Hilary Coon

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. doi request reprint A unified theory of autism revisited: linkage evidence points to chromosome X using a high-risk subset of AGRE families
    Kristina Allen-Brady
    Department of Psychiatry, Utah Autism Research Project, University of Utah, Salt Lake City, Utah, 84108, USA
    Autism Res 3:47-52. 2010
  2. ncbi request reprint Possible association between autism and variants in the brain-expressed tryptophan hydroxylase gene (TPH2)
    Hilary Coon
    Neurodevelopmental Genetics Project, Department of Psychiatry, University of Utah, Salt Lake City, Utah 84108, USA
    Am J Med Genet B Neuropsychiatr Genet 135:42-6. 2005
  3. ncbi request reprint Upstream stimulatory factor 1 associated with familial combined hyperlipidemia, LDL cholesterol, and triglycerides
    Hilary Coon
    Neurodevelopmental Genetics Project, Department of Psychiatry, University of Utah, Salt Lake City, UT 84108, USA
    Hum Genet 117:444-51. 2005
  4. ncbi request reprint Evidence for linkage on chromosome 3q25-27 in a large autism extended pedigree
    Hilary Coon
    Neurodevelopmental Genetics Project, Department of Psychiatry, University of Utah, Salt Lake City, Utah 84108, USA
    Hum Hered 60:220-6. 2005
  5. ncbi request reprint Current perspectives on the genetic analysis of autism
    Hilary Coon
    Utah Autism Research Program, University of Utah, 421 Wakara Way, Salt Lake City, UT 84108, USA
    Am J Med Genet C Semin Med Genet 142:24-32. 2006
  6. ncbi request reprint Linkage of serum creatinine and glomerular filtration rate to chromosome 2 in Utah pedigrees
    Steven C Hunt
    Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA
    Am J Hypertens 17:511-5. 2004
  7. ncbi request reprint Sodium bicarbonate cotransporter polymorphisms are associated with baseline and 10-year follow-up blood pressures
    Steven C Hunt
    Cardiovascular Genetics Division, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Hypertension 47:532-6. 2006
  8. ncbi request reprint Genome-wide multipoint parametric linkage analysis of pulse pressure in large, extended utah pedigrees
    Nicola J Camp
    Genetic Epidemiology, Department of Medical Informatics, University of Utah School of Medicine, 391 Chipeta Way, Suite D, Salt Lake City, UT 84108 1206, USA
    Hypertension 42:322-8. 2003
  9. ncbi request reprint TXNIP gene not associated with familial combined hyperlipidemia in the NHLBI Family Heart Study
    Hilary Coon
    Neurodevelopmental Genetics Project, University of Utah, 421 Wakara Way, Suite 143, Salt Lake City, UT 84108, USA
    Atherosclerosis 174:357-62. 2004
  10. ncbi request reprint Heterogeneous association between engrailed-2 and autism in the CPEA network
    Camille W Brune
    Department of Psychiatry, Institute for Juvenile Research, University of Illinois Chicago, Chicago, Illinois, USA
    Am J Med Genet B Neuropsychiatr Genet 147:187-93. 2008

Detail Information

Publications47

  1. doi request reprint A unified theory of autism revisited: linkage evidence points to chromosome X using a high-risk subset of AGRE families
    Kristina Allen-Brady
    Department of Psychiatry, Utah Autism Research Project, University of Utah, Salt Lake City, Utah, 84108, USA
    Autism Res 3:47-52. 2010
    ..These results demonstrate that identification of a more homogeneous subset of autism cases, which was based on family structure in this study, may help to identify, localize and further our understanding of autism predisposition genes...
  2. ncbi request reprint Possible association between autism and variants in the brain-expressed tryptophan hydroxylase gene (TPH2)
    Hilary Coon
    Neurodevelopmental Genetics Project, Department of Psychiatry, University of Utah, Salt Lake City, Utah 84108, USA
    Am J Med Genet B Neuropsychiatr Genet 135:42-6. 2005
    ..007). We conclude that TPH2 may play a modest role in autism susceptibility, perhaps relating specifically to repetitive behaviors, pending replication of this result...
