I A Cook

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Neuromodulation for depression: invasive and noninvasive (deep brain stimulation, transcranial magnetic stimulation, trigeminal nerve stimulation)
    Ian A Cook
    UCLA Depression Research and Clinic Program, Semel Institute for Neuroscience and Human Behavior at UCLA, David Geffen School of Medicine at UCLA, Henry Samueli School of Engineering at UCLA, 760 Westwood Plaza, Los Angeles, CA 90095, USA Electronic address
    Neurosurg Clin N Am 25:103-16. 2014
  2. doi request reprint Trigeminal nerve stimulation in major depressive disorder: acute outcomes in an open pilot study
    Ian A Cook
    UCLA Depression Research and Clinic Program, Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles, CA, USA
    Epilepsy Behav 28:221-6. 2013
  3. doi request reprint Quantitative electroencephalogram biomarkers for predicting likelihood and speed of achieving sustained remission in major depression: a report from the biomarkers for rapid identification of treatment effectiveness in major depression (BRITE-MD) trial
    Ian A Cook
    UCLA Semel Institute for Neuroscience and Human Behavior, Depression Research and Clinic Program and Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    J Clin Psychiatry 74:51-6. 2013
  4. ncbi request reprint Cognitive and physiologic correlates of subclinical structural brain disease in elderly healthy control subjects
    Ian A Cook
    University of California, Los Angeles, Neuropsychiatric Institute, 760 Westwood Plaza, Los Angeles, CA 90024 1759, USA
    Arch Neurol 59:1612-20. 2002
  5. ncbi request reprint Changes in prefrontal activity characterize clinical response in SSRI nonresponders: a pilot study
    Ian A Cook
    Laboratory of Behavioral Pharmacology, UCLA Neuropsychiatric Institute, 760 Westwood Plaza, 37 451, Los Angeles, CA 90024 1759, USA
    J Psychiatr Res 39:461-6. 2005
  6. ncbi request reprint Aging and brain activation with working memory tasks: an fMRI study of connectivity
    Ian A Cook
    UCLA Semel Institute for Neuroscience and Human Behavior, California 90024 1759, USA
    Int J Geriatr Psychiatry 22:332-42. 2007
  7. ncbi request reprint Electronic source materials in clinical research: acceptability and validity of symptom self-rating in major depressive disorder
    Ian A Cook
    UCLA Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, 760 Westwood Plaza, Los Angeles, CA 90024 1759, USA
    J Psychiatr Res 41:737-43. 2007
  8. ncbi request reprint Estrogen replacement therapy is associated with less progression of subclinical structural brain disease in normal elderly women: a pilot study
    Ian A Cook
    UCLA Neuropsychiatric Institute and the Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine Los Angeles, CA 90024 1759, USA
    Int J Geriatr Psychiatry 17:610-8. 2002
  9. ncbi request reprint Early changes in prefrontal activity characterize clinical responders to antidepressants
    Ian A Cook
    Quantitative EEG Laboratory, Neuropsychiatric Institute and Hospital, UCLA School of Medicine, University of California, 760 Westwood Plaza, Los Angeles, CA 90024 1759, USA
    Neuropsychopharmacology 27:120-31. 2002
  10. pmc Midline and right frontal brain function as a physiologic biomarker of remission in major depression
    Ian A Cook
    UCLA Depression Research and Clinic Program, Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles, CA, United States
    Psychiatry Res 174:152-7. 2009

Detail Information

Publications54

  1. doi request reprint Neuromodulation for depression: invasive and noninvasive (deep brain stimulation, transcranial magnetic stimulation, trigeminal nerve stimulation)
    Ian A Cook
    UCLA Depression Research and Clinic Program, Semel Institute for Neuroscience and Human Behavior at UCLA, David Geffen School of Medicine at UCLA, Henry Samueli School of Engineering at UCLA, 760 Westwood Plaza, Los Angeles, CA 90095, USA Electronic address
    Neurosurg Clin N Am 25:103-16. 2014
    ..Additional comparative research is needed to delineate the relative advantages of these treatments, and how best to match individual patients to neuromodulation intervention. ..
