Marco Conti

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc PDE4D and PDE4B function in distinct subcellular compartments in mouse embryonic fibroblasts
    Brigitte E Blackman
    Center for Reproductive Sciences, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco School of Medicine, San Francisco, California 94143, USA
    J Biol Chem 286:12590-601. 2011
  2. pmc Genetic dissection of epidermal growth factor receptor signaling during luteinizing hormone-induced oocyte maturation
    Minnie Hsieh
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 6:e21574. 2011
  3. ncbi request reprint Novel signaling mechanisms in the ovary during oocyte maturation and ovulation
    Marco Conti
    Center for Reproductive Sciences, Department of Obstetrics and Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA 94143, United States
    Mol Cell Endocrinol 356:65-73. 2012
  4. ncbi request reprint Signaling networks in somatic cells and oocytes activated during ovulation
    M Conti
    Center for Reproductive Sciences, Department of Obstetrics and Gynecology and Reproductive Sciences, University of California at San Francisco, San Francisco, CA 94143, United States
    Ann Endocrinol (Paris) 71:189-90. 2010
  5. ncbi request reprint Phosphodiesterases and regulation of female reproductive function
    Marco Conti
    Center for Reproductive Sciences, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, 513 Parnassus Avenue, HSW 1656, Box 0556, San Francisco, CA 94143 0556, United States
    Curr Opin Pharmacol 11:665-9. 2011
  6. ncbi request reprint The upstream conserved regions (UCRs) mediate homo- and hetero-oligomerization of type 4 cyclic nucleotide phosphodiesterases (PDE4s)
    Moses Xie
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA 94143, U S A
    Biochem J 459:539-50. 2014
  7. pmc Somatic cells regulate maternal mRNA translation and developmental competence of mouse oocytes
    Jing Chen
    1 Center for Reproductive Sciences, University of California, San Francisco, California 94143, USA 2 Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, California 94143, USA 3 Department of Obstetrics and Gynecology and Reproductive Sciences, University of California, San Francisco, California 94143, USA
    Nat Cell Biol 15:1415-23. 2013
  8. pmc Cyclic GMP signaling is involved in the luteinizing hormone-dependent meiotic maturation of mouse oocytes
    Sergio Vaccari
    Center for Reproductive Sciences, University of California, San Francisco, California 94143 0556, USA
    Biol Reprod 81:595-604. 2009
  9. ncbi request reprint Protein tyrosine kinase Wee1B is essential for metaphase II exit in mouse oocytes
    Jeong Su Oh
    Center for Reproductive Sciences, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, CA 94143 0556, USA
    Science 332:462-5. 2011
  10. pmc Wee1B, Myt1, and Cdc25 function in distinct compartments of the mouse oocyte to control meiotic resumption
    Jeong Su Oh
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Center for Reproductive Sciences, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 188:199-207. 2010

Research Grants

  1. Role of Cyclic Nucleotides in Sperm Function
    Marco Conti; Fiscal Year: 2005
  2. Role of Cyclic Nucleotides in Sperm Function
    Marco Conti; Fiscal Year: 2006
  3. HORMONAL REGULATION OF PHOSPHODIESTERASES
    Marco Conti; Fiscal Year: 2006
  4. Role of Cyclic Nucleotides in Sperm Function
    Marco Conti; Fiscal Year: 2007
  5. Cyclic AMP and the Control of the Meiotic Cell Cycle
    Marco Conti; Fiscal Year: 2007
  6. Role of the EGF Network in Ovulation
    Marco Conti; Fiscal Year: 2007
  7. Role of Cyclic Nucleotides in Sperm Function
    Marco Conti; Fiscal Year: 2009
  8. Cyclic AMP and the Control of the Meiotic Cell Cycle
    Marco Conti; Fiscal Year: 2009
  9. Role of the EGF Network in Ovulation
    Marco Conti; Fiscal Year: 2009
  10. Hormonal Regulation of Phosphodiestrases
    Marco Conti; Fiscal Year: 2009

