J M Conner

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Characterization of antibodies to nerve growth factor: assay-dependent variability in the cross-reactivity with other neurotrophins
    J M Conner
    Department of Biology, University of California at San Diego, La Jolla 92093 0506, USA
    J Neurosci Methods 65:93-9. 1996
  2. ncbi request reprint The basal forebrain cholinergic system is essential for cortical plasticity and functional recovery following brain injury
    James M Conner
    Department of Neurosciences, Unviersity of California, La Jolla, California 92093, USA
    Neuron 46:173-9. 2005
  3. ncbi request reprint Lesions of the Basal forebrain cholinergic system impair task acquisition and abolish cortical plasticity associated with motor skill learning
    James M Conner
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA
    Neuron 38:819-29. 2003
  4. ncbi request reprint Developmental profile of NGF immunoreactivity in the rat brain: a possible role of NGF in the establishment of cholinergic terminal fields in the hippocampus and cortex
    J M Conner
    Department of Biology, University of California, San Diego, La Jolla 92093, USA
    Brain Res Dev Brain Res 101:67-79. 1997
  5. pmc Unique contributions of distinct cholinergic projections to motor cortical plasticity and learning
    J M Conner
    Department of Neurosciences, University of California San Diego, La Jolla, CA 92093 0626, USA
    Cereb Cortex 20:2739-48. 2010
  6. doi request reprint The basal forebrain cholinergic system is required specifically for behaviorally mediated cortical map plasticity
    Dhakshin Ramanathan
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093 0626, USA
    J Neurosci 29:5992-6000. 2009
  7. pmc A form of motor cortical plasticity that correlates with recovery of function after brain injury
    Dhakshin Ramanathan
    Department of Neurosciences, University of California at San Diego, La Jolla, CA 92093 0626, USA
    Proc Natl Acad Sci U S A 103:11370-5. 2006
  8. ncbi request reprint Distribution of brain-derived neurotrophic factor (BDNF) protein and mRNA in the normal adult rat CNS: evidence for anterograde axonal transport
    J M Conner
    Department of Biology, 0506, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 17:2295-313. 1997
  9. pmc Nontropic actions of neurotrophins: subcortical nerve growth factor gene delivery reverses age-related degeneration of primate cortical cholinergic innervation
    J M Conner
    Department of Neurosciences, University of California at San Diego, La Jolla, CA 92093-0626, USA
    Proc Natl Acad Sci U S A 98:1941-6. 2001
  10. ncbi request reprint Nerve growth factor (NGF) content in adult rat brain tissues is several-fold higher than generally reported and is largely associated with sedimentable fractions
    M C Hoener
    Department of Biology 0506, University of California San Diego, La Jolla 92093, USA
    Brain Res 728:47-56. 1996

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Characterization of antibodies to nerve growth factor: assay-dependent variability in the cross-reactivity with other neurotrophins
    J M Conner
    Department of Biology, University of California at San Diego, La Jolla 92093 0506, USA
    J Neurosci Methods 65:93-9. 1996
    ..These data strongly argue against transferring cross-reactivity data across various assay systems...
  2. ncbi request reprint The basal forebrain cholinergic system is essential for cortical plasticity and functional recovery following brain injury
    James M Conner
    Department of Neurosciences, Unviersity of California, La Jolla, California 92093, USA
    Neuron 46:173-9. 2005
    ..These findings raise the intriguing possibility that deficits in cholinergic function may limit functional outcomes following nervous system injury...
  3. ncbi request reprint Lesions of the Basal forebrain cholinergic system impair task acquisition and abolish cortical plasticity associated with motor skill learning
    James M Conner
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA
    Neuron 38:819-29. 2003
    ..These results support the hypothesis that the basal forebrain cholinergic system may be specifically implicated in forms of learning requiring plasticity of cortical representations...
