David Conti

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. pmc Meta-analysis of 8q24 for seven cancers reveals a locus between NOV and ENPP2 associated with cancer development
    Abra G Brisbin
    Department of Health Sciences Research, Mayo Clinic, Rochester, USA
    BMC Med Genet 12:156. 2011
  2. pmc Variation in genetic admixture and population structure among Latinos: the Los Angeles Latino eye study (LALES)
    Corina J Shtir
    Department of Preventive Medicine, Division of Biostatistics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    BMC Genet 10:71. 2009
  3. pmc Comparison of missing data approaches in linkage analysis
    Chao Xing
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA
    BMC Genet 4:S44. 2003
  4. pmc Identifying susceptibility genes by using joint tests of association and linkage and accounting for epistasis
    Joshua Millstein
    National Oceanic and Atmospheric Administration National Marine Fisheries Service, Alaska Fisheries Science Center, 7600 Sand Point Way NE, Seattle, WA 98115, USA
    BMC Genet 6:S147. 2005
  5. pmc Prevalence of common disease-associated variants in Asian Indians
    Trevor J Pemberton
    Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    BMC Genet 9:13. 2008
  6. pmc Snagger: a user-friendly program for incorporating additional information for tagSNP selection
    Christopher K Edlund
    Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    BMC Bioinformatics 9:174. 2008
  7. ncbi request reprint Bayesian modeling of complex metabolic pathways
    David V Conti
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90089 9011, USA
    Hum Hered 56:83-93. 2003
  8. ncbi request reprint SNPs, haplotypes, and model selection in a candidate gene region: the SIMPle analysis for multilocus data
    David V Conti
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Genet Epidemiol 27:429-41. 2004
  9. pmc Nicotinic acetylcholine receptor beta2 subunit gene implicated in a systems-based candidate gene study of smoking cessation
    David V Conti
    Department of Preventive Medicine, Keck School of Medicine, Zilkha Neurogenetics Institute, University of Southern California, 1501 San Pablo Street, ZNI 445, Los Angeles, CA 90089, USA
    Hum Mol Genet 17:2834-48. 2008
  10. pmc Efficient genome-wide association testing of gene-environment interaction in case-parent trios
    W James Gauderman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, 90033, USA
    Am J Epidemiol 172:116-22. 2010

Detail Information

Publications54

  1. pmc Meta-analysis of 8q24 for seven cancers reveals a locus between NOV and ENPP2 associated with cancer development
    Abra G Brisbin
    Department of Health Sciences Research, Mayo Clinic, Rochester, USA
    BMC Med Genet 12:156. 2011
    ..However, the abundance of associations around 128 Mb on chromosome 8 could mask the appearance of a weaker, but important, association elsewhere on 8q24...
  2. pmc Variation in genetic admixture and population structure among Latinos: the Los Angeles Latino eye study (LALES)
    Corina J Shtir
    Department of Preventive Medicine, Division of Biostatistics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    BMC Genet 10:71. 2009
    ..Sensitivity of ancestry estimates to relative sample size was considered...
  3. pmc Comparison of missing data approaches in linkage analysis
    Chao Xing
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA
    BMC Genet 4:S44. 2003
    ..Therefore, we compare here six methods of imputing missing repeated phenotypes on results from genome-wide linkage analyses of four quantitative traits from the Framingham Heart Study cohort...
  4. pmc Identifying susceptibility genes by using joint tests of association and linkage and accounting for epistasis
    Joshua Millstein
    National Oceanic and Atmospheric Administration National Marine Fisheries Service, Alaska Fisheries Science Center, 7600 Sand Point Way NE, Seattle, WA 98115, USA
    BMC Genet 6:S147. 2005
    ..The strongest effect was for SNP B03T3056, which had a median p-value of 1.98 x 10(-34). No two- or three-locus effects were found in more than one replicate...
  5. pmc Prevalence of common disease-associated variants in Asian Indians
    Trevor J Pemberton
    Institute for Genetic Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    BMC Genet 9:13. 2008
    ....