Collaborators

Detail Information

Publications24

  1. pmc PDE4D and PDE4B function in distinct subcellular compartments in mouse embryonic fibroblasts
    Brigitte E Blackman
    Center for Reproductive Sciences, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco School of Medicine, San Francisco, California 94143, USA
    J Biol Chem 286:12590-601. 2011
    ..These findings demonstrate that PDE4D and PDE4B have specialized functions in mouse embryonic fibroblasts with PDE4B controlling cAMP in a discrete subdomain near the plasma membrane...
  2. pmc Genetic dissection of epidermal growth factor receptor signaling during luteinizing hormone-induced oocyte maturation
    Minnie Hsieh
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 6:e21574. 2011
    ..Thus, multiple signals and redundant pathways contribute to regulating oocyte reentry into the cell cycle...
  3. ncbi request reprint Novel signaling mechanisms in the ovary during oocyte maturation and ovulation
    Marco Conti
    Center for Reproductive Sciences, Department of Obstetrics and Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA 94143, United States
    Mol Cell Endocrinol 356:65-73. 2012
    ..This review will provide a summary of the current knowledge of the molecular events triggered by LH focusing mostly on the signaling pathways required for oocyte maturation...
  4. ncbi request reprint Signaling networks in somatic cells and oocytes activated during ovulation
    M Conti
    Center for Reproductive Sciences, Department of Obstetrics and Gynecology and Reproductive Sciences, University of California at San Francisco, San Francisco, CA 94143, United States
    Ann Endocrinol (Paris) 71:189-90. 2010
    ..Because these regulatory mechanisms are conserved in rodents and in humans, a better understanding of these signaling networks activated during ovulation will provide new pharmacological opportunities for the manipulation of fertility...
  5. ncbi request reprint Phosphodiesterases and regulation of female reproductive function
    Marco Conti
    Center for Reproductive Sciences, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, 513 Parnassus Avenue, HSW 1656, Box 0556, San Francisco, CA 94143 0556, United States
    Curr Opin Pharmacol 11:665-9. 2011
    ..This review summarizes the function and regulation of PDEs in the somatic compartment and in the oocyte, and highlights the potential of PDEs as targets to improve assisted reproduction, as well as for fertility control...
  6. ncbi request reprint The upstream conserved regions (UCRs) mediate homo- and hetero-oligomerization of type 4 cyclic nucleotide phosphodiesterases (PDE4s)
    Moses Xie
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA 94143, U S A
    Biochem J 459:539-50. 2014
    ..As a result, individual PDE4 protomers may independently mediate protein-protein interactions, providing a mechanism whereby PDE4s contribute to the assembly of macromolecular signalling complexes...
  7. pmc Somatic cells regulate maternal mRNA translation and developmental competence of mouse oocytes
    Jing Chen
    1 Center for Reproductive Sciences, University of California, San Francisco, California 94143, USA 2 Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, California 94143, USA 3 Department of Obstetrics and Gynecology and Reproductive Sciences, University of California, San Francisco, California 94143, USA
    Nat Cell Biol 15:1415-23. 2013
    ..These somatic cell signals that affect translation require activation of the PI(3)K-AKT-mTOR pathway. Thus, mRNA translation depends on somatic cell cues that are essential to reprogramme the oocyte for embryo development. ..
  8. pmc Cyclic GMP signaling is involved in the luteinizing hormone-dependent meiotic maturation of mouse oocytes
    Sergio Vaccari
    Center for Reproductive Sciences, University of California, San Francisco, California 94143 0556, USA
    Biol Reprod 81:595-604. 2009
    ....
  9. ncbi request reprint Protein tyrosine kinase Wee1B is essential for metaphase II exit in mouse oocytes
    Jeong Su Oh
    Center for Reproductive Sciences, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, CA 94143 0556, USA
    Science 332:462-5. 2011
    ....
  10. pmc Wee1B, Myt1, and Cdc25 function in distinct compartments of the mouse oocyte to control meiotic resumption
    Jeong Su Oh
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Center for Reproductive Sciences, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 188:199-207. 2010
    ..Mislocalized Wee1B or Myt1 is not able to maintain meiotic arrest. Thus, cooperation of Wee1B, Myt1, and Cdc25 is required to maintain meiotic arrest and relocation of these components before GVBD is necessary for meiotic reentry...
  11. pmc Cdc25A activity is required for the metaphase II arrest in mouse oocytes
    Jeong Su Oh
    Center for Reproductive Sciences and The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Department of Obstetrics, Gynecology and Reproductive Sciences at the University of California, San Francisco, CA 94143 0556, USA
    J Cell Sci 126:1081-5. 2013
    ..Thus, our data demonstrate that Cdk1 activity is maintained during MII arrest not only by cyclin turnover but also by steady state phosphorylation...
  12. ncbi request reprint Epidermal growth factor-like growth factors in the follicular fluid: role in oocyte development and maturation
    Minnie Hsieh
    Department of Obstetrics, Gynecology and Reproductive Sciences, Center for Reproductive Sciences, University of California, San Francisco, California 94143 0556, USA
    Semin Reprod Med 27:52-61. 2009
    ..This review summarizes the most recent findings on the EGF network during ovulation and the potential clinical applications of manipulating this intercellular communication pathway in the control of fertility...
