Graham Coop

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Variation in human recombination rates and its genetic determinants
    Adi Fledel-Alon
    Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America
    PLoS ONE 6:e20321. 2011
  2. pmc Patterns of neutral diversity under general models of selective sweeps
    Graham Coop
    Department of Evolution and Ecology and Center for Population Biology, University of California, Davis, California 95616, USA
    Genetics 192:205-24. 2012
  3. pmc Using environmental correlations to identify loci underlying local adaptation
    Graham Coop
    Department of Evolution and Ecology and Center for Population Biology, University of California, Davis, Calfornia 95616, USA
    Genetics 185:1411-23. 2010
  4. pmc The role of geography in human adaptation
    Graham Coop
    Department of Human Genetics, University of Chicago, Chicago, IL, USA
    PLoS Genet 5:e1000500. 2009
  5. ncbi request reprint High-resolution mapping of crossovers reveals extensive variation in fine-scale recombination patterns among humans
    Graham Coop
    Department of Human Genetics, University of Chicago, 920 East 58th Street, Cummings Life Science Center, Chicago, IL 60637, USA
    Science 319:1395-8. 2008
  6. pmc Adaptations to climate-mediated selective pressures in humans
    Angela M Hancock
    Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America
    PLoS Genet 7:e1001375. 2011
  7. doi request reprint Back to nature: ecological genomics of loblolly pine (Pinus taeda, Pinaceae)
    Andrew J Eckert
    Section of Evolution and Ecology, University of California Davis, Davis, CA 95616, USA
    Mol Ecol 19:3789-805. 2010
  8. pmc Signals of recent positive selection in a worldwide sample of human populations
    Joseph K Pickrell
    Department of Human Genetics, The University of Chicago, Chicago, IL 60637, USA
    Genome Res 19:826-37. 2009
  9. pmc Adaptations to climate in candidate genes for common metabolic disorders
    Angela M Hancock
    Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America
    PLoS Genet 4:e32. 2008
  10. ncbi request reprint A worldwide survey of haplotype variation and linkage disequilibrium in the human genome
    Donald F Conrad
    Department of Human Genetics, University of Chicago, 920 East 58th Street, Chicago, Illinois 60637, USA
    Nat Genet 38:1251-60. 2006