  6. pmc Snagger: a user-friendly program for incorporating additional information for tagSNP selection
    Christopher K Edlund
    Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    BMC Bioinformatics 9:174. 2008
    ..Many of these programs do not account for potential reduced genomic coverage resulting from genotyping failures nor do they preferentially select SNPs based on functionality, which may be more likely to be biologically important...
  7. ncbi request reprint Bayesian modeling of complex metabolic pathways
    David V Conti
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90089 9011, USA
    Hum Hered 56:83-93. 2003
    ..The new analyses are structured in a manner that attempts to take advantage of prior knowledge of the metabolism of these classes of compounds and the various genes that regulate these pathways...
  8. ncbi request reprint SNPs, haplotypes, and model selection in a candidate gene region: the SIMPle analysis for multilocus data
    David V Conti
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Genet Epidemiol 27:429-41. 2004
    ..Using simulations, we demonstrate the utility of the SIMPle model to identify crucial SNPs and underlying haplotype structures across a variety of causal models and genetic architectures...
  9. pmc Nicotinic acetylcholine receptor beta2 subunit gene implicated in a systems-based candidate gene study of smoking cessation
    David V Conti
    Department of Preventive Medicine, Keck School of Medicine, Zilkha Neurogenetics Institute, University of Southern California, 1501 San Pablo Street, ZNI 445, Los Angeles, CA 90089, USA
    Hum Mol Genet 17:2834-48. 2008
    ..0002) and an impact on withdrawal symptoms at target quit date (TQD) (P = 0.0009). Overall, while our results indicate strong evidence for CHRNB2 in ability to quit smoking, these results require replication in an independent sample...
  10. pmc Efficient genome-wide association testing of gene-environment interaction in case-parent trios
    W James Gauderman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, 90033, USA
    Am J Epidemiol 172:116-22. 2010
    ..This 2-step scan for G x E interaction is independent of any prior scan that may have been conducted for genetic main effects, and thus has the potential to uncover new genes in a GWAS that have not been previously identified...
  11. ncbi request reprint Bayesian spatial modeling of haplotype associations
    Duncan C Thomas
    University of Southern California, Los Angeles, CA 90089 9011, USA
    Hum Hered 56:32-40. 2003
    ..We conclude with a discussion of the implications of these methods for modeling cryptic relatedness, haplotype blocks, and haplotype tagging SNPs, and suggest a Bayesian framework for the HapMap project...
  12. doi request reprint Role of inducible nitric oxide synthase in asthma risk and lung function growth during adolescence
    Talat Islam
    Department of Preventive Medicine, USC Keck School of Medicine, University of Southern California, 1540 Alcazar Street, CHP 236, Los Angeles, CA 90033, USA
    Thorax 65:139-45. 2010
    ..Because nitrosative stress affects respiratory health, it was hypothesised that variants in NOS2A are associated with asthma incidence and lung function growth during adolescence...
  13. pmc Detecting gene-environment interactions using a combined case-only and case-control approach
    Dalin Li
    Department of Preventive Medicine and Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
    Am J Epidemiol 169:497-504. 2009
    ..Increased power or increased robustness to violations of the independence assumption may be obtained with more appropriate prior specification. The authors use an example data analysis to demonstrate the advantages of this approach...
  14. pmc Genetic variability in the MTHFR gene and colorectal cancer risk using the colorectal cancer family registry
    A Joan Levine
    USC Keck School of Medicine, Department of Preventive Medicine, Genetic Epidemiology, NRT 1450 Biggy Street, Room 1509A, Los Angeles, CA 90033, USA
    Cancer Epidemiol Biomarkers Prev 19:89-100. 2010
    ..The MTHFR C677T TT genotype is associated with a 15% to 18% reduction in colorectal cancer risk, but it is not clear if other variants of the gene are associated with colorectal cancer risk...
  15. pmc A survey of current Bayesian gene mapping methods
    John Molitor
    Department of Preventive Medicine, University of Southern California, 1540 Alcazar Street, CHP 220, Los Angeles, CA 90089 9011, USA
    Hum Genomics 1:371-4. 2004
    ..This review attempts to summarise some of the currently available methods and the software available to implement these methods...