  13. pmc Inactivation of multidrug resistance proteins disrupts both cellular extrusion and intracellular degradation of cAMP
    Moses Xie
    Department of Gynecology, Obstetrics and Reproductive Sciences, University of California San Francisco, 513 Parnassus Ave, Box 0556, San Francisco, CA 94143 0556, USA
    Mol Pharmacol 80:281-93. 2011
    ..Whether this regulation occurs in cells remains to be confirmed experimentally under conditions that do not affect PDE activity...
  14. pmc Critical role of PDE4D in beta2-adrenoceptor-dependent cAMP signaling in mouse embryonic fibroblasts
    Matthew D Bruss
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, California 94143, USA
    J Biol Chem 283:22430-42. 2008
    ..Finally, PDE4D ablation affected the kinetics of beta2AR desensitization as well as the interaction of the receptor with Galphai. These findings demonstrate that PDE4D plays a major role in shaping the beta2AR signal...
  15. doi request reprint Analysis of signaling pathways controlling flagellar movements in mammalian spermatozoa
    Fang Xie
    Center for Reproductive Sciences, University of California San Francisco, San Francisco, California, USA
    Methods Enzymol 524:91-104. 2013
    ..We will also describe methods to investigate the macromolecular complexes that bring together sAC and other signaling molecules...
  16. pmc The protein kinase A pathway-regulated transcriptome of endometrial stromal fibroblasts reveals compromised differentiation and persistent proliferative potential in endometriosis
    Lusine Aghajanova
    Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, California 94143 0132, USA
    Endocrinology 151:1341-55. 2010
    ....
  17. pmc Anchored PDE4 regulates chloride conductance in wild-type and ΔF508-CFTR human airway epithelia
    Elise Blanchard
    1Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco, 513 Parnassus Ave, Box 0556, San Francisco, CA 94143 0556, USA
    FASEB J 28:791-801. 2014
    ..Taken together, our results implicate PDE4 as an important determinant of CFTR activity in airway epithelia, and support the use of PDE4 inhibitors to potentiate the therapeutic benefits of CFTR correctors and potentiators...
  18. pmc Genome-wide analysis of translation reveals a critical role for deleted in azoospermia-like (Dazl) at the oocyte-to-zygote transition
    Jing Chen
    Center for Reproductive Sciences, University of California at San Francisco, San Francisco, California 94143, USA
    Genes Dev 25:755-66. 2011
    ..Therefore, Cpeb1 and Dazl function in a progressive, self-reinforcing pathway to promote oocyte maturation and early embryonic development...
  19. pmc Conserved expression and functions of PDE4 in rodent and human heart
    Wito Richter
    Department of Gynecology, Obstetrics, and Reproductive Sciences, Center for Reproductive Sciences, University of California San Francisco, Box 0556, 513 Parnassus Avenue, San Francisco, CA 94143 0556, USA
    Basic Res Cardiol 106:249-62. 2011
    ..These differences may explain the distinct pharmacological effects of PDE4 inhibition in rodent and human hearts...
  20. pmc β1-adrenergic receptor antagonists signal via PDE4 translocation
    Wito Richter
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, California 94143, USA
    EMBO Rep 14:276-83. 2013
    ..Our study identifies receptor/PDE4 complex dissociation as a novel mechanism of antagonist action that contributes to the pharmacological properties of β1AR antagonists and might be shared by other receptor subtypes...
  21. pmc PDE4B mediates local feedback regulation of β1-adrenergic cAMP signaling in a sarcolemmal compartment of cardiac myocytes
    Delphine Mika
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, CA 94143, USA
    J Cell Sci 127:1033-42. 2014
    ..Disruption of this feedback augments local cAMP/PKA signals, leading to an increased intracellular Ca(2+) level and contraction rate. ..
  22. pmc PDE4 as a target for cognition enhancement
    Wito Richter
    University of California San Francisco, Department of Obstetrics, Gynecology and Reproductive Sciences, San Francisco, CA 94143 0556, USA
    Expert Opin Ther Targets 17:1011-27. 2013
    ..Consequently, cyclic nucleotide phosphodiesterases (PDEs), the enzymes that inactivate the cyclic nucleotides, are promising targets for the development of cognition-enhancing drugs...
  23. ncbi request reprint Multiple Pathways Mediate Luteinizing Hormone Regulation of cGMP Signaling in the Mouse Ovarian Follicle
    Xueqing Liu
    College of Animal Science and Technology, Northwest Agriculture and Forestry University, Yangling, Shaanxi, People s Republic of China Department of Obstetrics, Gynecology and Reproductive Sciences, Center for Reproductive Sciences, The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco UCSF Medical Center, UCSF, San Francisco, California
    Biol Reprod 91:9. 2014
    ..These findings demonstrate that redundant pathways are involved in the regulation of cGMP. EGFR-dependent events are involved in the short-term regulation of cGMP, whereas the long-term effects may involve regulation of the CNP. ..
  24. ncbi request reprint Lowering cyclic adenosine-3',5'-monophosphate (cAMP) levels by expression of a cAMP-specific phosphodiesterase decreases intrinsic pulsatile gonadotropin-releasing hormone secretion from GT1 cells
    Hiroshi Yoshida
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, California 94143, USA
    Mol Endocrinol 17:1982-90. 2003
    ..Genetically targeted expression of PDE4D1 represents a powerful approach to study the role of cAMP levels in specific populations of neurons in transgenic animals...