  3. ncbi request reprint Upstream stimulatory factor 1 associated with familial combined hyperlipidemia, LDL cholesterol, and triglycerides
    Hilary Coon
    Neurodevelopmental Genetics Project, Department of Psychiatry, University of Utah, Salt Lake City, UT 84108, USA
    Hum Genet 117:444-51. 2005
    ..This study replicates the involvement of USF1 in FCHL and related lipid traits in a family sample not ascertained for FCHL...
  4. ncbi request reprint Evidence for linkage on chromosome 3q25-27 in a large autism extended pedigree
    Hilary Coon
    Neurodevelopmental Genetics Project, Department of Psychiatry, University of Utah, Salt Lake City, Utah 84108, USA
    Hum Hered 60:220-6. 2005
    ..No variants likely to contribute to autism were found in the coding sequence, exon-intron boundaries, or the promoter region of this gene...
  5. ncbi request reprint Current perspectives on the genetic analysis of autism
    Hilary Coon
    Utah Autism Research Program, University of Utah, 421 Wakara Way, Salt Lake City, UT 84108, USA
    Am J Med Genet C Semin Med Genet 142:24-32. 2006
    ..The study of intermediate phenotypes may allow investigators to find common gene variants that lead to autism susceptibility. Here we discuss the major intermediate phenotypes, and give an overview of current genetic analysis techniques...
  6. ncbi request reprint Linkage of serum creatinine and glomerular filtration rate to chromosome 2 in Utah pedigrees
    Steven C Hunt
    Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA
    Am J Hypertens 17:511-5. 2004
    ..This can lead to a loss in power to detect linkage. Therefore, in this study we also investigated serum creatinine and estimated glomerular filtration rates (GFR), both of which are more reliably measured...
  7. ncbi request reprint Sodium bicarbonate cotransporter polymorphisms are associated with baseline and 10-year follow-up blood pressures
    Steven C Hunt
    Cardiovascular Genetics Division, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Hypertension 47:532-6. 2006
    ..These results additionally confirm the involvement of SLC4A5 with blood pressure control, although the mechanism is still unclear...
  8. ncbi request reprint Genome-wide multipoint parametric linkage analysis of pulse pressure in large, extended utah pedigrees
    Nicola J Camp
    Genetic Epidemiology, Department of Medical Informatics, University of Utah School of Medicine, 391 Chipeta Way, Suite D, Salt Lake City, UT 84108 1206, USA
    Hypertension 42:322-8. 2003
    ..In conclusion, our results suggest that pulse pressure might be of use for identifying genes involved in blood pressure phenotypes and arterial aging...
  9. ncbi request reprint TXNIP gene not associated with familial combined hyperlipidemia in the NHLBI Family Heart Study
    Hilary Coon
    Neurodevelopmental Genetics Project, University of Utah, 421 Wakara Way, Suite 143, Salt Lake City, UT 84108, USA
    Atherosclerosis 174:357-62. 2004
    ..Our results suggest that in this sample, TXNIP does not play a major role in FCHL or related traits, and is unlikely to account for the positive evidence of linkage in this region...
  10. ncbi request reprint Heterogeneous association between engrailed-2 and autism in the CPEA network
    Camille W Brune
    Department of Psychiatry, Institute for Juvenile Research, University of Illinois Chicago, Chicago, Illinois, USA
    Am J Med Genet B Neuropsychiatr Genet 147:187-93. 2008
    ..Future studies investigating EN2 should consider how the association of variants in this gene with autism could be influenced by differences in phenotype and possible interactions with genotypes at other autism candidate genes...