  16. pmc Discovery of complex pathways from observational data
    James W Baurley
    Department of Preventive Medicine, University of Southern California, Los Angeles, USA
    Stat Med 29:1998-2011. 2010
    ..Our method can correctly identify the risk factors and interactions involved in the simulated pathway. We apply our framework to an asthma case-control data set with polymorphisms in 12 genes...
  17. ncbi request reprint Intercellular adhesion molecule-1 and childhood asthma
    Yu Fen Li
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, CHP 236, Los Angeles, CA 90033, USA
    Hum Genet 117:476-84. 2005
    ..3, 95% CI 0.1-0.8), as compared with two copies of the AGA haplotype. Consistent with information on variant function, the 241A and 469G variants may indicate haplotypes that are associated with reduced risk for asthma...
  18. doi request reprint Using extreme phenotype sampling to identify the rare causal variants of quantitative traits in association studies
    Dalin Li
    Medical Genetics Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Genet Epidemiol 35:790-9. 2011
    ..Finally, we expanded the current analysis and design framework to accommodate the CMC approach where multiple rare-variants in the same gene region are analyzed jointly...
  19. doi request reprint Effect of tidal volume in children with acute hypoxemic respiratory failure
    Robinder G Khemani
    Department of Anesthesia and Critical Care Medicine, Children s Hospital Los Angeles, 4650 Sunset Blvd, Mail Stop 12, Los Angeles, CA 90027, USA
    Intensive Care Med 35:1428-37. 2009
    ..To validate lung injury severity markers such as oxygenation index (OI), PaO2/FiO2 (PF) ratio, and lung injury score (LIS)...
  20. ncbi request reprint Interleukin-6-related genotypes, body mass index, and risk of multiple myeloma and plasmacytoma
    Wendy Cozen
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, MC 9175, Los Angeles, CA 90089 9175, USA
    Cancer Epidemiol Biomarkers Prev 15:2285-91. 2006
    ..These results suggest that IL-6 promoter genotypes may be associated with increased risk of plasma cell neoplasms...
  21. doi request reprint Water intake and bladder cancer risk in Los Angeles County
    Xuejuan Jiang
    USC Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA
    Int J Cancer 123:1649-56. 2008
    ..Similarly, the protection from water intake was confined to women who did not experience nocturia and to men who did. Results from our study suggest that water intake may be associated with a slight reduction in bladder cancer risk...
  22. pmc Sequence variant on 3q28 and urinary bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study
    Mariana C Stern
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90089, USA
    Cancer Epidemiol Biomarkers Prev 18:3057-61. 2009
    ..045). Our results suggest that a TP63 gene variant may increase susceptibility for the development of urinary bladder tumors with low risk of progression...
  23. pmc Genes involved with folate uptake and distribution and their association with colorectal cancer risk
    Jane C Figueiredo
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1450 Biggy Street Room 1509J, Los Angeles, CA 90033, USA
    Cancer Causes Control 21:597-608. 2010
    ..In conclusion, we found no significant evidence that genetic variants in FOLR1, GGH, FPGS and SLC19A1 are associated with the risk of colorectal cancer...
  24. pmc Genetic variation in the vitamin D receptor (VDR) and the vitamin D-binding protein (GC) and risk for colorectal cancer: results from the Colon Cancer Family Registry
    Jenny N Poynter
    Department of Preventive Medicine, University of Southern California, Los Angeles, California, USA
    Cancer Epidemiol Biomarkers Prev 19:525-36. 2010
    ..Overall, our results do not provide evidence for a role of common genetic variants in VDR or GC in susceptibility to CRC...
  25. pmc A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk
    A Joan Levine
    USC Keck School of Medicine, Department of Preventive Medicine, Genetic Epidemiology, NRT 1450 Biggy Street Room 1509A, Los Angeles, CA 90033, USA
    Cancer Epidemiol Biomarkers Prev 19:1812-21. 2010
    ..Folate-associated one-carbon metabolism (FOCM) may play an important role in colorectal carcinogenesis. Variation in FOCM genes may explain some of the underlying risk of colorectal cancer...
