Research Topics
Genomes and Genes
| Domenico CoppolaSummaryAffiliation: University of South Florida Country: USA Publications
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Detail Information
Publications
Bax-interacting factor-1 expression in prostate cancerDomenico Coppola
Department of Anatomic Pathology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612 9497, USA
Clin Genitourin Cancer 6:117-21. 2008..Loss of Bif-1 suppresses the intrinsic pathway of apoptosis and promotes tumorigenesis. We examined the expression levels of Bif-1 protein in human prostate cancer...- Sequence, "subtle" alternative splicing and expression of the CYYR1 (cysteine/tyrosine-rich 1) mRNA in human neuroendocrine tumorsLorenza Vitale
Department of Histology, Embryology and Applied Biology, University of Bologna, Bologna, Italy
BMC Cancer 7:66. 2007..These cells may be the origin of neuroendocrine (NE) tumors. The aim of this study was to conduct an initial analysis of sequence, splicing and expression of the CYYR1 mRNA in human NE tumors... - Microarray-based identification and RT-PCR test screening for epithelial-specific mRNAs in peripheral blood of patients with colon cancerRossella Solmi
Department of Histology, Embryology and Applied Biology, University of Bologna, Via Belmeloro 8, I 40126 Bologna, Italy
BMC Cancer 6:250. 2006..This method seems able to reduce colorectal cancer mortality and may replace colonoscopy as the most effective means of detecting colonic lesions... - IKKepsilon phosphorylation of estrogen receptor alpha Ser-167 and contribution to tamoxifen resistance in breast cancerJian Ping Guo
Department of Molecular Oncology, H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
J Biol Chem 285:3676-84. 2010..These data suggest that ERalpha is a bona fide substrate of IKKepsilon and IKKepsilon plays an important role in tamoxifen resistance. Thus, IKKepsilon represents a critical therapeutic target in breast cancer... 
Expression of the antiapoptotic protein survivin in colon cancerJonathan M Hernandez
Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, FL, USA
Clin Colorectal Cancer 10:188-93. 2011..We sought to evaluate survivin expression in colonic neoplasia and identify relationships with additional regulators of apoptosis...- SLC5A8 nuclear translocation and loss of expression are associated with poor outcome in pancreatic ductal adenocarcinomaJames Helm
Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, FL 33612, USA
Pancreas 41:904-9. 2012..This study aimed to assess the role of SLC5A8 expression in the survival of pancreatic cancer... - Ack1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancerKiran Mahajan
Department of Drug Discovery, Moffitt Cancer Center, Tampa, Florida 33612, USA
J Biol Chem 287:22112-22. 2012.... - ID1 facilitates the growth and metastasis of non-small cell lung cancer in response to nicotinic acetylcholine receptor and epidermal growth factor receptor signalingSmitha Pillai
H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, Florida 33612, USA
Mol Cell Biol 31:3052-67. 2011.... - Deregulation of IKBKE is associated with tumor progression, poor prognosis, and cisplatin resistance in ovarian cancerJian Ping Guo
Departments of Molecular Oncology, H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
Am J Pathol 175:324-33. 2009..IKKepsilon could also serve as a prognostic marker and potential therapeutic target for this malignancy... - ARRB1-mediated regulation of E2F target genes in nicotine-induced growth of lung tumorsPiyali Dasgupta
Department of Oncologic Sciences, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
J Natl Cancer Inst 103:317-33. 2011..However, whether ARRB1 translocates to the nucleus upon nicotinic acetylcholine receptor activation and how it regulates growth of human NSCLCs are not known... - MicroRNA-155 is regulated by the transforming growth factor beta/Smad pathway and contributes to epithelial cell plasticity by targeting RhoAWilliam Kong
Departments of Molecular Oncology, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Dr, SRB3, Tampa, FL 33612, USA
Mol Cell Biol 28:6773-84. 2008..These data suggest that miR-155 may play an important role in TGF-beta-induced EMT and cell migration and invasion by targeting RhoA and indicate that it is a potential therapeutic target for breast cancer intervention... - Histologic characteristics enhance predictive value of American Joint Committee on Cancer staging in resectable pancreas cancerJames Helm
Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, Florida, USA
Cancer 115:4080-9. 2009.... - Correlation between Mcl-1 and pAKT protein expression in colorectal cancerEvita B Henderson-Jackson
Departments of Oncologic Sciences Moffitt Cancer Center and Research Institute, at the University of South Florida, School of Medicine, Tampa, Florida 33612 3275, USA
Int J Clin Exp Pathol 3:768-74. 2010..008). We report the correlation of Mcl-1 protein expression with higher grade and stage in colorectal cancer. Mcl-1 correlated also with pAKT expression. We also report the up regulation of pAKT during the transition from NR to CRC... - RUNX1T1: a novel predictor of liver metastasis in primary pancreatic endocrine neoplasmsAejaz Nasir
Department of Pathology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA
Pancreas 40:627-33. 2011.... - Unique ectopic lymph node-like structures present in human primary colorectal carcinoma are identified by immune gene array profilingDomenico Coppola
Anatomic Pathology Division, Moffitt Cancer Center, Tampa, FL 33612 9497, USA
Am J Pathol 179:37-45. 2011.... 
