Research Topics
Species | Paul CookeSummaryAffiliation: University of Illinois Country: USA Publications
Research Grants
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Detail Information
Publications
The role of estrogen and estrogen receptor-alpha in male adipose tissueP S Cooke
Department of Veterinary Biosciences, University of Illinois, 2001 S Lincoln Avenue, Urbana, IL 61802, USA
Mol Cell Endocrinol 178:147-54. 2001..These results are the first evidence that the estrogen/ERalpha signaling system is critical in female and male WAT deposition, and may have clinical implications...- The F box protein S phase kinase-associated protein 2 regulates adipose mass and adipocyte number in vivoPaul S Cooke
Department of Veterinary Biosciences, 2001 South Lincoln Ave, University of Illinois at Urbana Champaign, Urbana, IL 61802, USA
Obesity (Silver Spring) 15:1400-8. 2007..We used Skp2 knockout (Skp2(-/-)) mice to test whether Skp2 loss decreased adipose mass and adipocyte number... - Genistein, estrogen receptors, and the acquired immune responsePaul S Cooke
Department of Veterinary Biosciences, University of Illinois, Urbana, 61802, USA
J Nutr 136:704-8. 2006.... - Effects of estrogens and the phytoestrogen genistein on adipogenesis and lipogenesis in males and femalesPaul S Cooke
Department of Veterinary Biosciences, University of Illinois-Urbana-Champaign, Urbana, Illinois 61802, USA
Birth Defects Res A Clin Mol Teratol 73:472-3. 2005 - Role of estrogens in adipocyte development and functionPaul S Cooke
Department of Veterinary Biosciences, University of Illinois, 2001 S Lincoln Ave, Urbana, IL 61802, USA
Exp Biol Med (Maywood) 229:1127-35. 2004.... 
Effects of ETV5 (ets variant gene 5) on testis and body growth, time course of spermatogonial stem cell loss, and fertility in miceHeather N Schlesser
Department of Veterinary Biosciences, University of Illinois at Urbana Champaign, Urbana, IL 61802, USA
Biol Reprod 78:483-9. 2008..Etv5(-/-) mice are infertile even when sperm is produced, indicating that ETV5 loss has other effects besides lack of SSC self-renewal that impair fertility...- The soy isoflavone genistein decreases adipose deposition in miceAfia Naaz
Department of Veterinary Biosciences, University of Illinois, Urbana, Illinois 61802, USA
Endocrinology 144:3315-20. 2003..79 +/- 0.32 microM, 2.55 +/- 0.18 microM, and 3.81 +/- 0.39 microM, respectively. These results indicate dietary genistein at 500-1500 ppm produces antilipogenic effects in mice at serum levels that humans are realistically exposed to... - Loss of Etv5 decreases proliferation and RET levels in neonatal mouse testicular germ cells and causes an abnormal first wave of spermatogenesisGaurav Tyagi
Department of Veterinary Biosciences and Pathobiology, Institute for Genomic Biology, University of Illinois at Urbana Champaign, Urbana, Illinois, USA
Biol Reprod 81:258-66. 2009..In addition, ETV5 has critical effects on neonatal spermatogonial proliferation, which may involve impaired signaling through the RET receptor... - Mechanistic insights into the regulation of the spermatogonial stem cell nicheRex A Hess
Department of Veterinary Biosciences, University of Illinois at Urbana Champaign, 61802 6199, USA
Cell Cycle 5:1164-70. 2006.... - Role of connexin 43 in Sertoli cells of testisSanthi Sridharan
Department of Veterinary Biosciences, University of Illinois at Urbana Champaign, 2001 South Lincoln Avenue, Urbana, IL 61802, USA
Ann N Y Acad Sci 1120:131-43. 2007..These model systems show that CX43 is important in Sertoli cell development, and will be useful in further studies of its role in Sertoli cell and testis biology... - Common and distinct factors regulate expression of mRNA for ETV5 and GDNF, Sertoli cell proteins essential for spermatogonial stem cell maintenanceLiz Simon
Department of Veterinary Biosciences, University of Illinois at Urbana Champaign, 2001 S Lincoln Ave, Urbana, IL 61802, USA
