Michael Conte

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc D-series resolvin attenuates vascular smooth muscle cell activation and neointimal hyperplasia following vascular injury
    Takuya Miyahara
    Division of Vascular and Endovascular Surgery, University of California San Francisco, San Francisco, CA 94143 0222, USA
    FASEB J 27:2220-32. 2013
  2. pmc A single nucleotide polymorphism in the p27(Kip1) gene is associated with primary patency of lower extremity vein bypass grafts
    Michael S Conte
    Division of Vascular and Endovascular Surgery, University of California, San Francisco, San Francisco, Calif 94143, USA
    J Vasc Surg 57:1179-85.e1-2. 2013
  3. doi request reprint Critical appraisal of surgical revascularization for critical limb ischemia
    Michael S Conte
    Division of Vascular and Endovascular Surgery, University of California, San Francisco, CA 94143, USA
    J Vasc Surg 57:8S-13S. 2013
  4. doi request reprint Diabetic revascularization: endovascular versus open bypass--do we have the answer?
    Michael S Conte
    Division of Vascular and Endovascular Surgery, Heart and Vascular Center, University of California, San Francisco, San Francisco, CA 94143, USA
    Semin Vasc Surg 25:108-14. 2012
  5. doi request reprint Multicenter phase I/II trial of the safety of allogeneic endothelial cell implants after the creation of arteriovenous access for hemodialysis use: the V-HEALTH study
    Michael S Conte
    Department of Vascular and Endovascular Surgery, University of California, San Francisco, Calif, USA
    J Vasc Surg 50:1359-68.e1. 2009
  6. doi request reprint Bypass versus Angioplasty in Severe Ischaemia of the Leg (BASIL) and the (hoped for) dawn of evidence-based treatment for advanced limb ischemia
    Michael S Conte
    Division of Vascular and Endovascular Surgery and the Heart and Vascular Center, University of California San Francisco, 400 Parnassus Ave, San Francisco, CA 94143, USA
    J Vasc Surg 51:69S-75S. 2010
  7. doi request reprint Challenges of distal bypass surgery in patients with diabetes: patient selection, techniques, and outcomes
    Michael S Conte
    Division of Vascular and Endovascular Surgery, University of California San Francisco, San Francisco, CA 94143, USA
    J Vasc Surg 52:96S-103S. 2010
  8. doi request reprint Understanding objective performance goals for critical limb ischemia trials
    Michael S Conte
    Division of Vascular and Endovascular Surgery, University of California, San Francisco, 400 Parnassus Avenue, Suite A 581, San Francisco, CA 94143, USA
    Semin Vasc Surg 23:129-37. 2010
  9. ncbi request reprint Challenges of distal bypass surgery in patients with diabetes: patient selection, techniques, and outcomes
    Michael S Conte
    Division of Vascular and Endovascular Surgery, University of California, San Francisco, 400 Parnassus Ave, Ste A 581, San Francisco, CA 94143, USA
    J Am Podiatr Med Assoc 100:429-38. 2010
  10. doi request reprint Influence of diabetes and perivascular allogeneic endothelial cell implants on arteriovenous fistula remodeling
    Michael S Conte
    Division of Vascular and Endovascular Surgery, University of California, San Francisco, CA 94143 0222, USA
    J Vasc Surg 54:1383-9. 2011

Collaborators

Detail Information

Publications32

  1. pmc D-series resolvin attenuates vascular smooth muscle cell activation and neointimal hyperplasia following vascular injury
    Takuya Miyahara
    Division of Vascular and Endovascular Surgery, University of California San Francisco, San Francisco, CA 94143 0222, USA
    FASEB J 27:2220-32. 2013
    ..RvDs broadly reduce VSMC responses and modulate vascular injury, suggesting that local activation of resolution mechanisms expedites vascular homeostasis...
  2. pmc A single nucleotide polymorphism in the p27(Kip1) gene is associated with primary patency of lower extremity vein bypass grafts
    Michael S Conte
    Division of Vascular and Endovascular Surgery, University of California, San Francisco, San Francisco, Calif 94143, USA
    J Vasc Surg 57:1179-85.e1-2. 2013
    ..We hypothesized an association with vein graft patency...