Activation of the serine/threonine protein kinase AKT during the progression of colorectal neoplasiaOzlen Saglam
Anatomic Pathology, Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center, Tampa, FL 33612 9497, USA
Clin Colorectal Cancer 6:652-6. 2007..AKT has been identified as a major regulator of cell proliferation, tumorigenesis, and apoptosis. In this study, we evaluated changes in the activity of AKT during colorectal cancer (CRC) progression...- MicroRNA-221/222 negatively regulates estrogen receptor alpha and is associated with tamoxifen resistance in breast cancerJian Jun Zhao
H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
J Biol Chem 283:31079-86. 2008.... - Complementary strand microRNAs mediate acquisition of metastatic potential in colonic adenocarcinomaDung Tsa Chen
Department of Biomedical Informatics, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA
J Gastrointest Surg 16:905-12; discussion 912-3. 2012..However, little is known about the genome-wide alterations in miRNA expression during the neoplastic progression of primary colorectal cancers... - Ack1 tyrosine kinase activation correlates with pancreatic cancer progressionKiran Mahajan
Department of Drug Discovery, Moffitt Cancer Center, Tampa, Florida 33612, USA
Am J Pathol 180:1386-93. 2012..Collectively, our data indicate that activated Ack1 could be a prognostic marker for ascertaining early or advanced pancreatic cancer. Thus, Ack1 inhibitors hold promise for therapeutic intervention to inhibit pancreatic tumor growth... - Prognostic and predictive value of a malignancy-risk gene signature in early-stage non-small cell lung cancerDung Tsa Chen
Department of Biostatistics, Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
J Natl Cancer Inst 103:1859-70. 2011..We hypothesized that the malignancy-risk gene signature has prognostic and predictive value for early-stage non-small cell lung cancer (NSCLC) patients... - Nicotine promotes tumor growth and metastasis in mouse models of lung cancerRebecca Davis
Department of Oncologic Sciences, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
PLoS ONE 4:e7524. 2009..This effect was observed when nicotine was administered through intraperitoneal injections, or through over-the-counter transdermal patches... - Down-regulation of Bax-interacting factor-1 in colorectal adenocarcinomaDomenico Coppola
Department of Anatomic Pathology, H Lee Moffitt Cancer Center, Tampa, Florida 33612 9497, USA
Cancer 113:2665-70. 2008..Loss of Bif-1 suppresses programmed cell death and promotes tumorigenesis. The connection of Bif-1 to colorectal cancer remains to be evaluated... - MicroRNA-155 regulates cell survival, growth, and chemosensitivity by targeting FOXO3a in breast cancerWilliam Kong
Department of Molecular Oncology, H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
J Biol Chem 285:17869-79. 2010..In conclusion, our study reveals a molecular link between miR-155 and FOXO3a and presents evidence that miR-155 is a critical therapeutic target in breast cancer... - SirT1 is an inhibitor of proliferation and tumor formation in colon cancerNeha Kabra
Molecular Oncology Program, Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
J Biol Chem 284:18210-7. 2009..These results suggest a rationale for the use of SirT1 activators and inhibitors in the prevention and treatment of colon cancer... - P53 enhances ascorbyl stearate-induced G2/M arrest of human ovarian cancer cellsK Akhilender Naidu
Division of Anatomic Pathology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
Anticancer Res 27:3927-34. 2007..We have previously demonstrated that Asc-S inhibits ovarian carcinoma cell proliferation through modulation of the cell cycle. This study was designed to further elucidate the mechanisms underlying such regulation... - IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformationJian Ping Guo
Department of Molecular Oncology, H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
J Biol Chem 286:37389-98. 2011..Our data also suggest that Akt inhibitors targeting the PH domain have no effect on the tumors in which hyperactive Akt resulted from elevated IKBKE... - Palladin is a marker of liver metastasis in primary pancreatic endocrine carcinomasEvita B Henderson-Jackson
Department of Pathology, Moffitt Cancer Center and Research Institute, Tampa, Florida, USA