  26. pmc Hypertension, diuretics and antihypertensives in relation to bladder cancer
    Xuejuan Jiang
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA
    Carcinogenesis 31:1964-71. 2010
    ..7 pg/g Hb) compared with individuals without hypertension (79.8 pg/g Hb) (P = 0.009). In conclusion, untreated hypertension was associated with a reduced risk of bladder cancer...
  27. pmc Risk of urinary bladder cancer is associated with 8q24 variant rs9642880[T] in multiple racial/ethnic groups: results from the Los Angeles-Shanghai case-control study
    Victoria K Cortessis
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Ave, MC 9175, Los Angeles, CA 90089, USA
    Cancer Epidemiol Biomarkers Prev 19:3150-6. 2010
    ..Recent genome-wide association studies of urinary bladder cancer report risk to be associated with the T allele of rs9642880 on 8q24 among individuals of European descent...
  28. pmc Use of pathway information in molecular epidemiology
    Duncan C Thomas
    Department of Preventive Medicine, University of Southern California, 1540 Alcazar St, CHP 220, Los Angeles, CA 90089 9011, USA
    Hum Genomics 4:21-42. 2009
    ..The review concludes with some thoughts about potential uses of pathways in genome-wide association studies...
  29. pmc Genetic variations on chromosomes 5p15 and 15q25 and bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study
    Manuela Gago-Dominguez
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089 9175, USA
    Carcinogenesis 32:197-202. 2011
    ..26; 95% CI, 1.04-1.54; P = 0.017). Our results support 5p15 and 15q25 as susceptibility regions for bladder cancer risk...
  30. pmc Variation in folate pathway genes and distal colorectal adenoma risk: a sigmoidoscopy-based case-control study
    A Joan Levine
    Department of Preventive Medicine, Genetic Epidemiology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Cancer Causes Control 22:541-52. 2011
    ..Folate-associated one-carbon metabolism (FOCM) is an important pathway in colorectal neoplasia risk but data on genetic variation in this pathway are largely limited to studies of single SNPs in selected genes...
  31. pmc Glutathione S-transferase P1, maternal smoking, and asthma in children: a haplotype-based analysis
    Yu Fen Li
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Environ Health Perspect 116:409-15. 2008
    ..Glutathione S-transferase P1 (GSTP1) plays a role in a spectrum of respiratory diseases; however, the effects of sequence variation across the entire locus in asthma pathogenesis have yet to be determined...
  32. doi request reprint Comprehensive evaluation of ESR2 variation and ovarian cancer risk
    Celeste Leigh Pearce
    USC Norris Comprehensive Cancer Center and Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90089, USA
    Cancer Epidemiol Biomarkers Prev 17:393-6. 2008
    ..28-11.73; P = 0.016). Haplotype D was also reported by the BPC3 to be associated with increased risk of breast cancer. This haplotype warrants further investigation to rule out any effect with invasive ovarian cancer risk...
  33. ncbi request reprint Common genetic variation in the sex steroid hormone-binding globulin (SHBG) gene and circulating shbg levels among postmenopausal women: the Multiethnic Cohort
    Christopher A Haiman
    University of Southern California Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, Los Angeles, California 90089, USA
    J Clin Endocrinol Metab 90:2198-204. 2005
    ....
  34. ncbi request reprint Age-related smoking progression among adolescents in China
    Wei Sun
    Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    J Adolesc Health 39:686-93. 2006
    ..This study examined the differences in smoking progression between middle and upper school students...
  35. ncbi request reprint XRCC1, XRCC3, and XPD polymorphisms as modifiers of the effect of smoking and alcohol on colorectal adenoma risk
    Mariana C Stern
    University of Southern California Norris Comprehensive Cancer Center, Keck School of Medicine, 1441 Eastlake Avenue, Room 5421A, Los Angeles, CA 90089, USA
    Cancer Epidemiol Biomarkers Prev 15:2384-90. 2006
    ..04). Our data suggest that the effects of smoking and alcohol may vary depending on the genetic background of proteins that participate in the base excision repair and nucleotide excision repair pathways...