  2. doi request reprint Trigeminal nerve stimulation in major depressive disorder: acute outcomes in an open pilot study
    Ian A Cook
    UCLA Depression Research and Clinic Program, Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles, CA, USA
    Epilepsy Behav 28:221-6. 2013
    ..01; effect sizes d 1.0-1.8), as did quality of life (p < 0.02). Four of the 11 achieved remission. These improvements from nightly adjunctive eTNS in treatment-resistant depression merit replication under double-blind conditions...
  3. doi request reprint Quantitative electroencephalogram biomarkers for predicting likelihood and speed of achieving sustained remission in major depression: a report from the biomarkers for rapid identification of treatment effectiveness in major depression (BRITE-MD) trial
    Ian A Cook
    UCLA Semel Institute for Neuroscience and Human Behavior, Depression Research and Clinic Program and Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    J Clin Psychiatry 74:51-6. 2013
    ....
  4. ncbi request reprint Cognitive and physiologic correlates of subclinical structural brain disease in elderly healthy control subjects
    Ian A Cook
    University of California, Los Angeles, Neuropsychiatric Institute, 760 Westwood Plaza, Los Angeles, CA 90024 1759, USA
    Arch Neurol 59:1612-20. 2002
    ..Healthy elderly persons commonly show 4 types of change in brain structure-cortical atrophy, central atrophy, deep white-matter hyperintensities, and periventricular hyperintensities-as forms of subclinical structural brain disease (SSBD)...
  5. ncbi request reprint Changes in prefrontal activity characterize clinical response in SSRI nonresponders: a pilot study
    Ian A Cook
    Laboratory of Behavioral Pharmacology, UCLA Neuropsychiatric Institute, 760 Westwood Plaza, 37 451, Los Angeles, CA 90024 1759, USA
    J Psychiatr Res 39:461-6. 2005
    ..These findings suggest that cordance biomarkers may be a useful tool in effectiveness trials that parallel clinical practices in SSRI nonresponders, and may not require a wash-out period between treatments...
  6. ncbi request reprint Aging and brain activation with working memory tasks: an fMRI study of connectivity
    Ian A Cook
    UCLA Semel Institute for Neuroscience and Human Behavior, California 90024 1759, USA
    Int J Geriatr Psychiatry 22:332-42. 2007
    ..We hypothesized healthy older subjects would show lower connectivity than younger subjects...
  7. ncbi request reprint Electronic source materials in clinical research: acceptability and validity of symptom self-rating in major depressive disorder
    Ian A Cook
    UCLA Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, 760 Westwood Plaza, Los Angeles, CA 90024 1759, USA
    J Psychiatr Res 41:737-43. 2007
    ..We then examined ease of use, the equivalence of responses between paper and electronic methods, and the acceptability of the tablet PC for this clinical population...
  8. ncbi request reprint Estrogen replacement therapy is associated with less progression of subclinical structural brain disease in normal elderly women: a pilot study
    Ian A Cook
    UCLA Neuropsychiatric Institute and the Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine Los Angeles, CA 90024 1759, USA
    Int J Geriatr Psychiatry 17:610-8. 2002
    ..Cortical atrophy, central atrophy, deep white-matter hyperintensities, and periventricular hyperintensities are reported in normal aging...
  9. ncbi request reprint Early changes in prefrontal activity characterize clinical responders to antidepressants
    Ian A Cook
    Quantitative EEG Laboratory, Neuropsychiatric Institute and Hospital, UCLA School of Medicine, University of California, 760 Westwood Plaza, Los Angeles, CA 90024 1759, USA
    Neuropsychopharmacology 27:120-31. 2002
    ..These findings implicate the prefrontal region in mediating response to antidepressant medications. Cordance may have clinical applicability as a leading indicator of individual response...