  11. pmc Linkage analysis of Tourette syndrome in a large Utah pedigree
    Stacey Knight
    Department of Biomedical Informatics, University of Utah, Salt Lake City, UT 84108, USA
    Am J Med Genet B Neuropsychiatr Genet 153:656-62. 2010
    ..03). The significant linkage peaks on chromosomes 1p and 3p are in new areas of the genome for TS, and replication of these findings is necessary...
  12. ncbi request reprint No evidence for IL1RAPL1 involvement in selected high-risk autism pedigrees from the AGRE data set
    Kristina Allen-Brady
    Utah ASD Research Project, Department of Psychiatry, University of Utah, Salt Lake City, Utah 84108, USA
    Autism Res 4:293-6. 2011
    ..In conclusion, coding changes of the IL1RAPL1 gene do not appear to be associated with ASD in selected AGRE families with linkage evidence to the chromosome Xp22.11-p21.2 region...
  13. ncbi request reprint Linkage of creatinine clearance to chromosome 10 in Utah pedigrees replicates a locus for end-stage renal disease in humans and renal failure in the fawn-hooded rat
    Steven C Hunt
    Cardiovascular Genetics, Department of Internal Medicine, University of Utah School of Medicine, 410 Chipeta Way, Salt Lake City, UT 84108, USA
    Kidney Int 62:1143-8. 2002
    ..4. An important question is whether this region can be detected in healthy subjects prior to onset of ESRD by examining creatinine clearance as an indicator of early renal damage...
  14. pmc Maternal prenatal weight gain and autism spectrum disorders
    Deborah A Bilder
    Utah Autism Research Program, 650 Komas Dr, Suite 206, Salt Lake City, UT 84108
    Pediatrics 132:e1276-83. 2013
    ..This study's objective is to determine whether prepregnancy BMI and pregnancy weight gain are associated with increased ASD risk across study designs and cohorts while controlling for important confounding variables...
  15. ncbi request reprint A genome-wide screen reveals evidence for a locus on chromosome 11 influencing variation in LDL cholesterol in the NHLBI Family Heart Study
    Hilary Coon
    Department of Psychiatry, University of Utah, Salt Lake City 84108, USA
    Hum Genet 111:263-9. 2002
    ..Other scores at or above 1.9 occurred on chromosomes 5 (lod=1.89 at 1.6 cM), 10 (lod=2.47 at 127.1 cM), 17 (lod=2.33 at 116.3 cM), and 21 (lod=2.74 at 45.2 cM)...
  16. ncbi request reprint Model-fitting and linkage analysis of sodium-lithium countertransport
    Sandra J Hasstedt
    Department of Human Genetics, University of Utah, Salt Lake City, UT 84112 5330, USA
    Eur J Hum Genet 12:1055-61. 2004
    ..Using the inferred model, lod scores >2 were obtained for D3S3038, D11S4464, and D10S677 for the BMI-responsive locus, and for D8S1048 for the TG-responsive locus...
  17. pmc Genome-wide linkage using the Social Responsiveness Scale in Utah autism pedigrees
    Hilary Coon
    Utah Autism Research Project, Department of Psychiatry and Division of Genetic Epidemiology, University of Utah, 650 Komas Drive, Suite 206, Salt Lake City, UT 84108, USA
    Mol Autism 1:8. 2010
    ..Such data are available from the Social Responsiveness Scale (SRS) which is a continuous, quantitative measure of social ability giving scores that range from significant impairment to above average ability...
  18. ncbi request reprint Head circumference and height in autism: a study by the Collaborative Program of Excellence in Autism
    Janet E Lainhart
    Department of Psychiatry, The Brain Institute at the University of Utah, Salt Lake City, Utah 84108, USA
    Am J Med Genet A 140:2257-74. 2006
    ..The wide distribution of head circumference in autism has major implications for genetic, neuroimaging, and other neurobiological research...