Anticancer Res 31:2957-62. 2011..Palladin is a metastasis-associated gene regulating cell motility. The expression of palladin protein in pancreatic neuroendocrine tumors (PET) and carcinomas (PECA) is not known... - Effect of Ack1 tyrosine kinase inhibitor on ligand-independent androgen receptor activityKiran Mahajan
Drug Discovery Department, Moffitt Cancer Center, Tampa, Florida 33612, USA
Prostate 70:1274-85. 2010..However, whether a small molecule inhibitor that can mitigate Ack1 activation is sufficient to abrogate AR activity on AR regulated promoters in androgen-depleted environment is not known... - First-line chemotherapy with capecitabine and temozolomide in patients with metastatic pancreatic endocrine carcinomasJonathan R Strosberg
Department of Gastrointestinal Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
Cancer 117:268-75. 2011..The authors retrospectively evaluated the efficacy of capecitabine and temozolomide in 30 patients with metastatic pancreatic endocrine carcinomas to assess response rate, progression free survival (PFS), and overall survival (OS)... - Increased cyclin D3 expression significantly correlates with p27 nuclear positivity in gastrointestinal stromal tumorsNicole Draper
Department of Pathology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612 9497, USA
Hum Pathol 39:1784-91. 2008..We report a direct correlation between cyclin D3 and p27 expression in gastrointestinal stromal tumors. Additional alterations in cyclin D1, Ki-67, and retinoblastoma protein expression indicate a disregulated cell cycle in these tumors... - IκB Kinase ε expression in pancreatic ductal adenocarcinomaAnna Cheng
Anatomic Pathology, Moffitt Cancer Center, Tampa, FL 33612, USA
Am J Clin Pathol 136:60-6. 2011..In addition, IKKε could serve as a prognostic marker and potential therapeutic target for PDA intervention... - Activation of the serine/threonine protein kinase Akt during the progression of Barrett neoplasiaElizabeth Sagatys
Division of Anatomic Pathology, Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center, Tampa, FL 33612 9497, USA
Hum Pathol 38:1526-31. 2007.... - Elucidation of a protein signature discriminating six common types of adenocarcinomaGregory C Bloom
Biostatistics Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
Int J Cancer 120:769-75. 2007.... - The ATDC (TRIM29) protein binds p53 and antagonizes p53-mediated functionsZhigang Yuan
H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA
Mol Cell Biol 30:3004-15. 2010..Together, these results provide novel mechanistic insights into the function of ATDC and offer an explanation for how ATDC promotes cancer cell proliferation... - A phase II study of RO4929097 in metastatic colorectal cancerJonathan R Strosberg
Dept of GI Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, United States
Eur J Cancer 48:997-1003. 2012..RO4929097 is a selective inhibitor of γ-secretase. We tested the activity of RO4929097 in patients with metastatic, refractory colorectal cancer... - Regulation of MDMX expression by mitogenic signalingDaniele M Gilkes
H Lee Moffitt Cancer Center, MRC3057A, 12902 Magnolia Drive, Tampa, FL 33612, USA
Mol Cell Biol 28:1999-2010. 2008..Therefore, MDMX expression is regulated by mitogenic signaling pathways. This mechanism may protect normal proliferating cells from p53 but also hamper p53 response during tumor development... - Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesisYoshinori Takahashi
H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive Tampa, FL 33612, USA
Nat Cell Biol 9:1142-51. 2007..Moreover, knockout of Bif-1 significantly enhances the development of spontaneous tumours in mice. These findings suggest that Bif-1 joins the UVRAG-Beclin 1 complex as a potential activator of autophagy and tumour suppressor... - Phase I pharmacokinetic and pharmacodynamic study of triciribine phosphate monohydrate, a small-molecule inhibitor of AKT phosphorylation, in adult subjects with solid tumors containing activated AKTChristopher R Garrett
Department of Experimental Therapeutics, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612 9497, USA
Invest New Drugs 29:1381-9. 2011..AKT is an intracellular protein that, when activated, leads to cellular division; it is dysregulated in a large number of malignancies, and constitutively activating AKT mutations are present in a minority of cancers... - Protein expressions and genetic variations of SLC5A8 in prostate cancer risk and aggressivenessHui Yi Lin
