Edward Cooper

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint M-channels: neurological diseases, neuromodulation, and drug development
    Edward C Cooper
    Department of Neurology, University of California San Francisco, USA
    Arch Neurol 60:496-500. 2003
  2. ncbi request reprint KCNQ2 is a nodal K+ channel
    Jérôme J Devaux
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 6077, USA
    J Neurosci 24:1236-44. 2004
  3. ncbi request reprint A common ankyrin-G-based mechanism retains KCNQ and NaV channels at electrically active domains of the axon
    Zongming Pan
    Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 26:2599-613. 2006
  4. ncbi request reprint Putting an end to DEND: a severe neonatal-onset epilepsy is treatable if recognized early
    Edward C Cooper
    Neurology 69:1310-1. 2007
  5. pmc Functional significance of axonal Kv7 channels in hippocampal pyramidal neurons
    Mala M Shah
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 105:7869-74. 2008

Research Grants

Collaborators

Detail Information

Publications5

  1. ncbi request reprint M-channels: neurological diseases, neuromodulation, and drug development
    Edward C Cooper
    Department of Neurology, University of California San Francisco, USA
    Arch Neurol 60:496-500. 2003
    ..Ongoing studies in humans and animal models will refine our understanding of KCNQ channel function and may reveal additional targets for therapeutic manipulation...
  2. ncbi request reprint KCNQ2 is a nodal K+ channel
    Jérôme J Devaux
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 6077, USA
    J Neurosci 24:1236-44. 2004
    ..The diminished activity of mutant KCNQ2 channels accounts for neonatal epilepsy and myokymia; the cellular locus of these effects may be axonal initial segments and nodes...
  3. ncbi request reprint A common ankyrin-G-based mechanism retains KCNQ and NaV channels at electrically active domains of the axon
    Zongming Pan
    Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 26:2599-613. 2006
    ..This includes the historical period when myelin also evolved...
  4. ncbi request reprint Putting an end to DEND: a severe neonatal-onset epilepsy is treatable if recognized early
    Edward C Cooper
    Neurology 69:1310-1. 2007
  5. pmc Functional significance of axonal Kv7 channels in hippocampal pyramidal neurons
    Mala M Shah
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 105:7869-74. 2008
    ..These results indicate that axonal Kv7 channels, by controlling axonal RMP and action potential threshold, are fundamental for regulating the inherent firing properties of CA1 hippocampal neurons...

Research Grants10

  1. Proteomic Dissection of M-channel Phosphorylation
    Edward Cooper; Fiscal Year: 2003
    ....
  2. KCNQ channel opener efficacy for neonatal seizures
    Edward Cooper; Fiscal Year: 2007
    ..Such in vivo preclinical experiments are an essential next step toward our overall goal toward introduction of more effective treatments for neonatal seizures in humans. ..
  3. Mechanisms of benign neonatal familial convulsions
    Edward Cooper; Fiscal Year: 2005
    ....
  4. Mechanisms of benign neonatal familial convulsions
    Edward Cooper; Fiscal Year: 2009
    ....