John A Copland
Affiliation: University of Texas Medical Branch
- Oxytocin receptor regulation and action in a human granulosa-lutein cell lineJohn A Copland
Department of Obstetrics and Gynecology, Department of Surgery, Sealy Center for Molecular Science, University of Texas Medical Branch, Galveston, TX 77555 1062, USA
Biol Reprod 66:1230-6. 2002..These cells also will be useful in the analysis of mechanisms of oxytocin receptor regulation, including regulation of its gene...
- Gene therapy of uterine leiomyomas: adenovirus-mediated expression of dominant negative estrogen receptor inhibits tumor growth in nude miceAyman Al-Hendy
Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Tex, USA
Am J Obstet Gynecol 191:1621-31. 2004..Leiomyomas (fibroids) are common estrogen-dependent uterine tumors with no effective medicinal treatment; hysterectomy is the mainstay of management...
- Potential nonhormonal therapeutics for medical treatment of leiomyomasSteven L Young
Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
Semin Reprod Med 22:121-30. 2004..The rationale, evidence, and potential for the use of each of these compounds in the treatment of leiomyomas are discussed...
- High sensitivity of in vivo detection of gold nanorods using a laser optoacoustic imaging systemMohammad Eghtedari
Center for Biomedical Engineering, University of Texas Medical Branch, Galveston, Texas 77555 0456, USA
Nano Lett 7:1914-8. 2007..Our results suggest that LOIS can be used for in vivo detection of gold nanorods at low concentrations and the nanoparticles can be engineered to enhance the diagnostic power of optoacoustic imaging...
- Engineering of hetero-functional gold nanorods for the in vivo molecular targeting of breast cancer cellsMohammad Eghtedari
Center for Biomedical Engineering, The University of Texas Medical Branch in Galveston, 301 University Boulevard, UTMB Route 0456, Galveston, Texas 77555, USA
Nano Lett 9:287-91. 2009..The results demonstrate successful tumor accumulation of functionalized gold nanorods within HER2/neu overexpressing breast tumors in tumor-bearing nude mice and support the notions that GNRs can be used for molecular imaging of tumor...
- Inhibition of proliferation and estrogen receptor signaling by peroxisome proliferator-activated receptor gamma ligands in uterine leiomyomaKevin D Houston
University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
Cancer Res 63:1221-7. 2003..These results suggest that in uterine leiomyomas PPARgamma activation is growth inhibitory and that this inhibition is mediated at least in part by negative cross-talk between ER and PPAR signaling pathways...
- Uterine leiomyomas express myometrial contractile-associated proteins involved in pregnancy-related hormone signalingKimberley Cesen-Cummings
Laboratory of Women s Health, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
J Soc Gynecol Investig 10:11-20. 2003..Signaling via the OTR appears to inhibit estrogen-induced cell proliferation, suggesting that signaling by this receptor might help mediate the protective effect of pregnancy on this disease...
- Atypical protein kinase Ciota plays a critical role in human lung cancer cell growth and tumorigenicityRoderick P Regala
Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, Florida 32224, USA
J Biol Chem 280:31109-15. 2005..Our data indicate that PKCiota may be an attractive molecular target for mechanism-based therapies for treatment of lung cancer...
- Lymphocyte activation antigen CD70 expressed by renal cell carcinoma is a potential therapeutic target for anti-CD70 antibody-drug conjugatesChe Leung Law
Seattle Genetics, Inc, Bothell, Washington 98021, USA
Cancer Res 66:2328-37. 2006....
- Secreted frizzled-related protein 1 loss contributes to tumor phenotype of clear cell renal cell carcinomaMichelle L Gumz
Department of Cancer Biology, Mayo Clinic Jacksonville, Florida 32224, USA
Clin Cancer Res 13:4740-9. 2007..In an effort to gain a better understanding of signaling events in clear cell RCC (cRCC), we investigated the antitumor activity of secreted frizzled-related protein 1 (sFRP1), a negative regulator of Wnt signaling...
- IGF-1 controls GLUT3 expression in muscle via the transcriptional factor Sp1John A Copland
The Mayo Clinic Cancer Center, Jacksonville, Florida, USA
Biochim Biophys Acta 1769:631-40. 2007..These data, using both a human GLUT3 5'-UTR construct and L6 cells' endogenous promoter, suggest that IGF-1 plays a role in maintaining muscle GLUT3 expression and basal glucose uptake via the transcriptional factor Sp1...
- Expression of the type III TGF-beta receptor is negatively regulated by TGF-betaNadine Hempel
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Carcinogenesis 29:905-12. 2008....
- Type III transforming growth factor-beta (TGF-beta) receptor mediates apoptosis in renal cell carcinoma independent of the canonical TGF-beta signaling pathwayVitaly Margulis
Department of Urology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 14:5722-30. 2008..We evaluated the role of TbetaRIII in mediation of apoptosis using in vitro cell culture and in vivo animal models of clear cell renal cell carcinoma...
- Molecular diagnosis of a BRAF papillary thyroid carcinoma with multiple chromosome abnormalities and rare adrenal and hypothalamic metastasesJohn A Copland
Department of Cancer Biology, Mayo Clinic College of Medicine, Jacksonville, Florida 32224, USA
Thyroid 16:1293-302. 2006..Molecular characterization of thyroid tumors is rarely applied to patient management. Our aim was to demonstrate the application of molecular and cell biology to patient care...