Paul Cooke

Summary

Affiliation: University of Illinois
Country: USA

Publications

  1. ncbi The role of estrogen and estrogen receptor-alpha in male adipose tissue
    P S Cooke
    Department of Veterinary Biosciences, University of Illinois, 2001 S Lincoln Avenue, Urbana, IL 61802, USA
    Mol Cell Endocrinol 178:147-54. 2001
  2. ncbi The F box protein S phase kinase-associated protein 2 regulates adipose mass and adipocyte number in vivo
    Paul S Cooke
    Department of Veterinary Biosciences, 2001 South Lincoln Ave, University of Illinois at Urbana Champaign, Urbana, IL 61802, USA
    Obesity (Silver Spring) 15:1400-8. 2007
  3. ncbi Genistein, estrogen receptors, and the acquired immune response
    Paul S Cooke
    Department of Veterinary Biosciences, University of Illinois, Urbana, 61802, USA
    J Nutr 136:704-8. 2006
  4. ncbi Effects of estrogens and the phytoestrogen genistein on adipogenesis and lipogenesis in males and females
    Paul S Cooke
    Department of Veterinary Biosciences, University of Illinois Urbana Champaign, Urbana, Illinois 61802, USA
    Birth Defects Res A Clin Mol Teratol 73:472-3. 2005
  5. ncbi Role of estrogens in adipocyte development and function
    Paul S Cooke
    Department of Veterinary Biosciences, University of Illinois, 2001 S Lincoln Ave, Urbana, IL 61802, USA
    Exp Biol Med (Maywood) 229:1127-35. 2004
  6. pmc Effects of ETV5 (ets variant gene 5) on testis and body growth, time course of spermatogonial stem cell loss, and fertility in mice
    Heather N Schlesser
    Department of Veterinary Biosciences, University of Illinois at Urbana Champaign, Urbana, IL 61802, USA
    Biol Reprod 78:483-9. 2008
  7. ncbi The soy isoflavone genistein decreases adipose deposition in mice
    Afia Naaz
    Department of Veterinary Biosciences, University of Illinois, Urbana, Illinois 61802, USA
    Endocrinology 144:3315-20. 2003
  8. pmc Loss of Etv5 decreases proliferation and RET levels in neonatal mouse testicular germ cells and causes an abnormal first wave of spermatogenesis
    Gaurav Tyagi
    Department of Veterinary Biosciences and Pathobiology, Institute for Genomic Biology, University of Illinois at Urbana Champaign, Urbana, Illinois, USA
    Biol Reprod 81:258-66. 2009
  9. pmc Mechanistic insights into the regulation of the spermatogonial stem cell niche
    Rex A Hess
    Department of Veterinary Biosciences, University of Illinois at Urbana Champaign, 61802 6199, USA
    Cell Cycle 5:1164-70. 2006
  10. ncbi Role of connexin 43 in Sertoli cells of testis
    Santhi Sridharan
    Department of Veterinary Biosciences, University of Illinois at Urbana Champaign, 2001 South Lincoln Avenue, Urbana, IL 61802, USA
    Ann N Y Acad Sci 1120:131-43. 2007

Research Grants

  1. Genistein induces thymic atrophy: a health concern?
    Paul Cooke; Fiscal Year: 2006
  2. Cell Fate Determination in Fetal Testes
    Paul S Cooke; Fiscal Year: 2010