Department of Biostatistics, H Lee Moffitt Cancer Center, Tampa, FL, USA
Urology 78:971.e1-9. 2011..Previous studies have suggested that SLC5A8 might function as a tumor suppressor gene, whose silencing by epigenetic changes might contribute to carcinogenesis... - Inhibiting angiogenesis and tumorigenesis by a synthetic molecule that blocks binding of both VEGF and PDGF to their receptorsJiazhi Sun
Drug Discovery Program, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, MRC DRDIS, Tampa, FL 33612, USA
Oncogene 24:4701-9. 2005..Finally, treatment of mice with GFB-204 suppresses human tumor growth and angiogenesis. Thus, inhibition of VEGF and PDGF receptor binding with a synthetic molecule results in potent inhibition of angiogenesis and tumorigenesis... - Purified human chorionic gonadotropin induces apoptosis in breast cancerDayami Lopez
Don and Erika Wallace Comprehensive Breast Program, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, WCB 2, Tampa, FL 33612 9416, USA
Mol Cancer Ther 7:2837-44. 2008..Preoperative apoptotic induction by factors such as purified hCG may improve local control or work synergistically with neoadjuvant chemotherapy to improve complete pathologic response of locally advanced breast cancer... - Correlation between grade and prognosis in metastatic gastroenteropancreatic neuroendocrine tumorsJonathan Strosberg
H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
Hum Pathol 40:1262-8. 2009..Both mitotic rates and Ki-67 indexes are inversely associated with survival and can be analyzed independently for assignment of grade... - Vitamin E delta-tocotrienol levels in tumor and pancreatic tissue of mice after oral administrationKazim Husain
Department of Gastrointestinal Oncology and Drug Discovery, Moffitt Cancer Center, Department of Oncological Sciences University of South Florida, Tampa, FL 33612, USA
Pharmacology 83:157-63. 2009..Our data suggest that bioactive levels of delta-tocotrienol can be achieved in the pancreas following oral administration and supports its clinical investigation in pancreatic cancer... - Roscovitine inhibits differentiation and invasion in a three-dimensional skin reconstruction model of metastatic melanomaSubhra Mohapatra
Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute and the University of South Florida Medical Center, 12902 Magnolia Drive, Tampa, FL 33612, USA
Mol Cancer Res 5:145-51. 2007..The results of this study show that roscovitine has the potential to inhibit the differentiation and invasion of metastatic melanoma and may be useful as a therapy for the treatment of patients with metastatic melanoma... - Identification and characterization of putative tumor suppressor NGB, a GTP-binding protein that interacts with the neurofibromatosis 2 proteinHansoo Lee
Department of Pathology, H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
Mol Cell Biol 27:2103-19. 2007..Collectively, these findings indicate that NGB is a tumor suppressor that regulates and requires merlin to suppress cell proliferation... - MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTENHua Yang
Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, Tampa, Florida 33612, USA
Cancer Res 68:425-33. 2008..These findings indicate that deregulation of miRNAs is a recurrent event in human ovarian cancer and that miR-214 induces cell survival and cisplatin resistance primarily through targeting the PTEN/Akt pathway... - Prognostic validity of a novel American Joint Committee on Cancer Staging Classification for pancreatic neuroendocrine tumorsJonathan R Strosberg
Moffitt Cancer Center, 12902 Magnolia Dr, Tampa, FL, USA
J Clin Oncol 29:3044-9. 2011..This classification has not yet been validated... - Over-expression of nicotinamide phosphoribosyltransferase in ovarian cancersRodney E Shackelford
Department of Pathology and Cell Biology, University of South Florida, 12901 Bruce B Downs Blvd, Tampa, FL, USA
Int J Clin Exp Pathol 3:522-7. 2010..Last, since an effective pharmacologic Nampt inhibitor is currently in clinical use, further studies of Nampt overexpression in OSA may be used in selecting patients for Nampt inhibitor therapy... - Identification of novel pancreatic adenocarcinoma cell-surface targets by gene expression profiling and tissue microarrayDavid L Morse
