR protein expression in three population-based samples of epithelial ovarian cancers...
  50. pmc Over-expression of nicotinamide phosphoribosyltransferase in ovarian cancers
    Rodney E Shackelford
    Department of Pathology and Cell Biology, University of South Florida, 12901 Bruce B Downs Blvd, Tampa, FL, USA
    Int J Clin Exp Pathol 3:522-7. 2010
    ..Last, since an effective pharmacologic Nampt inhibitor is currently in clinical use, further studies of Nampt overexpression in OSA may be used in selecting patients for Nampt inhibitor therapy...
  51. pmc Identification and characterization of putative tumor suppressor NGB, a GTP-binding protein that interacts with the neurofibromatosis 2 protein
    Hansoo Lee
    Department of Pathology, H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
    Mol Cell Biol 27:2103-19. 2007
    ..Collectively, these findings indicate that NGB is a tumor suppressor that regulates and requires merlin to suppress cell proliferation...
  52. ncbi Roscovitine inhibits differentiation and invasion in a three-dimensional skin reconstruction model of metastatic melanoma
    Subhra Mohapatra
    Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute and the University of South Florida Medical Center, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Mol Cancer Res 5:145-51. 2007
    ..The results of this study show that roscovitine has the potential to inhibit the differentiation and invasion of metastatic melanoma and may be useful as a therapy for the treatment of patients with metastatic melanoma...
  53. doi Prognostic validity of a novel American Joint Committee on Cancer Staging Classification for pancreatic neuroendocrine tumors
    Jonathan R Strosberg
    Moffitt Cancer Center, 12902 Magnolia Dr, Tampa, FL, USA
    J Clin Oncol 29:3044-9. 2011
    ..This classification has not yet been validated...
  54. ncbi Activation of the serine/theronine protein kinase Akt in enteropancreatic neuroendocrine tumors
    Masoumeh Ghayouri
    Department of Pathology, University of South Florida, College of Medicine, Tampa, FL, USA
    Anticancer Res 30:5063-7. 2010
    ..Akt is a regulator of cell proliferation, tumorigenesis and apoptosis. This study evaluated the incidence of Akt activation in a subset of neuroendocrine tumors (NETs) and its correlation to clinical pathological parameters...
  55. pmc Down-regulation of Bax-interacting factor 1 in human pancreatic ductal adenocarcinoma
    Domenico Coppola
    Department of Anatomic Pathology, University of South Florida, Tampa, FL, USA
    Pancreas 40:433-7. 2011
    ..Bax-interacting factor 1 (Bif-1) protein plays a critical role in apoptosis, mitochondrial morphogenesis, and autophagy, and its loss promotes tumorigenesis. The role of Bif-1 in pancreatic cancer has not been studied...
  56. pmc Identification of novel pancreatic adenocarcinoma cell-surface targets by gene expression profiling and tissue microarray
    David L Morse
    H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, United States
    Biochem Pharmacol 80:748-54. 2010
    ..These validated targets have potential for the development of diagnostic imaging and therapeutic agents for pancreatic cancer...
  57. doi 42. Epigenomic profiling of anal cancer: does size matter? An RTOG 98-11 specimen study
    Erin Siegel
    Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA
    Sex Health 10:590. 2013
    ..Similar epigenomic approaches may be useful at earlier stages of anal neoplastic progression for application in screening and early detection. ..
  58. doi Cytoplasmic Clusterin expression correlates with pancreatic neuroendocrine tumor size and pathological stage
    Evita B Henderson-Jackson
    Department of Anatomic Pathology, Moffitt Cancer Center and University of South Florida, College of Medicine, Tampa, FL 33612, USA
    Pancreas 42:967-70. 2013
    ..In this study, Clusterin expression was evaluated in a subset of PNETs, and the results were correlated with the clinical-pathological features of the tumors...
  59. ncbi Outcomes following resection of pancreatic adenocarcinoma: 20-year experience at a single institution
    James F Helm
    Gastrointestinal Tumor Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Cancer Control 15:288-94. 2008
    ....
  60. doi Substantially reduced expression of PIAS1 is associated with colon cancer development
    Domenico Coppola
    Department of Anatomic Pathology, H Lee Moffitt Cancer Center and Research Institute, Tampa, USA
    J Cancer Res Clin Oncol 135:1287-91. 2009
    ..PIAS's also regulate STAT family members not directly involved in IFN-gamma signaling. This project was designed to assess PIAS1 expression in colon cancer...
  61. doi Colonic angiolymphoid hyperplasia with eosinophilia masquerading as malignancy: a case report and review of the literature
    Marilyn M Bui
    Department of Anatomic Pathology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612 9497, USA
    Clin Colorectal Cancer 9:179-82. 2010
    ..However, it is important to recognize this entity as a cause of colonic mass to avoid a misdiagnosis of malignancy...
  62. pmc Phosphorylation and activation of androgen receptor by Aurora-A
    Shao Kun Shu
    Department of Molecular Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    J Biol Chem 285:33045-53. 2010
    ..These data indicate that AR is a substrate of Aurora-A and that elevated Aurora-A could contribute to androgen-independent cell growth by phosphorylation and activation of AR...
  63. pmc Nicotine induces cell proliferation, invasion and epithelial-mesenchymal transition in a variety of human cancer cell lines
    Piyali Dasgupta
    Drug Discovery Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Int J Cancer 124:36-45. 2009
    ..Therefore, it is probable that the ability of nicotine to induce invasion and EMT may contribute to the progression of breast and lung cancers...