Research Grants39

  1. Role of Cyclic Nucleotides in Sperm Function
    Marco Conti; Fiscal Year: 2005
    ..They will also provide the groundwork for validation of targets for pharmacological manipulation of the male gamete, and new diagnostic tools useful to define the male factor. ..
  2. Role of Cyclic Nucleotides in Sperm Function
    Marco Conti; Fiscal Year: 2006
    ..They will also provide the groundwork for validation of targets for pharmacological manipulation of the male gamete, and new diagnostic tools useful to define the male factor. ..
  3. HORMONAL REGULATION OF PHOSPHODIESTERASES
    Marco Conti; Fiscal Year: 2006
    ..The concepts developed will provide the basis for studies on the role of PDE dysfunction in human diseases and a rationale for pharmacological intervention in endocrine disorders using PDE4-selective inhibitors. ..
  4. Role of Cyclic Nucleotides in Sperm Function
    Marco Conti; Fiscal Year: 2007
    ..They will also provide the groundwork for validation of targets for pharmacological manipulation of the male gamete, and new diagnostic tools useful to define the male factor. ..
  5. Cyclic AMP and the Control of the Meiotic Cell Cycle
    Marco Conti; Fiscal Year: 2007
    ..The studies proposed will further our understanding of the regulation of the specialized meiotic cell cycle as well as the ..
  6. Role of the EGF Network in Ovulation
    Marco Conti; Fiscal Year: 2007
    ..Finally, a better understanding of the function of EGF-like growth factors will contribute to the understanding of the biology of some tumors of gynecological interest. ..
  7. Role of Cyclic Nucleotides in Sperm Function
    Marco Conti; Fiscal Year: 2009
    ..They will also provide the groundwork for validation of targets for pharmacological manipulation of the male gamete, and new diagnostic tools useful to define the male factor. ..
  8. Cyclic AMP and the Control of the Meiotic Cell Cycle
    Marco Conti; Fiscal Year: 2009
    ..The studies proposed will further our understanding of the regulation of the specialized meiotic cell cycle as well as the ..
  9. Role of the EGF Network in Ovulation
    Marco Conti; Fiscal Year: 2009
    ..Finally, a better understanding of the function of EGF-like growth factors will contribute to the understanding of the biology of some tumors of gynecological interest. ..
  10. Hormonal Regulation of Phosphodiestrases
    Marco Conti; Fiscal Year: 2009
    ..Finally, these studies will provide the foundation of data on which to search for human alleles of phosphodiesterase genes associated with increased risk for sudden cardiac death and other cardiovascular disorders. ..
  11. Role of the EGF Network in Ovulation
    Marco Conti; Fiscal Year: 2010
    ..Finally, a better understanding of the function of EGF-like growth factors will contribute to the understanding of the biology of some tumors of gynecological interest. ..
  12. Cyclic AMP and the Control of the Meiotic Cell Cycle
    Marco Conti; Fiscal Year: 2010
    ..The studies proposed will further our understanding of the regulation of the specialized meiotic cell cycle as well as the ..
  13. Hormonal Regulation of Phosphodiestrases
    Marco Conti; Fiscal Year: 2010
    ..Finally, these studies will provide the foundation of data on which to search for human alleles of phosphodiesterase genes associated with increased risk for sudden cardiac death and other cardiovascular disorders. ..