  4. ncbi request reprint Developmental profile of NGF immunoreactivity in the rat brain: a possible role of NGF in the establishment of cholinergic terminal fields in the hippocampus and cortex
    J M Conner
    Department of Biology, University of California, San Diego, La Jolla 92093, USA
    Brain Res Dev Brain Res 101:67-79. 1997
    ..Thus, the results of the current investigation clearly identify the presence of transiently occurring zones of NGF-ir during postnatal CNS development, although defining their exact functional role will require additional investigation...
  5. pmc Unique contributions of distinct cholinergic projections to motor cortical plasticity and learning
    J M Conner
    Department of Neurosciences, University of California San Diego, La Jolla, CA 92093 0626, USA
    Cereb Cortex 20:2739-48. 2010
    ..More globally acting cholinergic mechanisms provide additional support for the acquisition of skilled motor behaviors, beyond those associated with cortical map reorganization...
  6. doi request reprint The basal forebrain cholinergic system is required specifically for behaviorally mediated cortical map plasticity
    Dhakshin Ramanathan
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093 0626, USA
    J Neurosci 29:5992-6000. 2009
    ....
  7. pmc A form of motor cortical plasticity that correlates with recovery of function after brain injury
    Dhakshin Ramanathan
    Department of Neurosciences, University of California at San Diego, La Jolla, CA 92093 0626, USA
    Proc Natl Acad Sci U S A 103:11370-5. 2006
    ..This evidence suggests the existence of complex movement representations in the rat motor cortex that exhibit plasticity after injury and rehabilitation, serving as a relevant predictor of functional recovery...
  8. ncbi request reprint Distribution of brain-derived neurotrophic factor (BDNF) protein and mRNA in the normal adult rat CNS: evidence for anterograde axonal transport
    J M Conner
    Department of Biology, 0506, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 17:2295-313. 1997
    ....
  9. pmc Nontropic actions of neurotrophins: subcortical nerve growth factor gene delivery reverses age-related degeneration of primate cortical cholinergic innervation
    J M Conner
    Department of Neurosciences, University of California at San Diego, La Jolla, CA 92093-0626, USA
    Proc Natl Acad Sci U S A 98:1941-6. 2001
    ..e., administration of growth factors to cholinergic somata significantly increases axon density in terminal fields). These findings are relevant to potential clinical uses of growth factors to treat neurological disorders...
  10. ncbi request reprint Nerve growth factor (NGF) content in adult rat brain tissues is several-fold higher than generally reported and is largely associated with sedimentable fractions
    M C Hoener
    Department of Biology 0506, University of California San Diego, La Jolla 92093, USA
    Brain Res 728:47-56. 1996
    ..Further studies should clarify the nature of the association between NGF and the three subsets of pellet NGF and allow the investigation of the pellet molecules responsible for it...
  11. ncbi request reprint Modulation of neuronal survival and axonal growth in vivo by tetracycline-regulated neurotrophin expression
    A Blesch
    Department of Neurosciences-0626, University of California, San Diego, La Jolla, CA 92093-0626, USA
    Gene Ther 8:954-60. 2001
    ..These data constitute the first report of regulated neuronal rescue and axonal growth by controlled neurotrophin gene delivery and long-term, regulated expression using ex vivo CNS gene therapy...
  12. pmc NGF is essential for hippocampal plasticity and learning
    James M Conner
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 29:10883-9. 2009
    ..These findings reveal an essential role for NGF in regulating biological mechanisms related to plasticity and memory in the intact adult brain...
  13. pmc Long-term reversal of cholinergic neuronal decline in aged non-human primates by lentiviral NGF gene delivery
    Alan H Nagahara
    Department of Neurosciences 0626, University of California San Diego, La Jolla, California 92093, USA
    Exp Neurol 215:153-9. 2009
    ..These findings also support the safety and feasibility of lentiviral NGF gene transfer for potential testing in human clinical trials to protect degenerating cholinergic neurons in Alzheimer's disease...
  14. pmc Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury
    Laura Taylor Alto
    Department of Neurosciences, University of California, San Diego, La Jolla, California, USA
    Nat Neurosci 12:1106-13. 2009
    ..Thus, we report for the first time, to the best of our knowledge, the reinnervation of brainstem targets after SCI and an essential role for chemotropic axon guidance in target selection...