Bianca M Conti-Fine

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. doi request reprint CD4+ T cells and cytokines in the pathogenesis of acquired myasthenia gravis
    Bianca M Conti-Fine
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 6 155 Jackson Hall, 321 Church Street, Minneapolis, MN 55455, USA
    Ann N Y Acad Sci 1132:193-209. 2008
  2. pmc Myasthenia gravis: past, present, and future
    Bianca M Conti-Fine
    Department of Biochemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Clin Invest 116:2843-54. 2006
  3. ncbi request reprint Absence of IL-4 facilitates the development of chronic autoimmune myasthenia gravis in C57BL/6 mice
    Norma Ostlie
    Department of Biochemistry, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 170:604-12. 2003
  4. ncbi request reprint The susceptibility to experimental myasthenia gravis of STAT6-/- and STAT4-/- BALB/c mice suggests a pathogenic role of Th1 cells
    Wei Wang
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 321 Church Street, Minneapolis, MN 55455, USA
    J Immunol 172:97-103. 2004
  5. ncbi request reprint T cells and cytokines in the pathogenesis of acquired myasthenia gravis
    Monica Milani
    Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Ann N Y Acad Sci 998:284-307. 2003
  6. pmc C57BL/6 mice genetically deficient in IL-12/IL-23 and IFN-gamma are susceptible to experimental autoimmune myasthenia gravis, suggesting a pathogenic role of non-Th1 cells
    Wei Wang
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 178:7072-80. 2007
  7. ncbi request reprint CD4+ T and B cells cooperate in the immunoregulation of Experimental Autoimmune Myasthenia Gravis
    Monica Milani
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA
    J Neuroimmunol 179:152-62. 2006
  8. ncbi request reprint Epitope repertoire of Th1 and Th2 cells reactive with the mouse muscle AChR alpha subunit in C57Bl/6 mice
    Wei Wang
    Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Ann N Y Acad Sci 998:384-7. 2003
  9. ncbi request reprint Distribution of Th1- and Th2-induced anti-factor VIII IgG subclasses in congenital and acquired hemophilia patients
    Mark T Reding
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis St Paul, MN, USA
    Thromb Haemost 88:568-75. 2002
  10. ncbi request reprint Cytokine production by CD4+ T cells specific for coagulation factor VIII in healthy subjects and haemophilia A patients
    Genlin Hu
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 6 155 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
    Thromb Haemost 97:788-94. 2007