  3. doi request reprint Critical appraisal of surgical revascularization for critical limb ischemia
    Michael S Conte
    Division of Vascular and Endovascular Surgery, University of California, San Francisco, CA 94143, USA
    J Vasc Surg 57:8S-13S. 2013
    ..This review summarizes some of the existing data and suggests a selective approach to revascularization in CLI, which continues to rely on vein bypass surgery as a primary option in appropriately selected patients...
  4. doi request reprint Diabetic revascularization: endovascular versus open bypass--do we have the answer?
    Michael S Conte
    Division of Vascular and Endovascular Surgery, Heart and Vascular Center, University of California, San Francisco, San Francisco, CA 94143, USA
    Semin Vasc Surg 25:108-14. 2012
    ..Vascular specialists should understand and be able to apply both types of interventions to optimize patient outcomes...
  5. doi request reprint Multicenter phase I/II trial of the safety of allogeneic endothelial cell implants after the creation of arteriovenous access for hemodialysis use: the V-HEALTH study
    Michael S Conte
    Department of Vascular and Endovascular Surgery, University of California, San Francisco, Calif, USA
    J Vasc Surg 50:1359-68.e1. 2009
    ..We conducted a phase I/II clinical study to investigate the safety of Vascugel placement around the surgical anastomotic sites of newly constructed dialysis accesses...
  6. doi request reprint Bypass versus Angioplasty in Severe Ischaemia of the Leg (BASIL) and the (hoped for) dawn of evidence-based treatment for advanced limb ischemia
    Michael S Conte
    Division of Vascular and Endovascular Surgery and the Heart and Vascular Center, University of California San Francisco, 400 Parnassus Ave, San Francisco, CA 94143, USA
    J Vasc Surg 51:69S-75S. 2010
    ..Further multicenter trials are needed to address the large gap in evidence for treatment selection in this patient population...
  7. doi request reprint Challenges of distal bypass surgery in patients with diabetes: patient selection, techniques, and outcomes
    Michael S Conte
    Division of Vascular and Endovascular Surgery, University of California San Francisco, San Francisco, CA 94143, USA
    J Vasc Surg 52:96S-103S. 2010
    ..This review summarizes the available data linking patient selection and technical factors to outcomes, and highlights the importance of surgical judgment and operative planning in the current practice of infrainguinal bypass surgery...
  8. doi request reprint Understanding objective performance goals for critical limb ischemia trials
    Michael S Conte
    Division of Vascular and Endovascular Surgery, University of California, San Francisco, 400 Parnassus Avenue, Suite A 581, San Francisco, CA 94143, USA
    Semin Vasc Surg 23:129-37. 2010
    ..These OPGs define a new set of benchmarks for assessing the performance of revascularization therapies in CLI, and should facilitate clinical trial design and device development in this arena...
  9. ncbi request reprint Challenges of distal bypass surgery in patients with diabetes: patient selection, techniques, and outcomes
    Michael S Conte
    Division of Vascular and Endovascular Surgery, University of California, San Francisco, 400 Parnassus Ave, Ste A 581, San Francisco, CA 94143, USA
    J Am Podiatr Med Assoc 100:429-38. 2010
    ..This review summarizes the available data linking patient selection and technical factors to outcomes and highlights the importance of surgical judgment and operative planning in the current practice of infrainguinal bypass surgery...
  10. doi request reprint Influence of diabetes and perivascular allogeneic endothelial cell implants on arteriovenous fistula remodeling
    Michael S Conte
    Division of Vascular and Endovascular Surgery, University of California, San Francisco, CA 94143 0222, USA
    J Vasc Surg 54:1383-9. 2011
    ..We hypothesized that providing healthy endothelial cells and their secreted factors immediately after surgery could enhance venous remodeling in the setting of vascular injury...
  11. pmc RNA interference-mediated survivin gene knockdown induces growth arrest and reduced migration of vascular smooth muscle cells
    Christoph S Nabzdyk
    Division of Vascular and Endovascular Surgery, Laboratory for Accelerated Vascular Research, University of California, San Francisco, CA 94143, USA
    Am J Physiol Heart Circ Physiol 301:H1841-9. 2011
    ..Thus, treatment of VSMC with RNAi targeting SVV might limit the response to vascular injury without destabilizing the vessel wall...