  64. doi Multimodality management of a polyfunctional pancreatic endocrine carcinoma with markedly elevated serum vasoactive intestinal polypeptide and calcitonin levels
    Aejaz Nasir
    Department of Interdisciplinary Oncology, Neuroendocrine Cancer Research Group, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA
    Pancreas 36:309-13. 2008
    ..In summary, this is a unique case of metastatic VIP- and calcitonin-secreting pancreatic ECA with dramatic sustained clinical, biochemical, and objective tumor response to peptide receptor radionuclide therapy...
  65. pmc Natriuretic peptide receptor a as a novel target for prostate cancer
    Xiaoqin Wang
    Department of Molecular Medicine, University of South Florida, Tampa, FL 33612, USA
    Mol Cancer 10:56. 2011
    ..However, the direct role of NPRA signaling in prostate cancer remains unclear...
  66. ncbi Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity
    Jiazhi Sun
    Department of Interdisciplinary Oncology, Drug Discovery and Molecular Oncology Programs, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, 12902 Magnolia Drive, MRC DRDIS, Tampa, FL 33612 9497, USA
    Oncogene 24:3236-45. 2005
    ..These studies further validate STAT3 as a drug discovery target and provide evidence that pharmacological agents that can selectively reduce the P-STAT3 levels in human cancer cells result in tumor apoptosis and growth inhibition...
  67. doi HPV L1 capsid protein detection and progression of anal squamous neoplasia
    Jonathan Hernandez
    Gastrointestinal Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Am J Clin Pathol 135:436-41. 2011
    ..02). Nuclear expression of L1 is lost in the progression of anal SCC-IS to SCC and may serve as a possible prognostic marker of enhanced malignant potential...
  68. ncbi Molecular staging for survival prediction of colorectal cancer patients
    Steven Eschrich
    Department of Surgery, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    J Clin Oncol 23:3526-35. 2005
    ..We hypothesized that molecular fingerprints could provide more accurate staging and potentially assist in directing adjuvant therapy...
  69. ncbi Tumor response to neoadjuvant chemoradiation therapy for rectal adenocarcinoma is mediated by p53-dependent and caspase 8-dependent apoptotic pathways
    Scott T Kelley
    H Lee Moffitt Cancer Center and Department of Surgery, Tampa, FL, USA
    Clin Colorectal Cancer 5:114-8. 2005
    ..We tested the hypothesis that rectal tumors are most responsive to neoadjuvant therapy if they possess p53 and/or caspase 8 activity...
  70. ncbi Autocrine interleukin-6/interleukin-6 receptor stimulation in non-small-cell lung cancer
    Eric B Haura
    Thoracic Oncology Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Clin Lung Cancer 7:273-5. 2006
    ..These results suggest that IL-6 autocrine signaling might contribute to downstream signaling events in NSCLC and further support the concept of multiple autocrine pathways contributing to the pathogenesis of NSCLC...
  71. ncbi Altered expression of cell cycle regulatory proteins in benign and malignant bone and soft tissue neoplasms
    Marilyn M Bui
    Department of Interdisciplinary Oncology, University of South Florida, College of Medicine, Tampa, FL 33612 9497, USA
    In Vivo 21:729-37. 2007
    ..Here the expression of G1 cyclins D1 and D3, and of Ki-67 in a variety of bone and soft tissue sarcomas was assessed as compared to adjacent normal tissue and to a subset of leiomyomas...
  72. pmc Sampling strategies for tissue microarrays to evaluate biomarkers in ovarian cancer
    Jenny Permuth-Wey
    H Lee Moffitt Cancer Center, Tampa, FL, USA
    Cancer Epidemiol Biomarkers Prev 18:28-34. 2009
    ..Tissue microarrays (TMA) enable rapid analysis of biomarkers in large-scale studies involving archival tumor specimens, however, their utility in heterogeneous tumors such as ovarian cancer is limited...
  73. ncbi Ascorbyl stearate inhibits cell proliferation and tumor growth in human ovarian carcinoma cells by targeting the PI3K/AKT pathway
    Quan Fang
    Department of Pathology Oncology, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, College of Medicine, Tampa, FL 33612, USA
    Anticancer Res 26:203-9. 2006
    ..These studies indicate that the antiproliferative effect of ascorbyl stearate on ovarian epithelial cancer cells is associated with decreased PI3K/AKT activity, and point toward the PI3K/AKT signaling pathway as a target for this drug...
  74. pmc Primary mixed lymphoepithelioma-like carcinoma and intra-hepatic cholangiocarcinoma: a case report and review of literature
    Evita Henderson-Jackson
    University of South Florida, College of Medicine, Tampa, Florida, USA
    Int J Clin Exp Pathol 3:736-41. 2010
    ..The presence of EBV in ICC and LELC suggests that the virus may be linked to the pathogenesis of both components of the tumor. The mechanism of virus-driven neoplastic transformation needs further study...
  75. ncbi Mcl-1 regulates survival and sensitivity to diverse apoptotic stimuli in human non-small cell lung cancer cells
    Lanxi Song
    Thoracic Oncology Experimental Therapeutics, University of South Florida College of Medicine, Tampa, Florida, USA
    Cancer Biol Ther 4:267-76. 2005
    ..Mcl-1 protein is overexpressed in a subset of human NSCLC and enhanced levels of Mcl-1 may protect lung cancer cells from death induced by a variety of pro-apoptotic stimuli...
  76. pmc Loss of nuclear p21(Cip1/WAF1) during neoplastic progression to metastasis in gamma-irradiated p21 hemizygous mice
    Robert W Engelman
    Department of Pathology and Cell Biology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Exp Mol Pathol 82:234-44. 2007
    ..Cellular subclones of malignant tumors, especially those of mesenchymal cell origin, which lack nuclear p21 may more readily acquire the genetic alterations of the metastatic phenotype...