Collaborators

Detail Information

Publications15

  1. doi request reprint CD4+ T cells and cytokines in the pathogenesis of acquired myasthenia gravis
    Bianca M Conti-Fine
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 6 155 Jackson Hall, 321 Church Street, Minneapolis, MN 55455, USA
    Ann N Y Acad Sci 1132:193-209. 2008
    ..In this chapter, we will review studies on the effects on the development of acquired MG symptoms of several cytokines secreted by activated CD4(+) T cells or influencing the activation of particular CD4(+) T cell subsets...
  2. pmc Myasthenia gravis: past, present, and future
    Bianca M Conti-Fine
    Department of Biochemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Clin Invest 116:2843-54. 2006
    ..This insight has led to the development of improved diagnostic methods and to the design of specific immunosuppressive or immunomodulatory treatments...
  3. ncbi request reprint Absence of IL-4 facilitates the development of chronic autoimmune myasthenia gravis in C57BL/6 mice
    Norma Ostlie
    Department of Biochemistry, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 170:604-12. 2003
    ..These results suggest that in B6 mice, regulatory mechanisms that involve IL-4 contribute to preventing the development of a chronic Ab-mediated autoimmune response to the AChR...
  4. ncbi request reprint The susceptibility to experimental myasthenia gravis of STAT6-/- and STAT4-/- BALB/c mice suggests a pathogenic role of Th1 cells
    Wei Wang
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 321 Church Street, Minneapolis, MN 55455, USA
    J Immunol 172:97-103. 2004
    ....
  5. ncbi request reprint T cells and cytokines in the pathogenesis of acquired myasthenia gravis
    Monica Milani
    Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Ann N Y Acad Sci 998:284-307. 2003
    ..Circumstantial evidence supports a pathogenic role of IL-10 also in human MG. On the other hand, there is no direct or circumstantial evidence yet indicating a role of IL-4 in the modulatory or immunosuppressive circuits in MG...
  6. pmc C57BL/6 mice genetically deficient in IL-12/IL-23 and IFN-gamma are susceptible to experimental autoimmune myasthenia gravis, suggesting a pathogenic role of non-Th1 cells
    Wei Wang
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 178:7072-80. 2007
    ..The susceptibility of dKO mice to EAMG may be due to reduced Treg function, in the presence of a normal function of pathogenic Th17 cells...
  7. ncbi request reprint CD4+ T and B cells cooperate in the immunoregulation of Experimental Autoimmune Myasthenia Gravis
    Monica Milani
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA
    J Neuroimmunol 179:152-62. 2006
    ..Cell transfer experiments demonstrated that B and CD4+ T cells mediated the protective effect by causing intense reduction of complement-fixing anti-TAChR IgG subclasses...
  8. ncbi request reprint Epitope repertoire of Th1 and Th2 cells reactive with the mouse muscle AChR alpha subunit in C57Bl/6 mice
    Wei Wang
    Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Ann N Y Acad Sci 998:384-7. 2003
  9. ncbi request reprint Distribution of Th1- and Th2-induced anti-factor VIII IgG subclasses in congenital and acquired hemophilia patients
    Mark T Reding
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis St Paul, MN, USA
    Thromb Haemost 88:568-75. 2002
    ..Thus, synthesis of Th2-driven inhibitors occurs when the anti-fVIII Ab response is intense, while Th1 cells may be involved in the long-term maintenance of anti-fVIII Ab synthesis...
  10. ncbi request reprint Cytokine production by CD4+ T cells specific for coagulation factor VIII in healthy subjects and haemophilia A patients
    Genlin Hu
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 6 155 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
    Thromb Haemost 97:788-94. 2007
    ..The polarized high ratios of Th3/Th1 and Th3/Th2 in controls and patients without inhibitors suggest that a preponderance ofTh3 cells in the response to fVIII may help to maintain tolerance to fVIII...
  11. ncbi request reprint Adoptive protection from experimental myasthenia gravis with T cells from mice treated nasally with acetylcholine receptor epitopes
    Cristina Monfardini
    Department of Biochemistry, Molecular Biology and Biophysics, College of Biological Sciences, University of Minnesota, St Paul, MN 55108, USA
    J Neuroimmunol 123:123-34. 2002
    ..CD4(+) cells from C57Bl/6 mice treated with just one AChR peptide protected IL4(-/-) mice from EMG without affecting antibody synthesis...
  12. pmc Markedly enhanced susceptibility to experimental autoimmune myasthenia gravis in the absence of decay-accelerating factor protection
    Feng Lin
    Institute of Pathology, Case Western Reserve University, University Hospitals of Cleveland, and Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
    J Clin Invest 110:1269-74. 2002
    ....
  13. ncbi request reprint Cryptic determinants and promiscuous sequences on human acetylcholine receptor: HLA-dependent dichotomy in T-cell function
    Raghavanpillai Raju
    Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA
    Hum Immunol 63:237-47. 2002
    ....
  14. ncbi request reprint CD4(+) T cells from healthy subjects and colon cancer patients recognize a carcinoembryonic antigen-specific immunodominant epitope
    Gabriele Campi
    Experimental Immunology Unit, Cancer Immunotherapy and Gene Therapy Program, Scientific Institute H San Raffaele, 20132 Milan, Italy
    Cancer Res 63:8481-6. 2003
    ..The features of strong immunogenicity and immunodominance in the absence of potential induction of autoimmunity make the identified CEA epitope of particular interest for the development of antitumor vaccines...
  15. ncbi request reprint Identification of immunodominant regions among promiscuous HLA-DR-restricted CD4+ T-cell epitopes on the tumor antigen MAGE-3
    Giuseppe Consogno
    Laboratory of Tumor Immunology, Cancer Immunotherapy and Gene Therapy Program, Functional Proteomics Centre HRS IFOM, Universita Vita Salute San Raffaele, and MOLMED, SPA, DIBIT, Scientific Institute H San Raffaele, Milan, Italy
    Blood 101:1038-44. 2003
    ..The immunodominant epitopes identified will be useful in the design of peptide-based cancer vaccines and in the study of the functional state of tumor-specific CD4(+) T cells in patients bearing tumors expressing MAGE-3...