J E Conte

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Intrapulmonary concentrations of pyrazinamide
    J E Conte
    Infectious Diseases Research Laboratory, Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California 94143 0208, USA
    Antimicrob Agents Chemother 43:1329-33. 1999
  2. pmc Intrapulmonary pharmacokinetics of linezolid
    John E Conte
    Infectious Diseases Research Group, Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California 94143 0919, USA
    Antimicrob Agents Chemother 46:1475-80. 2002
  3. pmc Effects of gender, AIDS, and acetylator status on intrapulmonary concentrations of isoniazid
    John E Conte
    Infectious Diseases Research Laboratory, Department of Epidemiology and Biostatistics, University of California San Francisco, 350 Parnassus Avenue, Suite 507, San Francisco, CA 94117, USA
    Antimicrob Agents Chemother 46:2358-64. 2002
  4. pmc Effects of AIDS and gender on steady-state plasma and intrapulmonary ethionamide concentrations
    J E Conte
    Infectious Diseases Research Laboratory, Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94143 0208, USA
    Antimicrob Agents Chemother 44:1337-41. 2000
  5. ncbi request reprint High-performance liquid chromatographic-tandem mass spectrometric method for the determination of ethionamide in human plasma, bronchoalveolar lavage fluid and alveolar cells
    J E Conte
    Department of Epidemiology and Biostatistics, University of California, San Francisco, 94117, USA
    J Chromatogr B Biomed Sci Appl 753:343-53. 2001
  6. pmc Effects of AIDS and gender on steady-state plasma and intrapulmonary ethambutol concentrations
    J E Conte
    Infectious Diseases Research Laboratory, Department of Epidemiology and Biostatistics, University of California San Francisco, 350 Parnassus Ave, San Francisco, CA 94117, USA
    Antimicrob Agents Chemother 45:2891-6. 2001
  7. ncbi request reprint Prevention of Pneumocystis carinii pneumonia by inhaled pentamidine
    J A Golden
    Department of Medicine, School of Medicine, University of California, San Francisco
    Lancet 1:654-7. 1989
  8. ncbi request reprint Steady-state serum and intrapulmonary pharmacokinetics and pharmacodynamics of tigecycline
    John E Conte
    Infectious Diseases Research Group, Department of Epidemiology and Biostatistics, University of California San Francisco, 500 Parnassus Avenue, Box 560, San Francisco, CA 94117, USA
    Int J Antimicrob Agents 25:523-9. 2005
  9. ncbi request reprint Intrapulmonary pharmacokinetics and pharmacodynamics of meropenem
    John E Conte
    Department of Epidemiology and Biostatistics, Infectious Diseases Research Group, University of California at San Francisco, San Francisco, CA 94143 0919, USA
    Int J Antimicrob Agents 26:449-56. 2005
  10. ncbi request reprint Intrapulmonary pharmacokinetics and pharmacodynamics of high-dose levofloxacin in healthy volunteer subjects
    John E Conte
    Department of Epidemiology and Biostatistics, Infectious Diseases Research Group, University of California at San Francisco, San Francisco, CA 94143 0919, USA
    Int J Antimicrob Agents 28:114-21. 2006

Collaborators

  • E L Kaplan
  • Qiulei Ren
  • Anthony Kakis
  • Elisabeth Zurlinden
  • Emil T Lin
  • Dennis Stevens
  • Laurel Gibbs
  • Joe Kimura
  • Nancy Troup
  • Diane Vogelei
  • Jose Eguia
  • Dwight R Johnson
  • J A Golden
  • D Feigal
  • D Chernoff
  • H Hollander