  10. pmc Midline and right frontal brain function as a physiologic biomarker of remission in major depression
    Ian A Cook
    UCLA Depression Research and Clinic Program, Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles, CA, United States
    Psychiatry Res 174:152-7. 2009
    ..These results suggest that remission may be predictable from physiologic measurements after 1 week of treatment, and that this region merits further investigation in the neurobiology of treatment response...
  11. ncbi request reprint Prefrontal changes and treatment response prediction in depression
    I A Cook
    Quantitative EEG Laboratory and Clinical Neurophysiology Program, Department of Psychiatry and Biobehavioral Sciences, Neuropsychiatric Institute and Hospital, UCLA School of Medicine, Los Angeles, CA, USA
    Semin Clin Neuropsychiatry 6:113-20. 2001
    ....
  12. ncbi request reprint Neurophysiologic predictors of treatment response to fluoxetine in major depression
    I A Cook
    Neuropsychiatric Institute Hospital, Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, University of California, Los Angeles 90024 1759, USA
    Psychiatry Res 85:263-73. 1999
    ..This measure detects a propensity to respond to fluoxetine and may indicate a more general responsiveness to antidepressants...
  13. ncbi request reprint Assessing the accuracy of topographic EEG mapping for determining local brain function
    I A Cook
    Neuropsychiatric Institute and Hospital and Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, University of California, Los Angeles, USA
    Electroencephalogr Clin Neurophysiol 107:408-14. 1998
    ..We performed this study to test the accuracy of EEG mapping by examining the association between electrical activity and the perfusion under each electrode as another measure of local cerebral function...
  14. ncbi request reprint Altered cerebral energy utilization in late life depression
    I A Cook
    Quantitative EEG Laboratory, Neuropsychiatric Institute and Hospital, UCLA School of Medicine, University of California, Los Angeles, USA
    J Affect Disord 49:89-99. 1998
    ..Global and regional changes in cerebral energy utilization are reported to characterize late life depression...
  15. ncbi request reprint Longitudinal progression of subclinical structural brain disease in normal aging
    Ian A Cook
    UCLA Neuropsychiatric Institute and the Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, CA 90024 1759, USA
    Am J Geriatr Psychiatry 12:190-200. 2004
    ..Greater volumes were also associated with poorer cognition, even though subjects performed within the normal range. The natural history of these forms of SSBD and their functional impact are not well established...
  16. ncbi request reprint Executive dysfunction predicts nonresponse to fluoxetine in major depression
    J J Dunkin
    Department of Psychiatry and Biobehavioral Sciences, UCLA NPI 37 439 School of Medicine, 760 Westwood Plaza, Los Angeles, CA 90024, USA
    J Affect Disord 60:13-23. 2000
    ..In this study, we explored this heterogeneity among depressed subjects by examining the relationship between cognitive functioning and treatment outcome...
  17. doi request reprint Brain functional changes (QEEG cordance) and worsening suicidal ideation and mood symptoms during antidepressant treatment
    A M Hunter
    Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles, CA 90024 1759, USA
    Acta Psychiatr Scand 122:461-9. 2010
    ..We examined the quantitative electroencephalographic (QEEG) cordance biomarker of brain function biomarker in relation to treatment-emergent symptom worsening...
  18. ncbi request reprint Relationship between brain electrical activity and cortical perfusion in normal subjects
    A F Leuchter
    Quantitative EEG Laboratory, UCLA Neuropsychiatric Institute and Hospital, Los Angeles, CA 90024, USA
    Psychiatry Res 90:125-40. 1999
    ..Cordance may be the most useful QEEG measure for monitoring cerebral perfusion in subjects without chronic brain disease...
  19. doi request reprint Brain functional changes and duloxetine treatment response in fibromyalgia: a pilot study
    Aimee M Hunter
    Laboratory of Brain, Behavior, and Pharmacology, Semel Institute for Neuroscience and Human Behavior at the University of California, Los Angeles, CA, USA
    Pain Med 10:730-8. 2009
    ..We hypothesized that cordance might also predict response to antidepressant medications for symptoms of FMS...