H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, United States
Biochem Pharmacol 80:748-54. 2010..These validated targets have potential for the development of diagnostic imaging and therapeutic agents for pancreatic cancer... - Activation of the serine/theronine protein kinase Akt in enteropancreatic neuroendocrine tumorsMasoumeh Ghayouri
Department of Pathology, University of South Florida, College of Medicine, Tampa, FL, USA
Anticancer Res 30:5063-7. 2010..Akt is a regulator of cell proliferation, tumorigenesis and apoptosis. This study evaluated the incidence of Akt activation in a subset of neuroendocrine tumors (NETs) and its correlation to clinical pathological parameters... - Down-regulation of Bax-interacting factor 1 in human pancreatic ductal adenocarcinomaDomenico Coppola
Department of Anatomic Pathology, University of South Florida, Tampa, FL, USA
Pancreas 40:433-7. 2011..Bax-interacting factor 1 (Bif-1) protein plays a critical role in apoptosis, mitochondrial morphogenesis, and autophagy, and its loss promotes tumorigenesis. The role of Bif-1 in pancreatic cancer has not been studied... - Natriuretic peptide receptor a as a novel target for prostate cancerXiaoqin Wang
Department of Molecular Medicine, University of South Florida, Tampa, FL 33612, USA
Mol Cancer 10:56. 2011..However, the direct role of NPRA signaling in prostate cancer remains unclear... - Outcomes following resection of pancreatic adenocarcinoma: 20-year experience at a single institutionJames F Helm
Gastrointestinal Tumor Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
Cancer Control 15:288-94. 2008.... - Substantially reduced expression of PIAS1 is associated with colon cancer developmentDomenico Coppola
Department of Anatomic Pathology, H Lee Moffitt Cancer Center and Research Institute, Tampa, USA
J Cancer Res Clin Oncol 135:1287-91. 2009..PIAS's also regulate STAT family members not directly involved in IFN-gamma signaling. This project was designed to assess PIAS1 expression in colon cancer... - Nicotine induces cell proliferation, invasion and epithelial-mesenchymal transition in a variety of human cancer cell linesPiyali Dasgupta
Drug Discovery Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
Int J Cancer 124:36-45. 2009..Therefore, it is probable that the ability of nicotine to induce invasion and EMT may contribute to the progression of breast and lung cancers... - Phosphorylation and activation of androgen receptor by Aurora-AShao Kun Shu
Department of Molecular Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
J Biol Chem 285:33045-53. 2010..These data indicate that AR is a substrate of Aurora-A and that elevated Aurora-A could contribute to androgen-independent cell growth by phosphorylation and activation of AR... - Multimodality management of a polyfunctional pancreatic endocrine carcinoma with markedly elevated serum vasoactive intestinal polypeptide and calcitonin levelsAejaz Nasir
Department of Interdisciplinary Oncology, Neuroendocrine Cancer Research Group, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA
Pancreas 36:309-13. 2008..In summary, this is a unique case of metastatic VIP- and calcitonin-secreting pancreatic ECA with dramatic sustained clinical, biochemical, and objective tumor response to peptide receptor radionuclide therapy... - Colonic angiolymphoid hyperplasia with eosinophilia masquerading as malignancy: a case report and review of the literatureMarilyn M Bui
Department of Anatomic Pathology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612 9497, USA
Clin Colorectal Cancer 9:179-82. 2010..However, it is important to recognize this entity as a cause of colonic mass to avoid a misdiagnosis of malignancy... - DNA methylation profiling across the spectrum of HPV-associated anal squamous neoplasiaJonathan M Hernandez
Department of Gastrointestinal Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
PLoS ONE 7:e50533. 2012..We sought to characterize broad methylation profiles across the spectrum of anal squamous neoplasia... - HPV L1 capsid protein detection and progression of anal squamous neoplasiaJonathan Hernandez
Gastrointestinal Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