  19. ncbi request reprint A genome scan for loci influencing anti-atherogenic serum bilirubin levels
    Florian Kronenberg
    Cardiovascular Genetics, University of Utah, Salt Lake City, Utah, USA
    Eur J Hum Genet 10:539-46. 2002
    ..These results provide evidence that loci influencing bilirubin variation exist on chromosomes 2q34-37, 9q21, 10q25-26, and 18q12 and confirms the association of low bilirubin levels with coronary artery disease in males...
  20. pmc Association of the CHRNA4 Neuronal Nicotinic Receptor Subunit Gene with Frequency of Binge Drinking in Young Adults
    Hilary Coon
    Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, Utah
    Alcohol Clin Exp Res 38:930-7. 2014
    ..Knowledge of genetic aspects of this behavior, particularly as it emerges in young adulthood, could lead to improved treatment and prevention programs...
  21. pmc Effect of Neuronal Nicotinic Acetylcholine Receptor Genes (CHRN) on Longitudinal Cigarettes per Day in Adolescents and Young Adults
    Dale S Cannon
    Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT
    Nicotine Tob Res 16:137-44. 2014
    ..Few studies have sought to identify specific genetic markers associated with cigarettes per day (CPD) during adolescence and young adulthood, the period of greatest vulnerability for the development of nicotine dependence...
  22. ncbi request reprint Segregation analysis of HDL cholesterol in the NHLBI Family Heart Study and in Utah pedigrees
    Florian Kronenberg
    Department of Cardiovascular Genetics, University of Utah, Salt Lake City, Utah, USA
    Eur J Hum Genet 10:367-74. 2002
    ..Instead we found some evidence for the segregation of an allele associated with high HDL-C. d..
  23. ncbi request reprint The PHQ-9 as a brief assessment of lifetime major depression
    Dale S Cannon
    Department of Psychiatry, University of Utah, Salt Lake City, UT, USA
    Psychol Assess 19:247-51. 2007
    ..09, p<.001; was correlated with number of MDE Criterion A symptoms, r(525)=.67, p<.001; and detected MDE Criterion A (AUC=0.88). The PHQ-9 as a lifetime measure may be used to complement or replace more costly interview assessments...
  24. ncbi request reprint Use of a genealogical database demonstrates heritability of pulmonary fibrosis
    Mary Beth Scholand
    University of Utah, Salt Lake City, UT, USA
    Lung 191:475-81. 2013
    ..This approach has led to gene discovery in diseases, such as breast cancer and colon cancer and is used here for PF to quantify the heritability...
  25. doi request reprint Autism spectrum disorder reclassified: a second look at the 1980s Utah/UCLA Autism Epidemiologic Study
    Judith S Miller
    Department of Psychiatry, University of Utah, 650 Komas Drive, Salt Lake City, UT 84108, USA
    J Autism Dev Disord 43:200-10. 2013
    ..The current analysis puts this historic work into context and highlights differences in ascertainment between epidemiological studies performed decades ago and those of today...
  26. doi request reprint Excess mortality and causes of death in autism spectrum disorders: a follow up of the 1980s Utah/UCLA autism epidemiologic study
    Deborah Bilder
    Department of Psychiatry, University of Utah, 650 Komas Drive, Suite 206, Salt Lake City, UT 84108, USA
    J Autism Dev Disord 43:1196-204. 2013
    ....
  27. doi request reprint Twenty-year outcome for individuals with autism and average or near-average cognitive abilities
    Megan A Farley
    Utah Autism Research Program, Department of Psychiatry, University of Utah, 650 Komas Dr, Ste 206, Salt Lake City, UT 84108, USA
    Autism Res 2:109-18. 2009
    ..While all participants had baseline IQs in the nonimpaired range, there was limited evidence to support the use of other early childhood variables to predict adult outcome...
  28. pmc A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction
    Robert B Weiss
    Department of Human Genetics, Eccles Institute of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
    PLoS Genet 4:e1000125. 2008
    ..The identification of an age-dependent susceptibility haplotype reinforces the importance of preventing early exposure to tobacco through public health policies...