  20. doi request reprint Brain functional changes during placebo lead-in and changes in specific symptoms during pharmacotherapy for major depression
    A M Hunter
    Laboratory of Brain, Behavior, and Pharmacology, Semel Institute for Neuroscience and Human Behavior at UCLA, 760 Westwood Plaza, Rm 37 359, Los Angeles, CA 90024 1759, USA
    Acta Psychiatr Scand 119:266-73. 2009
    ....
  21. doi request reprint Painful physical symptoms and treatment outcome in major depressive disorder: a STAR*D (Sequenced Treatment Alternatives to Relieve Depression) report
    A F Leuchter
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90024 1759, USA
    Psychol Med 40:239-51. 2010
    ..Whether PPS significantly contribute to poorer treatment outcome overall in primary or specialty psychiatric care settings remains unclear...
  22. pmc fMRI activation in the amygdala and the orbitofrontal cortex in unmedicated subjects with major depressive disorder
    Jennifer D Townsend
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, and Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA
    Psychiatry Res 183:209-17. 2010
    ..The current study replicates previous research on unmedicated subjects showing no significant differences in amygdala function in depressed vs. control subjects with respect to simple tasks involving emotion observation...
  23. ncbi request reprint Amygdala lateralization at rest and during viewing of neutral faces in major depressive disorder using low-resolution brain electromagnetic tomography
    Haleh Farahbod
    Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles, CA 90024 1759, USA
    Clin EEG Neurosci 41:19-23. 2010
    ..Findings suggest a more pronounced lateralization effect in normal healthy controls than in MDD subjects when changing from a resting (eyes-closed) condition to viewing faces without emotional valence...
  24. ncbi request reprint Influence of age, gender, health status, and depression on quantitative EEG
    Melinda L Morgan
    Behavioral Pharmacology Laboratory, UCLA Neuropsychiatric Institute, USA
    Neuropsychobiology 52:71-6. 2005
    ..Global measures of power, and to a lesser extent prefrontal absolute power, must be interpreted with regard to confounding factors of age, gender, physical illness, and severity of depression...
  25. ncbi request reprint Use of clinical neurophysiology for the selection of medication in the treatment of major depressive disorder: the state of the evidence
    Andrew F Leuchter
    Laboratory of Brain, Behavior, and Pharmacology, Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles, CA 90024 1759, USA
    Clin EEG Neurosci 40:78-83. 2009
    ..The current state of evidence supporting the use of each technique is reviewed...
  26. pmc Rostral anterior cingulate cortex theta current density and response to antidepressants and placebo in major depression
    Alexander S Korb
    Laboratory of Brain, Behavior, and Pharmacology, Semel Institute for Neuroscience and Human Behavior at UCLA, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90024 1759, USA
    Clin Neurophysiol 120:1313-9. 2009
    ....
  27. doi request reprint Monoamine oxidase a and catechol-o-methyltransferase functional polymorphisms and the placebo response in major depressive disorder
    Andrew F Leuchter
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, 760 Westwood Plaza, Rm 37 452, Los Angeles, CA 90024 1759, USA
    J Clin Psychopharmacol 29:372-7. 2009
    ..These findings support the hypothesis that genetic polymorphisms modulating monoaminergic tone are related to degree of placebo responsiveness in major depressive disorder...
  28. ncbi request reprint A web-based data management system to improve care for depression in a multicenter clinical trial
    Jurgen Unutzer
    Center for Health Services Research, Neuropsychiatric Institute of the University of California, Los Angeles 90024, USA
    Psychiatr Serv 53:671-3, 678. 2002
  29. doi request reprint Effectiveness of a quantitative electroencephalographic biomarker for predicting differential response or remission with escitalopram and bupropion in major depressive disorder
    Andrew F Leuchter
    Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles, CA 90024 1759, USA
    Psychiatry Res 169:132-8. 2009
    ..28%). The ATR index did not provide a useful prediction of response to combination treatment. The ATR index may prove useful in predicting responsiveness to different antidepressant medications...