Collaborators

Detail Information

Publications32

  1. ncbi The role of estrogen and estrogen receptor-alpha in male adipose tissue
    P S Cooke
    Department of Veterinary Biosciences, University of Illinois, 2001 S Lincoln Avenue, Urbana, IL 61802, USA
    Mol Cell Endocrinol 178:147-54. 2001
    ..These results are the first evidence that the estrogen/ERalpha signaling system is critical in female and male WAT deposition, and may have clinical implications...
  2. ncbi The F box protein S phase kinase-associated protein 2 regulates adipose mass and adipocyte number in vivo
    Paul S Cooke
    Department of Veterinary Biosciences, 2001 South Lincoln Ave, University of Illinois at Urbana Champaign, Urbana, IL 61802, USA
    Obesity (Silver Spring) 15:1400-8. 2007
    ..We used Skp2 knockout (Skp2(-/-)) mice to test whether Skp2 loss decreased adipose mass and adipocyte number...
  3. ncbi Genistein, estrogen receptors, and the acquired immune response
    Paul S Cooke
    Department of Veterinary Biosciences, University of Illinois, Urbana, 61802, USA
    J Nutr 136:704-8. 2006
    ....
  4. ncbi Effects of estrogens and the phytoestrogen genistein on adipogenesis and lipogenesis in males and females
    Paul S Cooke
    Department of Veterinary Biosciences, University of Illinois Urbana Champaign, Urbana, Illinois 61802, USA
    Birth Defects Res A Clin Mol Teratol 73:472-3. 2005
  5. ncbi Role of estrogens in adipocyte development and function
    Paul S Cooke
    Department of Veterinary Biosciences, University of Illinois, 2001 S Lincoln Ave, Urbana, IL 61802, USA
    Exp Biol Med (Maywood) 229:1127-35. 2004
    ....
  6. pmc Effects of ETV5 (ets variant gene 5) on testis and body growth, time course of spermatogonial stem cell loss, and fertility in mice
    Heather N Schlesser
    Department of Veterinary Biosciences, University of Illinois at Urbana Champaign, Urbana, IL 61802, USA
    Biol Reprod 78:483-9. 2008
    ..Etv5(-/-) mice are infertile even when sperm is produced, indicating that ETV5 loss has other effects besides lack of SSC self-renewal that impair fertility...
  7. ncbi The soy isoflavone genistein decreases adipose deposition in mice
    Afia Naaz
    Department of Veterinary Biosciences, University of Illinois, Urbana, Illinois 61802, USA
    Endocrinology 144:3315-20. 2003
    ..79 +/- 0.32 microM, 2.55 +/- 0.18 microM, and 3.81 +/- 0.39 microM, respectively. These results indicate dietary genistein at 500-1500 ppm produces antilipogenic effects in mice at serum levels that humans are realistically exposed to...
  8. pmc Loss of Etv5 decreases proliferation and RET levels in neonatal mouse testicular germ cells and causes an abnormal first wave of spermatogenesis
    Gaurav Tyagi
    Department of Veterinary Biosciences and Pathobiology, Institute for Genomic Biology, University of Illinois at Urbana Champaign, Urbana, Illinois, USA
    Biol Reprod 81:258-66. 2009
    ..In addition, ETV5 has critical effects on neonatal spermatogonial proliferation, which may involve impaired signaling through the RET receptor...
  9. pmc Mechanistic insights into the regulation of the spermatogonial stem cell niche
    Rex A Hess
    Department of Veterinary Biosciences, University of Illinois at Urbana Champaign, 61802 6199, USA
    Cell Cycle 5:1164-70. 2006
    ....
  10. ncbi Role of connexin 43 in Sertoli cells of testis
    Santhi Sridharan
    Department of Veterinary Biosciences, University of Illinois at Urbana Champaign, 2001 South Lincoln Avenue, Urbana, IL 61802, USA
    Ann N Y Acad Sci 1120:131-43. 2007
    ..These model systems show that CX43 is important in Sertoli cell development, and will be useful in further studies of its role in Sertoli cell and testis biology...
  11. ncbi Common and distinct factors regulate expression of mRNA for ETV5 and GDNF, Sertoli cell proteins essential for spermatogonial stem cell maintenance
    Liz Simon
    Department of Veterinary Biosciences, University of Illinois at Urbana Champaign, 2001 S Lincoln Ave, Urbana, IL 61802, USA
    Exp Cell Res 313:3090-9. 2007
    ..In conclusion, we have identified common and unique pathways that regulate Etv5 and Gdnf mRNA in Sertoli cells, and FGFs are emerging as key regulators of the Sertoli cell proteins that control SSCs...
  12. ncbi Cell-cycle inhibitors p27Kip1 and p21Cip1 regulate murine Sertoli cell proliferation
    Denise R Holsberger
    Department of Veterinary Biosciences, University of Illinois, Urbana 61802, USA
    Biol Reprod 72:1429-36. 2005
    ..Furthermore, loss of both CDKIs causes additive effects on DSP and testis weight, suggesting a central role for these CDKIs in testis development...