  12. doi request reprint Suggested objective performance goals and clinical trial design for evaluating catheter-based treatment of critical limb ischemia
    Michael S Conte
    Division of Vascular and Endovascular Surgery, University of California, San Francisco, Calif, USA
    J Vasc Surg 50:1462-73.e1-3. 2009
    ..To develop a set of suggested objective performance goals (OPG) for evaluating new catheter-based treatments in critical limb ischemia (CLI), based on evidence from historical controls...
  13. ncbi request reprint Comparative analysis of autogenous infrainguinal bypass grafts in African Americans and Caucasians: the association of race with graft function and limb salvage
    David K Chew
    Division of Vascular and Endovascular Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Vasc Surg 42:695-701. 2005
    ..The purpose of this study was to compare the results of autogenous infrainguinal bypasses in AAs and Caucasians to determine the association of race with graft function and limb salvage...
  14. ncbi request reprint Technical factors affecting autogenous vein graft failure: observations from a large multicenter trial
    Andres Schanzer
    Division of Vascular and Endovascular Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Vasc Surg 46:1180-90; discussion 1190. 2007
    ..We utilized data from a prospective, multicenter trial to identify technical variables that were significantly associated with early and midterm results of autogenous LEB for limb salvage...
  15. doi request reprint Technical factors in lower-extremity vein bypass surgery: how can we improve outcomes?
    Michael S Conte
    Division of Vascular and Endovascular Surgery, University of California, San Francisco, CA 94143, USA
    Semin Vasc Surg 22:227-33. 2009
    ..This review summarizes the data linking technical factors with graft patency, highlighting the importance of surgical judgment and operative planning in the current practice of infrainguinal bypass surgery...
  16. ncbi request reprint Molecular engineering of vein bypass grafts
    Michael S Conte
    Department of Vascular and Endovascular Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Vasc Surg 45:A74-81. 2007
    ..A better understanding of the remodeling response of vein grafts in humans is required to design effective molecular therapies and to define the appropriate target populations and surrogate markers for future clinical trials...
  17. pmc Disparity in outcomes of surgical revascularization for limb salvage: race and gender are synergistic determinants of vein graft failure and limb loss
    Louis L Nguyen
    Division of Vascular and Endovascular Surgery, University of California San Francisco Medical Center, San Francisco, CA 94143 0222, USA
    Circulation 119:123-30. 2009
    ..In particular, the relationship of race/ethnicity and gender to the outcomes of peripheral bypass surgery has been controversial...
  18. doi request reprint Lower extremity vein graft failure: a translational approach
    Christopher D Owens
    Division of Vascular and Endovascular Surgery, Brigham and Womens Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Vasc Med 13:63-74. 2008
    ..This article reviews the definition and diagnosis of vein graft failure and summarizes our current efforts to understand the mechanisms of normal and abnormal vein graft adaptation to the arterial environment...
  19. doi request reprint Statins are independently associated with reduced mortality in patients undergoing infrainguinal bypass graft surgery for critical limb ischemia
    Andres Schanzer
    Division of Vascular and Endovascular Surgery, University of Massachusetts, Worcester, MA, USA
    J Vasc Surg 47:774-781. 2008
    ..Patients with critical limb ischemia (CLI) have a large atherosclerotic burden with related high mortality. The effect of such therapies in this population is largely inferred and unproven...
  20. pmc Novel adipokines, high molecular weight adiponectin and resistin, are associated with outcomes following lower extremity revascularization with autogenous vein
    Christopher D Owens
    Division of Vascular and Endovascular Surgery, University of California, San Francisco, Calif, USA
    J Vasc Surg 51:1152-9. 2010
    ..We hypothesized that serum biomarkers of insulin resistance and inflammation would identify a subgroup at elevated risk for graft failure, limb loss, and mortality...
  21. pmc In vivo human lower extremity saphenous vein bypass grafts manifest flow mediated vasodilation
    Christopher D Owens
    Division of Vascular and Endovascular Surgery, University of California San Francisco, San Francisco, CA 94143 0222, USA
    J Vasc Surg 50:1063-70. 2009
    ..We hypothesized that mature SVGs would exhibit endothelium-dependent, flow-mediated vasodilation (FMD). We further hypothesized that endothelium-derived nitric oxide (NO) was an important mediator...