Exp Cell Res 313:3090-9. 2007..In conclusion, we have identified common and unique pathways that regulate Etv5 and Gdnf mRNA in Sertoli cells, and FGFs are emerging as key regulators of the Sertoli cell proteins that control SSCs... - Cell-cycle inhibitors p27Kip1 and p21Cip1 regulate murine Sertoli cell proliferationDenise R Holsberger
Department of Veterinary Biosciences, University of Illinois, Urbana 61802, USA
Biol Reprod 72:1429-36. 2005..Furthermore, loss of both CDKIs causes additive effects on DSP and testis weight, suggesting a central role for these CDKIs in testis development... - ETV5 is required for continuous spermatogenesis in adult mice and may mediate blood testes barrier function and testicular immune privilegeCarla M K Morrow
Department of Veterinary Bioscience, University of Illinois at Urbana Champaign, Urbana, Illinois, USA
Ann N Y Acad Sci 1120:144-51. 2007..Preliminary studies suggest that the blood-testis barrier (Sertoli-Sertoli tight junctional complex) is abnormal in the Etv5(-/-) mouse... - Gene expression profiling of 17beta-estradiol and genistein effects on mouse thymusVimal Selvaraj
Department of Veterinary Biosciences, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802, USA
Toxicol Sci 87:97-112. 2005..These findings provide new mechanistic insights toward explaining estrogen action on thymocyte development, selection, and maturation, as well as the effects of genistein on prenatal and neonatal thymic development and function... - The phytoestrogen genistein induces thymic and immune changes: a human health concern?Srikanth Yellayi
Department of Veterinary Biosciences, University of Illinois, Urbana, IL 61802, USA
Proc Natl Acad Sci U S A 99:7616-21. 2002.... - Claudin 5 expression in mouse seminiferous epithelium is dependent upon the transcription factor ets variant 5 and contributes to blood-testis barrier functionCarla M K Morrow
Department of Veterinary Biosciences, University of Illinois at Urbana Champaign, Urbana, Illinois 61802, USA
Biol Reprod 81:871-9. 2009..In conclusion, CLDN5 is expressed in the seminiferous epithelium, appears to be regulated by multiple influences, and contributes to BTB function... - Role of systemic and local IGF-I in the effects of estrogen on growth and epithelial proliferation of mouse uterusTomomi Sato
Department of Veterinary Biosciences, University of Illinois, Urbana 61802, USA
Endocrinology 143:2673-9. 2002..Local IGF-I is not a direct mediator of E2 action in uterus, and systemic IGF-I may be more important than previously thought for growth of the uterus and other tissues... - Understanding the role of thyroid hormone in Sertoli cell development: a mechanistic hypothesisDenise R Holsberger
Department of Veterinary Biosciences, University of Illinois, 2001 S. Lincoln Avenue, Urbana, IL 61802, USA
Cell Tissue Res 322:133-40. 2005..Although significant gaps in our knowledge still remain, advances have been made toward appreciation of the molecular sequence of events that occur when thyroid hormone stimulates Sertoli cell maturation... - Loss of cyclin-dependent kinase inhibitors produces adipocyte hyperplasia and obesityAfia Naaz
Department of Veterinary Biosciences, University of Illinois Urbana, Urbana, Illinois 61802, USA
FASEB J 18:1925-7. 2004..p27 and p21 are major regulators of adipocyte number in vivo, and knockouts lacking one or both of these proteins provide models for producing adipocyte hyperplasia and understanding its metabolic consequences... - Estrogenicity of the isoflavone metabolite equol on reproductive and non-reproductive organs in miceVimal Selvaraj
Department of Veterinary Biosciences, University of Illinois at Urbana-Champaign, Urbana, Illinois 61802, USA
Biol Reprod 71:966-72. 2004.... - Proliferation of adult sertoli cells following conditional knockout of the Gap junctional protein GJA1 (connexin 43) in miceSanthi Sridharan
Department of Veterinary Biosciences, University of Illinois at Urbana Champaign, Urbana, Illinois 61802, USA
Biol Reprod 76:804-12. 2007..SC-Cx43 KO mice showed continued Sertoli cell proliferation and delayed maturation in adulthood, indicating that CX43 plays key roles in Sertoli cell development... 
