Kathleen Conway

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint Prevalence and spectrum of p53 mutations associated with smoking in breast cancer
    Kathleen Conway
    Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Cancer Res 62:1987-95. 2002
  2. pmc Risk factors for breast cancer characterized by the estrogen receptor alpha A908G (K303R) mutation
    Kathleen Conway
    Department of Epidemiology, School of Public Health, CB 7435, University of North Carolina, Chapel Hill, NC 27599, USA
    Breast Cancer Res 9:R36. 2007
  3. pmc DNA-methylation profiling distinguishes malignant melanomas from benign nevi
    Kathleen Conway
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
    Pigment Cell Melanoma Res 24:352-60. 2011
  4. pmc The estrogen receptor-alpha A908G (K303R) mutation occurs at a low frequency in invasive breast tumors: results from a population-based study
    Kathleen Conway
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
    Breast Cancer Res 7:R871-80. 2005
  5. ncbi request reprint Number of nevi and early-life ambient UV exposure are associated with BRAF-mutant melanoma
    Nancy E Thomas
    Department of Dermatology, University of North Carolina, Chapel Hill, NC 27599, USA
    Cancer Epidemiol Biomarkers Prev 16:991-7. 2007
  6. pmc Polychlorinated biphenyls, cytochrome P450 1A1 (CYP1A1) polymorphisms, and breast cancer risk among African American women and white women in North Carolina: a population-based case-control study
    Yu Li
    Department of Epidemiology, School of Public Heath, University of North Carolina, Chapel Hill, North Carolina, USA
    Breast Cancer Res 7:R12-8. 2005
  7. ncbi request reprint No association between the MDM2 -309 T/G promoter polymorphism and breast cancer in African-Americans or Whites
    Robert C Millikan
    Department of Epidemiology, School of Public Health and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599 7435, USA
    Cancer Epidemiol Biomarkers Prev 15:175-7. 2006
  8. pmc Epidemiology of basal-like breast cancer
    Robert C Millikan
    Department of Epidemiology, CB 7435, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7435, USA
    Breast Cancer Res Treat 109:123-39. 2008
  9. ncbi request reprint Tandem BRAF mutations in primary invasive melanomas
    Nancy E Thomas
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA
    J Invest Dermatol 122:1245-50. 2004
  10. pmc Cigarette smoking, cytochrome P4501A1 polymorphisms, and breast cancer among African-American and white women
    Yu Li
    Department of Epidemiology, School of Public Heath and Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
    Breast Cancer Res 6:R460-73. 2004

