William J Cook

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. ncbi Structure of human desArg-C5a
    William J Cook
    University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Acta Crystallogr D Biol Crystallogr 66:190-7. 2010
  2. ncbi An unexpected phosphate binding site in glyceraldehyde 3-phosphate dehydrogenase: crystal structures of apo, holo and ternary complex of Cryptosporidium parvum enzyme
    William J Cook
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    BMC Struct Biol 9:9. 2009
  3. ncbi Structure of a complex of human lactoferrin N-lobe with pneumococcal surface protein a provides insight into microbial defense mechanism
    Olga Senkovich
    Center for Biophysical Sciences and Engineering, University of Alabama at Birmingham, AL 35294, USA
    J Mol Biol 370:701-13. 2007
  4. ncbi Structure of the catalytic domain of Plasmodium falciparum ARF GTPase-activating protein (ARFGAP)
    William J Cook
    Department of Medicine, University of Alabama at Birmingham, CBSE 250, 1015 18th Street South, Birmingham, AL 35294, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 67:1339-44. 2011
  5. ncbi Calmodulin binding to cellular FLICE-like inhibitory protein modulates Fas-induced signalling
    Pritish S Pawar
    Department of Pathology, University of Alabama at Birmingham, LHRB 533, 1530 3rd Ave South, Birmingham, AL 35294, USA
    Biochem J 412:459-68. 2008
  6. ncbi Protein crystallization
    Champion Deivanayagam
    Center for Biophysical Sciences and Engineering, Department of Vision Sciences, University of Alabama at Birmingham, USA
    Methods Mol Biol 383:337-49. 2007
  7. ncbi Structures of vaccinia virus dUTPase and its nucleotide complexes
    Alexandra Samal
    Center for Biophysical Sciences and Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Acta Crystallogr D Biol Crystallogr 63:571-80. 2007
  8. ncbi Crystal structure of Cryptosporidium parvum pyruvate kinase
    William J Cook
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 7:e46875. 2012
  9. ncbi Calmodulin binding to the Fas death domain. Regulation by Fas activation
    Eun Young Ahn
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
    J Biol Chem 279:5661-6. 2004
  10. ncbi Structure of Plasmodium falciparum ADP-ribosylation factor 1
    William J Cook
    University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 66:1426-31. 2010

Collaborators

Detail Information

Publications12

  1. ncbi Structure of human desArg-C5a
    William J Cook
    University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Acta Crystallogr D Biol Crystallogr 66:190-7. 2010
    ..The physiological significance of these structural differences is unknown...
  2. ncbi An unexpected phosphate binding site in glyceraldehyde 3-phosphate dehydrogenase: crystal structures of apo, holo and ternary complex of Cryptosporidium parvum enzyme
    William J Cook
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    BMC Struct Biol 9:9. 2009
    ....
  3. ncbi Structure of a complex of human lactoferrin N-lobe with pneumococcal surface protein a provides insight into microbial defense mechanism
    Olga Senkovich
    Center for Biophysical Sciences and Engineering, University of Alabama at Birmingham, AL 35294, USA
    J Mol Biol 370:701-13. 2007
    ..Insights from the structure of the complex have implications for designing therapeutic strategies for treatment and prevention of pneumococcal diseases that remain a major public health problem worldwide...
  4. ncbi Structure of the catalytic domain of Plasmodium falciparum ARF GTPase-activating protein (ARFGAP)
    William J Cook
    Department of Medicine, University of Alabama at Birmingham, CBSE 250, 1015 18th Street South, Birmingham, AL 35294, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 67:1339-44. 2011
    ..However, several amino-acid residues in the area where GAP interacts with ARF1 differ in P. falciparum ARFGAP. Moreover, a number of residues that form the dimer interface in the crystal structure are unique in P. falciparum ARFGAP...
  5. ncbi Calmodulin binding to cellular FLICE-like inhibitory protein modulates Fas-induced signalling
    Pritish S Pawar
    Department of Pathology, University of Alabama at Birmingham, LHRB 533, 1530 3rd Ave South, Birmingham, AL 35294, USA
    Biochem J 412:459-68. 2008
    ..Understanding the biology of CaM-FLIP binding may provide new therapeutic targets for cholangiocarcinoma and possibly other cancers...
  6. ncbi Protein crystallization
    Champion Deivanayagam
    Center for Biophysical Sciences and Engineering, Department of Vision Sciences, University of Alabama at Birmingham, USA
    Methods Mol Biol 383:337-49. 2007
    ..This chapter describes essential information on standard protein production and crystallization methods and ongoing efforts to perform this work using high-throughput robotics...
  7. ncbi Structures of vaccinia virus dUTPase and its nucleotide complexes
    Alexandra Samal
    Center for Biophysical Sciences and Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Acta Crystallogr D Biol Crystallogr 63:571-80. 2007
    ..In particular, the much larger size of the central channel at the trimer interface suggests new possibilities for structure-based drug design. Vaccinia virus is a prototype of the poxviruses...
  8. ncbi Crystal structure of Cryptosporidium parvum pyruvate kinase
    William J Cook
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 7:e46875. 2012
    ..Both cysteine residues are unique to C. parvum, and the disulfide bond remained intact in a reduced environment. However, the significance of this bond, if any, remains unknown at this time...
  9. ncbi Calmodulin binding to the Fas death domain. Regulation by Fas activation
    Eun Young Ahn
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
    J Biol Chem 279:5661-6. 2004
    ..These findings suggest a novel function of CaM in Fas-mediated apoptosis...
  10. ncbi Structure of Plasmodium falciparum ADP-ribosylation factor 1
    William J Cook
    University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 66:1426-31. 2010
    ..The crystal structure of ARF1 GTPase from Plasmodium falciparum has been determined in the GDP-bound conformation at 2.5 Å resolution and is compared with the structures of mammalian ARF1s...
  11. ncbi Structure of variant 2 scorpion toxin from Centruroides sculpturatus Ewing
    William J Cook
    Department of Pathology, University of Alabama at Birmingham, 35294, USA
    Protein Sci 11:479-86. 2002
    ..The shorter loop in alpha toxins exposes a critical lysine side chain, whereas the longer loop in beta toxins buries the corresponding basic residue (either arginine or lysine)...
  12. ncbi Crystallization of cytokine-receptor complexes
    William J Cook
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Methods Mol Biol 249:81-92. 2004