  30. doi request reprint Comparative effectiveness of biomarkers and clinical indicators for predicting outcomes of SSRI treatment in Major Depressive Disorder: results of the BRITE-MD study
    Andrew F Leuchter
    Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles, CA 90024 1759, USA
    Psychiatry Res 169:124-31. 2009
    ..Logistic regression showed that the ATR and early Ham-D(17) changes were additive predictors of response, but the ATR was the only significant predictor of remission. Future studies should replicate these results prior to clinical use...
  31. ncbi request reprint Changes in brain function of depressed subjects during treatment with placebo
    Andrew F Leuchter
    UCLA Neuropsychiatric Institute, Los Angeles, CA 90024 1759, USA
    Am J Psychiatry 159:122-9. 2002
    ..Both QEEG power and cordance, a new measure that reflects cerebral perfusion and is sensitive to the effect of antidepressant medication, were examined...
  32. pmc A new paradigm for the prediction of antidepressant treatment response
    Andrew F Leuchter
    Laboratory of Brain Behavior, and Pharmacology, Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles, CA 90024, USA
    Dialogues Clin Neurosci 11:435-46. 2009
    ..We posit that this new paradigm could lead to earlier recovery from depressive illness and ultimately produce profound health and economic benefits...
  33. ncbi request reprint Neurophysiologic changes during estrogen augmentation in perimenopausal depression
    Melinda L Morgan
    Laboratory of Brain, Behavior, and Pharmacology, Department of Psychiatry and Biobehavioral Sciences, UCLA Neuropsychiatric Institute, 760 Westwood Plaza, Suite 37 439, Los Angeles, CA 90024 1759, United States
    Maturitas 56:54-60. 2007
    ..We also assessed whether such changes were correlated with serum hormone levels...
  34. pmc Biomarkers to predict antidepressant response
    Andrew F Leuchter
    Semel Institute for Neuroscience and Human Behavior at UCLA, David Geffen School of Medicine at UCLA, Los Angeles, CA 90024, USA
    Curr Psychiatry Rep 12:553-62. 2010
    ..Once such biomarkers are validated, they could form the basis of new paradigms for antidepressant treatment selection...
  35. ncbi request reprint Pretreatment neurophysiological and clinical characteristics of placebo responders in treatment trials for major depression
    Andrew F Leuchter
    UCLA NPI, 760 Westwood Plaza, Suite 37 452, Los Angeles, CA 90024 1759, USA
    Psychopharmacology (Berl) 177:15-22. 2004
    ..High placebo response rates are a confound in treatment trials for major depressive disorder (MDD). A method for prospective identification of placebo responders could enhance the efficiency of clinical trials...
  36. ncbi request reprint Changes in brain function during administration of venlafaxine or placebo to normal subjects
    Andrew F Leuchter
    Laboratory of Brain, Behavior, and Pharmacology, Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles, CA 90024 1759, USA
    Clin EEG Neurosci 39:175-81. 2008
    ..Future studies should examine other classes of medication, as well as antidepressants with other mechanisms of action, to determine if cordance detects antidepressant medication effects in general in normal subjects...
  37. ncbi request reprint Subject expectations of treatment effectiveness and outcome of treatment with an experimental antidepressant
    Heather V Krell
    Laboratory of Behavioral Pharmacology, UCLA Neuropsychiatric Institute, and the Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90024 1759, USA
    J Clin Psychiatry 65:1174-9. 2004
    ..To evaluate the association between treatment expectations and response in a 9-week, single-blind experimental antidepressant treatment study...
  38. ncbi request reprint Neurophysiologic correlates of side effects in normal subjects randomized to venlafaxine or placebo
    Aimee M Hunter
    Behavioral Pharmacology Laboratory, Department of Psychiatry and Biobehavioral Sciences, UCLA Neuropsychiatric Institute, David Geffen School of Medicine, Los Angeles, CA 90024 1759, USA
    Neuropsychopharmacology 30:792-9. 2005
    ..Results of these exploratory hypothesis-generating analyses should be considered tentative until replicated...