Am J Clin Pathol 135:436-41. 2011..02). Nuclear expression of L1 is lost in the progression of anal SCC-IS to SCC and may serve as a possible prognostic marker of enhanced malignant potential... - Tumor response to neoadjuvant chemoradiation therapy for rectal adenocarcinoma is mediated by p53-dependent and caspase 8-dependent apoptotic pathwaysScott T Kelley
H. Lee Moffitt Cancer Center and Department of Surgery, Tampa, FL, USA
Clin Colorectal Cancer 5:114-8. 2005.... - Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activityJiazhi Sun
Department of Interdisciplinary Oncology, Drug Discovery and Molecular Oncology Programs, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, 12902 Magnolia Drive, MRC DRDIS, Tampa, FL 33612 9497, USA
Oncogene 24:3236-45. 2005..These studies further validate STAT3 as a drug discovery target and provide evidence that pharmacological agents that can selectively reduce the P-STAT3 levels in human cancer cells result in tumor apoptosis and growth inhibition... - Autocrine interleukin-6/interleukin-6 receptor stimulation in non-small-cell lung cancerEric B Haura
Thoracic Oncology Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
Clin Lung Cancer 7:273-5. 2006..These results suggest that IL-6 autocrine signaling might contribute to downstream signaling events in NSCLC and further support the concept of multiple autocrine pathways contributing to the pathogenesis of NSCLC... - Sampling strategies for tissue microarrays to evaluate biomarkers in ovarian cancerJenny Permuth-Wey
H Lee Moffitt Cancer Center, Tampa, FL, USA
Cancer Epidemiol Biomarkers Prev 18:28-34. 2009..Tissue microarrays (TMA) enable rapid analysis of biomarkers in large-scale studies involving archival tumor specimens, however, their utility in heterogeneous tumors such as ovarian cancer is limited... - Altered expression of cell cycle regulatory proteins in benign and malignant bone and soft tissue neoplasmsMarilyn M Bui
Department of Interdisciplinary Oncology, University of South Florida, College of Medicine, Tampa, FL 33612 9497, USA
In Vivo 21:729-37. 2007..Here the expression of G1 cyclins D1 and D3, and of Ki-67 in a variety of bone and soft tissue sarcomas was assessed as compared to adjacent normal tissue and to a subset of leiomyomas... - Molecular staging for survival prediction of colorectal cancer patientsSteven Eschrich
Department of Surgery, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
J Clin Oncol 23:3526-35. 2005..CONCLUSION: These data support further evaluation of molecular staging to discriminate good from poor prognosis patients, with the potential to direct adjuvant therapy... - Ascorbyl stearate inhibits cell proliferation and tumor growth in human ovarian carcinoma cells by targeting the PI3K/AKT pathwayQuan Fang
Department of Pathology Oncology, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, College of Medicine, Tampa, FL 33612, USA
Anticancer Res 26:203-9. 2006..These studies indicate that the antiproliferative effect of ascorbyl stearate on ovarian epithelial cancer cells is associated with decreased PI3K/AKT activity, and point toward the PI3K/AKT signaling pathway as a target for this drug... - Mcl-1 regulates survival and sensitivity to diverse apoptotic stimuli in human non-small cell lung cancer cellsLanxi Song
Thoracic Oncology Experimental Therapeutics, University of South Florida College of Medicine, Tampa, Florida, USA
Cancer Biol Ther 4:267-76. 2005..Mcl-1 protein is overexpressed in a subset of human NSCLC and enhanced levels of Mcl-1 may protect lung cancer cells from death induced by a variety of pro-apoptotic stimuli... - Primary mixed lymphoepithelioma-like carcinoma and intra-hepatic cholangiocarcinoma: a case report and review of literatureEvita Henderson-Jackson
University of South Florida, College of Medicine, Tampa, Florida, USA
Int J Clin Exp Pathol 3:736-41. 2010..The presence of EBV in ICC and LELC suggests that the virus may be linked to the pathogenesis of both components of the tumor. The mechanism of virus-driven neoplastic transformation needs further study... - Loss of nuclear p21(Cip1/WAF1) during neoplastic progression to metastasis in gamma-irradiated p21 hemizygous miceRobert W Engelman
Department of Pathology and Cell Biology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
Exp Mol Pathol 82:234-44. 2007..Cellular subclones of malignant tumors, especially those of mesenchymal cell origin, which lack nuclear p21 may more readily acquire the genetic alterations of the metastatic phenotype...