Detail Information

Publications17

  1. pmc Intrapulmonary concentrations of pyrazinamide
    J E Conte
    Infectious Diseases Research Laboratory, Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California 94143 0208, USA
    Antimicrob Agents Chemother 43:1329-33. 1999
    ..The high concentration of pyrazinamide in ELF may contribute in part to the effectiveness of the drug in treating pulmonary tuberculosis...
  2. pmc Intrapulmonary pharmacokinetics of linezolid
    John E Conte
    Infectious Diseases Research Group, Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California 94143 0919, USA
    Antimicrob Agents Chemother 46:1475-80. 2002
    ....
  3. pmc Effects of gender, AIDS, and acetylator status on intrapulmonary concentrations of isoniazid
    John E Conte
    Infectious Diseases Research Laboratory, Department of Epidemiology and Biostatistics, University of California San Francisco, 350 Parnassus Avenue, Suite 507, San Francisco, CA 94117, USA
    Antimicrob Agents Chemother 46:2358-64. 2002
    ..The optimal concentrations of isoniazid in ACs and ELF are unknown, but these data suggest that the drug enters these compartments by passive diffusion and achieves concentrations similar to those found in plasma...
  4. pmc Effects of AIDS and gender on steady-state plasma and intrapulmonary ethionamide concentrations
    J E Conte
    Infectious Diseases Research Laboratory, Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA 94143 0208, USA
    Antimicrob Agents Chemother 44:1337-41. 2000
    ..Ethionamide concentrations were significantly greater in ELF than in plasma or AC, suggesting that substantial antimycobacterial activity resides in this compartment...
  5. ncbi request reprint High-performance liquid chromatographic-tandem mass spectrometric method for the determination of ethionamide in human plasma, bronchoalveolar lavage fluid and alveolar cells
    J E Conte
    Department of Epidemiology and Biostatistics, University of California, San Francisco, 94117, USA
    J Chromatogr B Biomed Sci Appl 753:343-53. 2001
    ..Manchester, UK). The detection limits for ethionamide were 0.05 microg/ml for plasma, and 0.005 microg/ml for BAL supernatants and alveolar cell suspensions...
  6. pmc Effects of AIDS and gender on steady-state plasma and intrapulmonary ethambutol concentrations
    J E Conte
    Infectious Diseases Research Laboratory, Department of Epidemiology and Biostatistics, University of California San Francisco, 350 Parnassus Ave, San Francisco, CA 94117, USA
    Antimicrob Agents Chemother 45:2891-6. 2001
    ..The high AC/plasma and AC/ELF concentration ratios suggest that substantial antimycobacterial activity resides in these cells. The data confirm earlier observations of active transport ex vivo of ethambutol into pulmonary macrophages...
  7. ncbi request reprint Prevention of Pneumocystis carinii pneumonia by inhaled pentamidine
    J A Golden
    Department of Medicine, School of Medicine, University of California, San Francisco
    Lancet 1:654-7. 1989
    ..PCP acquired while patients were inhaling pentamidine prophylactically was mild and had a case-fatality rate of only 9%. Further investigation of the prophylactic value of inhaled pentamidine is warranted...
  8. ncbi request reprint Steady-state serum and intrapulmonary pharmacokinetics and pharmacodynamics of tigecycline
    John E Conte
    Infectious Diseases Research Group, Department of Epidemiology and Biostatistics, University of California San Francisco, 500 Parnassus Avenue, Box 560, San Francisco, CA 94117, USA
    Int J Antimicrob Agents 25:523-9. 2005
    ..The C(max)/MIC(90), AUC/MIC(90) ratios, T>MIC(90) and extended serum and intrapulmonary half-lives following the regimen used in this study are favourable for the treatment of tigecycline-susceptible pulmonary infections...
  9. ncbi request reprint Intrapulmonary pharmacokinetics and pharmacodynamics of meropenem
    John E Conte
    Department of Epidemiology and Biostatistics, Infectious Diseases Research Group, University of California at San Francisco, San Francisco, CA 94143 0919, USA
    Int J Antimicrob Agents 26:449-56. 2005