  14. ROLE OF CYCLIC NUCLEOTIDES IN SPERMATID DIFFERENTIATION
    Marco Conti; Fiscal Year: 2004
    ..Moreover, they will help to identify novel targets for pharmacological manipulation of gamete production and fertility. ..
  15. HORMONAL REGULATION OF PHOSPHODIESTERASES
    Marco Conti; Fiscal Year: 2003
    ..The concepts developed will provide the basis for studies on the role of PDE dysfunction in human diseases and a rationale for pharmacological intervention in endocrine disorders using PDE4-selective inhibitors. ..
  16. ROLE OF CYCLIC NUCLEOTIDES IN SPERMATID DIFFERENTIATION
    Marco Conti; Fiscal Year: 2003
    ..Moreover, they will help to identify novel targets for pharmacological manipulation of gamete production and fertility. ..
  17. HORMONAL REGULATION OF PHOSPHODIESTERASES
    Marco Conti; Fiscal Year: 1999
    ..These studies will further our understanding of the mechanism of TSH and FSH action in the endocrine target cell. They will also help define new targets for pharmacological intervention in endocrine disorders. ..
  18. HORMONAL REGULATION OF GAMETOGENESIS
    Marco Conti; Fiscal Year: 1992
    ..These studies will improve the understanding of the mechanisms of gonadotropin action and will provide insight into the mechanisms controlling gametogenesis...
  19. HORMONAL REGULATION OF GAMETOGENESIS
    Marco Conti; Fiscal Year: 1993
    ..These studies will improve the understanding of the mechanisms of gonadotropin action and will provide insight into the mechanisms controlling gametogenesis...
  20. ROLE OF CYCLIC NUCLEOTIDES IN SPERMATID DIFFERENTIATION
    Marco Conti; Fiscal Year: 2000
    ..Moreover, they will help to identify novel targets for pharmacological manipulation of gamete production and fertility. ..
  21. HORMONAL REGULATION OF PHOSPHODIESTERASES
    Marco Conti; Fiscal Year: 2000
    ..These studies will further our understanding of the mechanism of TSH and FSH action in the endocrine target cell. They will also help define new targets for pharmacological intervention in endocrine disorders. ..
  22. ROLE OF CYCLIC NUCLEOTIDES IN SPERMATID DIFFERENTIATION
    Marco Conti; Fiscal Year: 2001
    ..Moreover, they will help to identify novel targets for pharmacological manipulation of gamete production and fertility. ..
  23. HORMONAL REGULATION OF PHOSPHODIESTERASES
    Marco Conti; Fiscal Year: 2001
    ..These studies will further our understanding of the mechanism of TSH and FSH action in the endocrine target cell. They will also help define new targets for pharmacological intervention in endocrine disorders. ..
  24. ROLE OF CYCLIC NUCLEOTIDES IN SPERMATID DIFFERENTIATION
    Marco Conti; Fiscal Year: 2002
    ..Moreover, they will help to identify novel targets for pharmacological manipulation of gamete production and fertility. ..
  25. HORMONAL REGULATION OF PHOSPHODIESTERASES
    Marco Conti; Fiscal Year: 2002
    ..The concepts developed will provide the basis for studies on the role of PDE dysfunction in human diseases and a rationale for pharmacological intervention in endocrine disorders using PDE4-selective inhibitors. ..
  26. Cyclic AMP and the Control of the Meiotic Cell Cycle
    Marco Conti; Fiscal Year: 2010
    ..The studies proposed will further our understanding of the regulation of the specialized meiotic cell cycle as well as the ..