Joan M Cook-Mills

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. ncbi request reprint Reactive oxygen species regulation of immune function
    Joan M Cook-Mills
    Mol Immunol 39:497-8. 2002
  2. pmc VCAM-1 signals during lymphocyte migration: role of reactive oxygen species
    Joan M Cook-Mills
    Pathology and Laboratory Medicine Department, University of Cincinnati, 231 Albert Sabin Way, ML 529, Cincinnati, OH 45267 0529, USA
    Mol Immunol 39:499-508. 2002
  3. pmc Calcium mobilization and Rac1 activation are required for VCAM-1 (vascular cell adhesion molecule-1) stimulation of NADPH oxidase activity
    Joan M Cook-Mills
    Department of Pathology, University of Cincinnati, Cincinnati, OH 45267 0529, USA
    Biochem J 378:539-47. 2004
  4. pmc Active participation of endothelial cells in inflammation
    Joan M Cook-Mills
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45267 0529, USA
    J Leukoc Biol 77:487-95. 2005
  5. pmc Vascular cell adhesion molecule 1 (VCAM-1) activation of endothelial cell matrix metalloproteinases: role of reactive oxygen species
    Tracy L Deem
    Department of Pathology and Laboratory Medicine, PO Box 670529, University of Cincinnati, Cincinnati, OH 45267 0529, USA
    Blood 104:2385-93. 2004
  6. ncbi request reprint Unconjugated bilirubin inhibits VCAM-1-mediated transendothelial leukocyte migration
    Pavitra Keshavan
    Division of Digestive Diseases, University of Cincinnati, Cincinnati, OH 45267, USA
    J Immunol 174:3709-18. 2005
  7. pmc CD44, alpha(4) integrin, and fucoidin receptor-mediated phagocytosis of apoptotic leukocytes
    Jacob D Johnson
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45267 0529, USA
    J Leukoc Biol 74:810-20. 2003
  8. pmc Galphai2-mediated signaling events in the endothelium are involved in controlling leukocyte extravasation
    Ralph S Pero
    Division of Hematology Oncology, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA
    Proc Natl Acad Sci U S A 104:4371-6. 2007
  9. pmc VCAM-1 activation of endothelial cell protein tyrosine phosphatase 1B
    Tracy L Deem
    Allergy Immunology Division, Northwestern University, Feinberg School of Medicine, 240 East Huron, Chicago, IL 60611, USA
    J Immunol 178:3865-73. 2007
  10. pmc Nonhematopoietic NADPH oxidase regulation of lung eosinophilia and airway hyperresponsiveness in experimentally induced asthma
    Hiam Abdala-Valencia
    Allergy Immunology Division, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1111-25. 2007

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Reactive oxygen species regulation of immune function
    Joan M Cook-Mills
    Mol Immunol 39:497-8. 2002
  2. pmc VCAM-1 signals during lymphocyte migration: role of reactive oxygen species
    Joan M Cook-Mills
    Pathology and Laboratory Medicine Department, University of Cincinnati, 231 Albert Sabin Way, ML 529, Cincinnati, OH 45267 0529, USA
    Mol Immunol 39:499-508. 2002
    ..In addition, VCAM-1-activated signals in endothelial cells are regulated by cytokines indicating that it is important to consider both endothelial cell adhesion molecule expression and function during inflammatory processes...
  3. pmc Calcium mobilization and Rac1 activation are required for VCAM-1 (vascular cell adhesion molecule-1) stimulation of NADPH oxidase activity
    Joan M Cook-Mills
    Department of Pathology, University of Cincinnati, Cincinnati, OH 45267 0529, USA
    Biochem J 378:539-47. 2004
    ..Thus VCAM-1 stimulates the mobilization of intracellular and extracellular calcium and Rac1 activity that are required for the activation of NADPH oxidase...
  4. pmc Active participation of endothelial cells in inflammation
    Joan M Cook-Mills
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45267 0529, USA
    J Leukoc Biol 77:487-95. 2005
    ....
  5. pmc Vascular cell adhesion molecule 1 (VCAM-1) activation of endothelial cell matrix metalloproteinases: role of reactive oxygen species
    Tracy L Deem
    Department of Pathology and Laboratory Medicine, PO Box 670529, University of Cincinnati, Cincinnati, OH 45267 0529, USA
    Blood 104:2385-93. 2004
    ..In summary, this is the first report of a mechanism for ROS function in VCAM-1 activation of endothelial cell MMPs during VCAM-1-dependent lymphocyte migration...
  6. ncbi request reprint Unconjugated bilirubin inhibits VCAM-1-mediated transendothelial leukocyte migration
    Pavitra Keshavan
    Division of Digestive Diseases, University of Cincinnati, Cincinnati, OH 45267, USA
    J Immunol 174:3709-18. 2005
    ..These findings support a potential role for bilirubin as an endogenous immunomodulatory agent...
  7. pmc CD44, alpha(4) integrin, and fucoidin receptor-mediated phagocytosis of apoptotic leukocytes
    Jacob D Johnson
    Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45267 0529, USA
    J Leukoc Biol 74:810-20. 2003
    ..The removal of apoptotic leukocytes by endothelial cells may protect the microvasculature, thus ensuring that viable lymphocytes can successfully migrate into tissues...
  8. pmc Galphai2-mediated signaling events in the endothelium are involved in controlling leukocyte extravasation
    Ralph S Pero
    Division of Hematology Oncology, Department of Biochemistry and Molecular Biology, Mayo Clinic Arizona, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA
    Proc Natl Acad Sci U S A 104:4371-6. 2007
    ..Collectively, these data suggest that specific Galpha(i2)-mediated signaling between endothelial cells and leukocytes is required for the extravasation of leukocytes and for tissue-specific accumulation...
  9. pmc VCAM-1 activation of endothelial cell protein tyrosine phosphatase 1B
    Tracy L Deem
    Allergy Immunology Division, Northwestern University, Feinberg School of Medicine, 240 East Huron, Chicago, IL 60611, USA
    J Immunol 178:3865-73. 2007
    ..This PTP1B activity is necessary for VCAM-1-dependent transendothelial lymphocyte migration. These data show, for the first time, a function for PTP1B in VCAM-1-dependent lymphocyte migration...
  10. pmc Nonhematopoietic NADPH oxidase regulation of lung eosinophilia and airway hyperresponsiveness in experimentally induced asthma
    Hiam Abdala-Valencia
    Allergy Immunology Division, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Am J Physiol Lung Cell Mol Physiol 292:L1111-25. 2007
    ..Moreover, these studies provide a basis for targeting VCAM-1-dependent signaling pathways in asthma therapies...
  11. pmc VCAM-1 signals activate endothelial cell protein kinase Calpha via oxidation
    Hiam Abdala-Valencia
    Allergy Immunology Division, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Immunol 177:6379-87. 2006
    ..This oxidation was blocked by inhibition of NADPH oxidase. In summary, VCAM-1 activation of endothelial cell NADPH oxidase induces transient PKCalpha activation that is necessary for VCAM-1-dependent transendothelial cell migration...
  12. pmc Hydrogen peroxide activation of endothelial cell-associated MMPs during VCAM-1-dependent leukocyte migration
    Joan M Cook-Mills
    Allergy Immunology Division, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Cell Mol Biol (Noisy-le-grand) 52:8-16. 2006
    ..In summary, endothelial cells are not simply a scaffold for leukocyte adhesion. Instead, endothelial cells have an active function during VCAM-1-dependent leukocyte transendothelial migration...