  22. pmc Endothelial function predicts positive arterial-venous fistula remodeling in subjects with stage IV and V chronic kidney disease
    Christopher D Owens
    Division of Vascular and Endovascular Surgery, University of California, San Francisco, CA 94143 0222, USA
    J Vasc Access 11:329-34. 2010
    ..However, factors influencing remodeling of AVF are poorly understood. We hypothesized that AVF remodeling was an endothelium-dependent process...
  23. doi request reprint Risk factors for failure of lower-extremity revascularization procedures: are they different for bypass and percutaneous procedures?
    Christopher D Owens
    Division of Vascular and Endovascular Surgery, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, USA
    Semin Vasc Surg 21:143-53. 2008
    ....
  24. ncbi request reprint Thoracovisceral segment aneurysm repair after previous infrarenal abdominal aortic aneurysm surgery
    Matthew T Menard
    Division of Vascular and Endovascular Surgery, Department of Surgery, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    J Vasc Surg 39:1163-70. 2004
    ..We sought to better characterize such recurrent aneurysms and to evaluate their operative outcome...
  25. ncbi request reprint Resource utilization in the treatment of critical limb ischemia: The effect of tissue loss, comorbidities, and graft-related events
    Louis L Nguyen
    Division of Vascular and Endovascular Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Vasc Surg 44:971-5; discussion 975-6. 2006
    ..We present a cohort study to quantify in-hospital RU and analyze the role of tissue loss (TL), comorbidities, and vascular graft-related events (GREs) in patients undergoing peripheral bypass for CLI...
  26. doi request reprint Clinical results of carotid artery stenting compared with carotid endarterectomy
    Soma Brahmanandam
    Division of Vascular and Endovascular Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Vasc Surg 47:343-9. 2008
    ..We conducted a systematic review and meta-analysis of the clinical trials to date comparing these two procedures to determine their relative safety and efficacy...
  27. pmc C-reactive protein and vein graft disease: evidence for a direct effect on smooth muscle cell phenotype via modulation of PDGF receptor-beta
    Karen J Ho
    Division of Vascular and Endovascular Surgery, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Physiol Heart Circ Physiol 295:H1132-H1140. 2008
    ..Clinically relevant levels of CRP can stimulate SMC migration by a mechanism that may involve upregulation and activation of PDGFRbeta...
  28. ncbi request reprint Carotid endarterectomy: who is the high-risk patient?
    Louis L Nguyen
    Division of Vascular and Endovascular Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 01115, USA
    Semin Vasc Surg 17:219-23. 2004
    ..Truly "high-risk" patients with shortened life expectancy are best served with no intervention...
  29. pmc Mineralocorticoid receptor expression in human venous smooth muscle cells: a potential role for aldosterone signaling in vein graft arterialization
    Richard Bafford
    Div of Vascular and Endovascular Surgery, Univ of California San Francisco, 400 Parnassus Ave, Ste A581, San Francisco, CA 94143 0222, USA
    Am J Physiol Heart Circ Physiol 301:H41-7. 2011
    ..The upregulation of MR and 11╬▓HSD2 suggests that aldosterone-mediated tissue injury plays a role in vein graft arterialization...
  30. ncbi request reprint Edifoligide: a transcription factor decoy to modulate smooth muscle cell proliferation in vein bypass
    Andrew W Hoel
    Division of Vascular and Endovascular Surgery, Brigham and Women s Hospital, Boston, MA 02115, USA
    Cardiovasc Drug Rev 25:221-34. 2007
    ..In this review we address the rationale for targeting E2F in vascular disease, the pharmacology of edifoligide, and the results of preclinical and clinical studies using this novel compound...
  31. ncbi request reprint Lower-extremity arterial disease
    Leslie D Cunningham
    Division of Vascular and Endovascular Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Perspect Vasc Surg Endovasc Ther 17:351-61. 2005
    ..Embolic and aneurysmal diseases of the lower-extremity arteries are also briefly reviewed. All surgeons should be aware of these common conditions and their applicable management strategies...

Research Grants2