Research Topics
Genomes and GenesSpecies | Roshan CoolsSummaryAffiliation: University of California Country: USA Publications
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Publications
Dopaminergic modulation of cognitive function-implications for L-DOPA treatment in Parkinson's diseaseRoshan Cools
Helen Wills Neuroscience Institute, University of California, 132 Barker Hall, Berkeley, USA
Neurosci Biobehav Rev 30:1-23. 2006....- Individual differences in threat sensitivity predict serotonergic modulation of amygdala response to fearful facesRoshan Cools
MRC Behavioural and Clinical Neuroscience Centre
Psychopharmacology (Berl) 180:670-9. 2005.... - Tryptophan depletion disrupts the motivational guidance of goal-directed behavior as a function of trait impulsivityRoshan Cools
Department of Experimental Psychology, University of Cambridge, Cambridge, UK
Neuropsychopharmacology 30:1362-73. 2005..By contrast, ATD left unaltered the ability to inhibit prepotent responses. Our findings may have implications for a variety of neuropsychiatric disorders including impulsive aggressive disorders and depression... 
Switching between abstract rules reflects disease severity but not dopaminergic status in Parkinson's diseaseAngie A Kehagia
Behavioural and Clinical Neuroscience Institute, University of Cambridge, UK
Neuropsychologia 47:1117-27. 2009..These findings suggest that switching entire task sets may be a function of extrastriatal, possibly non-dopaminergic pathology which increases as the disease progresses...- L-DOPA disrupts activity in the nucleus accumbens during reversal learning in Parkinson's diseaseRoshan Cools
Department of Experimental Psychology, Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge, UK
Neuropsychopharmacology 32:180-9. 2007..These data concur with evidence from studies with experimental animals and indicate an important role for the human nucleus accumbens in the dopaminergic modulation of reversal learning... 
Dissociable responses to punishment in distinct striatal regions during reversal learningOliver J Robinson
Department of Psychiatry and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, Addenbrooke s Hospital, P O Box 189, Level E4, Hills Road, Cambridge, CB2 2QQ, UK
Neuroimage 51:1459-67. 2010..These data help to reconcile conflicting findings from previous studies by showing that distinct regions of the striatum exhibit dissociable responses to punishment during reversal learning...- Impulsive personality predicts dopamine-dependent changes in frontostriatal activity during component processes of working memoryRoshan Cools
Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California 94720 3190, USA
J Neurosci 27:5506-14. 2007..The present results provide a key link between dopamine D2 receptor function, impulsivity, and frontostriatal activity during component processes of working memory... - Differential responses in human striatum and prefrontal cortex to changes in object and rule relevanceRoshan Cools
Department of Experimental Psychology, University of Cambridge, Cambridge, CB2 3EB, United Kingdom
J Neurosci 24:1129-35. 2004.... - Serotonin transporter polymorphism mediates vulnerability to loss of incentive motivation following acute tryptophan depletionJonathan P Roiser
Department of Psychiatry, Addenbrooke s Hospital, Cambridge, UK, and Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA
Neuropsychopharmacology 31:2264-72. 2006.... - Tryptophan depletion disinhibits punishment but not reward prediction: implications for resilienceOliver J Robinson
Department of Psychiatry and MRC Wellcome Trust Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, Addenbrooke s Hospital, P O Box 189, Level E4, Hills Road, Cambridge, CB2 2QQ, UK
Psychopharmacology (Berl) 219:599-605. 2012..in J Neurosci 29:11993-11999, 2009) approaches have, however, further specified this role by showing that serotonin is critical for punishment-induced inhibition... - Dopamine precursor depletion improves punishment prediction during reversal learning in healthy females but not malesOliver J Robinson
Department of Psychiatry and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, Addenbrooke s Hospital, P O Box 189, Level E4, Hills Road, Cambridge, CB2 2QQ, UK
Psychopharmacology (Berl) 211:187-95. 2010..Here, we extend these prior findings by examining the effects of artificially reducing DA synthesis in healthy individuals performing this previously employed task... - L-Dopa medication remediates cognitive inflexibility, but increases impulsivity in patients with Parkinson's diseaseRoshan Cools
Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB3 9DF, UK
Neuropsychologia 41:1431-41. 2003.... - Incentive motivation in first-episode psychosis: a behavioural studyGraham K Murray
Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, UK