  29. ncbi request reprint Associations between phenylthiocarbamide gene polymorphisms and cigarette smoking
    Dale S Cannon
    Department of Psychiatry, University of Utah, Salt Lake City, UT, USA
    Nicotine Tob Res 7:853-8. 2005
    ..392, p = .001. The predicted relationship between PAV and AVI and taste motivation was found, F(2, 348) = 3.303, p = .038. The results encourage further exploration of the role of taste/sensory processes in tobacco dependence...
  30. pmc Genome-wide linkage analyses of two repetitive behavior phenotypes in Utah pedigrees with autism spectrum disorders
    Dale S Cannon
    Utah Autism Research Project, Department of Psychiatry, University of Utah, 650 Komas Drive, Suite 206, Salt Lake City, UT, 84108 3528, USA
    Mol Autism 1:3. 2010
    ..Secondary aims were to examine the correlates of IS and RSMA and to assess the heritability of both scales...
  31. ncbi request reprint Autism, regression, and the broader autism phenotype
    Janet E Lainhart
    Department of Psychiatry, University of Utah, Salt Lake City, UT 84108 1236, USA
    Am J Med Genet 113:231-7. 2002
    ..Environmental events are therefore unlikely to be the sole cause of regressive autism in our sample. Environmental events, however, may act in an additive or "second-hit" fashion in individuals with a genetic vulnerability to autism...
  32. ncbi request reprint Performance on Cambridge Neuropsychological Test Automated Battery subtests sensitive to frontal lobe function in people with autistic disorder: evidence from the Collaborative Programs of Excellence in Autism network
    Sally Ozonoff
    Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, Utah, USA
    J Autism Dev Disord 34:139-50. 2004
    ....
  33. ncbi request reprint A new NOS2 promoter polymorphism associated with increased nitric oxide production and protection from severe malaria in Tanzanian and Kenyan children
    Maurine R Hobbs
    Department of Internal Medicine, University of Utah and VA Medical Centers, Salt Lake City, UT, USA
    Lancet 360:1468-75. 2002
    ..We postulated that NOS2 promoter polymorphisms would affect resistance to severe malaria...
  34. ncbi request reprint Genetic analysis of a complex trait in the Utah Genetic Reference Project: a major locus for PTC taste ability on chromosome 7q and a secondary locus on chromosome 16p
    Dennis Drayna
    National Institute on Deafness and Other Communication Disorders, NIH, Rockville, MD 20850, USA
    Hum Genet 112:567-72. 2003
    ..31 at 344 cM) and 16 (lod=2.01 at 14 cM). A subsequent two-locus whole-genome scan conditional on the chromosome 7 quantitative trait locus identified the chromosome 16 locus (two-locus lod=3.33 at 14 cM)...
  35. ncbi request reprint Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide
    Un Kyung Kim
    National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5 Research Court, Rockville, MD 20850, USA
    Science 299:1221-5. 2003
    ....
  36. ncbi request reprint Confirmation of the association of the C4B null allelle in autism
    Dennis Odell
    Center for Persons with Disabilities, Utah State University, Logan, UT 84322, USA
    Hum Immunol 66:140-5. 2005
    ..1 that lacks a C4B gene and has 2 C4A genes was also observed. The results of this study suggest that the human leukocyte antigen class III C4BQ0 significantly increases the risk for autism...
  37. ncbi request reprint Evidence for a gene influencing fasting LDL cholesterol and triglyceride levels on chromosome 21q
    Kari E North
    Department of Epidemiology, University of North Carolina, Bank of America Center, 137 E Franklin St, Suite 306, Chapel Hill, NC 27514, USA
    Atherosclerosis 179:119-25. 2005
    ....