  13. pmc ETV5 is required for continuous spermatogenesis in adult mice and may mediate blood testes barrier function and testicular immune privilege
    Carla M K Morrow
    Department of Veterinary Bioscience, University of Illinois at Urbana Champaign, Urbana, Illinois, USA
    Ann N Y Acad Sci 1120:144-51. 2007
    ..Preliminary studies suggest that the blood-testis barrier (Sertoli-Sertoli tight junctional complex) is abnormal in the Etv5(-/-) mouse...
  14. ncbi Gene expression profiling of 17beta-estradiol and genistein effects on mouse thymus
    Vimal Selvaraj
    Department of Veterinary Biosciences, University of Illinois at Urbana Champaign, Urbana, Illinois 61802, USA
    Toxicol Sci 87:97-112. 2005
    ..These findings provide new mechanistic insights toward explaining estrogen action on thymocyte development, selection, and maturation, as well as the effects of genistein on prenatal and neonatal thymic development and function...
  15. pmc The phytoestrogen genistein induces thymic and immune changes: a human health concern?
    Srikanth Yellayi
    Department of Veterinary Biosciences, University of Illinois, Urbana, IL 61802, USA
    Proc Natl Acad Sci U S A 99:7616-21. 2002
    ....
  16. pmc Claudin 5 expression in mouse seminiferous epithelium is dependent upon the transcription factor ets variant 5 and contributes to blood-testis barrier function
    Carla M K Morrow
    Department of Veterinary Biosciences, University of Illinois at Urbana Champaign, Urbana, Illinois 61802, USA
    Biol Reprod 81:871-9. 2009
    ..In conclusion, CLDN5 is expressed in the seminiferous epithelium, appears to be regulated by multiple influences, and contributes to BTB function...
  17. ncbi Role of systemic and local IGF-I in the effects of estrogen on growth and epithelial proliferation of mouse uterus
    Tomomi Sato
    Department of Veterinary Biosciences, University of Illinois, Urbana 61802, USA
    Endocrinology 143:2673-9. 2002
    ..Local IGF-I is not a direct mediator of E2 action in uterus, and systemic IGF-I may be more important than previously thought for growth of the uterus and other tissues...
  18. ncbi Understanding the role of thyroid hormone in Sertoli cell development: a mechanistic hypothesis
    Denise R Holsberger
    Department of Veterinary Biosciences, University of Illinois, 2001 S Lincoln Avenue, Urbana, IL 61802, USA
    Cell Tissue Res 322:133-40. 2005
    ..Although significant gaps in our knowledge still remain, advances have been made toward appreciation of the molecular sequence of events that occur when thyroid hormone stimulates Sertoli cell maturation...
  19. ncbi Loss of cyclin-dependent kinase inhibitors produces adipocyte hyperplasia and obesity
    Afia Naaz
    Department of Veterinary Biosciences, University of Illinois Urbana, Urbana, Illinois 61802, USA
    FASEB J 18:1925-7. 2004
    ..p27 and p21 are major regulators of adipocyte number in vivo, and knockouts lacking one or both of these proteins provide models for producing adipocyte hyperplasia and understanding its metabolic consequences...
  20. ncbi Estrogenicity of the isoflavone metabolite equol on reproductive and non-reproductive organs in mice
    Vimal Selvaraj
    Department of Veterinary Biosciences, University of Illinois at Urbana Champaign, Urbana, Illinois 61802, USA
    Biol Reprod 71:966-72. 2004
    ....
  21. ncbi Proliferation of adult sertoli cells following conditional knockout of the Gap junctional protein GJA1 (connexin 43) in mice
    Santhi Sridharan
    Department of Veterinary Biosciences, University of Illinois at Urbana Champaign, Urbana, Illinois 61802, USA
    Biol Reprod 76:804-12. 2007
    ..SC-Cx43 KO mice showed continued Sertoli cell proliferation and delayed maturation in adulthood, indicating that CX43 plays key roles in Sertoli cell development...
  22. doi Spermatogonial stem cells, in vivo transdifferentiation and human regenerative medicine
    Liz Simon
    University of Illinois at Urbana Champaign, Veterinary Biosciences, VMBSB, 2001, S Lincoln Avenue, Urbana, IL 61802, USA
    Expert Opin Biol Ther 10:519-30. 2010
    ....
  23. pmc The effect of relaxin on cell proliferation in mouse cervix requires estrogen receptor {alpha} binding to estrogen response elements in stromal cells
    LiJuan Yao
    Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, 524 Burrill Hall, 407 South Goodwin Avenue, Urbana, Illinois 61801, USA
    Endocrinology 151:2811-8. 2010
    ..In conclusion, this study shows that ERalpha-expressing cells in St, using a classical signaling pathway, are necessary for relaxin to promote marked proliferation in both stromal and epithelial cells of the mouse cervix...