  36. ncbi request reprint Testing association between disease and multiple SNPs in a candidate gene
    W James Gauderman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Genet Epidemiol 31:383-95. 2007
    ..We observe stronger evidence of an association using the PC approach (p = 0.044) than using either a genotype-based (p = 0.13) or haplotype-based (p = 0.052) approach...
  37. ncbi request reprint Alcohol consumption and risk of bladder cancer in Los Angeles County
    Xuejuan Jiang
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Int J Cancer 121:839-45. 2007
    ..Alcohol consumption was strongly associated with a reduced risk of bladder cancer. The effect was modified by the type of alcoholic beverage, cigarette smoking and frequency of urination...
  38. ncbi request reprint The effect of montelukast and low-dose theophylline on cardiovascular disease risk factors in asthmatics
    Hooman Allayee
    Department of Preventive Medicine, USC Keck School of Medicine, 2250 Alcazar St, IGM 206, Los Angeles, CA 90033, USA
    Chest 132:868-74. 2007
    ..We sought to determine whether montelukast, a cysteinyl LT antagonist, and low-dose theophylline affected serum inflammatory and lipid CVD risk factors in a recently completed clinical trial in asthmatic patients...
  39. ncbi request reprint Hierarchical Bayes prioritization of marker associations from a genome-wide association scan for further investigation
    Juan Pablo Lewinger
    Department of Preventive Medicine, University of Southern California, Los Angeles, California 90089 9011, USA
    Genet Epidemiol 31:871-82. 2007
    ..We show that the ranking by posterior expectations performs better at selecting the true positive association than a simple ranking of p-values if at least some of the prior covariates have predictive value...
  40. ncbi request reprint DNA repair single-nucleotide polymorphisms in colorectal cancer and their role as modifiers of the effect of cigarette smoking and alcohol in the Singapore Chinese Health Study
    Mariana C Stern
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Avenue, Room 5421A, Los Angeles, CA 90089, USA
    Cancer Epidemiol Biomarkers Prev 16:2363-72. 2007
    ..8; 95% CI, 1.0-8.1). Our results support a role for reactive oxygen species as relevant genotoxins that may account for the effects of both smoking and alcohol on colorectal cancer risk...
  41. ncbi request reprint Variants on 9p24 and 8q24 are associated with risk of colorectal cancer: results from the Colon Cancer Family Registry
    Jenny N Poynter
    Department of Preventive Medicine, University of Southern California, 1441 Eastlake Avenue, NOR4411A, Los Angeles, CA 90089 9175, USA
    Cancer Res 67:11128-32. 2007
    ..These data suggest that common variants may play important roles in the risk of CRC...
  42. ncbi request reprint Commentary: the concept of 'Mendelian Randomization'
    Duncan C Thomas
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA 9089 9011, USA
    Int J Epidemiol 33:21-5. 2004
  43. doi request reprint Complex system approaches to genetic analysis Bayesian approaches
    Melanie A Wilson
    Department of Preventive Medicine, University of Southern California, Los Angeles, California, USA
    Adv Genet 72:47-71. 2010
    ..In particular, we highlight the ability of Bayesian methods to construct complex probability models via a hierarchical structure and to account for uncertainty in model specification by averaging over large spaces of alternative models...
  44. ncbi request reprint DNA repair gene XRCC1 and XPD polymorphisms and risk of prostate cancer
    Benjamin A Rybicki
    Department of Biostatistics and Research Epidemiology, Henry Ford Health System, Detroit, Michigan, USA
    Cancer Epidemiol Biomarkers Prev 13:23-9. 2004
    ....
  45. ncbi request reprint Testing association and linkage using affected-sib-parent study designs
    Joshua Millstein
    National Oceanic and Atmospheric Administration National Marine Fisheries Service, Alaska Fisheries Science Center, Seattle, Washington 98115, USA
    Genet Epidemiol 29:225-33. 2005
    ..8% by FBAT, and 82.5% by our joint test of linkage and association. Our model can also be used to obtain tests of linkage conditional on association and association conditional on linkage, which can be helpful in fine mapping...