  38. ncbi request reprint Genome-wide linkage analysis replicates susceptibility locus for fasting plasma triglycerides: NHLBI Family Heart Study
    Donna K Arnett
    Division of Epidemiology, University of Minnesota, 1300 South Second Street, Suite 300, Minneapolis, MN 55454, USA
    Hum Genet 115:468-74. 2004
    ..Chromosome 15 likely harbors a susceptibility locus with an influence on triglycerides and HDL. Regions on chromosomes 6 and 8 may also contain loci contributing to inter-individual variation in plasma triglycerides...
  39. pmc An investigation of the effects of lipid-lowering medications: genome-wide linkage analysis of lipids in the HyperGEN study
    Jun Wu
    Division of Statistical Genomics, Washington University School of Medicine, Campus Box 8506, 4444 Forest Park Boulevard, Saint Louis, MO 63108, USA
    BMC Genet 8:60. 2007
    ..We propose an empirical method to adjust lipid levels for medication effects so that the adjusted lipid values substitute the unmedicated lipid values in the genetic analysis...
  40. ncbi request reprint Mapping autism risk loci using genetic linkage and chromosomal rearrangements
    Peter Szatmari
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    Nat Genet 39:319-28. 2007
    ..Neurexins team with previously implicated neuroligins for glutamatergic synaptogenesis, highlighting glutamate-related genes as promising candidates for contributing to ASDs...
  41. ncbi request reprint Temporal lobe, autism, and macrocephaly
    Erin D Bigler
    Department of Psychology and Neuroscience, Brigham Young University, Provo, UT, USA
    AJNR Am J Neuroradiol 24:2066-76. 2003
    ..The rationale for the reading disorder group was to have control subjects with potential temporal lobe anomalies, but who were not autistic...
  42. ncbi request reprint Familial aggregation and genome-wide linkage analysis of carotid artery plaque: the NHLBI family heart study
    James S Pankow
    Division of Epidemiology, University of Minnesota, 1300 South Second Street, Ste 300, Minneapolis, MN 55454, USA
    Hum Hered 57:80-9. 2004
    ..To evaluate familial and genetic influences on carotid artery plaque, a qualitative marker of the systemic burden of atherosclerosis...
  43. ncbi request reprint Meta-analysis of genome-wide linkage studies for quantitative lipid traits in African Americans
    Alka Malhotra
    Diabetes and Obesity Research Unit, Translational Genomics Research Institute, Phoenix, AZ 85004, USA
    Hum Mol Genet 14:3955-62. 2005
    ..0429) for TG. Statistically significant evidence for linkage and low heterogeneity on chromosome 1q therefore suggest that this region may harbor a gene underlying the inheritance of LDL in African Americans...
  44. ncbi request reprint Fruit and vegetable consumption and LDL cholesterol: the National Heart, Lung, and Blood Institute Family Heart Study
    Luc Djousse
    Section of Preventive Medicine and Epidemiology, Evans Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Am J Clin Nutr 79:213-7. 2004
    ..An elevated LDL-cholesterol concentration is associated with an increased risk of cardiovascular disease. The association between fruit and vegetable consumption and LDL has been inconsistent...
  45. pmc Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia
    Cathryn M Lewis
    Division of Genetics and Development, Guy s, King s and St Thomas School of Medicine, London, UK
    Am J Hum Genet 73:34-48. 2003
    ..There is greater consistency of linkage results across studies than has been previously recognized. The results suggest that some or all of these regions contain loci that increase susceptibility to schizophrenia in diverse populations...
  46. pmc Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder
    Ricardo Segurado
    Neuropsychiatric Genetics Unit, Department of Genetics, Trinity College, Dublin 2, Ireland
    Am J Hum Genet 73:49-62. 2003
    ..We note that meta-analysis can sometimes provide support for linkage but cannot disprove linkage in any candidate region...
  47. pmc Neuropathy target esterase gene mutations cause motor neuron disease
    Shirley Rainier
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
    Am J Hum Genet 82:780-5. 2008
    ....