  24. pmc Acute and chronic effects of oral genistein administration in neonatal mice
    Melissa A Cimafranca
    Department of Veterinary Biosciences, Division of Nutritional Sciences, University of Illinois, 2001 S Lincoln Ave, Urbana, IL 61802, USA
    Biol Reprod 83:114-21. 2010
    ..The immediate and long-term effects in this neonatal animal model raise concerns that high serum concentrations of genistein are estrogenic and could potentially impact the development of human infants fed soy formula...
  25. ncbi Altered prostatic epithelial proliferation and apoptosis, prostatic development, and serum testosterone in mice lacking cyclin-dependent kinase inhibitors
    Motoko Mukai
    Department of Veterinary Biosciences, University of Illinois, Urbana, Illinois 61802, USA
    Biol Reprod 73:951-8. 2005
    ..Loss of p27 or of both p21 and p27 results in serum testosterone deficiency, complicating analysis of the prostatic effects of these cell-cycle regulators...
  26. ncbi Regulation of neonatal Sertoli cell development by thyroid hormone receptor alpha1
    Denise R Holsberger
    Department of Veterinary Biosciences, University of Illinois, Urbana, Illinois 61802, USA
    Biol Reprod 73:396-403. 2005
    ..Thus, effects of exogenous manipulation of T3 on neonatal Sertoli cell development are predominately mediated through TRalpha1...
  27. pmc Behavioral rhythmicity of mice lacking AhR and attenuation of light-induced phase shift by 2,3,7,8-tetrachlorodibenzo-p-dioxin
    Motoko Mukai
    Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois, Urbana, Illinois, USA
    J Biol Rhythms 23:200-10. 2008
    ....
  28. pmc Direct transdifferentiation of stem/progenitor spermatogonia into reproductive and nonreproductive tissues of all germ layers
    Liz Simon
    Department of Veterinary Biosciences, University of Illinois, Urbana, Illinois 61802, USA
    Stem Cells 27:1666-75. 2009
    ..The ability of stem/progenitor spermatogonia to directly generate various epithelia emphasizes their clinical potential, and if adult human SSCs have similar properties, this may have applications in human regenerative medicine...
  29. ncbi Thyroid hormone regulates the cell cycle inhibitor p27Kip1 in postnatal murine Sertoli cells
    Denise R Holsberger
    Department of Veterinary Biosciences, University of Illinois Urbana, Urbana, Illinois 61802, USA
    Endocrinology 144:3732-8. 2003
    ..These results indicate that thyroid hormone status affects p27(Kip1) expression in neonatal Sertoli cells, suggesting that T(3) effects on Sertoli cell proliferation may be mediated through this CDKI...
  30. ncbi Dioxin inhibition of estrogen-induced mouse uterine epithelial mitogenesis involves changes in cyclin and transforming growth factor-beta expression
    David L Buchanan
    Center for Integrative Bioscience, Okazaki National Research Institutes, Okazaki, Aichi 444 8585, Japan
    Toxicol Sci 66:62-8. 2002
    ..Thus, TCDD alters specific E2-regulated Ut G(1) phase activities and may inhibit E2-induced Ut epithelial mitogenesis by disrupting specific cell signaling mechanisms necessary for S phase initiation in vivo...
  31. ncbi Impact of neonatal hypothyroidism on reproduction in the male hamster, Mesocricetus auratus
    Heiko T Jansen
    Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, 205 Wegner Hall Pullman, WA 99164 6520, United States
    Physiol Behav 90:771-81. 2007
    ..The severity of the effects induced by early hypothyroidism in this species varies from transient to permanent, depending on the endpoint...
  32. ncbi In utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure: effects on the prostate and its response to castration in senescent C57BL/6J mice
    Wayne A Fritz
    School of Pharmacy and Molecular and Environmental Toxicology Center, University of Wisconsin, Madison, Wisconsin 53705, USA
    Toxicol Sci 86:387-95. 2005
    ..However, because cribriform structures are often considered to be associated with prostate carcinogenesis, these results also suggest that TCDD exposure early in development may increase susceptibility to prostate cancer...

Research Grants5

  1. Genistein induces thymic atrophy: a health concern?
    Paul Cooke; Fiscal Year: 2006
    ..These studies will advance our understanding of isoflavone effects on the immune system, and also may have relevance for soy-fed infants and laboratory rodents consuming soy-based feed. ..
  2. Cell Fate Determination in Fetal Testes
    Paul S Cooke; Fiscal Year: 2010
    ..abstract_text> ..