  39. ncbi request reprint Estrogen augmentation of antidepressants in perimenopausal depression: a pilot study
    Melinda L Morgan
    Laboratory of Behavioral Pharmacology, University of California Los Angeles Neuropsychiatric Institute and Hospital, Department of Psychiatry and Biobehavioral Sciences, 90024, USA
    J Clin Psychiatry 66:774-80. 2005
    ..To investigate the effects of estrogen augmentation on mood and memory in women with perimenopausal depression who had experienced a partial response to antidepressant medications...
  40. ncbi request reprint Association between quantitative EEG and neurocognition in methamphetamine-dependent volunteers
    Thomas F Newton
    Department of Psychiatry and Biobehavioral Sciences, Neuropsychiatric Institute, UCLA School of Medicine, Room A7 372, 760 Westwood Plaza, Los Angeles, CA 90024, USA
    Clin Neurophysiol 115:194-8. 2004
    ..Exposure to methamphetamine is associated with long-lasting reductions in markers for dopaminergic neurons in preclinical models and in humans. These changes may be associated with alterations in brain electrical activity and in cognition...
  41. ncbi request reprint Evaluation of reboxetine, a noradrenergic antidepressant, for the treatment of fibromyalgia and chronic low back pain
    Heather V Krell
    Laboratory of Behavioral Pharmacology, UCLA Neuropsychiatric Institute, 37 452 NPI, 760 Westwood Plaza, Los Angeles, CA 90024, USA
    Psychosomatics 46:379-84. 2005
    ..Our experience with reboxetine suggests that this noradrenergic antidepressant may have efficacy in the treatment of chronic pain in patients with depression...
  42. ncbi request reprint Quantitative EEG abnormalities in recently abstinent methamphetamine dependent individuals
    Thomas F Newton
    Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, CA, USA
    Clin Neurophysiol 114:410-5. 2003
    ....
  43. ncbi request reprint Changes in brain function (quantitative EEG cordance) during placebo lead-in and treatment outcomes in clinical trials for major depression
    Aimee M Hunter
    Semel Institute for Neuroscience and Human Behavior at UCLA, 760 Westwood Plaza, Rm 37 359, Los Angeles, CA 90024 1759, USA
    Am J Psychiatry 163:1426-32. 2006
    ..The authors hypothesized that decreases in prefrontal cordance during the placebo lead-in phase would be associated with better clinical outcome in subjects treated with antidepressants...
  44. doi request reprint Brain electrical source differences between depressed subjects and healthy controls
    Alexander S Korb
    Laboratory of Brain, Behavior, and Pharmacology, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior at UCLA, David Geffen School of Medicine at UCLA, Los Angeles, CA 90024 1759, USA
    Brain Topogr 21:138-46. 2008
    ..Inconsistent findings among LORETA studies, and between LORETA studies and those using other functional imaging techniques, may result from differences in electrode montages...
  45. ncbi request reprint The promise of the quantitative electroencephalogram as a predictor of antidepressant treatment outcomes in major depressive disorder
    Aimee M Hunter
    Laboratory of Brain, Behavior, and Pharmacology, Semel Institute for Neuroscience and Human Behavior at UCLA, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90024 1759, USA
    Psychiatr Clin North Am 30:105-24. 2007
    ....
  46. ncbi request reprint White matter injury, neural connectivity and the pathophysiology of psychiatric disorders
    Anand Kumar
    Department of Psychiatry and The Neuropsychiatric Institute, University of California, Los Angeles, Calif 90024, USA
    Dev Neurosci 24:255-61. 2002
    ..Focused translational research aimed at identifying the links between white matter compromise and specific behaviors are necessary for a more thorough understanding of the etiology of mental illness to emerge...