BMC Psychiatry 8:34. 2008..It has been proposed that there are abnormalities in incentive motivational processing in psychosis, possibly secondary to subcortical dopamine abnormalities, but few empirical studies have addressed this issue... - Acute tryptophan depletion in healthy volunteers enhances punishment prediction but does not affect reward predictionRoshan Cools
Department of Experimental Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
Neuropsychopharmacology 33:2291-9. 2008..Furthermore, the finding highlights the importance of central 5-HT in resilience to adversity and may have implications for a variety of neuropsychiatric disorders including depression and anxiety... - Working memory capacity predicts dopamine synthesis capacity in the human striatumRoshan Cools
Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720 3190, USA
J Neurosci 28:1208-12. 2008.... - Using executive heterogeneity to explore the nature of working memory deficits in Parkinson's diseaseSimon J G Lewis
Cambridge Centre for Brain Repair, Forvie Site, Addenbrooke s Hospital, University of Cambridge, CB2 2PY, UK
Neuropsychologia 41:645-54. 2003..The results also suggest that performance on the Tower of London task may prove to be a useful discriminant variable in defining the nature of cognitive heterogeneity in Parkinson's disease... - Reversal learning in Parkinson's disease depends on medication status and outcome valenceRoshan Cools
University of Cambridge, Behavioural and Clinical Neuroscience Institute, Cambridge, UK
Neuropsychologia 44:1663-73. 2006..These data indicate that dopaminergic medication in PD impairs reversal shifting depending on the motivational valence of unexpected outcomes... - Defining the neural mechanisms of probabilistic reversal learning using event-related functional magnetic resonance imagingRoshan Cools
Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
J Neurosci 22:4563-7. 2002..Overall, these data concur with findings in rodents and nonhuman primates of reversal-learning deficits after damage to ventral frontostriatal circuitry, and also support recent clinical findings using this task... - Feedback-related negativity codes prediction error but not behavioral adjustment during probabilistic reversal learningHenry W Chase
University of Cambridge, UK
J Cogn Neurosci 23:936-46. 2011..These data suggest that the FRN reflects prediction error and associated RL-based adjustment of decision values, whereas the P3 reflects adjustment of behavior on the basis of explicit rules... - Dopaminergic modulation of high-level cognition in Parkinson's disease: the role of the prefrontal cortex revealed by PETRoshan Cools
Department of Experimental Psychology, University of Cambridge, Cambridge, UK
Brain 125:584-94. 2002..These data suggest that L-dopa ameliorates high-level cognitive deficits in Parkinson's disease by inducing relative blood flow changes in the right dorsolateral prefrontal cortex... - Chemistry of the adaptive mindRoshan Cools
Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
Philos Trans A Math Phys Eng Sci 362:2871-88. 2004..The work has considerable implications for the understanding of and treatment development for abnormalities such as Parkinson's disease, attention deficit hyperactivity disorder and drug addiction... - Methylphenidate has differential effects on blood oxygenation level-dependent signal related to cognitive subprocesses of reversal learningChris M Dodds
Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, United Kingdom
J Neurosci 28:5976-82. 2008..The results show that the precise neural site of modulation by methylphenidate depends on the nature of the cognitive subprocess recruited... - Role of dopamine in the motivational and cognitive control of behaviorRoshan Cools
F C Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, The Netherlands
Neuroscientist 14:381-95. 2008.... - Serotoninergic regulation of emotional and behavioural control processesRoshan Cools
F C Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
Trends Cogn Sci 12:31-40. 2008..We review evidence from studies with human volunteers and experimental animals that begins to elucidate the neurobiological systems underlying these different effects... - Effects of levodopa and subthalamic nucleus stimulation on cognitive and affective functioning in Parkinson's diseaseAurélie Funkiewiez
Department of Clinical and Biological Neurosciences, University Hospital of Grenoble, and INSERM U318, Joseph Fourier University of Grenoble, Grenoble, France
Mov Disord 21:1656-62. 2006..To conclude, there were significant but contrasting effects of levodopa and STN stimulation on cognition and affective functions... - Serotonergic modulation of prefrontal cortex during negative feedback in probabilistic reversal learningElizabeth A T Evers
Brain and Behavior Institute, University of Maastricht, Maastricht, The Netherlands
Neuropsychopharmacology 30:1138-47. 2005..These data suggest that ATD affects reversal learning and the processing of aversive signals by modulation of the dorsomedial PFC...