Research Grants

  1. Molecular Epidemiology of Smoking & Breast Cancer
    KATHLEEN CONWAY DORSEY; Fiscal Year: 2005

Detail Information

Publications16

  1. ncbi request reprint Prevalence and spectrum of p53 mutations associated with smoking in breast cancer
    Kathleen Conway
    Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Cancer Res 62:1987-95. 2002
    ..Moreover, the difference in mutational spectra observed between smokers and nonsmokers is suggestive of the genotoxic effects of smoking in breast tissue...
  2. pmc Risk factors for breast cancer characterized by the estrogen receptor alpha A908G (K303R) mutation
    Kathleen Conway
    Department of Epidemiology, School of Public Health, CB 7435, University of North Carolina, Chapel Hill, NC 27599, USA
    Breast Cancer Res 9:R36. 2007
    ..We recently detected this mutation at a low frequency of 6% in invasive breast tumors of the Carolina Breast Cancer Study (CBCS)...
  3. pmc DNA-methylation profiling distinguishes malignant melanomas from benign nevi
    Kathleen Conway
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
    Pigment Cell Melanoma Res 24:352-60. 2011
    ..This first report of a DNA-methylation signature discriminating melanomas from nevi indicates that DNA methylation appears promising as an additional tool for enhancing melanoma diagnosis...
  4. pmc The estrogen receptor-alpha A908G (K303R) mutation occurs at a low frequency in invasive breast tumors: results from a population-based study
    Kathleen Conway
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
    Breast Cancer Res 7:R871-80. 2005
    ..This mutation was initially reported in one-third of hyperplastic benign breast lesions, although several recent studies failed to detect it in benign or malignant breast tissues...
  5. ncbi request reprint Number of nevi and early-life ambient UV exposure are associated with BRAF-mutant melanoma
    Nancy E Thomas
    Department of Dermatology, University of North Carolina, Chapel Hill, NC 27599, USA
    Cancer Epidemiol Biomarkers Prev 16:991-7. 2007
    ..The association of BRAF mutations with early-life UV exposure provides evidence in support of childhood sun protection for melanoma prevention...
  6. pmc Polychlorinated biphenyls, cytochrome P450 1A1 (CYP1A1) polymorphisms, and breast cancer risk among African American women and white women in North Carolina: a population-based case-control study
    Yu Li
    Department of Epidemiology, School of Public Heath, University of North Carolina, Chapel Hill, North Carolina, USA
    Breast Cancer Res 7:R12-8. 2005
    ..However, two recent studies showed a stronger association among postmenopausal white women with the inducible M2 polymorphism in the cytochrome P450 1A1 (CYP1A1) gene...
  7. ncbi request reprint No association between the MDM2 -309 T/G promoter polymorphism and breast cancer in African-Americans or Whites
    Robert C Millikan
    Department of Epidemiology, School of Public Health and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599 7435, USA
    Cancer Epidemiol Biomarkers Prev 15:175-7. 2006
  8. pmc Epidemiology of basal-like breast cancer
    Robert C Millikan
    Department of Epidemiology, CB 7435, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7435, USA
    Breast Cancer Res Treat 109:123-39. 2008
    ..Among younger African-American women, we estimate that up to 68% of basal-like breast cancer could be prevented by promoting breastfeeding and reducing abdominal adiposity...
  9. ncbi request reprint Tandem BRAF mutations in primary invasive melanomas
    Nancy E Thomas
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA
    J Invest Dermatol 122:1245-50. 2004
    ..The finding of tandem mutations in thin melanomas makes it more likely that they arise as a simultaneous rather than sequential event...
  10. pmc Cigarette smoking, cytochrome P4501A1 polymorphisms, and breast cancer among African-American and white women
    Yu Li
    Department of Epidemiology, School of Public Heath and Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
    Breast Cancer Res 6:R460-73. 2004
    ..Previous epidemiologic studies suggest that women with variant cytochrome P4501A1 (CYP1A1) genotypes who smoke cigarettes are at increased risk for breast cancer...
  11. ncbi request reprint IGF1 CA repeat polymorphisms, lifestyle factors and breast cancer risk in the Long Island Breast Cancer Study Project
    Rebecca J Cleveland
    Department of Epidemiology, School of Public Health and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599 7435, USA
    Carcinogenesis 27:758-65. 2006
    ..Our results demonstrate a role for alleles with fewer than (CA)19 repeats as a risk factor for breast cancer and also suggest that several traditional breast cancer risk factors modify the association of the IGF1 (CA)19 repeat genotype...
  12. ncbi request reprint HER2 codon 655 polymorphism and risk of breast cancer in African Americans and whites
    Robert Millikan
    Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7435, USA
    Breast Cancer Res Treat 79:355-64. 2003
    ..Results of previous studies have been mixed, with most studies showing no association but some suggesting an association in younger women or women with a family history of breast cancer...
  13. pmc Melanoma molecular subtypes: unifying and paradoxical results
    Nancy E Thomas
    Department of Dermatology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA
    J Invest Dermatol 130:12-4. 2010
    ..The authors did not find an association between somatic BRAF-mutant melanoma and germline melanocortin-1 receptor (MC1R) gene status. We discuss this seeming paradox in light of previous studies demonstrating strong associations...
  14. ncbi request reprint Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study
    Lisa A Carey
    Division of Hematology Oncology, School of Public Health, Department of Epidemiology, University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599 7305, USA
    JAMA 295:2492-502. 2006
    ..Gene expression analysis has identified several breast cancer subtypes, including basal-like, human epidermal growth factor receptor-2 positive/estrogen receptor negative (HER2+/ER-), luminal A, and luminal B...
  15. pmc Associations between polycyclic aromatic hydrocarbon-related exposures and p53 mutations in breast tumors
    Irina Mordukhovich
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599 7435, USA
    Environ Health Perspect 118:511-8. 2010
    ..Objectives: We hypothesized that associations of PAH-related exposures with breast cancer would differ according to tumor p53 mutation status, effect, type, and number...
  16. ncbi request reprint Mini-and microsatellite mutations in children from Chernobyl accident cleanup workers
    Robbert J C Slebos
    Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA
    Mutat Res 559:143-51. 2004
    ..In conclusion, our results do not support an increased level of germline minisatellite mutations but suggest a modest increase in germline mutations in tetranucleotide repeats. Small sample size, however, limited statistical power...

Research Grants3

  1. Molecular Epidemiology of Smoking & Breast Cancer
    KATHLEEN CONWAY DORSEY; Fiscal Year: 2005
    ..If breast cancer can be attributed, in part, to cigarette smoking, then smoking prevention or cessation should reduce exposure and thus decrease the incidence of breast cancer. ..