  47. pmc Antidepressant response trajectories and quantitative electroencephalography (QEEG) biomarkers in major depressive disorder
    Aimee M Hunter
    Semel Institute for Neuroscience and Human Behavior at UCLA, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90024 1759, United States
    J Psychiatr Res 44:90-8. 2010
    ..Statistical methods such as GMM are needed to identify clinically relevant symptom response trajectories...
  48. ncbi request reprint Synaptic dysfunction in Alzheimer's disease: clinical assessment using quantitative EEG
    I A Cook
    UCLA Neuropsychiatric Institute, USA
    Behav Brain Res 78:15-23. 1996
    ....
  49. pmc Evaluation of quantitative EEG by classification and regression trees to characterize responders to antidepressant and placebo treatment
    M Rabinoff
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA
    Open Med Inform J 5:1-8. 2011
    ..The results of our study suggest that CART may be a useful method for identifying potential outcome predictors in the treatment of major depression...
  50. ncbi request reprint Quantitative EEG effects of nicotine replacement by cigarette smoking
    T F Newton
    Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, USA
    Neuropsychobiology 37:112-6. 1998
    ....
  51. ncbi request reprint Pretreatment neurophysiologic function and ECT response in depression
    William F Stubbeman
    Laboratory of Behavioral Pharmacology, UCLA Neuropsychiatric Institute, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90024, USA
    J ECT 20:142-4. 2004
    ..The present study tested the hypothesis that brain activity in midline apical quantitative EEG (QEEG) electrodes would be associated with therapeutic response to electroconvulsive therapy (ECT)...
  52. ncbi request reprint Clinical and demographic features of atypical depression in outpatients with major depressive disorder: preliminary findings from STAR*D
    Jon S Novick
    Zucker Hillside Hospital, Glen Oaks, NY, USA
    J Clin Psychiatry 66:1002-11. 2005
    ..To determine the frequency and demographic and clinical characteristics of depression with atypical features in a broadly representative sample of outpatients...
  53. ncbi request reprint Baroreflex mechanisms in major depression
    Dmitry M Davydov
    Department of Neurophysiology, Moscow Research Center of Narcology, 156 3 68 Leninsky pr t, Moscow 117571, Russia
    Prog Neuropsychopharmacol Biol Psychiatry 31:164-77. 2007
    ..The objective of this study was to gain more insight into autonomic functioning in depressive disorder to more fully examine the potential basis for increased cardiac mortality...
  54. ncbi request reprint Variation in neurophysiological function and evidence of quantitative electroencephalogram discordance: predicting cocaine-dependent treatment attrition
    Sandy Venneman
    Medication Development Unit, Research Service, and Psychiatry Service, West Los Angeles VA Medical Center, California, USA
    J Neuropsychiatry Clin Neurosci 18:208-16. 2006
    ..Failure to complete the trial was not explained by depression, craving, benzoylecgonine levels or quantitative electroencephalogram (QEEG) power; thus cordance may help identify attrition risk...

Research Grants7

  1. DRUG SENSITIVITY IN ELDERLY PSYCHIATRIC PATIENTS
    Ian Cook; Fiscal Year: 2002
    ..Cook will be well prepared to undertake independent and collaborative investigations, to expand his teaching roles, and to play a role in bridging basic science and clinical research within the Department. ..
  2. RESPONSE VARIABILITY IN TREATMENT RESISTANT DEPRESSION
    Ian Cook; Fiscal Year: 2006
    ..Secondary analyses will use general linear models and growth mixture modeling to examine how early cordance changes relate to patient and illness factors and to functional outcomes. ..
  3. Personalized Response Indicators of SSRI Effectiveness in Major Depression
    Ian Cook; Fiscal Year: 2009
    ....
  4. Personalized Response Indicators of SSRI Effectiveness in Major Depression
    Ian A Cook; Fiscal Year: 2010
    ....
  5. Personalized Response Indicators of SSRI Effectiveness in Major Depression
    Ian A Cook; Fiscal Year: 2010
    ....