Spermatogonial stem cells, in vivo transdifferentiation and human regenerative medicineLiz Simon
University of Illinois at Urbana Champaign, Veterinary Biosciences, VMBSB, 2001, S Lincoln Avenue, Urbana, IL 61802, USA
Expert Opin Biol Ther 10:519-30. 2010....- The effect of relaxin on cell proliferation in mouse cervix requires estrogen receptor {alpha} binding to estrogen response elements in stromal cellsLiJuan Yao
Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, 524 Burrill Hall, 407 South Goodwin Avenue, Urbana, Illinois 61801, USA
Endocrinology 151:2811-8. 2010..In conclusion, this study shows that ERalpha-expressing cells in St, using a classical signaling pathway, are necessary for relaxin to promote marked proliferation in both stromal and epithelial cells of the mouse cervix... - Acute and chronic effects of oral genistein administration in neonatal miceMelissa A Cimafranca
Department of Veterinary Biosciences, Division of Nutritional Sciences, University of Illinois, 2001 S Lincoln Ave, Urbana, IL 61802, USA
Biol Reprod 83:114-21. 2010..The immediate and long-term effects in this neonatal animal model raise concerns that high serum concentrations of genistein are estrogenic and could potentially impact the development of human infants fed soy formula... - Altered prostatic epithelial proliferation and apoptosis, prostatic development, and serum testosterone in mice lacking cyclin-dependent kinase inhibitorsMotoko Mukai
Department of Veterinary Biosciences, University of Illinois, Urbana, Illinois 61802, USA
Biol Reprod 73:951-8. 2005..Loss of p27 or of both p21 and p27 results in serum testosterone deficiency, complicating analysis of the prostatic effects of these cell-cycle regulators... - Regulation of neonatal Sertoli cell development by thyroid hormone receptor alpha1Denise R Holsberger
Department of Veterinary Biosciences, University of Illinois, Urbana, Illinois 61802, USA
Biol Reprod 73:396-403. 2005..Thus, effects of exogenous manipulation of T3 on neonatal Sertoli cell development are predominately mediated through TRalpha1... - Behavioral rhythmicity of mice lacking AhR and attenuation of light-induced phase shift by 2,3,7,8-tetrachlorodibenzo-p-dioxinMotoko Mukai
Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois, Urbana, Illinois, USA
J Biol Rhythms 23:200-10. 2008.... - Direct transdifferentiation of stem/progenitor spermatogonia into reproductive and nonreproductive tissues of all germ layersLiz Simon
Department of Veterinary Biosciences, University of Illinois, Urbana, Illinois 61802, USA
Stem Cells 27:1666-75. 2009..The ability of stem/progenitor spermatogonia to directly generate various epithelia emphasizes their clinical potential, and if adult human SSCs have similar properties, this may have applications in human regenerative medicine... - Thyroid hormone regulates the cell cycle inhibitor p27Kip1 in postnatal murine Sertoli cellsDenise R Holsberger
Department of Veterinary Biosciences, University of Illinois Urbana, Urbana, Illinois 61802, USA
Endocrinology 144:3732-8. 2003..These results indicate that thyroid hormone status affects p27(Kip1) expression in neonatal Sertoli cells, suggesting that T(3) effects on Sertoli cell proliferation may be mediated through this CDKI... - Dioxin inhibition of estrogen-induced mouse uterine epithelial mitogenesis involves changes in cyclin and transforming growth factor-beta expressionDavid L Buchanan
Center for Integrative Bioscience, Okazaki National Research Institutes, Okazaki, Aichi 444 8585, Japan
Toxicol Sci 66:62-8. 2002..Thus, TCDD alters specific E2-regulated Ut G(1) phase activities and may inhibit E2-induced Ut epithelial mitogenesis by disrupting specific cell signaling mechanisms necessary for S phase initiation in vivo... - Impact of neonatal hypothyroidism on reproduction in the male hamster, Mesocricetus auratusHeiko T Jansen
Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, 205 Wegner Hall Pullman, WA 99164 6520, United States
Physiol Behav 90:771-81. 2007..The severity of the effects induced by early hypothyroidism in this species varies from transient to permanent, depending on the endpoint... - In utero and lactational 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure: effects on the prostate and its response to castration in senescent C57BL/6J miceWayne A Fritz
School of Pharmacy and Molecular and Environmental Toxicology Center, University of Wisconsin, Madison, Wisconsin 53705, USA
Toxicol Sci 86:387-95. 2005..However, because cribriform structures are often considered to be associated with prostate carcinogenesis, these results also suggest that TCDD exposure early in development may increase susceptibility to prostate cancer...
Research Grants
- Genistein induces thymic atrophy: a health concern?Paul Cooke; Fiscal Year: 2006..These studies will advance our understanding of isoflavone effects on the immune system, and also may have relevance for soy-fed infants and laboratory rodents consuming soy-based feed. ..
- Cell Fate Determination in Fetal TestesPaul S Cooke; Fiscal Year: 2010..abstract_text> ..