Detail Information

Publications26

  1. pmc Variation in human recombination rates and its genetic determinants
    Adi Fledel-Alon
    Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America
    PLoS ONE 6:e20321. 2011
    ..Characterizing this variation and identifying its determinants are essential steps in our understanding of the human recombination process and its evolution...
  2. pmc Patterns of neutral diversity under general models of selective sweeps
    Graham Coop
    Department of Evolution and Ecology and Center for Population Biology, University of California, Davis, California 95616, USA
    Genetics 192:205-24. 2012
    ..The general model of selective sweeps we describe goes some way toward providing a more flexible framework to describe genomic patterns of diversity than is currently available...
  3. pmc Using environmental correlations to identify loci underlying local adaptation
    Graham Coop
    Department of Evolution and Ecology and Center for Population Biology, University of California, Davis, Calfornia 95616, USA
    Genetics 185:1411-23. 2010
    ..Software is available at http://www.eve.ucdavis.edu/gmcoop/...
  4. pmc The role of geography in human adaptation
    Graham Coop
    Department of Human Genetics, University of Chicago, Chicago, IL, USA
    PLoS Genet 5:e1000500. 2009
    ..These patterns suggest that selection is often weak enough that neutral processes -- especially population history, migration, and drift -- exert powerful influences over the fate and geographic distribution of selected alleles...
  5. ncbi request reprint High-resolution mapping of crossovers reveals extensive variation in fine-scale recombination patterns among humans
    Graham Coop
    Department of Human Genetics, University of Chicago, 920 East 58th Street, Cummings Life Science Center, Chicago, IL 60637, USA
    Science 319:1395-8. 2008
    ..Notably, however, we found extensive and heritable variation among both males and females in the proportion of crossovers occurring in these hotspots...
  6. pmc Adaptations to climate-mediated selective pressures in humans
    Angela M Hancock
    Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America
    PLoS Genet 7:e1001375. 2011
    ..Further, we find an enrichment of strong signals in gene sets related to UV radiation, infection and immunity, and cancer. Our results imply that adaptations to climate shaped the spatial distribution of variation in humans...
  7. doi request reprint Back to nature: ecological genomics of loblolly pine (Pinus taeda, Pinaceae)
    Andrew J Eckert
    Section of Evolution and Ecology, University of California Davis, Davis, CA 95616, USA
    Mol Ecol 19:3789-805. 2010
    ....
  8. pmc Signals of recent positive selection in a worldwide sample of human populations
    Joseph K Pickrell
    Department of Human Genetics, The University of Chicago, Chicago, IL 60637, USA
    Genome Res 19:826-37. 2009
    ..Finally, we search for local adaptation between geographically close populations, and highlight several examples...
  9. pmc Adaptations to climate in candidate genes for common metabolic disorders
    Angela M Hancock
    Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America
    PLoS Genet 4:e32. 2008
    ..Nevertheless, our results are consistent with the idea that climate has been an important selective pressure acting on candidate genes for common metabolic disorders...
  10. ncbi request reprint A worldwide survey of haplotype variation and linkage disequilibrium in the human genome
    Donald F Conrad
    Department of Human Genetics, University of Chicago, 920 East 58th Street, Chicago, Illinois 60637, USA
    Nat Genet 38:1251-60. 2006
    ..Consequently, although the portability of tag SNPs based on the HapMap is reduced in low-LD Africans, the HapMap will be helpful for the design of genome-wide association mapping studies in nearly all human populations...
  11. pmc Broad-scale recombination patterns underlying proper disjunction in humans
    Adi Fledel-Alon
    Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America
    PLoS Genet 5:e1000658. 2009
    ..These findings point to multiple mechanisms that shape the distribution of crossovers, influencing proper disjunction in humans...
  12. pmc Live hot, die young: transmission distortion in recombination hotspots
    Graham Coop
    Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America
    PLoS Genet 3:e35. 2007
    ..We explore the impact of hotspot alleles on patterns of haplotype variation, and show that such alleles mask their presence in population genetic data, making them difficult to detect...
  13. pmc Combining sperm typing and linkage disequilibrium analyses reveals differences in selective pressures or recombination rates across human populations
    Vanessa J Clark
    Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA
    Genetics 175:795-804. 2007
    ....
  14. ncbi request reprint An evolutionary view of human recombination
    Graham Coop
    Department of Human Genetics, University of Chicago, 920 East 58th Street, Chicago, Illinois 60637, USA
    Nat Rev Genet 8:23-34. 2007
    ....
  15. pmc Colloquium paper: human adaptations to diet, subsistence, and ecoregion are due to subtle shifts in allele frequency
    Angela M Hancock
    Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 107:8924-30. 2010
    ....
  16. pmc No effect of recombination on the efficacy of natural selection in primates
    Kevin Bullaughey
    Department of Ecology and Evolution, University of Chicago, Chicago, Illinois 60637, USA
    Genome Res 18:544-54. 2008
    ..An interesting implication is that indirect selection for recombination modifiers has probably been a weak force in primate evolution...
  17. pmc The geography of recent genetic ancestry across Europe
    Peter Ralph
    Department of Evolution and Ecology and Center for Population Biology, University of California, Davis, California, United States of America
    PLoS Biol 11:e1001555. 2013
    ..Population genomic datasets have considerable power to uncover recent demographic history, and will allow a much fuller picture of the close genealogical kinship of individuals across the world...
  18. pmc How reliable are empirical genomic scans for selective sweeps?
    Kosuke M Teshima
    Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA
    Genome Res 16:702-12. 2006
    ..g., the dominance coefficient) affect the power to detect targets of selection, genomic scans will yield an unrepresentative subset of loci that contribute to adaptations...
  19. pmc Is your phylogeny informative? Measuring the power of comparative methods
    Carl Boettiger
    Center for Population Biology, University of California, Davis, California 95616, USA
    Evolution 66:2240-51. 2012
    ..We provide an open-source implementation in the pmc ("Phylogenetic Monte Carlo") package for the R programming language. We hope such power analysis becomes a routine part of model comparison in comparative methods...
  20. pmc Scrambling eggs: meiotic drive and the evolution of female recombination rates
    Yaniv Brandvain
    Center for Population Biology and Department of Evolution and Ecology, University of California, Davis, California 95616, USA
    Genetics 190:709-23. 2012
    ..We discuss how selection to modify the efficacy of meiotic drive may contribute to commonly observed patterns of sex differences in recombination...
  21. pmc The genetics of human adaptation: hard sweeps, soft sweeps, and polygenic adaptation
    Jonathan K Pritchard
    Department of Human Genetics, The University of Chicago, Room 507, 929 E 58th St, Chicago, IL 60637, USA
    Curr Biol 20:R208-15. 2010
    ..We close by discussing some of the likely opportunities for progress in the field...
  22. pmc Genomic identification of founding haplotypes reveals the history of the selfing species Capsella rubella
    Yaniv Brandvain
    Department of Evolution and Ecology and Center for Population Biology, University of California Davis, Davis, California, United States of America
    PLoS Genet 9:e1003754. 2013
    ....
  23. pmc Parallel adaptation: one or many waves of advance of an advantageous allele?
    Peter Ralph
    Department of Evolution and Ecology and Center for Population Biology, University of California, Davis, CA 95616, USA
    Genetics 186:647-68. 2010
    ..Thus, we predict that as more data become available, many more examples of intraspecies parallel adaptation will be uncovered...
  24. pmc Expression quantitative trait loci detected in cell lines are often present in primary tissues
    Kevin Bullaughey
    Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637, USA
    Hum Mol Genet 18:4296-303. 2009
    ..Our results indicate that functional studies in cell lines may uncover a substantial amount of genetic variation that affects gene expression levels in human primary tissues...
  25. pmc Speciation and introgression between Mimulus nasutus and Mimulus guttatus
    Yaniv Brandvain
    Department of Evolution and Ecology and Center for Population Biology, University of California Davis, Davis, California, United States of America Department of Plant Biology, University of Minnesota Twin Cities St Paul, Minnesota, United States of America
    PLoS Genet 10:e1004410. 2014
    ..We observe a negative relationship between the recombination rate and divergence between M. nasutus and sympatric M. guttatus samples, suggesting that selection acts against M. nasutus ancestry in M. guttatus. ..
  26. ncbi request reprint The signature of positive selection on standing genetic variation
    Molly Przeworski
    Department of Human Genetics, University of Chicago, Illinois 60637, USA
    Evolution 59:2312-23. 2005
    ..These findings highlight the importance of an accurate characterization of the effects of positive selection, if we are to reliably identify recent adaptations from polymorphism data...