Research Topics
Genomes and GenesSpecies | Hilary CoonSummaryAffiliation: University of Utah Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Genome-wide linkage analyses of two repetitive behavior phenotypes in Utah pedigrees with autism spectrum disordersDale S Cannon
Utah Autism Research Project, Department of Psychiatry, University of Utah, 650 Komas Drive, Suite 206, Salt Lake City, UT, 84108 3528, USA
Mol Autism 1:3. 2010..Secondary aims were to examine the correlates of IS and RSMA and to assess the heritability of both scales...- Genome-wide linkage using the Social Responsiveness Scale in Utah autism pedigreesHilary Coon
Utah Autism Research Project, Department of Psychiatry and Division of Genetic Epidemiology, University of Utah, 650 Komas Drive, Suite 206, Salt Lake City, UT 84108, USA
Mol Autism 1:8. 2010..Such data are available from the Social Responsiveness Scale (SRS) which is a continuous, quantitative measure of social ability giving scores that range from significant impairment to above average ability... 
A genome scan for loci influencing anti-atherogenic serum bilirubin levelsFlorian Kronenberg
Cardiovascular Genetics, University of Utah, Salt Lake City, Utah, USA
Eur J Hum Genet 10:539-46. 2002..These results provide evidence that loci influencing bilirubin variation exist on chromosomes 2q34-37, 9q21, 10q25-26, and 18q12 and confirms the association of low bilirubin levels with coronary artery disease in males...- Heterogeneous association between engrailed-2 and autism in the CPEA networkCamille W Brune
Department of Psychiatry, Institute for Juvenile Research, University of Illinois Chicago, Chicago, Illinois, USA
Am J Med Genet B Neuropsychiatr Genet 147:187-93. 2008..Future studies investigating EN2 should consider how the association of variants in this gene with autism could be influenced by differences in phenotype and possible interactions with genotypes at other autism candidate genes... 
No evidence for IL1RAPL1 involvement in selected high-risk autism pedigrees from the AGRE data setKristina Allen-Brady
Utah ASD Research Project, Department of Psychiatry, University of Utah, Salt Lake City, Utah 84108, USA
Autism Res 4:293-6. 2011..In conclusion, coding changes of the IL1RAPL1 gene do not appear to be associated with ASD in selected AGRE families with linkage evidence to the chromosome Xp22.11-p21.2 region...- Evidence for linkage on chromosome 3q25-27 in a large autism extended pedigreeHilary Coon
Neurodevelopmental Genetics Project, Department of Psychiatry, University of Utah, Salt Lake City, Utah 84108, USA
Hum Hered 60:220-6. 2005..No variants likely to contribute to autism were found in the coding sequence, exon-intron boundaries, or the promoter region of this gene... - Current perspectives on the genetic analysis of autismHilary Coon
Utah Autism Research Program, University of Utah, 421 Wakara Way, Salt Lake City, UT 84108, USA
Am J Med Genet C Semin Med Genet 142:24-32. 2006..The study of intermediate phenotypes may allow investigators to find common gene variants that lead to autism susceptibility. Here we discuss the major intermediate phenotypes, and give an overview of current genetic analysis techniques... - Head circumference and height in autism: a study by the Collaborative Program of Excellence in AutismJanet E Lainhart
Department of Psychiatry, The Brain Institute at the University of Utah, Salt Lake City, Utah 84108, USA
Am J Med Genet A 140:2257-74. 2006..The wide distribution of head circumference in autism has major implications for genetic, neuroimaging, and other neurobiological research... - The PHQ-9 as a brief assessment of lifetime major depressionDale S Cannon
Department of Psychiatry, University of Utah, Salt Lake City, UT, USA
Psychol Assess 19:247-51. 2007..09, p<.001; was correlated with number of MDE Criterion A symptoms, r(525)=.67, p<.001; and detected MDE Criterion A (AUC=0.88). The PHQ-9 as a lifetime measure may be used to complement or replace more costly interview assessments... - A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addictionRobert B Weiss
