Sean Conner

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi request reprint CVAK104 is a novel poly-L-lysine-stimulated kinase that targets the beta2-subunit of AP2
    Sean D Conner
    Department of Genetics, Cell Biology, and Development, The University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 280:21539-44. 2005
  2. doi request reprint AAK1 regulates Numb function at an early step in clathrin-mediated endocytosis
    Erika B Sorensen
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Traffic 9:1791-800. 2008
  3. pmc A novel AAK1 splice variant functions at multiple steps of the endocytic pathway
    Davin M Henderson
    Department of Genetics, University of Minnesota, Minneapolis, MN 55455, USA
    Mol Biol Cell 18:2698-706. 2007
  4. pmc Identification of an adaptor-associated kinase, AAK1, as a regulator of clathrin-mediated endocytosis
    Sean D Conner
    The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Biol 156:921-9. 2002
  5. ncbi request reprint AAK1-mediated micro2 phosphorylation is stimulated by assembled clathrin
    Sean D Conner
    The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Traffic 4:885-90. 2003
  6. pmc Phosphorylation of the AP2 mu subunit by AAK1 mediates high affinity binding to membrane protein sorting signals
    Doris Ricotta
    Institute for Biochemistry II, University of Gottingen, 37073 Gottingen, Germany
    J Cell Biol 156:791-5. 2002
  7. ncbi request reprint Regulated portals of entry into the cell
    Sean D Conner
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nature 422:37-44. 2003
  8. pmc Differential requirements for AP-2 in clathrin-mediated endocytosis
    Sean D Conner
    The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Biol 162:773-9. 2003

Collaborators

  • S L Schmid
  • Erika B Sorensen
  • Davin M Henderson
  • Doris Ricotta
  • Kurt von Figura
  • Stefan Honing

Detail Information

Publications8

  1. ncbi request reprint CVAK104 is a novel poly-L-lysine-stimulated kinase that targets the beta2-subunit of AP2
    Sean D Conner
    Department of Genetics, Cell Biology, and Development, The University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 280:21539-44. 2005
    ..CVAK104 binds ATP, and kinase assays indicate that it functions in vitro as a poly-L-lysine-stimulated kinase that is capable of autophosphorylation and phosphorylating the beta2-adaptin subunit of AP2...
  2. doi request reprint AAK1 regulates Numb function at an early step in clathrin-mediated endocytosis
    Erika B Sorensen
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Traffic 9:1791-800. 2008
    ..Collectively, these observations demonstrate that Numb endocytic activity is regulated by AAK1 and that phosphorylation may be a critical step in promoting coated pit maturation...
  3. pmc A novel AAK1 splice variant functions at multiple steps of the endocytic pathway
    Davin M Henderson
    Department of Genetics, University of Minnesota, Minneapolis, MN 55455, USA
    Mol Biol Cell 18:2698-706. 2007
    ..These observations suggest that AAK1 functions at multiple steps of the endosomal pathway by regulating transferrin internalization and its rapid recycling back to the plasma membrane from early/sorting endosome...
  4. pmc Identification of an adaptor-associated kinase, AAK1, as a regulator of clathrin-mediated endocytosis
    Sean D Conner
    The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Biol 156:921-9. 2002
    ..These results also lend support to the idea that clathrin-mediated endocytosis is controlled by cycles of phosphorylation/desphosphorylation...
  5. ncbi request reprint AAK1-mediated micro2 phosphorylation is stimulated by assembled clathrin
    Sean D Conner
    The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Traffic 4:885-90. 2003
    ..We suggest a model in which AAK1 is specifically activated in coated pits to enhance cargo recruitment and efficient internalization...
  6. pmc Phosphorylation of the AP2 mu subunit by AAK1 mediates high affinity binding to membrane protein sorting signals
    Doris Ricotta
    Institute for Biochemistry II, University of Gottingen, 37073 Gottingen, Germany
    J Cell Biol 156:791-5. 2002
    ..We propose that phosphorylation of the AP2 mu 2 subunit by AAK1 ensures high affinity binding of AP2 to sorting signals of cargo membrane proteins during the initial steps of receptor-mediated endocytosis...
  7. ncbi request reprint Regulated portals of entry into the cell
    Sean D Conner
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nature 422:37-44. 2003
    ....
  8. pmc Differential requirements for AP-2 in clathrin-mediated endocytosis
    Sean D Conner
    The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Biol 162:773-9. 2003
    ..Surprisingly, clathrin distribution and EGF uptake were unaffected by AAK1 overexpression. Thus, AP-2 may not be stoichiometrically required for coat assembly, and may have a more cargo-selective function in CME than previously thought...

Research Grants2

  1. The Role of Adaptor Protein Phosphorylation in Regulating Receptor Transport
    Sean D Conner; Fiscal Year: 2010
    ..Public Health Relevance: This project seeks to better define how the liver regulates cholesterol removal from the blood by understanding the key events that control the uptake machinery. ..