  46. pmc A testing framework for identifying susceptibility genes in the presence of epistasis
    Joshua Millstein
    National Oceanic and Atmospheric Administration National Marine Fisheries Service, Alaska Fisheries Science Center, Seattle, WA 98115, USA
    Am J Hum Genet 78:15-27. 2006
    ..In an independent data set consisting primarily of African American and Asian American children, these three genes also showed a significant association with asthma status (P = .0008)...
  47. ncbi request reprint Association of prostate cancer risk and aggressiveness to androgen pathway genes: SRD5A2, CYP17, and the AR
    Mine S Cicek
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Prostate 59:69-76. 2004
    ....
  48. ncbi request reprint Relationship between methylenetetrahydrofolate reductase C677T and A1298C genotypes and haplotypes and prostate cancer risk and aggressiveness
    Mine S Cicek
    Department of Cancer Biology, Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio, USA
    Cancer Epidemiol Biomarkers Prev 13:1331-6. 2004
    ..47, 95% CI 0.29-0.76; P = 0.002). Our findings suggest that 677T and 1298A, or another variant on their haplotype, may be associated with a reduced risk of progression to more advanced prostate cancer...
  49. pmc Hierarchical modeling of linkage disequilibrium: genetic structure and spatial relations
    David V Conti
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, 44106, USA
    Am J Hum Genet 72:351-63. 2003
    ..This work demonstrates that hierarchical modeling of linkage disequilibrium is a valuable and flexible approach for fine-scale mapping...
  50. ncbi request reprint Comprehensive evaluation of the association between prostate cancer and genotypes/haplotypes in CYP17A1, CYP3A4, and SRD5A2
    Anu Loukola
    Amersham Biosciences, Sunnyvale, CA 94085, USA
    Eur J Hum Genet 12:321-32. 2004
    ..02). Undertaking a two-phase study comprising SNP discovery, haplotype tagging, and association analyses allowed us to more fully decipher the relation between CYP17A1, CYP3A4, and SRD5A2 and prostate cancer...
  51. ncbi request reprint CYP3A4 and CYP3A5 genotypes, haplotypes, and risk of prostate cancer
    Sarah J Plummer
    Department of Cancer Biology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Cancer Epidemiol Biomarkers Prev 12:928-32. 2003
    ..07; 95% CI, 0.01-0.51; P=0.009). These findings suggest that the CYP3A4 and CYP3A5 variants, or other alleles on the haplotypes they help distinguish, are associated with prostate cancer risk and aggressiveness...
  52. ncbi request reprint Prostate cancer aggressiveness locus on chromosome segment 19q12-q13.1 identified by linkage and allelic imbalance studies
    Phillippa J Neville
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Genes Chromosomes Cancer 36:332-9. 2003
    ..06). These data provide strong evidence that we have mapped a prostate tumor aggressiveness locus to chromosome segments 19q12-q13.11 that may play a role in both familial and non-familial forms of prostate cancer...
  53. pmc Prostate cancer aggressiveness locus on chromosome 7q32-q33 identified by linkage and allelic imbalance studies
    Phillippa J Neville
    Department of Cancer Biology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Neoplasia 4:424-31. 2002
    ..05). These data imply that we have localized a prostate cancer tumor aggressiveness loci to chromosome 7q32-q33 that is involved in familial and nonfamilial forms of prostate cancer...
  54. ncbi request reprint Genetic dissection of complex traits with chromosome substitution strains of mice
    Jonathan B Singer
    Broad Institute, Cambridge, MA 02142, USA
    Science 304:445-8. 2004
    ..These results demonstrate that CSSs greatly facilitate the detection and identification of genes that control the wide diversity of naturally occurring phenotypic variation in the A/J and C57BL/6J inbred strains...

Research Grants2

  1. HIERARCHICAL MODELING OF INTERACTIONS IN GENOME-WIDE AND PATHWAY-BASED STUDIES
    David V Conti; Fiscal Year: 2010
    ..By identifying both genetic and environmental factors, we will make progress in understanding the underlying mechanism that leads to disease and potentially identify ways in which to both prevent and treat complex diseases. ..