Department of Human Genetics, Eccles Institute of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
PLoS Genet 4:e1000125. 2008..The identification of an age-dependent susceptibility haplotype reinforces the importance of preventing early exposure to tobacco through public health policies... - Twenty-year outcome for individuals with autism and average or near-average cognitive abilitiesMegan A Farley
Utah Autism Research Program, Department of Psychiatry, University of Utah, 650 Komas Dr, Ste 206, Salt Lake City, UT 84108, USA
Autism Res 2:109-18. 2009..While all participants had baseline IQs in the nonimpaired range, there was limited evidence to support the use of other early childhood variables to predict adult outcome... - Linkage analysis of Tourette syndrome in a large Utah pedigreeStacey Knight
Department of Biomedical Informatics, University of Utah, Salt Lake City, UT 84108, USA
Am J Med Genet B Neuropsychiatr Genet 153:656-62. 2010..03). The significant linkage peaks on chromosomes 1p and 3p are in new areas of the genome for TS, and replication of these findings is necessary... - A unified theory of autism revisited: linkage evidence points to chromosome X using a high-risk subset of AGRE familiesKristina Allen-Brady
Department of Psychiatry, Utah Autism Research Project, University of Utah, Salt Lake City, Utah, 84108, USA
Autism Res 3:47-52. 2010..These results demonstrate that identification of a more homogeneous subset of autism cases, which was based on family structure in this study, may help to identify, localize and further our understanding of autism predisposition genes... - Sodium bicarbonate cotransporter polymorphisms are associated with baseline and 10-year follow-up blood pressuresSteven C Hunt
Cardiovascular Genetics Division, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, USA
Hypertension 47:532-6. 2006..These results additionally confirm the involvement of SLC4A5 with blood pressure control, although the mechanism is still unclear... - Associations between phenylthiocarbamide gene polymorphisms and cigarette smokingDale S Cannon
Department of Psychiatry, University of Utah, Salt Lake City, UT, USA
Nicotine Tob Res 7:853-8. 2005..392, p = .001. The predicted relationship between PAV and AVI and taste motivation was found, F(2, 348) = 3.303, p = .038. The results encourage further exploration of the role of taste/sensory processes in tobacco dependence... - Upstream stimulatory factor 1 associated with familial combined hyperlipidemia, LDL cholesterol, and triglyceridesHilary Coon
Neurodevelopmental Genetics Project, Department of Psychiatry, University of Utah, Salt Lake City, UT 84108, USA
Hum Genet 117:444-51. 2005..This study replicates the involvement of USF1 in FCHL and related lipid traits in a family sample not ascertained for FCHL... - Possible association between autism and variants in the brain-expressed tryptophan hydroxylase gene (TPH2)Hilary Coon
Neurodevelopmental Genetics Project, Department of Psychiatry, University of Utah, Salt Lake City, Utah 84108, USA
Am J Med Genet B Neuropsychiatr Genet 135:42-6. 2005..007). We conclude that TPH2 may play a modest role in autism susceptibility, perhaps relating specifically to repetitive behaviors, pending replication of this result... - Model-fitting and linkage analysis of sodium-lithium countertransportSandra J Hasstedt
Department of Human Genetics, University of Utah, Salt Lake City, UT 84112 5330, USA
Eur J Hum Genet 12:1055-61. 2004..Using the inferred model, lod scores >2 were obtained for D3S3038, D11S4464, and D10S677 for the BMI-responsive locus, and for D8S1048 for the TG-responsive locus... - Linkage of serum creatinine and glomerular filtration rate to chromosome 2 in Utah pedigreesSteven C Hunt
Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA
Am J Hypertens 17:511-5. 2004..This can lead to a loss in power to detect linkage. Therefore, in this study we also investigated serum creatinine and estimated glomerular filtration rates (GFR), both of which are more reliably measured... - A genome-wide screen reveals evidence for a locus on chromosome 11 influencing variation in LDL cholesterol in the NHLBI Family Heart StudyHilary Coon
Department of Psychiatry, University of Utah, Salt Lake City 84108, USA
Hum Genet 111:263-9. 2002..Other scores at or above 1.9 occurred on chromosomes 5 (lod=1.89 at 1.6 cM), 10 (lod=2.47 at 127.1 cM), 17 (lod=2.33 at 116.3 cM), and 21 (lod=2.74 at 45.2 cM)... - TXNIP gene not associated with familial combined hyperlipidemia in the NHLBI Family Heart StudyHilary Coon
Neurodevelopmental Genetics Project, University of Utah, 421 Wakara Way, Suite 143, Salt Lake City, UT 84108, USA
Atherosclerosis 174:357-62. 2004..Our results suggest that in this sample, TXNIP does not play a major role in FCHL or related traits, and is unlikely to account for the positive evidence of linkage in this region... - Linkage of creatinine clearance to chromosome 10 in Utah pedigrees replicates a locus for end-stage renal disease in humans and renal failure in the fawn-hooded ratSteven C Hunt
Cardiovascular Genetics, Department of Internal Medicine, University of Utah School of Medicine, 410 Chipeta Way, Salt Lake City, UT 84108, USA
Kidney Int 62:1143-8. 2002..4. An important question is whether this region can be detected in healthy subjects prior to onset of ESRD by examining creatinine clearance as an indicator of early renal damage... - Genome-wide multipoint parametric linkage analysis of pulse pressure in large, extended utah pedigreesNicola J Camp
Genetic Epidemiology, Department of Medical Informatics, University of Utah School of Medicine, 391 Chipeta Way, Suite D, Salt Lake City, UT 84108 1206, USA
Hypertension 42:322-8. 2003..In conclusion, our results suggest that pulse pressure might be of use for identifying genes involved in blood pressure phenotypes and arterial aging... - Autism, regression, and the broader autism phenotypeJanet E Lainhart
Department of Psychiatry, University of Utah, Salt Lake City, UT 84108 1236, USA
Am J Med Genet 113:231-7. 2002..Environmental events, however, may act in an additive or "second-hit" fashion in individuals with a genetic vulnerability to autism... - Temporal lobe, autism, and macrocephalyErin D Bigler
Department of Psychology and Neuroscience, Brigham Young University, Provo, UT, USA
AJNR Am J Neuroradiol 24:2066-76. 2003..Temporal lobe abnormalities that may be associated with autism are likely to be more related to functional organization within the temporal lobe than to any gross volumetric difference... - Performance on Cambridge Neuropsychological Test Automated Battery subtests sensitive to frontal lobe function in people with autistic disorder: evidence from the Collaborative Programs of Excellence in Autism networkSally Ozonoff
Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, Utah, USA
J Autism Dev Disord 34:139-50. 2004.... - Segregation analysis of HDL cholesterol in the NHLBI Family Heart Study and in Utah pedigreesFlorian Kronenberg
Department of Cardiovascular Genetics, University of Utah, Salt Lake City, Utah, USA
Eur J Hum Genet 10:367-74. 2002..Instead we found some evidence for the segregation of an allele associated with high HDL-C. d.. - A new NOS2 promoter polymorphism associated with increased nitric oxide production and protection from severe malaria in Tanzanian and Kenyan childrenMaurine R Hobbs
Department of Internal Medicine, University of Utah and VA Medical Centers, Salt Lake City, UT, USA
Lancet 360:1468-75. 2002..We postulated that NOS2 promoter polymorphisms would affect resistance to severe malaria...
Research Grants
- Genetics of Autism Intermediate PhenotypesHilary Coon; Fiscal Year: 2009..Test intermediate phenotypes for heritable variation. Use a whole genome scan to search for linkage using intermediate phenotypes. Fine map regions of interest. Study the two best positional candidate genes using pedigrees and trios. ..