    ..The prolonged T > MIC90 and high intrapulmonary drug concentrations following every 8 h administration of 0.5-2.0 g doses of meropenem are favourable for the treatment of common respiratory pathogens...
  10. ncbi request reprint Intrapulmonary pharmacokinetics and pharmacodynamics of high-dose levofloxacin in healthy volunteer subjects
    John E Conte
    Department of Epidemiology and Biostatistics, Infectious Diseases Research Group, University of California at San Francisco, San Francisco, CA 94143 0919, USA
    Int J Antimicrob Agents 28:114-21. 2006
    ..The C(max)/MIC(90) and AUC/MIC(90) ratios provide a pharmacokinetic rationale for once-daily administration of a 1000 mg dose of levofloxacin and are favourable for the treatment of community-acquired respiratory pathogens...
  11. pmc Intrapulmonary pharmacokinetics and pharmacodynamics of itraconazole and 14-hydroxyitraconazole at steady state
    John E Conte
    University of California, San Francisco, 350 Parnassus Ave, Suite 507, San Francisco, CA 94117, USA
    Antimicrob Agents Chemother 48:3823-7. 2004
    ..i.d. results in concentrations of ITRA and OH-ITRA in AC that are significantly greater than those in plasma or ELF and intrapulmonary pharmacodynamics that are favorable for the treatment of fungal respiratory infection...
  12. pmc Steady-state plasma and intrapulmonary pharmacokinetics and pharmacodynamics of cethromycin
    John E Conte
    Infectious Diseases Research Group, Department of Epidemiology and Biostatistics, University of California, San Francisco, 350 Parnassus Ave, Suite 507, San Francisco, CA 94117, USA
    Antimicrob Agents Chemother 48:3508-15. 2004
    ....
  13. ncbi request reprint Effect of sex and AIDS status on the plasma and intrapulmonary pharmacokinetics of rifampicin
    John E Conte
    Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, USA
    Clin Pharmacokinet 43:395-404. 2004
    ..To compare the steady-state plasma and intrapulmonary concentrations of oral rifampicin (rifampin) in men and women with and without AIDS...
  14. ncbi request reprint A high-performance liquid chromatographic-tandem mass spectrometric method for the determination of cethromycin (ABT-773) in human plasma, bronchoalveolar lavage fluid, and alveolar cells
    Qiulei Ren
    Department of Biopharmaceutical Sciences, University of California, San Francisco, San Francisco, CA 94117, USA
    J Chromatogr Sci 41:494-9. 2003
    ..2 ng/mL for BAL supernatants and AC suspensions. The assay has excellent performance characteristics and has been used to support a study of the intrapulmonary pharmacokinetics of cethromycin in human subjects...
  15. ncbi request reprint Intrapulmonary pharmacodynamics of high-dose levofloxacin in subjects with chronic bronchitis or chronic obstructive pulmonary disease
    John E Conte
    Infectious Diseases Research Group, Department of Epidemiology and Biostatistics, University of California at San Francisco, 901F Health Sciences East, 513 Parnassus Avenue, San Francisco, CA 94143 0919, USA
    Int J Antimicrob Agents 30:422-7. 2007
    ....
  16. ncbi request reprint A high-pressure liquid chromatographic-tandem mass spectrometric method for the determination of ethambutol in human plasma, bronchoalveolar lavage fluid, and alveolar cells
    John E Conte
    Department of Epidemiology and Biostatistics, Infectious Diseases Research Laboratory, University of California, San Francisco, 94117, USA
    J Chromatogr Sci 40:113-8. 2002
    ..005 microg/mL for the BAL supernatants and AC suspensions. The assay has excellent performance characteristics and has been used to support a study of the intrapulmonary pharmacokinetics of ethambutol in human subjects...
  17. ncbi request reprint An outbreak of group A Streptococcal infection among health care workers
    Anthony Kakis
    Department of Hospital Epidemiology and Infection Control, University of California San Francisco Medical Center, San Francisco, CA 94117, USA
    Clin Infect Dis 35:1353-9. 2002
    ..Invasive GAS disease in a nosocomial setting can be highly transmissible. Rapid identification, early treatment, and adherence to infection-control practices may prevent or control outbreaks of infection...